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COVID-19 prevention measures

Beware fake cures: "for every complex problem there is an answer that is clear, simple, and wrong." ~H L Menken

For the latest list of snake oil type of recommendations and cures see The Coronavirus Collection Prevention and Treatments - Snopes.com

News COVID-19 Epidemic Recommended Links  COVID-19 epidemic handing in the USA The threat of "Coronavirus recession" COVID-19 hoarding epidemics COVID-19 as a bioweapon hypothisis
COVID-19 fearmongering COVID-19 epidemic as the second stage of the crisis of neoliberalism   Absurdity of bureaucracies US Presidential Elections of 2020 Trump's impulsivity and incompetence The Real War on Reality
Media as a weapon of mass deception  Stability is destabilizing: The idea of Minsky moment Manufactured consent Groupthink The importance of controlling the narrative Trumpcare scam Nation under attack meme
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Despite the regime of self isolation, you need additional physical load to prepare for the infection. In this sense walking is less efficient then running, biking, paying tennis/badmin, or swimming for training your lungs and heart, but of course better then nothing.  At least, walking outside  increases the level of vitamin D due to expose to the sun. Which to a certain extent determines the efficiency of your immune response to the infection. which decline in winter months.

Also standard hygienic measures allow to lessen the virus load which acts somewhat similar to the the dose of radiation; the higher the load the more chances you have to develop pneumonia.

With respiratory diseases no matter what level of precautions you adopt the question for people who are susceptible is not if you get it, but when. You need either be vaccinated, or infected and recover from the virus.  If you are susceptible, you simply can't escape your fate "in a long run". But, first of all,  not all people are susceptible to this virus. Among passengers and crew of Diamond Princess only 20% were susceptible despite large virus load typical for ship environment.  Similar picture can be found on the other cruise ships and USS Theodor Roosevelt. 

Also self-isolation can postpone infection until better methods treating the disease are found. What we will probably get is the temporary decline of epidemic in a month or two and then possibly the second, less drastic, wave starting from November-December.  Look at  the Hispanic Flu propagation: it was in three waves with the second wave being the most devastating.  The most victims were young people. For COVID-19 the main category of victims are old and frail people (especially 70+). 

Along with the status of your immune system, the health and excess volume of your lungs are two factors that determine whether you will survive acute form of  pneumonia in case of infection (or whatever this condition is -- is not very clear what it is ). But again, most people just get acute bronchitis type of disease. In this sense swimmers, singers, runners and serious badminton/tennis or similar sports players have a distinct advantage.  

https://www.webmd.com/lung/what-does-covid-do-to-your-lungs#1

Other then known "generic" facts it is not clear why some people get severe cases  while other do not.  And that's the most important question to answer. Looks like in play are such factors as your  sex, age, medications you take, arterial pressure, blood group, and chronic conditions (especially cardiovascular, being overweight, and diabetis ), if any. Some like taking ACE medication for arterial pressure have significant influence on the outcome.  For obvious reasons cardiovascular diseases diminish your chances to survive as soon as you get pneumonia as this is a stress for the cardiovascular system.

Virus load definitely have a huge influence -- people with high virus load (medical workers) typically get more serious form of COVID-19.   People who take ACE inhibitors for arterial pressure might also be especially vulnerable and more often get severe forms.

It looks like younger people who do not smoke and exercise have some advantage (there are contradictory data that smokers are more affected but more rarely  get into severe levels of the disease) , although after 50-55  this advantage diminishes for men, as immune system became less and less efficient each year. Women of the same age are in better shape in this respect.   And generally constitute only around 33% of all patients. 

I hope that methods of treating this virus pneumonia will improve in a couple of months so winning the time before you get sick is very important.  In this sense, CDC is completely dysfunctional organization as it could get direct information from Korea autopsies and treatments. That was not done.

Add to this corruption and perverse incentives (hospitals get  more money putting you on ventilator, despite some evidence that it is not optimal way to treat COVID-19 and in most case oxygen is enough)

For example, there is some information that usage of ventilators actually worsen the prognosis for the severe cases of COVID-19 due to the additional damage to the lungs. It looks like oxygen-only treatment and less invasive methods are a better deal.

The disease is very nasty even in medium form. There are somewhat interesting interview with those those suffered from COVID-19 which gives you some clues what to expect:

One recent hypothesis that I have read is the virus among other thing attacks hemoglobin in blood (like malaria) and essentially  put you in conditions of high altitude living. If this is true, then NY Governor Cuomo quest for 40K ventilators is deeply misguided.  That's probably why anti-malarial drugs are somewhat effective  for treating COVID-19.  But this is still a pure speculation.

NOTE: In France, the sudden loss of smell is considered proof of Covid-19 infection, no further tests required

It is interesting how vulnerable modern interconnected society is to such viruses, despite all the progress in genomics. This virus actually in an extremely clever virus as it has long incubation period and hit hard only around 7% of infected. All others spread it while sick (around three weeks I think) but personally do not experience much inconvenience.  There are also rumors about the existence of a completely "asymptomatic" patients. But even if such exists they are a very small percentage of infected. Some (often minor) symptoms usually are present. Can asymptomatic patients transmit the virus is unclear and some researchers say that yes they can. If true this makes this epidemic almost impossible to contain. But I hope that this is false.

This infection is transmitted mostly from an infected person with symptoms like with cough of sneezing via aerosol with viruses and occurs in closed space (churches proved to be an idea place for spreading the infection), or at densely packed spaces outside (stadiums, lines, festivals, etc) over 80% of infected were infected in family settings. 

So wearing masks in public places is a necessary precaution. As here we are talking not about filtering of the viruses but about filtering of droplets. In this sense any mask is OK but of course it is not hermetic and decrease your chances to be infected five times or more. And if you are infected it prevent you from infecting many other people. 

For 93% of infected this is like a regular flu and does not have any adverse health consequences. Only around 7% get virus pneumonia detectable with X-rays. It usually develops one week or so from the onset of the disease.

All or most affected get some scarring of lungs (fibrosis) visible via X-ray. In severe cases (for example for people who were on ventilator) this is serious consequences that increase your chances dying later. But out of those unlucky 7%, only around 20% develop breathing problems. They are progressively worse for older population and, probably, smokers. Some tiny percent (do not remember exact percentage) need oxygen and in worst cases ventilator. Approximately half of those who need ventilator dies. Total mortality is probably around 0.2% (based of cruise ship data, where 100% of people were tested) despite the fact that often cited range is much higher (because total number of infected is probably much larger in countries affected than the number of tested positively.)

If you are less that 55 I would not worry too much. Your chances to get virus pneumonia are negligible, especially if  you are wearing a mask while shopping and in other public places, and take recommended hygienic measures. Viruses survive on phones and keyboards for a couple of days. So disinfection of such things on daily basis might be also a good precaution. On cardboard and clothing virus does not survive for long enough to represent a real danger outside of hospital setting or other settings with very high concentration of viruses.

There are half-dozen elementary measures that would lower your risk.  You might wish to watch WHO presentation Q&A on Coronavirus - COVID-19 with WHO's Dr Maria Van Kerkhove - YouTube

But the main factor -- your age and the state of your health can't be changed. And state of your immune system -- the main barrier for the virus can't be changed too.  Also spending more time on fresh air and under direct sun exposure might improve it a little bit.

Please avoid quackery and snake oil salesmen which now are propagating via Internet, especially Facebook. See A Doctor's Tips for Spotting Fake COVID-19 News

A good news is that judging from Diamond Princess cruise ship experience less then 20% of people are susceptible to the virus even if they are over 50.  For everybody else the immune system simply kills the virus and the person never becomes infected. Also a large number of people who are tested positive never develop any symptoms and might be false positives of the test. 

Like with everything luck depends on your lack.: contact with infected person often lead to infection. Especially in public transport where people are very close to each other.

Below are somewhat reworded CDC recommendations

Stop touching your face, especially eyes and nose!

The CDC also recommends that you avoid touching your face — specifically, your eyes, nose, and mouth, which are entry portals for coronavirus and other germs. If an infected person coughs or sneezes on a surface, and you touch that contaminated surface and then touch your facial mucous membranes — the eyes, nose, and mouth — you could become infected.

Wash your hands.

Washing your hands regularly is the best way to protect yourself from coronavirus — assuming you’re doing it correctly. The CDC recommends getting your hands wet with warm or cold water; lathering your entire hands, including under the nails, with soap; scrubbing your hands for 20 seconds; rinsing with clean water; and finally, either letting your hands air-dry or using a clean towel.

“Wash them especially well if you’re about to eat,” Aaron E. Carroll, a professor of pediatrics at Indiana University School of Medicine, wrote in the New York Times. “Wash them after you’ve blown your nose, coughed or sneezed. Make it routine that all members of the household wash their hands when they get home.”

It’s also not a bad idea to carry around a hand sanitizer for times when you’re not near a sink, though you should make sure it contains at least 60 percent alcohol. However, experts stress that washing your hands thoroughly — and frequently — is the best preventative measure.

If you have a chronic illness, are elderly, or have a compromised immune system …

While COVID-19 will cause mild symptoms in the majority of infected people, Jan Carette, associate professor at the Department of Microbiology and Immunology at Stanford University’s School of Medicine, says that the elderly — especially those with chronic conditions, like hypertension or diabetes — are at greater risk for more severe disease. In this case, he recommends that those who are especially susceptible practice the above precautions as well as avoid people who display flulike symptoms.

If you’re traveling …

If you have upcoming travel plans, it’s a good idea to stay up-to-date on the CDC’s travel warnings for specific countries. In general, it’s safest to avoid nonessential travel to countries with a sustained COVID-19 presence; right now, this includes Iran, China, South Korea, and Italy. For individuals who are especially susceptible to viral infections, including the elderly and those with existing medical conditions, the CDC advises avoiding travel to Japan as well.

Currently, the CDC doesn’t have any additional recommendations for domestic travel, though this could change as the virus spreads further in the United States. But according to the CDC’s website, the risk of infection on an airplane is low. “Because of how air circulates and is filtered on airplanes, most viruses and other germs do not spread easily,” they write. However, they recommend that travelers wash their hands frequently and avoid contact with sick passengers.


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Old News ;-)

[Aug 03, 2020] Red Flags Soar As Big Pharma Will Be Exempt From COVID-19 Vaccine Liability Claims -

Aug 03, 2020 | www.zerohedge.com

Last week we warned readers to be cautious about new COVID-19 vaccines, highlighting how key parts of the clinical trials are being skipped as big pharma will not be held accountable for adverse side effects for administering the experimental drugs.

A senior executive from AstraZeneca, Britain's second-largest drugmaker, told Reuters that his company was just granted protection from all legal action if the company's vaccine led to damaging side effects.

...

For more color on leading vaccines in development that produce "severe" side effects, read our latest piece titled "Moderna COVID-19 Vaccine Induced Adverse Reactions In "More Than Half" Of Trial Participants."

Maybe these rushed vaccines are more for optics, get consumers back into airplanes, hotels, resorts, and malls.

The major red flag is how governments are allowing big pharma to rush experimental vaccines, with no legal recourse if something goes terribly wrong.

[Aug 03, 2020] Next big COVID-19 treatment may be manufactured antibodies

Aug 03, 2020 | www.msn.com

As the world awaits a COVID-19 vaccine, the next big advance in battling the pandemic could come from a class of biotech therapies widely used against cancer and other disorders - antibodies designed specifically to attack this new virus.

[Aug 02, 2020] Red Flags Soar As Big Pharma Will Be Exempt From COVID-19 Vaccine Liability Claims

Aug 02, 2020 | www.zerohedge.com

Last week we warned readers to be cautious about new COVID-19 vaccines, highlighting how key parts of the clinical trials are being skipped as big pharma will not be held accountable for adverse side effects for administering the experimental drugs.

A senior executive from AstraZeneca, Britain's second-largest drugmaker, told Reuters that his company was just granted protection from all legal action if the company's vaccine led to damaging side effects.

[Aug 02, 2020] Obese People Are Twice As Likely To Die From Covid

Notable quotes:
"... And while being overweight does not seem to increase people's chances of contracting COVID-19 according to the study, it can affect the respiratory system, and potentially immune function as well. ..."
Aug 02, 2020 | www.zerohedge.com

Just in case Americans - the most obese nation in the world - needed another reason to lose some weight, here it is.

In what is emerging as a perfidious Catch 22, at a time when the US population is rapidly gaining weight due to mandatory work from home regulation (hence the Covid 19 pounds ) as described here and here , while a surge in domestic alcohol consumption is only making the matters worse...

... Public Health England has published a paper titled " Excess Weight and COVID-19 Insights from new evidence ", indicating that the risks of hospitalization, intensive care treatment and death increase progressively with increasing body mass index (BMI) above the healthy weight range even after adjustment for potential confounding factors, including demographic and socioeconomic factors. In other words, the fatter one is, the higher the risk that person may die from covid.

Some more details: according to the Public Health England paper, the hazard ratios of ICU admission patients who are overweight (BMI ≥25-29.9), obese (BMI ≥30-34.9) or severely obese (BMI ≥35) are 1.64, 2.59 and 4.35, respectively see figure below) relative to patients with a BMI of ≥20-24.9.

And while being overweight does not seem to increase people's chances of contracting COVID-19 according to the study, it can affect the respiratory system, and potentially immune function as well.

And since no crisis will ever be put to waste by a nanny state which after the covid pandemic will control virtually every aspect of our lives, the British government plans to initiate an anti-obesity campaign including strict rules on how junk food is advertised and sold in the UK.

[Aug 02, 2020] The Coronavirus Recovery Handbook: 19 Rehab Exercises for Mild to Severe Cases of COVID-19

Aug 02, 2020 | www.moonofalabama.org

Richard Steven Hack , Aug 1 2020 10:46 utc | 89

This book is likely required reading for those who have suffered from COVID-19. It's only 76 pages, but only costs $1.99 for the Kindle edition. I downloaded a copy from the Internet and will tuck it away for when I'm unlucky (assuming I would live long enough to try them.)

The Coronavirus Recovery Handbook: 19 Rehab Exercises for Mild to Severe Cases of COVID-19 - Dr. Liu Xiaodan and Dr. Shan Chunlei and their colleagues at the Shanghai Public Health Clinical Center and Lei Shenshan Hospital in Wuhan.

[Aug 01, 2020] Russia preparing mass vaccination against coronavirus for October

Aug 01, 2020 | www.msn.com

Russia's health minister is preparing a mass vaccination campaign against the novel coronavirus for October, local news agencies reported on Saturday, after a vaccine completed clinical trials.

Health Minister Mikhail Murashko said the Gamaleya Institute, a state research facility in Moscow, had completed clinical trials of the vaccine and paperwork is being prepared to register it, Interfax news agency reported.

He said doctors and teachers would be the first to be vaccinated.

[Aug 01, 2020] Length of interaction with tan infected person matter

Highly recommended!
Aug 01, 2020 | www.zerohedge.com

monty42 , 2 hours ago

" We know that wearing a mask outside health care facilities offers little, if any, protection from infection. Public health authorities define a significant exposure to Covid-19 as face-to-face contact within 6 feet with a patient with symptomatic Covid-19 that is sustained for at least a few minutes (and some say more than 10 minutes or even 30 minutes). The chance of catching Covid-19 from a passing interaction in a public space is therefore minimal. In many cases, the desire for widespread masking is a reflexive reaction to anxiety over the pandemic."

https://www.nejm.org/doi/full/10.1056/NEJMp2006372

Revisionist claims now- " In truth, the intent of our article was to push for more masking, not less." "

[Jul 27, 2020] How and when to wear masks

I remember signs on businesses that said "No shirts, no shoes: no service". I don't recall morons screaming at underpaid clerks about their constitutional right not to wear a shirt or shoes.
Population density has at least something to do with it. Big cities are the hardest hit, as would be expected. The US death rate per capita is below that of Belgium, the UK, Spain, Italy, Sweden, Peru (which is surprising), Chile (another surprise), and France.
Jul 27, 2020 | www.theamericanconservative.com

John Michener20 hours ago

I fail to see your problem with masks. My grandfather wore a gas mask on the front during World War 1. I wear a mask, indeed a N99 mask, when sawing concrete or doing fine wood sanding. When I was in the chemical process industry, some stations had Oxygen rebreathers to deal with the hazards in case of accidents.

Medical staff have always worn respirators around patients with airborne diseases, as have researchers handling such agents. Covid-19, Tuberculosis, and late stage plague are all airborne. Wearing a mask when in a situation when you are potentially exposed is common sense.

So wearing my N99 mask when I go shopping is a trivial additional step. I actually wear nitrile gloves as well - I had them for dealing with paints and solvents.

Now I have had to give up eating out and going to my professional society meetings. I am not happy about that, but I am not willfully stupid. I am approaching 70...

[Jul 27, 2020] One element of being a proper person is having some regard for the wellbeing of other people.

Jul 27, 2020 | www.theamericanconservative.com

d_hochberg Bradley Perry6 hours ago

One element of being a proper person is having some regard for the wellbeing of other people.

stephen pickard Bradley Perry5 hours ago

To me : A proper person dresses properly for the occasion. A proper person has high regard for both himself and others. A proper person does not smoke in a no smoking zone. A proper person places his child in a child restraint seat while riding in a car. And on and on with other safety festures that we accept.You get my point.

What I would have you do is to do the three things that I mentioned.

Social distance. Good hygiene protocol. And yes wear a mask. A rhetorical question. Would you permit a surgeon and every other person in an operating room go about the surgery masklessess?

SatirevFlesti Bradley Perry10 hours ago

Real science and evidence won't convince the Coronadoom kool-aid drinkers. Masks are all about signalling one's virtue and submission to arbitrary rules and to be seen as "doing something". That the virus has an IFR in the range of flu and that mask are ineffective in stopping spread of viruses doesn't matter to them. They want to force everyone to abdicate human dignity and act in the same paranoid, abject manner as they do. It's all political and has been form the beginning.

njoseph18 SatirevFlesti8 hours ago

So if masks are ineffective, are you comfortable having your surgery team not wear masks and breathe all over you while you're cut open? If not, why not, since masks are ineffective?

I work in a hospital. The people who say Covid is just flu both don't understand how bad Covid is and also don't understand how deadly the flu can be.

A third thing they don't understand is that cloth or surgical masks are about preventing asymptomatic transmission, which is a real thing. I've seen people die from Covid that they caught from someone who was "perfectly healthy."

It is such a simple, small thing to do, and has nothing to do with virtue signalling and everything to do with not killing other people because you're carrying a virus and don't know it. Some of the most Trump supporting people I've ever met work in this hospital and wear masks everywhere they go to protect others, because they understand what Covid is. C'mon people, if other countries can get this right without all the hand-wringing, so
can we.

Gswag99 njoseph188 hours ago • edited

weak straw man emotive argument with no basis in reason or education whatsoever.

njoseph18 Gswag997 hours ago

Umm, actually I am a frontline non clinical hospital worker. I guess you're a bot but if my reasoning is emotive can you kindly share the peer reviewed data upon which you base your perspective?

stephen pickard Gswag995 hours ago

It is a good counter point. One I made above using the same anology. Relevant anologies are powerful antidotes to careless thinking like yours.

Curious SatirevFlesti4 hours ago

I didn't realize Fisher Price ran a medical school

[Jul 27, 2020] The problem of false positives from Covid-19 tests means UK is inflating its numbers – and taking wrong decisions by Rob Lyons

Jul 27, 2020 | www.rt.com

The problem of false positives from Covid-19 tests means UK is inflating its numbers – and taking wrong decisions Rob Lyons

Rob Lyons is a UK journalist specialising in science, environmental and health issues. He is the author of ' Panic on a Plate: How Society Developed an Eating Disorder'.

A sign is seen at a drive-through coronavirus disease (COVID-19) testing facility in Hyde Park, following the outbreak of the coronavirus disease, London, Britain, June 11, 2020

When seven staff at a Scottish football club tested positive for coronavirus, alarm bells went off. But really alarming was when six of those results turned out to be wrong. Such inaccurate tests are exaggerating the problem.

Last weekend, at very short notice, the UK reintroduced quarantine measures for people arriving from Spain. For those already in Spain, or for whom it was too late to postpone their trip, the decision is very inconvenient. For those who can't work at home when they return, it may mean missing out on wages for the two weeks they will have to spend in isolation when they get back. But what if the apparent rise in cases has been exaggerated by seemingly small flaws with testing?

The potential for problems was illustrated by Scottish football team St Mirren last week. The club, based in Paisley, a town just west of Glasgow, reported seven positive test results for Covid-19 among its staff. Alarm bells went off about what this might mean for the new Scottish football season. But this "cluster" was a mirage. When the seven people were re-tested using a more accurate method, just one of them was found to be Covid-positive.

In Spain, half of the reported cases have been in people who had no symptoms. We know that many people who test positive never suffer any symptoms. But what if many of these people don't have Covid-19 at all?

READ MORE International airline body slams UK's 'unilaterally decided blanket quarantine' on travellers from Spain

If that sounds implausible, it's important to know that tests are not perfect. There are currently two kinds of tests to see if you have the disease. One kind, the molecular real-time polymerase chain reaction (RT-PCR) test, looks for genetic material from the virus. This kind seems to be very accurate, but it's expensive and time-consuming. The other kind, the antigen test, detects specific proteins on the surface of the virus. This is quicker, easier and cheaper, but it's much less accurate. In developed countries, RT-PCR testing is the norm, but poorer countries may have to make do with antigen testing.

The difficulty at the moment is that there are relatively few cases of Covid-19 in the community, but more and more testing is being done. So even if the RT-PCR test has a high "specificity" – that is, a tiny fraction of test results are false positives – the number could actually be quite significant. For example, let's say that 99.9 percent of the time, a test correctly identifies someone without the disease as negative. Just 0.1 percent of tests produce false positives.

Recently, in the UK, it was estimated that 0.04 percent of people had the virus outside of care homes and hospitals. So, if we tested 10,000 people, we should find four cases of Covid-19, on average. Of the 9,996 other people tested, in this hypothetical example, 0.1 percent who don't have the virus would also test positive – that's 9.996 – in other words, 10 people. So, even if the test is very accurate indeed, we could easily end up with four positive tests from people who really do have the virus and 10 false positives from people who don't.

For any particular individual, the chances of the test being a false positive is small. But when we look at the big picture, we could easily be fooled into thinking that there are many more cases than there really are. Indeed, with a test accuracy of 99.9 percent, if you tested a million people, none of whom actually had the disease, you would produce 1,000 positive results. And for tests with less accuracy – as with St Mirren FC – the situation could be even worse.

The UK government has now performed nearly 11 million tests. Could there be 11,000 "cases" that are simply a mistake ? In turn, that means governments and other authorities might be introducing additional restrictions on people's lives that are actually unnecessary.

The problem of false positives is much less significant when the disease really is in wide circulation. It doesn't change the picture much for the period from mid-March through to the start of June. (In any event, in the UK at least, there was very little testing capacity thanks to the jaw-dropping incompetence of bodies like Public Health England.)

Let's look at the latest figures. On Sunday, July 26, for example, 142,954 tests were processed. Of these, 747 were found to be positive. If 0.1 percent of tests are false positives, we would expect 142 of those 747 positives to be false. If the test turns out to be slightly less accurate – perhaps 'only' 99.5 percent accurate (which still seems very good), then 710, almost all the reported positives, could be false.

We should also bear in mind, when trying to assess the overall situation, that there will be some false negatives. There will also be people who don't show symptoms who do have the virus and never get tested. But this understanding shows that we do need to be careful about reading too much into every small blip in the number of cases. We should be particularly sceptical about imposing new restrictions like mandatory quarantine. And if we rely solely on these tests, we could have the crazy situation where Covid-19 apparently never disappears, even when nobody has got it.

Think your friends would be interested? Share this story!

[Jul 25, 2020] Corporate Insiders Pocket $1 Billion in Rush for Coronavirus Vaccine

Jul 25, 2020 | www.msn.com

Corporate Insiders Pocket $1 Billion in Rush for Coronavirus Vaccine David Gelles and Jesse Drucker 11 hrs ago


Opinion: There is more to picking a place to retire than low taxes -- avoid these 5 Reserving a 2021 Ford Bronco? Get Ready To Wait 18 Months to Take Delivery The New York Times logo Corporate Insiders Pocket $1 Billion in Rush for Coronavirus Vaccine

On June 26, a small South San Francisco company called Vaxart made a surprise announcement: A coronavirus vaccine it was working on had been selected by the U.S. government to be part of Operation Warp Speed, the flagship federal initiative to quickly develop drugs to combat Covid-19.

a close up of a cell phone screen with text: Selling Vaxart stock made more than $197 million in profit for Armistice Capital, a hedge fund that owned two-thirds of the company's shares. © Rafael Henrique/Getty Images Selling Vaxart stock made more than $197 million in profit for Armistice Capital, a hedge fund that owned two-thirds of the company's shares.

Vaxart's shares soared. Company insiders, who weeks earlier had received stock options worth a few million dollars, saw the value of those awards increase sixfold. And a hedge fund that partly controlled the company walked away with more than $200 million in instant profits.

https://products.gobankingrates.com/r/d9360ea31bf06ea8b9d0ef49288e28fb

The race is on to develop a coronavirus vaccine, and some companies and investors are betting that the winners stand to earn vast profits from selling hundreds of millions -- or even billions -- of doses to a desperate public.

Across the pharmaceutical and medical industries, senior executives and board members are capitalizing on that dynamic.

They are making millions of dollars after announcing positive developments, including support from the government, in their efforts to fight Covid-19. After such announcements, insiders from at least 11 companies -- most of them smaller firms whose fortunes often hinge on the success or failure of a single drug -- have sold shares worth well over $1 billion since March, according to figures compiled for The New York Times by Equilar, a data provider.

A trial of a potential coronavirus vaccine announced by Moderna in January. Since then, Moderna insiders have sold shares totaling about $248 million. © Ted S. Warren/Associated Press A trial of a potential coronavirus vaccine announced by Moderna in January. Since then, Moderna insiders have sold shares totaling about $248 million.

In some cases, company insiders are profiting from regularly scheduled compensation or automatic stock trades. But in other situations, senior officials appear to be pouncing on opportunities to cash out while their stock prices are sky high. And some companies have awarded stock options to executives shortly before market-moving announcements about their vaccine progress.

a man smiling for the camera: Andrei Floroiu, the chief executive of Vaxart, received stock options worth about $4.3 million in June. A month later, they were worth more than $28 million. © Will Ragozzino/Patrick McMullan Andrei Floroiu, the chief executive of Vaxart, received stock options worth about $4.3 million in June. A month later, they were worth more than $28 million.

The sudden windfalls highlight the powerful financial incentives for company officials to generate positive headlines in the race for coronavirus vaccines and treatments , even if the drugs might never pan out.

Some companies are attracting government scrutiny for potentially using their associations with Operation Warp Speed as marketing ploys.

For example, the headline on Vaxart's news release declared: "Vaxart's Covid-19 Vaccine Selected for the U.S. Government's Operation Warp Speed." But the reality is more complex.

Vaxart's vaccine candidate was included in a trial on primates that a federal agency was organizing in conjunction with Operation Warp Speed. But Vaxart is not among the companies selected to receive significant financial support from Warp Speed to produce hundreds of millions of vaccine doses.

"The U.S. Department of Health and Human Services has entered into funding agreements with certain vaccine manufacturers, and we are negotiating with others. Neither is the case with Vaxart," said Michael R. Caputo, the department's assistant secretary for public affairs. "Vaxart's vaccine candidate was selected to participate in preliminary U.S. government studies to determine potential areas for possible Operation Warp Speed partnership and support. At this time, those studies are ongoing, and no determinations have been made."

Some officials at the Department of Health and Human Services have grown concerned about whether companies including Vaxart are trying to inflate their stock prices by exaggerating their roles in Warp Speed, a senior Trump administration official said. The department has relayed those concerns to the Securities and Exchange Commission, said the official, who spoke on the condition of anonymity.

It isn't clear if the commission is looking into the matter. An S.E.C. spokeswoman declined to comment.

"Vaxart abides by good corporate governance guidelines and policies and makes decisions in accordance with the best interests of the company and its shareholders," Vaxart's chief executive, Andrei Floroiu, said in a statement on Friday. Referring to Operation Warp Speed, he added, "We believe that Vaxart's Covid-19 vaccine is the most exciting one in O.W.S. because it is the only oral vaccine (a pill) in O.W.S."

Well-timed stock transactions are generally legal. But investors and corporate governance experts say they can create the appearance that executives are profiting from inside information, and could erode public confidence in the pharmaceutical industry when the world is looking to these companies to cure Covid-19.

"It is inappropriate for drug company executives to cash in on a crisis," said Ben Wakana, executive director of Patients for Affordable Drugs, a nonprofit advocacy group. "Every day, Americans wake up and make sacrifices during this pandemic. Drug companies see this as a payday."

Executives at a long list of companies have reaped seven- or eight-figure profits thanks to their work on coronavirus vaccines and treatments.

Shares of Regeneron, a biotech company in Tarrytown, N.Y., have climbed nearly 80 percent since early February, when it announced a collaboration with the Department of Health and Human Services to develop a Covid-19 treatment. Since then, the company's top executives and board members have sold nearly $700 million in stock. The chief executive, Leonard Schleifer, sold $178 million of shares on a single day in May.

Alexandra Bowie, a spokeswoman for Regeneron, said most of those sales had been scheduled in advance through programs that automatically sell executives' shares if the stock hits a certain price.

Moderna, a 10-year-old vaccine developer based in Cambridge, Mass., that has never brought a product to market, announced in late January that it was working on a coronavirus vaccine. It has issued a stream of news releases hailing its vaccine progress, and its stock has more than tripled, giving the company a market value of almost $30 billion.

Moderna insiders have sold about $248 million of shares since that January announcement, most of it after the company was selected in April to receive federal funding to support its vaccine efforts.

While some of those sales were scheduled in advance, others were more spur of the moment. Flagship Ventures, an investment fund run by the company's founder and chairman, Noubar Afeyan, sold more than $68 million worth of Moderna shares on May 21. Those transactions were not scheduled in advance, according to securities filings.

Executives and board members at Luminex, Quidel and Emergent BioSolutions have sold shares worth a combined $85 million after announcing they were working on vaccines, treatments or testing solutions.

At other companies, executives and board members received large grants of stock options shortly before the companies announced good news that lifted the value of those options.

Novavax, a drugmaker in Gaithersburg, Md., began working on a vaccine early this year. This spring, the company reported promising preliminary test results and a $1.6 billion deal with the Trump administration.

In April, with its shares below $24, Novavax issued a batch of new stock awards to all its employees "in acknowledgment of the extraordinary work of our employees to implement a new vaccine program." Four senior executives, including the chief executive, Stanley Erck, received stock options that were worth less than $20 million at the time.

Since then, Novavax's stock has rocketed to more than $130 a share. At least on paper, the four executives' stock options are worth more than $100 million.

So long as the company hits a milestone with its vaccine testing, which it is expected to achieve soon, the executives will be able to use the options to buy discounted Novavax shares as early as next year, regardless of whether the company develops a successful vaccine.

Silvia Taylor, a Novavax spokeswoman, said the stock awards were designed "to incentivize and retain our employees during this critical time." She added that "there is no guarantee they will retain their value."

Two other drugmakers, Translate Bio and Inovio, awarded large batches of stock options to executives and board members shortly before they announced progress on their coronavirus vaccines, sending shares higher. Representatives of the companies said the options were regularly scheduled annual grants.

Vaxart, though, is where the most money was made the fastest.

At the start of the year, its shares were around 35 cents. Then in late January, Vaxart began working on an orally administered coronavirus vaccine, and its shares started rising.

Vaxart's largest shareholder was a New York hedge fund, Armistice Capital, which last year acquired nearly two-thirds of the company's shares. Two Armistice executives, including the hedge fund's founder, Steven Boyd, joined Vaxart's board of directors. The hedge fund also purchased rights, known as warrants, to buy 21 million more Vaxart shares at some point in the future for as little as 30 cents each.

Vaxart has never brought a vaccine to market. It has just 15 employees. But throughout the spring, Vaxart announced positive preliminary data for its vaccine, along with a partnership with a company that could manufacture it. By late April, with investors sensing the potential for big profits, the company's shares had reached $3.66 -- a tenfold increase from January.

On June 8, Vaxart changed the terms of its warrants agreement with Armistice, making it easier for the hedge fund to rapidly acquire the 21 million shares, rather than having to buy and sell in smaller batches.

One week later, Vaxart announced that its chief executive was stepping down, though he would remain chairman. The new C.E.O., Mr. Floroiu, had previously worked with Mr. Boyd, Armistice's founder, at the hedge fund and the consulting firm McKinsey.

On June 25, Vaxart announced that it had signed a letter of intent with another company that might help it mass-produce a coronavirus vaccine. Vaxart's shares nearly doubled that day.

The next day, Vaxart issued its news release saying it had been selected for Operation Warp Speed. Its shares instantly doubled again, at one pointing hitting $14, their highest level in years.

"We are very pleased to be one of the few companies selected by Operation Warp Speed, and that ours is the only oral vaccine being evaluated," Mr. Floroiu said.

Armistice took advantage of the stock's exponential increase -- at that point up more than 3,600 percent since January. On June 26, a Friday, and the next Monday, the hedge fund exercised its warrants to buy nearly 21 million Vaxart shares for either 30 cents or $1.10 a share -- purchases it would not have been able to make as quickly had its agreement with Vaxart not been modified weeks earlier.

Armistice then immediately sold the shares at prices from $6.58 to $12.89 a share, according to securities filings. The hedge fund's profits were immense: more than $197 million.

"It looks like the warrants may have been reconfigured at a time when they knew good news was coming," said Robert Daines, a professor at Stanford Law School who is an expert on corporate governance. "That's a valuable change, made right as the company's stock price was about to rise."

At the same time, the hedge fund also unloaded some of the Vaxart shares it had previously bought, notching tens of millions of dollars in additional profits.

By the end of that Monday, June 29, Armistice had sold almost all of its Vaxart shares.

Mr. Boyd and Armistice declined to comment.

Mr. Floroiu said the change to the Armistice agreement "was in the best interests of Vaxart and its stockholders" and helped it raise money to work on the Covid-19 vaccine.

He and other Vaxart board members also were positioned for big personal profits. When he became chief executive in mid-June, Mr. Floroiu received stock options that were worth about $4.3 million. A month later, those options were worth more than $28 million.

Normally when companies issue stock options to executives, the options can't be exercised for months or years. Because of the unusual terms and the run-up in Vaxart's stock price, most of Mr. Floroiu's can be cashed in now.

Vaxart's board members also received large grants of stock options, giving them the right to buy shares in the company at prices well below where the stock is now trading. The higher the shares fly, the bigger the profits.

"Vaxart is disrupting the vaccine world," Mr. Floroiu boasted during a virtual investor conference on Thursday. He added that his impression was that "it's OK to make a profit from Covid vaccines, as long as you're not profiteering."

Noah Weiland contributed reporting.

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[Jul 24, 2020] Cold Wars Profit by Craig Murray

Jul 24, 2020 | consortiumnews.com

Consortiumnews Volume 26, Number 206 – Friday, July 24, 2020

AFGHANISTAN , COMMENTARY , FOREIGN POLICY , HISTORY , HUMAN RIGHTS , MEDIA , PROPAGANDA , RUSSIA , RUSSIAGATE , UKRAINE , UNITED KINGDON , UNTIL THIS DAY--HISTORICAL PERSPECTIVES ON THE NEWS Cold Wars & Profit July 21, 2020 Save

Craig Murray lambasts a Russophobic media that celebrates a supposed cyber attack on UK vaccine research, ignores collapse of key evidence of a "hack" and dabbles in dubious memorabilia.

The Guardian's headquarters in London. (Bryantbob, CC BY-SA 3.0, via Wikimedia Commons)

By Craig Murray
CraigMurray.org.uk

... ... ...

Attack on UK Vaccine Research

Andrew Marr, center, in 2014. ( Financial Times , Flickr)

A whole slew of these were rehearsed by Andrew Marr on his flagship BBC1 morning show. The latest is the accusation that Russia is responsible for a cyber attack on Covid-19 vaccination research. This is another totally evidence-free accusation. But it misses the point anyway.

The alleged cyber attack, if it happened, was a hack not an attack -- the allegation is that there was an effort to obtain the results of research, not to disrupt research. It is appalling that the U.K. is trying to keep its research results secret rather than share them freely with the world scientific community.

As I have reported before , the U.K. and the USA have been preventing the WHO from implementing a common research and common vaccine solution for Covid-19, insisting instead on a profit driven approach to benefit the big pharmaceutical companies (and disadvantage the global poor).

What makes the accusation that Russia tried to hack the research even more dubious is the fact that Russia had just bought the very research specified. You don't steal things you already own.

Evidence of CIA Hacks

If anybody had indeed hacked the research, we all know it is impossible to trace with certainty the whereabouts of hackers. My VPNs [virtual private networks] are habitually set to India, Australia or South Africa depending on where I am trying to watch the cricket, dodging broadcasting restrictions.

More pertinently, WikiLeaks' Vault 7 release of CIA material showed the specific programs for the CIA in how to leave clues to make a leak look like it came from Russia. This irrefutable evidence that the CIA do computer hacks with apparent Russian "fingerprints" deliberately left, like little bits of Cyrillic script, is an absolutely classic example of a fact that everybody working in the mainstream media knows to be true, but which they all contrive never to mention.

Thus when last week's "Russian hacking" story was briefed by the security services -- that former Labour Party Leader Jeremy Corbyn deployed secret documents on U.K./U.S. trade talks which had been posted on Reddit, after being stolen by an evil Russian who left his name of Grigor in his Reddit handle -- there was no questioning in the media of this narrative. Instead, we had another round of McCarthyite witch-hunt aimed at the rather tired looking Corbyn.

Personally, if the Russians had been responsible for revealing that the Tories are prepared to open up the NHS "market" to big American companies, including ending or raising caps on pharmaceutical prices, I should be very grateful to the Russians for telling us. Just as the world would owe the Russians a favor if it were indeed them who leaked evidence of just how systematically the DNC rigged the 2016 primaries against Bernie Sanders.

But as it happens, it was not the Russians. The latter case was a leak by a disgusted insider, and I very much suspect the NHS U.S. trade deal link was also from a disgusted insider.

When governments do appalling things, very often somebody manages to blow the whistle.

On the core subject here: By necessity, a pandemic requires a cooperative international response. Only one country has refused to do so: The US. In their supreme arrogance, our ruling class lost track the fact that the US needs the rest of the world, not the other way way around.

[Jul 24, 2020] Study identifies six different types of COVID-19

Jul 24, 2020 | www.msn.com

We Find the Best $500 Cars to Field in the 24 Hours of Lemons Race Series Sources: Trump erupted over Esper's flag ban

Study identifies six different "types" of COVID-19

A new study of COVID-19 , based on data from a symptom tracker app, determined that there are six distinct "types" of the disease involving different clusters of symptoms. The discovery could potentially open new possibilities for how doctors can better treat individual patients and predict what level of hospital care they would need.

Researchers from King's College London studied data from approximately 1,600 U.K. and U.S. patients who regularly logged their symptoms in the COVID Symptom Tracker App in March and April.

Typically, doctors will look for key symptoms such as cough, fever and loss of the sense of smell to detect COVID-19. The study, which has not been peer-reviewed, says the six different "types" of COVID-19 can vary by severity and come with their own set of symptoms.

"I think it's very, very interesting," Dr. Bob Lahita, who is not affiliated with the study, told CBSN anchors Vladimir Duthiers and Anne-Marie Green. "Among the patients I see, those who recovered, many of them present different ways: some people with fever and some without fever, and some with nausea and vomiting, some people with diarrhea , etc."

The six clusters of symptoms outlined in the study are:

  1. Flu-like with no fever: Headache, loss of smell, muscle pains, cough, sore throat, chest pain, no fever.
  2. Flu-like with fever: Headache, loss of smell, cough, sore throat, hoarseness, fever, loss of appetite.
  3. Gastrointestinal: Headache, loss of smell, loss of appetite, diarrhea, sore throat, chest pain, no cough.
  4. Severe level one, fatigue: Headache, loss of smell, cough, fever, hoarseness, chest pain, fatigue.
  5. Severe level two, confusion: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain.
  6. Severe level three, abdominal and respiratory: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain, shortness of breath, diarrhea, abdominal pain.

The first level, "flu-like with no fever," is associated with headaches, loss of smell, muscle pains, cough, sore throat and chest pain. Patients at this level have a 1.5% chance of needing breathing support such as oxygen or a ventilator.

The second type, "flu-like with fever," includes symptoms like loss of appetite, headache, loss of smell, cough, sore throat, hoarseness and fever. Researchers say about 4.4% of patients at this level needed breathing support.

Patients with the third type, simply described as "gastrointestinal," do not have a cough as part of their illness. Instead, they experience headache, diarrhea, loss of smell, loss of appetite, sore throat and chest pain, and about 3.3% needed breathing support.

Lahita referred to the following three clusters of COVID-19 as the "really severe types."

In type four, or "severe level one," patients experience fatigue along with headache, loss of smell, cough, fever, hoarseness and chest pain. Patients at this level needed breathing support at a rate of 8.6%.

Type five, "severe level two," includes the symptoms of type four along with loss of appetite, sore throat and muscle pain, and is mainly distinguished by confusion .

"That means you don't know where you are or where you live, whether you are in or out of the hospital, who your relatives are," Lahita explained. "That is very scary." Almost 10% of patients at that level need breathing support.

The most severe type of COVID-19 is referred to as "severe level three, abdominal and respiratory," and has all the above symptoms along with abdominal pain, shortness of breath and diarrhea. Nearly 20% of these patients need breathing support.

"Those are the severe level threes who wind up on a ventilator, and then it is touch-and-go as to whether they survive the infection entirely," Lahita said.

The U.K. researchers also found that only 16% of patients with type one COVID-19 required hospitalization, compared with nearly half of the patients with type six.

Patients in the severe clusters also tended to be older or with pre-existing conditions and weakened immune systems, compared to those in the first three.

Scientists hope the discovery, once further studied, could help predict what types of care patients with COVID-19 might need, and give doctors the ability to predict which patients would fall into which category.

"I'm very happy that these six types have been identified and can give us an idea of a prognosis going forward for patients who are afflicted with this virus," Lahita said.

[Jul 23, 2020] COVID-19/nCOV/SARS-2 immunity comes from T-cell and B-cell activity

Jul 23, 2020 | www.moonofalabama.org

c1ue , Jul 23 2020 15:30 utc | 8

More talk about T-cells and B-cells (per Volchkov)
Australia T-cell and B-cell research
To recap: Volchkov, a Russian geneticist/medical researcher, was quoted in a John Helmer article that he believes the true COVID-19/nCOV/SARS-2 immunity comes from T-cell and B-cell activity. His view is based upon multiple European studies employing a very expensive T-cell/B-cell test called ELISPOT - and is that the actual nCOV infection rate is likely far higher than spot PCR or antibody tests can ever detect. In particular, if 20% of people tested by PCR or antibody tests show exposure, the likely actual exposure rate is 3 times higher (60% vs. 20%).
This has huge ramifications if true: it means places with high nCOV death rates have likely already achieved herd immunity levels.
One thing is true: death rates in every single nation and region with a high nCOV death/million count have fallen dramatically.
People are still dying, but they are dying at a far lower CFR/IFR rate.
IF, and I mean *IF*, this is true, this means the lockdown strategies actually did very little to "contain" the outbreak.
This is why looking at the historical behavior in different US states is so important.
California locked down early, but the nCOV mortality rates (both absolute and relative) have basically been flat from April until now.

[Jul 21, 2020] Scientists report that airborne coronavirus is probably infectious

Notable quotes:
"... This boosts the hypothesis that normal speaking and breathing, not just coughing and sneezing, are responsible for spreading COVID-19 -- and that infectious doses of the virus can travel distances far greater than the six feet (two meters) urged by social distancing guidelines. ..."
"... The paper was posted to the medrxiv.org website, where most cutting-edge research during the pandemic has first been made public. ..."
"... The team managed to collect microdroplets as small as one micron in diameter. They then placed these samples into a culture to make them grow, finding that three of the 18 samples tested were able to replicate. For Santarpia, this represents proof that microdroplets, which also travel much greater distances than big droplets, are capable of infecting people. "It is replicated in cell culture and therefore infectious," he said. ..."
Jul 21, 2020 | www.msn.com

Scientists have known for several months the new coronavirus can become suspended in microdroplets expelled by patients when they speak and breathe, but until now there was no proof that these tiny particles are infectious.

A new study by scientists at the University of Nebraska that was uploaded to a medical preprint site this week has shown for the first time that SARS-CoV-2 taken from microdroplets, defined as under five microns, can replicate in lab conditions.

This boosts the hypothesis that normal speaking and breathing, not just coughing and sneezing, are responsible for spreading COVID-19 -- and that infectious doses of the virus can travel distances far greater than the six feet (two meters) urged by social distancing guidelines.

The results are still considered preliminary and have not yet appeared in a peer-reviewed journal, which would lend more credibility to the methods devised by the scientists.

The paper was posted to the medrxiv.org website, where most cutting-edge research during the pandemic has first been made public.

The same team wrote a paper in March showing that the virus remains airborne in the rooms of hospitalized COVID-19 patients, and this study will soon be published in a journal, according to the lead author.

"It is actually fairly difficult" to collect the samples, Joshua Santarpia, an associate professor at the University of Nebraska Medical Center told AFP.

The team used a device the size of a cell phone for the purpose, but "the concentrations are typically very low, your chances of recovering material are small."

The scientists took air samples from five rooms of bedridden patients, at a height of about a foot (30 centimeters) over the foot of their beds.

The patients were talking, which produces microdroplets that become suspended in the air for several hours in what is referred to as an "aerosol," and some were coughing.

The team managed to collect microdroplets as small as one micron in diameter. They then placed these samples into a culture to make them grow, finding that three of the 18 samples tested were able to replicate. For Santarpia, this represents proof that microdroplets, which also travel much greater distances than big droplets, are capable of infecting people. "It is replicated in cell culture and therefore infectious," he said.

Why we wear masks

The potential for microdroplet transmission of the coronavirus was at one stage thought to be improbable by health authorities across the world. Later, scientists began to change their mind and acknowledge it may be a possibility, which is the rationale for universal masking.

The World Health Organization was among the last to shift its position, doing so on July 7.

"I feel like the debate has become more political than scientific," said Santarpia. "I think most scientists that work on infectious diseases agree that there's likely an airborne component, though we may quibble over how large."

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Linsey Marr, a professor at Virginia Tech who is a leading expert on aerial transmission of viruses and wasn't involved in the study, said it was rare to obtain measurements of the amount of virus present in air.

"Based on what we know about other diseases and what we know so far about SARS-CoV-2, I think we can assume that if the virus is 'infectious in aerosols,' then we can become infected by breathing them in," she told AFP.

[Jul 20, 2020] Russian Elite Received 'Experimental' COVID-19 Vaccine As Early As April -

Jul 20, 2020 | www.zerohedge.com

Russian Elite Received 'Experimental' COVID-19 Vaccine As Early As April by Tyler Durden Mon, 07/20/2020 - 07:22 Twitter Facebook Reddit Email Print

Last week, we shared news of what Russia's scientific community had touted as a major breakthrough in the development of a vaccine for SARS-CoV-2: A vaccine trial at Moscow's Sechenov First Moscow State Medical University had yielded the first successful human trials. The American business press slavishly parrots every Moderna press release as the company regurgitates its Phase 1 trial results, despite the fact that the politically-connected biotech company's stage 3 clinical trials won't begin until later this month. Meanwhile, its CEO Stephane Bancel and other executives have cashed in on their Moderna shares, prompting SEC chief Jay Clayton to sheepishly caution against credibility-destroying insider selling.

Despite all of this, we didn't hear a peep out of the western press about the Sechenov trial's accomplishments . However, a few days later, with anxieties about Russia-backed electoral interference intensifying and 'national polls' hinting at a Biden landslide, the British press reported on a new 'policy paper' accusing those pesky Ruskies of trying to steal British research involving COVID-19 vaccines. Intel shared by Canada and the US purportedly supported this conclusion, though Russia has vehemently denied the accusations.

But that's not all: Around the same time, Foreign Secretary Dominic Raab accused Russia of trying to meddle in the UK's December election (which returned the Tories to power and ended the reign of opposition leader Jeremy Corbyn).

Were these reports about Russia's vaccine-trial successes merely a smokescreen? The British might see it that way, but on Monday, US-based Bloomberg News published an interesting report claiming that certain Russian VIPs had been administered experimental doses of a vaccine prototype as early as April. Reportedly developed by Moscow's Gamaleya Institute and financed by the state-run Russian Direct Investment Fund, this Russian vaccine candidate is a so-called "viral vector vaccine" based on human adenovirus - a common cold virus fused with the spike protein of SARS CoV-2 to stimulate a human immune response.

It's similar to a vaccine being developed by China's CanSino Biologics, according to Bloomberg.

Scores of members of Russia's business and political elite have been given early access to an experimental vaccine against Covid-19, according to people familiar with the effort, as the country races to be among the first to develop an inoculation.

Top executives at companies including aluminum giant United Co. Rusal, as well as billionaire tycoons and government officials began getting shots developed by the state-run Gamaleya Institute in Moscow as early as April, the people said. They declined to be identified as the information isn't public.

The Gamaleya vaccine, financed by the state-run Russian Direct Investment Fund and backed by the military, last week completed a phase 1 trial involving Russian military personnel. The institute hasn't published results for the study, which involved about 40 people, but has begun the next stage of trials with a larger group.

Gamaleya's press office couldn't be reached by phone Sunday. Kremlin spokesman Dmitry Peskov didn't respond to a text message asking whether President Vladimir Putin or others in his administration have had the shots. A government spokesman couldn't immediately comment.

Wait... so the Russians hacked the British vaccine research, traveled back in time, then decided to test their vaccine prototype on some of the most powerful people in Russia's (highly unequal) society? Well, they had to first travel to the future to steal the time-travel technology from the Americans (bear with us...we're still piecing it all together).

The program under which members of Russia's business and political elite have been given the chance to volunteer for doses of the experimental vaccine is legal but kept under wraps to avoid a crush of potential participants, according to a researcher familiar with the effort. He said several hundred people have been involved. Bloomberg confirmed dozens who have had the shots but none would allow their names to be published.

It's not clear how participants are selected and they aren't part of the official studies, though they are monitored and their results logged by the institute. Patients usually get the shots - two are needed to produce an immune response Gamaleya says will last for about two years - at a Moscow clinic connected to the institute. Participants aren't charged a fee and sign releases that they know the risks involved.

Dmitriev of the RDIF said he and his family had taken the shots and noted that a significant number of other volunteers have also been given the opportunity. He declined to provide further details. The Gamaleya Institute said it vaccinated its director, as well as the team working on the trial, when it started. In May, state-controlled Sberbank recruited volunteers among employees to test the institute's vaccine.

O ne top executive who had the vaccine said he experienced no side effects. He said he decided to risk taking the experimental shots in order to be able to live a normal life and have business meetings as usual. Other participants have reported fever and muscle aches after getting the shots.

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Is it so hard to believe that Russia had enough faith in its vaccine prototype that it would allow certain individuals the choice of receiving an early dose? After all, EU governments are already buying up millions of doses of Moderna's still-largely-untested vaccine candidate.

Similarly, is it possible that Russian spies were simply monitoring the competition?

Who knows? When it comes to the shadowy world of espionage, the public rarely hears the full story. Russia's outbreak has slowed in recent weeks as it has been overtaken by India, which now counts more than 1 million confirmed cases. Meanwhile Russia has confirmed more than 750,000 cases of Covid-19, the fourth-largest total in the world.

[Jul 20, 2020] Oxford-AstraZeneca COVID-19 Vaccine Trials Show -No Adverse Effects- -

Jul 20, 2020 | www.zerohedge.com

pdate (0935ET): A coronavirus vaccine candidate developed by Oxford and AstraZeneca has shown promise in an early trial which found it to be safe for human consumption while reliably producing antibodies that are effective at stopping the virus.

In what looked like a coordinated one-two punch, one of the top researchers leading the Oxford-Astrazeneca trials said in an interview published Monday morning that the research was making "good progress". Minutes later, the Lancet published the first Phase 1/2 trial results, which showed that the Oxford-AstraZeneca vaccine caused "robust immune responses" and was "tolerated" by all study subjects.

That interview was published Monday morning in the US, just minutes before the Lancet released the results of a Phase 1/2 study of the Oxford-AZ vaccine, the most highly anticipated COVID-19 news of the day.

There are currently more than 137 vaccine candidates undergoing preclinical development, and 23 in early clinical development, according to WHO. Of these, candidates from Moderna and the Oxford-AstraZeneca partnership are two of the most closely followed prototypes. Governments have already started ordering the vaccine from Moderna, even though approval is still months, perhaps years, away.

According to the Lancet, research has shown that vaccine candidates from Cansino and Astra-Oxford trial have been making good progress, and while they couldn't say much conclusively, the Astra-Oxford trial showed no worrisome "adverse effects".

The Phase 1/2 trial, one of the first human studies of the vaccine, showed an appropriate "immune response". Patients who received 2 doses instead of one saw a stronger response. All patients who received the vaccine generated the desired immune response.

Oxford's candidate "showed an acceptable safety profile, and homologous boosting increased antibody responses. These results "support large scale evaluation of this candidate vaccine in an ongoing phase 3 program." The Oxford-AZ study included 1,077 participants spread across 5 test sites in and around the UK.

By comparison, Moderna has released press releases touting findings from studies with fewer than 100 patients. The fact that 8 patients developed neutralizing antibodies in a study that involved dozens of additional subjects was apparently news enough for Moderna, which released a market-pumping press release on those findings a few weeks back.

Though to be sure, not everybody was impressed.

In the study, researchers measured the number of antibodies, and the strength of the immune response, after administering single doses and double doses of the vaccine to various groups of study subjects, and compared those results with a control group who received another vaccine. Pain and swelling caused by the injection were easily treated with paracetemol.

There were no serious adverse events related to ChAdOx1 nCoV-19. In the ChAdOx1 nCoV-19 group, spike-specific T-cell responses peaked on day 14 (median 856 spot-forming cells per million peripheral blood mononuclear cells, IQR 493–1802; n=43). Anti-spike IgG responses rose by day 28 (median 157 ELISA units [EU], 96–317; n=127), and were boosted following a second dose (639 EU, 360–792; n=10). Neutralising antibody responses against SARS-CoV-2 were detected in 32 (91%) of 35 participants after a single dose when measured in MNA80 and in 35 (100%) participants when measured in PRNT50. After a booster dose, all participants had neutralising activity (nine of nine in MNA80 at day 42 and ten of ten in Marburg VN on day 56). Neutralising antibody responses correlated strongly with antibody levels measured by ELISA (R²=0·67 by Marburg VN; p<0·001).

The result: The vaccine candidate has been deemed safe enough to move on to 'Phase 3', which would involve large-scale human trials.

ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support largescale evaluation of this candidate vaccine in an ongoing phase 3 programme.

Read the full Lancet paper below:

[Jul 18, 2020] COVID-19- What Does Being Positive Really Mean- What Are We Really Detecting- - Fort Russ

Jul 18, 2020 | fort-russ.com

By Dr. Sherri Tenpenny – May 21, 2020an osteopathic medical doctor, board-certified in three specialties. She is the founder of Tenpenny Integrative Medical Center, a medical clinic located near Cleveland, Ohio. Her company, Courses4Mastery.com provides online education and training regarding all aspects of vaccines and vaccination.

_____________________________

In 1965, scientists identified the first human coronavirus; it was associated with the common cold. The Coronavirus family, named for their crown-like appearance, currently includes 36 viruses. Within that group, there are 4 common viruses that have been causing infection in humans for more than sixty years. In addition, three pandemic coronaviruses that can infect humans: SARS, MERS, and now, SARS-CoV-2.

As the news of deaths in China, South Korea, Italy, and Iran began to saturate every form of media 24/7, we became familiar with a new term: COVID-19. To be clear, the name of the newly identified coronavirus is SARS-CoV-2, short for Severe Acute Respiratory Syndrome Coronavirus-2. This virus is associated with fever, cough, chest pain, and shortness of breath, the complex of symptoms that form the diagnosis of COVID-19.

The Trump administration declared a public health emergency on January 31, 2020, then on February 2 placed a ban on the entry of most travelers who had recently been in China. On February 4, Alex Azar, the Secretary of Health and Human Services (HHS) issued a declaration of public health emergency and activated the Public Readiness and Emergency Preparedness Act, otherwise known as the PREP Act. This nefarious legislation provides complete protection of manufacturers from liability for all products, technologies, biologics, or any vaccine developed as a medical countermeasure against COVID-19. For those nervously waiting for the vaccine to become available, be sure to understand the PREP Act before rushing to the get in line.

Calls for testing – to see if a person is or isn't infected – began soon after the emergency was declared, but performing those tests was initially slow due to an inadequate number of test kits. As the kits became available, those developed by the CDC had a defect: The reagents reacted to the negative control sample , making the test inaccurate and the kits unusable.

In various countries, thousands of test kits purchased from China were found to be contaminated with the SARS-CoV-2 viruses. No one really knows how that happened, but theories spread like wildfire. Could the test kit infect the person being tested? Or, did it mean the test would return a false-positive result, driving up the numbers of those said to be infected so those in power could implement stronger lockdowns and accelerate the hockey-stick unemployment rates? Neither of those questions has been adequately answered.

Mandatory Testing of what?

Authorities claim that testing is important for public health officials to assess if their mitigation efforts – "shelter in place" and "social distancing" and "wearing a mask" – are making a difference to "flatten the curve." Officials also claim that testing is necessary to know how many persons are infected within a community and to understand the nature of how coronaviruses spread.

Are these reasons sufficient to give up our health freedom and our personal rights, being tested and shamed in public?

Despite the challenges with test kits, testing began. By the end of March 2020, more than 1 million people had been tested across the US. By May 9, the number tested had grown to over 8.7M. Testing methods include a swab of the nasal passages or by inserting a long, uncomfortable swab through the nose to scrape the back of the throat. Specimens have also been obtained bronchoalveolar lavage, from sputum , and from stool specimens.

The call for mandatory testing has been gathering steam and becoming ever more onerous. In Washington state, Governor Inslee has declared:

Individuals that refuse to cooperate with contact tracers and/or refuse testing, those individuals will not be allowed to leave their homes to purchase basic necessities such as groceries and/or prescriptions. Those persons will need to make arrangements through friends, family, or state provided 'family support' personnel .

But what do the results really mean?

Who Should Be Tested

On May 8, 2020, the CDC has listed specific priorities for when testing should be done. As of May 16, more than 11-million samples have been collected and more than 3700 specimens have not yet been evaluated.

High Priority

Priority

Read that last priority again: That means virtually everyone can be required to get a test.

Is that a violation of your personal rights? And, if you submit to testing, what does a "positive test" actually mean?

Types of Testing: RT-PCR

PCR, short for polymerase chain reaction , is a highly specific laboratory technique. The key to understanding PCR testing is that PCR can identify an individual specific virus within a viral family.

Has COVID-19 Testing Made the Problem Worse? Confusion Regarding "The True Health Impacts"

However, a PCR test can only be used to identify DNA viruses; the SARS-CoV2 virus is an RNA virus. Therefore, multiple steps must be taken to "magnify" the amount of genetic material in the specimen. Researchers used a method called RT-PCR, reverse transcription-polymerase chain reaction, to specifically identify the SARS-CoV-2 virus. It's a complicated process. To read more about it, go here and here.

If a nasal or a blood sample contains a tiny snip of RNA from the SARS-CoV-2 virus, RT-PCR can identify it, leading to a high probability that the person has been exposed to the SARS-CoV-2 virus.

However – and this is important – a positive RT-PCR test result does not necessarily indicate a full virus is present. The virus must be fully intact to be transmitted and cause illness.

RT-PCR Testing: The Importance of Timing

Even if a person has had all the symptoms associated with a coronavirus infection or has been closely exposed to persons who have been diagnosed with COVID-19, the probability of a RT-PCR test being positive decreases with the number of days past the onset of symptoms.

According to a study done by Paul Wikramaratna and others:

In other words, the longer the time frame between the onset of symptoms and the time a person is tested, the more likely the test will be negative.

Repeat testing of persons who have a negative test may (eventually) confirm the presence of viral RNA, but this is impractical. Additionally, repeated testing of the same person can lead to even more confusing results: The test may go from negative, to positive, then back to negative again as the immune system clears out the coronavirus infection and moves to recovery.

And what makes this testing even more confusing is that the FDA admits that "The detection of viral RNA by RT-PCR does not necessarily equate with an infectious virus."

Let's break that down:

You've had all the symptoms of COVID19, but your RT-PCR test for SARS-CoV-2 is negative.

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So, what does a "positive" test actually mean? And that's the problem:

No one knows for sure.

Another Type of Testing: Antibodies

According to the nonprofit Foundation for Innovative New Diagnostics (FIND) , more than 200 serologic blood tests, to test for antibodies, are either now available or in development.

There are two primary types of antibodies that are assessed for nearly any type of infection: IgM and IgG. While several new testing devices are being touted as a home test, they are not the same as a home pregnancy test or a glucometer to you're your blood sugar. The blood spot or saliva specimen can be collected at home, must it must then be sent to a laboratory for analysis. It can take a few days – or longer – to get the results. With so many tests in the pipeline, the ability to test at home will be changing over time.

The first antibody to rise is IgM. It rises quickly after the onset of the infection and is usually a sign of an acute, or current, infection. The IgM levels diminish quickly as the infection resolves. The FDA admits they do not know how long the IgM remains present for SARS-CoV-2 as the infection is being cleared.

The interpretation of an IgG antibody is more difficult. This antibody is an indicator of a past infection. The test is often not specific enough to determine if the past infection was caused by the SARS-CoV-2 virus or one of the four common coronaviruses that cause influenza-like illness.

The FDA says:

Because serology testing can yield a negative test result even if the patient is actively infected (e.g., the body has not yet developed in response to the virus) or maybe falsely positive (e.g., if the antibody indicates a past infection by a different coronavirus), this type of testing should not be used to diagnose an acute or active COVID-19 infection.

Similarly, the CDC says the following regarding antibody testing:

What? Wait!

If the FDA does not know if an IgG antibody to SARS-CoV-2 after recovering from the infection is protective against a future infection, then they certainly don't know if an antibody caused by a vaccine will prevent infection either.

Doesn't this completely eliminate the theory that antibodies afford protection and antibodies from vaccines are necessary to keep you from getting sick?

Mandatory Testing – New Job Creation

Illinois U.S. Rep. Bobby L. Rush introduced the H.R. 6666 TRACE Act on May 1. On his website, Rush said ,

Until we have a vaccine to defeat this dreaded disease, contact tracing in order to understand the full breadth and depth of the spread of this virus is the only way we will be able to get out from under this.

H.R.6666 would authorize the Secretary of Health and Human Services (HHS), acting through the Director of the CDC to award grants to eligible entities to conduct diagnostic testing and then to trace and monitor the contacts of infected individuals. The contact tracers would be authorized to test people in their homes and as necessary, quarantine people in place.

Where do they intend to do this testing? Besides mobile units to test people in their homes, the bill identifies eight specific locations where the testing and contract tracing could occur: schools, health clinics, universities, churches, and "any other type of entity" the secretary of HHS wants to use.

The bill would allocate $100 billion in 2020 "and such sums as may be necessary for fiscal year 2021 and any subsequent fiscal year during which the emergency period continues."

But what are they looking for?

The virus is rapidly mutating, which is rather typical of RNA viruses. In a study published in April 2020, researchers have discovered that the novel coronavirus has mutated into at least 30 different genetic variations. If your RT-PCR test is positive, does this identify exposure to the pandemic virus or exposure to one of the genetic variations? The same can be said about the vaccines under development: With each mutation, is the vaccine more likely to be all risk and no benefit when it reaches the market?

What You Can Do

Across the nation, police are being told to not apprehend criminals but instead, to arrest parents at playgrounds, to arrest lone surfers on public beaches, to fine ministers and congregation members sitting in their cars listening to a service on the radio, and to restrict movement by creating one-way sidewalks.

People have had enough. They are beginning to see the huge scam that has been perpetrated on the entire world over a viral infection with a global death rate of 1.4% (meaning, 1.4% of people infected with SARS-CoV-2 have a fatal outcome, while 98.6% recover). This is far fewer deaths than a severe flu season.

We're already starting to see the thrust to take our power back:

While they shut us down and held us hostage in our homes, they changed our society, our lives, our world.

It's time for Americans to resist with non-violent civil disobedience. Be brave. Be bold. Put on the full armor of God, as found in Ephesians 6:10-20 in the Bible, to stand against the world rulers of this present darkness. With God on our side, all things are possible.

*

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[Jul 18, 2020] Lee Camp- The Life-Saving COVID-19 Drugs You've Never Heard Of (and Why)

Jul 18, 2020 | www.mintpressnews.com

he American profit-based healthcare system impacts us in more ways than just our gargantuan bill at the excretion end of an emergency room visit. Right now, our lovable idiotic inhumane healthcare system is acting as a hurdle to the manufacture and procurement of the right drugs to treat Covid-19.

One of the drugs currently trumpeted as our savior is Remdesivir . Despite sounding like the name of a Hobbit in Middle Earth, some reports from the corporate media make it sound like the drug will thrust us face-first into a fresh world of happiness -- water parks and restaurants and random no-holds-barred make-outs with strangers. A world where when someone sneezes, we don't dive under our desk with an adult diaper strapped on our face as a makeshift mask.

There's only one problem. The big pharma company that owns Remdesivir, Gilead, has already made clear their plans to profiteer from this pandemic. As The LA Times put it

Drugmaker Gillead says it's doing you a favor by setting the price for its pending COVID-19 treatment, Remdesivir, at more than $2,000 for government agencies and over $3,000 for private insurers."

How does the CEO of Gilead, Daniel O'Day, justify this disgusting price point? He claims they're under-pricing Remdesivir. He said , "In normal circumstances, we would price a medicine according to the value it provides. Earlier hospital discharge would result in hospital savings of approximately $12,000 per patient."

Public Outcry Follows Gilead Decision to Charge $3000 for COVID Drug that Costs Pennies to Produce Gilead announced that a five-day course of its drug Remdesivir -- used to fight COVID-19 -- will cost $3,120 despite costing pennies to produce.

MintPress News | Alan Macleod | Jul 1

The value it provides?? So, if a doctor saves someone's life with heart surgery, then that guy owes the doctor the entire worth of the rest of his life? Millions of dollars? Maybe he should become the surgeon's butler or wet nurse.

Saying something should cost even close to the value it provides ranks up there as one of the stupidest arguments ever spoken. (Second only to when the people at Mountain Dew argued that human beings would love a Doritos-flavored soft drink named "Dewitos.") So, for a dude taking Viagra who can now get it up, he owes the makers of Viagra – what? – sex with his wife? Or does he just owe them 300 orgasms? Or perhaps he owes them the child he's able to produce while taking the pills. ("Dear Cialis Folks, I'm emailing to ask for a mailing address to send you my 2-year-old, Robbie. Fair is fair. I want to give you the value of your goods. Just be careful – he bites a lot. And he's already totally racist. Not sure how he picked that up so young.")

But there's another catch to Gilead's price-gouging shenanigans. They didn't create Remdesivir. We did. You and me.

Public Citizen revealed that Gilead raked in over $70 million from taxpayers. Plus, federal scientists ran the team that found out Remdesivir also worked against Coronaviruses. And, " The National Institutes of Health ran the trial that led to Remdesivir's emergency use authorization, and public funding is supporting clinical trials around the world today."

You and I paid for the creation and research behind Remdesivir. There is absolutely no reason we should fill the pockets of Gilead's preposterously rich CEO and its board. Most countries realize this. Most countries don't behave this way. Most countries have some tiny modicum of respect for the lives of their citizens. America is not most countries.

Back to the LA Times , "Nearly all other developed countries limit how much pharmaceutical companies can charge for prescription meds. The U.S. doesn't operate like that. We allow drug companies to charge as much as they please "

Perhaps prescription meds that cost the same as landing a man on Mars (in a pair of Jimmy Choo heels) are the reason 42 percent of new cancer patients have their entire life savings wiped out within two years. The average amount drained from a patient is nearly $100,000, and the entire medical costs for U.S. cancer patients per year is $80 billion . Why ever change a system that piles such bulbous mountains of cash in the vaults of those running the show?

Apparently most other national governments don't want to ruin the lives of every cancer survivor. As to why not, one can only guess.

But this story gets crazier. Not only is Remdesivir way over-priced, we're not even sure it does much. Some studies show it achieves almost nothing. Meanwhile, according to the Intercept

[A]nother Covid-19 treatment has quietly been shown to be more effective. A three-drug regimen offered a greater reduction in the time it took patients to recover than Remdesivir did. People who took the combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin got better in seven days as opposed to 12 days for those who didn't take it."

However, I have yet to hear of a mad rush to hoard those drugs. Why is that? Probably because those drugs don't have colossal marketing campaigns that would make Coca-Cola blush. In fact there appears to be no marketing campaign whatsoever for the more effective drugs. To figure out why that is, one simply must follow the money.

New Research Shows Anti-Coronavirus Drugs Could Be Produced for Pennies A new study shows that several drugs that have shown promise in fighting the coronavirus could be produced cheaply and in en masse.

MintPress News | Alan Macleod | Apr 10

[E]ach of the three drugs in the new combination is generic, or no longer under patent, which means that no company stands to profit significantly from its use."

Must cut-throat late-stage capitalism always be so predictable?

Only the ridiculously profitable drugs are worth hyping. Only the money makers deserve 80,000 commercials telling every consumer to irrationally demand them. The cheap drugs that simply – save lives – those are garbage. What's the point of saving a life if you can't make a bundle from it? I've always said, "A life saved without extracting a shitload of money from it, is a life lost."

I don't know that this last part needs saying, but I'm going to do it anyway. When a society has a system built on profit, run by sociopaths, based on the manipulation of lizard-brain impulses, then it will always end up in a race to the bottom. With unfettered capitalism we inevitably find ourselves with the worst drugs, priced at the highest amounts, hoarded by those who need them the least.

Unless we're talking about recreational illegal drugs. Those are cheaper than ever.

If you feel this column is important, please share it.

Feature photo | A lab technician works at the Eva Pharma facility in Cairo, Egypt, July 12, 2020, where Remdesivir is being produced. Nariman El-Mofty | AP

Lee Camp is the host of the hit comedy news show "Redacted Tonight." His new book "Bullet Points and Punch Lines" is available at LeeCampBook.com and his standup comedy special can be streamed for free at LeeCampAmerican.com .

This article was published with special permission from the author. It originally appeared at Consortium News .

Stories published in our Daily Digests section are chosen based on the interest of our readers. They are republished from a number of sources, and are not produced by MintPress News. The views expressed in these articles are the author's own and do not necessarily reflect MintPress News editorial policy.

The views expressed in this article are the author's own and do not necessarily reflect MintPress News editorial policy.


[Jul 15, 2020] These Are the Drugs and Vaccines That Might End the Coronavirus Pandemic

Jul 15, 2020 | www.bloomberg.com

Vaccines Vaccines give broad parts of the population some level of immunity and are considered crucial to ending the pandemic. They also take longer to develop, in part because they must be proven to be extremely safe since they're given to healthy people. While some researchers say a vaccine could be ready by the end of the year, others say it could take far longer.
COMPANY Oxford University, AstraZeneca Plc NAME ChAdOx1 nCov-19 PROGRESS Phase 3

The vaccine is made from a harmless virus that's been altered to produce the surface spike protein from SARS-CoV-2.

LATEST NEWS With human trials underway, the U.S. government has pledged as much as $1.2 billion, and the company plans to produce as many as 30 million doses available in the U.K. by September. Other groups are moving to line up access elsewhere. COMPANY Moderna Inc. NAME mRNA-1273 RECENTLY UPDATED Phase 2

Moderna's mRNA-1273 uses messenger RNA to prompt the body to make a key protein from the virus, creating an immune response.

LATEST NEWS Moderna's vaccine produced antibodies to the coronavirus in all patients tested in an initial safety trial. The company expects a phase 3 trial to begin July 27. COMPANY CanSino Biologics Inc. NAME Ad5-nCoV PROGRESS Phase 2

CanSino's vaccine was developed alongside China's military and is genetically engineered with a replication-defective mutant virus.

LATEST NEWS CanSino's vaccine has received a special authorization to be used by China's military after a study showed it generated an immune response. President Xi Jinping says the country will make any vaccine available as a global public good. COMPANY BioNTech SE, Pfizer Inc. NAME multiple candidates PROGRESS Phase 2

BioNTech's BNT162 is another messenger RNA vaccine platform that the German company is developing with Pfizer. In China, BioNTech is co-developing vaccines with Shanghai Fosun Pharmaceutical Group.

LATEST NEWS One of the companies' vaccine candidates has shown promising antibody responses. Further testing in up to 30,000 people may start as early as July. COMPANY Sinovac Biotech Ltd NAME No name yet PROGRESS Phase 3

The vaccine uses inactivated virus, which can help the body develop antibodies to the pathogen without risking infection.

LATEST NEWS Sinovac has begun human trials in China. The company says its vaccine candidate can neutralize different strains of the virus. COMPANY China National Biotec Group Co., Beijing Institute of Biological Products NAME No name yet PROGRESS Phase 3

The vaccine uses inactivated virus, which can help the body develop antibodies to the pathogen without risking infection.

LATEST NEWS With phase 2 trials complete, a vaccine could be available as soon as the end of this year, according to an official report in May. COMPANY Novavax Inc. NAME NVX-CoV2373 RECENTLY UPDATED Phase 2

Novavax's vaccine is meant to create antibodies that block a protein "spike" that the virus uses to infect its host.

LATEST NEWS Novavax has received $1.6 billion from the U.S. government as it prepares for a final-stage study as early as this fall. COMPANY Johnson & Johnson NAME No name yet PROGRESS Preclinical

J&J is working on an unnamed adenovirus-based vaccine as well as two backups.

LATEST NEWS J&J accelerated plans for human studies and aims to make up to 1 billion doses by the end of 2021 . J&J has said its vaccine could be ready for emergency use by January, and it has received $456 million from the U.S. COMPANY Sanofi, GlaxoSmithKline Plc NAME No name yet PROGRESS Preclinical

Sanofi is working on a vaccine using technology already employed in one of its flu vaccines, which could speed development and production.

LATEST NEWS France's Sanofi has partnered with the U.K.'s Glaxo on a project backed by U.S. funding. The companies plan to start human trials in the second half of this year. Sanofi is also developing an mRNA vaccine with Translate Bio. COMPANY Inovio Pharmaceuticals Inc. NAME INO-4800 RECENTLY UPDATED Phase 1

Inovio's experimental vaccine uses DNA to activate a patient's immune system.

LATEST NEWS Inovio says an early trial showed positive immune responses but investors complained about a lack of detail. COMPANY Merck & Co. NAME No names yet PROGRESS Preclinical

Merck's two vaccine candidates employ exisiting technology behind its Ebola virus shot and a measles virus vector platform discovered by the Pasteur Institute, respectively.

LATEST NEWS Merck has partnered with AIDS researchers to develop a vaccine using technology already employed in its Ebola virus shot. The company has also agreed to buy biotech Themis, gaining a vaccine candidate that uses an existing measles virus vector platform. COMPANY Imperial College London NAME No name yet PROGRESS Phase 1

When injected, the RNA vaccine candidate delivers genetic instructions to muscle cells to make the "spike" protein on the surface of the coronavirus.

LATEST NEWS Researchers have received U.K. funding and have begun human trials.

[Jul 11, 2020] The Great Covid-19 Deception and What You Need to Know to Survive by Gary Heavin

Jul 11, 2020 | www.unz.com
The Great Covid-19 Deception and What You Need to Know to Survive GARY HEAVIN JULY 10, 2020 1,600 WORDS 74 COMMENTS REPLY Tweet Reddit Share Share Email Print More RSS

I've been speaking with my friends who include medical doctors and other highly educated people about the treatments that they would seek if they were diagnosed with Covid 19. Most of them had no idea what course of treatment they or their families might seek. This conundrum is in part due to the massive volume of information that is being thrown at us. Much of this information is deliberately deceptive. I am writing this article to cut through the deception so that you and your physician can make informed decisions if and when the time comes.

This article has two purposes. First, it's imperative that you understand the great deceit that Big Pharma, their minions at the FDA, CDC, NIH, the WHO, the MSM, and officials in high government positions are perpetrating on you, your family, and likely your doctor.

The second purpose is to assure that you are armed with the necessary information to insure that you receive the best treatment options from your health care provider. Knowledge is power.

Allow me to repeat, you need to know you are being duped and you need a plan for you and your family if you become infected with Covid 19. So let's get to it. Let me begin by stating that I'm not a medical doctor and I m not offering medical advice. I do have a bachelors of science degree in health, nutrition, and counseling. I've written two NY Times bestselling books on women's health and fitness and I have been awarded an honorary doctorate degree. However, you will need to determine your treatment options with your personal physician.

The Great Deception

When it comes to safe, effective and affordable therapies for Covid 19, Big Pharma and its agents, i.e. Dr. Fauci and Dr. Birx and many others, appear to have an agenda to lie to you and your physician.

The most obvious example is their ongoing effort to ridicule the treatment option of hydroxychloroquine, Azithromycin, and Zinc. We've all watched the harsh criticism that President Trump received when he promoted this protocol for Covid 19.

So, hydroxychloroquine has been around for almost 70 years as a treatment for malaria, lupus, and rheumatoid arthritis. The WHO has designated it as a safe and effective medication akin to taking an aspirin. A survey of 6,000 medical doctors affirmed it as their treatment of choice for Covid 19.

The treatment works like this. hydroxychloroquine is an ionophore, which means it can transport material through the cellular wall. Zinc is a mineral that stops the replication of the Covid 19 virus within the cell. hydroxychloroquine transports Zinc into the cell so that it can stop the replication of the virus. The Z-pak antibiotic is given to prevent opportunistic bacterial infections like pneumonia that can occur while your immune system is engaged in fighting your viral infection. The key to its effectiveness is to start this treatment at the early onset of Covid 19 so that it has time to work.

How much effort has Big Pharma put into subverting this treatment regimen? In addition to denouncing its effectiveness, from Dr. Fauci and company, constant MSM hit pieces, the censoring of medical doctor's articles and videos from the internet, there has also been a number of "studies" done that were literally sabotaged from the onset.

The VA hospital system reported in March that they had given hydroxychloroquine to a number of patients. Following their release of information, the MSM ran the story with the headlines, "VA hospital found that hydoxychloroquine doesn't work and increases the fatality rate of Covid 19." However, if you actually read the study (see link ) you will find that only the sickest of the cohorts were given the drug. They got the drug only after they were so far along that it would not have a chance to work and they were not given zinc. None of these details made the MSM articles.

Another example of the Great Deception came from the British medical journal, The Lancet. The Lancet reported that a meta study showed that hydroxychloroquine was ineffective. As a result of this published study, France, Italy and other European countries immediately prohibited the use of this treatment option. Within a few weeks, it was found that the study was so badly designed and that the results were literally fabricated . The Lancet was forced to make a retraction of the "study." Of course in the meantime the MSM ran the original Lancet story and mislead millions of people and their physicians.

So what could possibly be the motive behind Big Pharma's Great Deception. Well there's three answers, money, money and money. That brings up the treatment option that Big Pharma is promoting, Remdesivir. This lovely experimental drug, costs above $3,000 per regimen, must be given intravenously in a hospital (five days stay around 15 grand) and evidence shows it doesn't really work .

The other treatment option is the promised Covid 19 vaccine that they allege is forthcoming. The NHS in Great Britain has committed to purchase a vaccine for the entire population of Great Britain. That's a commitment of 80,000,000 doses at an agreed price of around $600 for each vaccination. That's about $50,000,000,000. (50 Billion) That's a lot of incentive to mislead people. This week, a US pharmaceutical company received $1.6 billion dollars towards their efforts to make this vaccine which in the opinion of many experts, won't work on a coronavirus and will be untested and experimental.

How does Big Pharma have so much control over the dissemination of this information or should I say propaganda? Well, the same answer pops up again, money. Big Pharma gave $2 billion dollars during the last election cycle to US politicians. Big AG, the military/security complex and big oil each gave only a paltry $1.0 billion dollars to buy the votes of our political leadership.

The MSM counts Big Pharma's advertising revenue at up to 80 percent of their income. The internet's "masters of the universe" also kowtow to Big Pharma's influence and advertising dollars by censoring anyone who tries to tell the American people the truth about Covid 19. It certainly appears that anyone who is complicit in this Great Deception, a deception that is designed to kill and terrify enough people to ultimately beg for an experimental vaccine, well, these people would be accessories to murder.

What You Need to Know to Survive

Now, for some good news. There are several therapies that are being offered that appear to be safe, effective and affordable. However, these therapies must be utilized early in the disease progression.

Budesonide

Japan, Taiwan and other Asian countries have maintained a much lower fatality rate with Covid 19 then we have here in America, in spite of the fact they live in densely populated communities. Many people believe that it is due to their preferred method of treatment. They use a steroid medication that is inhaled in a mist through a home use nebulizer. I'm familiar with this since my 2 year old granddaughter needed this treatment with a similar drug for an upper respiratory issue that she had recently. That speaks to the safety and the commonality of this treatment. Watch the link of a Texas doctor who shares his patient's experiences with this therapy method using the drug Budesonide and a course of antibiotics.

Ivermectin

Another treatment option that appears to be safe and effective is the use of the antiparasitic drug Ivermectin with the antibiotic Doxycycline. Just one Ivermectin pill and then the course of antibiotics for ten days resulted in a 100 percent cure rate for Covid 19 patients according to the attached study. Ivermectin has been widely used on the continent of Africa for many years as an anti-parasitic and is believed to be a primary reason that Covid 19 has not severely impacted the African population.

Hydroxychloroquine & Zinc

As we've seen above, this therapeutic regimen should be considered simply due to the efforts to prevent you from knowing the truth about it . As Shakespeare wrote, "Doth thou protest too much?"

The challenge with this therapeutic is both finding a doctor who will prescribe it and finding a pharmacy that will sell it. This should be between you and your doctor. Not the governors of certain states. Considering that 20 percent of all drugs are prescribed "off label", meaning that they are prescribed for a use other than intended, you and your doctor should have the liberty and the responsibility to make this health care decision.

There are several other therapies that appear to be safe, effective and affordable. You may want to research Chlorine Dioxide, intravenous ozone, high dose intravenous vitamin C and another, glutathione which are popular treatments in the homeopathic communities.

As for me and my family, we are going to make informed and responsible decisions regarding our health care. I hope the information I've given to you today along with the links for further information will help you, your family and your doctor make the best decisions as well.

Gary Heavin and his wife Diane are the founders of Curves, the world's largest fitness franchise. Gary is the author of two NY Times bestselling books, Curves and Curves on the go. Gary co-wrote and starred in the movie Amerigeddon. Gary is a pro-life libertarian and serves on the advisory board of Dr. Ron Paul's Institute for Peace and Prosperity. Gary and his wife are philanthropists who feed 10,000 children a day in Haiti and operate an orphanage outside the slums of Mumbai. Most importantly, they are bible believing Christians.


Anon [694] Disclaimer , says: July 11, 2020 at 4:42 am GMT

Excellent article. Early treatment is definitely key. The French doctor who recommended hydroxychloroquine way back in Feb. said that it needs to be given early, by the time they go on ventilator it's no longer effective. I read in Zerohedge last week that in TX, doctors said they simply give patients who come into the emergency room a steroid shot and send them home with antibiotics. Usually they are already feeling much better after the steroid shot. Even those who are hospitalized are now only staying 3-5 days.

I find it incredulous that on their website, CDC is still telling people to stay home if they are sick, that "many people" get over it themselves without treatment, and to *not* go to the doctor's until we are having difficulty breathing. By then it is too late! Doctors have said that the main difference btwn Covid patients and flu patients is, with a flu patient, when their lungs are 10% fluid, they are already having difficulty breathing, but for some reason for Covid19, the patient does not have difficulty breathing until the lungs are 50 to 60% fluid, which is why it's too late by the time they sought treatment.

This article discusses the low fatality rate in HK(0.4%) and Singapore(<0.1%), the doctors there attributed it to early treatment using a different cocktail of drugs: interferon beta-1b, which was developed to treat multiple sclerosis; ribavirin, which is used in the treatment of hepatitis C; and lopinavir-ritonavir, also known by its brand name, Kaletra. But again, early treatment is key.
https://www.msn.com/en-sg/news/singapore/how-hong-kong-singapore-kept-coronavirus-death-rates-low/ar-BB14CLbM

CDC is an absolute fail. I'm beginning to believe they want more people to die so Trump would lose the election. They need to change their advice on their website before more lives are senselessly lost. Pence as the Covid Tzar is also totally failing on his job by not calling him out.

I'm also beginning to believe those who claim hydroxychloroquine doesn't work simply want to keep it for themselves and their cronies to take as preventive drug. Trump has been on it and he hasn't gotten sick, even though he's been exposed to lots of people. Something tells me many of our congress critters and the effing Jews are already loaded up on it.

Anonymous [426] Disclaimer , says: July 11, 2020 at 4:50 am GMT

I can't wait for November 4th when COVID-19 ends for good and all the masks and social distancing bullshit ends. Thankfully this C-19 psyops will last just 8 months and not the 2+ years the Russian collusion BS was drawn out to. Though sadly with the former it has further eviscerated working/middle-class America. I'm guessing that was part of the plan as well.

Quinsat , says: July 11, 2020 at 5:24 am GMT

The great Covid deception is it hasn't fulfilled Koch's postulates.

Smokey , says: July 11, 2020 at 5:51 am GMT

I believe Mr. Heavin more than I believe the government, and the CDC in particular.

But that could also apply to a Numerologist vs the gov't, so there's that.

I don't believe Jeffrey Epstein died a natural death any more than I believe the mainstream media is the least bit impartial. They used to try. They tried to keep the news and the Op-Ed pages separate. But that was then and this is now

This is getting fun!

So, I used to believe that cops were always the good guys, and that federal judges were above politics. Oh, and they would never lie, or take a bribe. And I believed that priests would never, ever molest a boy, or even girl (did I get that backward?), or even use bad words around them. And I believed Scoutmasters took Boy Scouts up into the mountains for the fresh air and Indian lore OK, this is starting to sound ridiculous.

Except, now I'm not sure what to believe any more.

Can anyone tell me ?

Chris in Cackalacky , says: July 11, 2020 at 5:57 am GMT
@Kirt

No offense but do you know how many people claim to have had Covid before Covid was cool? I don't know anyone who has tested positive but I know 25 people who claim they had or have it. In the past three years there have been severe influenzas making the rounds, there is no denying that. And why should routine flu and colds take a holiday just because our criminal elites tell us there is a special disease we need to watch out for? My point is we are so deceived that nobody knows up from down anymore. But at least we know one thing for sure -- hostile elites are working to deceive us.

Achilles Wannabe , says: July 11, 2020 at 6:33 am GMT

My doctor suffers from a delusion common to her profession. She thinks she is a "Medical Scientist". Actually she is a retailer for pharmaceuticals and medical technologies. She is a sales person in a capitalist industry And should she have any questions about her real role in a health care field which is really a substance and med tech pushing industry, her colleagues – fellow sales people – will remind her of her professional obligations by threatening her board certification to insure her near absolute conformity to market standards.

But there is no getting her to understand her real role in the medical industry. She believes her own hype or the hype created about her profession back in the 1950s when a few genuinely useful drugs and technologies were discovered which then afforded the money making corporate establishment the opportunity to take a humane craft and, thru the "science" of Epidemiology -Medical speak for lying with statistics – turn professional Medicine into probably the largest boondoggle in history. Consider the flag ship for usurious medicine – cholesterol lowering statin drugs.

But why don't I get rid of my essentially brain dead doctor, go to to someone else? Practically speaking, there is no one else. There are doctors who understand all this and write books about it but they are so rare as to be useless when real sickness like bacterial infections for which there are useful technologies like antibiotics actually occur. The most useful thing these real scientific doctors have to say is "Don't see your doctor" unless you have a real emergency – like an old fashion visceral type sickness – as opposed to some epidemiologically hyped condition like, again, "high cholesterol" as the "cause" of heart disease.

But now we have a genuine epidemic that is killing and injuring people and Medical Science is lying to us about possible treatments. Even a Medical skeptic like myself could not have predicted this level of base greed by our Medical pharmaceutical establishment This is tantamount to MURDER. And we have no government -whether it be run by Democrats or Republicans- who will take action. They are all on the Med Pharm tit and/or deluded by "Medical Science" as well. Until we learn to help ourselves and overthrow this system, God help us

Valka , says: July 11, 2020 at 6:48 am GMT

$50 billion just for Britain America doesn't stand a chance.

TheTrumanShow , says: July 11, 2020 at 6:58 am GMT

Thanks, Gary.

I've been reading everything counter-&-alternative to the deception I could find since it first appeared, but had never thought to investigate therapies until reading your article. Fortuitously, for me (in Thailand), Hydroxychloroquine is being used therapeutically and may even be available OTC.

However, Big Medicine & Big Pharma are already here and steadily making inroads into health care and medicine.

Gleimhart Mantooso , says: July 11, 2020 at 7:10 am GMT

Whatever happened to that vaccine that some Israeli Genius Doctors claimed would be ready in a few weeks, which was months ago now? What a shock that that never materialized.

Trygve Blodøks , says: July 11, 2020 at 7:38 am GMT

You should also look into coodial silver water. I got rid of an hpv infection using it. No side effects.

Herald , says: July 11, 2020 at 9:14 am GMT

The author doesn't mention Vitamin D, which is rather strange.

skrik , says: July 11, 2020 at 9:29 am GMT

@Gary Heavin

The Great Covid-19 Deception and

Click-baitish, much? Well, you got me in, but you seem to have a good 'treatment' argument, and 'good luck,' both by avoiding Covid-19 in the 1st place and finding a 'collaborative+pursuasive' Dr in the 2nd = worst case, should you or one of yours gets 'hit.' [Perish the thought.]

But IMHO, the Great est Covid-19 Deception is the negligent way most 'Western' governments have *not* taken Covid-19 properly seriously, starting of course with US = Trump and UK = Johnson then perhaps SE 'led' by so-called expert Tegnell next in a looong list of apparent delinquents.

Again IMHO, when Wuhan realised that they were under a bio-warfare-like attack [possibly when they 1st saw the PRRA inclusion in the decoded genome], they reacted like cut snakes and proceeded with the speed of fear-stricken Gazelles in a very largely successful attempt to *suppress* the virus. But, of course, they are communists, eh? So-called 'democratic' [in-name-only governments, many largely bolshie 'wo/men in the street'] think differently [even to their own detriment; they just can't help themselves.]

With the possible exception of NZ = Ardern, most 'Western' governments went for 'mitigation' = 'flattening the curve,' if they took any action at all, see BR = Bolsonaro "has accused the media of "fear-mongering"" and IIRC said something like "What can I do?"

Here is an article, 1st found by me in March on MoA :

"Coronavirus: The Hammer and the Dance"
https://medium.com/@tomaspueyo/coronavirus-the-hammer-and-the-dance-be9337092b56

MoA blurb: 'Here is his latest in which he argues not only to "flatten the curve" but to eradicate the virus.'

For my last IMHO, all 'Western' leaders who have acted with less than full effort = incompetently meaning ineffectively on behalf of their 'own people' should be prosecuted for their negligence. rgds

GeeBee , says: July 11, 2020 at 9:34 am GMT

A good article all around, except that the population of the UK is nowhere near eighty million. The latest figure I can find gives 66 million. Also, your attempt to invoke the Bard ('As Shakespeare wrote, "Doth thou protest too much?"') is lamentably botched. Try 'Methinks the lady doth protest too much'. (Hamlet's mother Gertrude says it of what she regards as overacting in a play that Hamlet has arranged for his mother and her husband, the usurper Claudius, to watch).

Justvisiting , says: July 11, 2020 at 10:37 am GMT

It is a great idea to have a candid discussion with your doctor/nurse on the issue of big pharma's economic power and how it creates conflicts of interest in the medical profession.

Many doctors/nurses already knew it and will quickly agree, many more "get it" after you explain it to them.

If your doctor is so brainwashed by "experts" that they think you are an "anti-science kook", time to get a new doctor!

gotmituns , says: July 11, 2020 at 10:40 am GMT
@Kirt

Bingo – it's all a total bunch of malarkey. All the BS isn't aimed at people our age (I'm 76), it's aimed at the milennials and younger. It is shaping them for the "Brave New World" that they will live.

Simon Tugmutton , says: July 11, 2020 at 10:48 am GMT

First let me say that the virus has never been satisfactorily isolated and does not meet Koch's postulates, which leads some people to speculate that it does not exist at all. The symptoms are so various as to be nonsensical; whatever the virus may be, last winter, that led to all the hospitalizations is open to question. Certainly the fear-porn spewed out 24/7 by the corporate media led to high levels of anxiety among the credulous and many of these no doubt presented as Covid-19 patients even though they were in fact suffering from the flu or a bad cold. Once in the hands of the quacks, nosocomial infections and intubation really made them sick – or dead.

As for protection against any respiratory illness, vitamin D is essential and I am surprised the author fails to understand this. 4000 IU per day maximum.

All that aside, Covid-19 a gigantic psyop designed to usher in a world government. It was even rehearsed in 2019 and all the wrinkles worked out beforehand.

[MORE]
Mark G. , says: July 11, 2020 at 10:56 am GMT

If you can't get hydroxychloroquine there is some evidence that the natural substance quercetin found in apples and onions can act as an ionophore that transports zinc into the cell. Instead of the z-pak, a natural antibiotic like oregano or cinnamon oil might suffice. These items quercetin, zinc and oregano and cinnamon oil are all available down at the local health food store. There is more evidence for the hydroxychloroquine, zinc, z-pak combination so those would be the preferred combination if you can get them but these natural substances might help if you can't get them and might act as a preventative to keep from getting the virus if you use them regularly.

I have found only a few studies that support the use of these natural substances but you need to understand that since these aren't drugs they can't be patented so there isn't the same financial incentive to prove their effectiveness as there would be with drugs that can be patented and then sold exclusively by one company.

UncommonGround , says: July 11, 2020 at 10:59 am GMT

Whether hydoxy/chloroquine works or not is something that will be clear only after there are studies that allow to take a final conclusion. The question has been discussed critically by the press, by medical doctors, by people. Of course, everybody knows that it's possible that no vaccination will function or be available (we can hear this everyday on television). Contrary to what the author says, a phamaceutical firm was happy that the medicament could be possibly used when the question came up and some people were optimistic about it. The web site of a German television wrote in may that it was still conceivable that hydoxychloroquine could work in the very early stages of the disease (after first negative results). This was only speculation.

The author mentions a talk with some friends of him and some information that he has. But there have been a few studies, good or bad, with chloroquine with negative results. The study of the Lancet was taken back because the data that they used was apparently not trustworthy. This shows how difficult it is to have good and conclusive results in a short time. We can say the same about the evidence used by the author. It doesn't mean very much. We still have to see what happens and until now we don't know. There are efforts to find ways to treat better the disease. In German, I read yesterday:

https://www.swr.de/swraktuell/baden-wuerttemberg/mannheim/heidelberg-neue-corona-behandlungsmethode-100.html

chuckywiz , says: July 11, 2020 at 11:15 am GMT

The media never talks about those who recovered from Corona virus like BOJO, the prime minister of UK or others. What treatment the recovered patients received, how it helped them and other information. We hear only the scary stuff.
Dr. Fauci and associates could never develop his promised HIV vaccine. I read somewhere that he had been on the same job for the last 37 years. Go figure.

"DR" Bill Gate of MS is an expert of globalized vaccination and his articles on the subject have been published in several Medical Journals.
New Economy. Question More.

Linux_tyro , says: July 11, 2020 at 11:31 am GMT

I was diagnosed with an upper respiratory infection in April. Was given a Z-pack for 5 days, an inhaler, Albuterol Sulfate that I am going to refill and a pill for cough, Benzonatate 200mg. They tested me for Flu, Pneumonia, Strep and Covid. All test came back negative.

Now I have a sinus infection and was prescribed another Z-pack with Prednisone 250mg twice a day for five days.

I've been feeling under the weather for months now.

Oh! Now I remember my question. How much zinc daily should we be taking?

Emslander , says: July 11, 2020 at 11:39 am GMT

So, now we know who the enemy is. When can we start arresting and executing them?

I've had a condition common to old men for a long time. I went to some MD from the Far East who started immediately talking about cutting me up. I went to a second doctor, a young American, and told him I guess I needed to be sliced and diced. He said, "Not so fast" and recommended the regular use of two substances I could get at the vitamin store. I did so and the matter improved to the point that I felt effectively cured.

Last week, I went back to him. He works at a large establishment that includes my regular MD. I started telling him about how miraculous and enlightened his advice was. He quickly shut me up and started talking about operations and antibiotics. He wouldn't even listen when I told him that his earlier advice had worked. My presumption is that the financial people got to him. I'd guess that they do a regular review of medical care by each physician to see how they can better monetize their practice. Anyway, his changed tone was remarkable enough that it had to be something like money that was involved.

mark tapley , says: July 11, 2020 at 11:47 am GMT

Covid 19 is just another in a long line of fake or hyped up illnesses. Remember H1N1, H5n1, SARS1, Swine flu, Bird flu, Zika and others. AIDS was another fake disease (read Dr. Peter Duesberg on this). The same type of hoax is being perpetrated with the current Corona "epidemic."

Notice it supposedly began in Wuhan China. This city of 11 million has the worlds worst air pollution. 350,000 people per year die of pneumonia in China. There are lots of people there that can be tagged as Covid 19 victims. Also quickly touted as a hot spot by our Jew controlled MSM was deaths in Italy. Official autopsies revealed over 99% of victims had pre existing illness, most of them had multiple ones at an avg. age go 69.5. Latter the age went up but I can't remember the exact figure. Remember CDC criminal Debra Brix said "we have told the hospitals to tag everything possible as Covid 19."

Remember the fake tents set up all over and the hospital ship that looked like a relic of WW1. The MSM kept talking about overflowing hospitals. Several people took videos of near vacant hospitals at this time including Brian Ruhe's exposure of Vancouver's practically empty hospital. Whenever you see the media jump all over something with all the official spokesmen and there is no alternative opinion allowed, you known it is a gov. false flag. All of a sudden climate change is no longer the critical topic of the day. I guess Greta Thunberg got the covid.

The covid 19 has never been identified by the standard scientific method of the Koch's postulates because they can't. If you have a fake virus you must have a fake test. That is the PCR test that gives ap. 200 false positives, does not determine one Corona (cold from another) and is not quantitative is a fake test. The numbers given by the CDC (holds 50 vaccine related patents) that is really an adjunct of big Pharma are a crock of baloney. Most of these figures are generated from old people in the nursing homes that are given a "visual" conformation as having covid. Note that Fauci said in February that the masks did more harm than good. Hospitals get paid big money for labeling patients as Covid victims and many times doctors just write it on the report.

The Zionists have hit a home run with this medical hoax and they will never give it up unless the cucks start using their brain a little bit and figure some things out. The next move will be manditory dangerous vaccines for all the cattle. There is big money to be made in the vaccine scam. To get the truth on vaccines read Dissolving Illusions by Dr. Suzanne Humphries and books by Forrest Maready.

The Covid scam has been planned for many years, this was an opportune time to spring it as a cover for the central banks theft of trillions more while bankrupting the workers and small businesses. The Jews at Blak Rock are big investors in masks and will now be scooping up failed businesses everywhere just like in 08.

Emslander , says: July 11, 2020 at 11:47 am GMT
@Smokey

Except, now I'm not sure what to believe any more.

Can anyone tell me ?

My uncle told me a story a long time ago about a man who had his young son climb a tree in the back yard. He let him get pretty high and then said, "Jump Johnny, Jump!" Johnny said, "If I jump, I'll get hurt." The Dad said, "No, I'll catch you." Johnny jumped and the Dad did nothing. The boy hit the ground and was crying, though not permanently injured.

He said to his Dad, "Father, you promised to catch me."

"Let that be a lesson," the Dad said. "Don't trust NOBODY."

Brás Cubas , says: July 11, 2020 at 12:03 pm GMT

Gary is a pro-life libertarian

Well, seeing as libertarians are against government action to stop abortions, I suppose all that a libertarian who opposes abortion is allowed to do is acting against it in their private life; seeing as that is exactly what the pro-choice option means, you see that Gary's position is rigorously meaningless: he is pro-life and pro-choice at the same time.

That is a really grand deception, regardless of any other claimed by this article, and all I need to know about it.

Giancarlo M. Kumquat , says: July 11, 2020 at 12:17 pm GMT

Stop feeding those Haitians!

St-Germain , says: July 11, 2020 at 12:24 pm GMT

Thanks for your article.

I also prefer plain facts to eloquent fiction (MSM). Your article has obvious practical value for the public. It's a keeper. I also hope it circulates widely as an effective antidote to virulant MSM viruses.

BTW, my first act following retirement from four decades of professional news writing was to cancel all newspaper and magazine subscriptions. There is no utility in paying to be misinformed.

It never ceases to amaze me that so many people who have never set foot in a news room now regurgitate MSM propaganda as though it came down from Mt. Sinai. MSM journalism has now run the gamut from the duty to reveal what is true, even if it hurts, to the need to say what sounds nice, even if the reporter himself doesn't believe it. That's the definition of PR.

anonymous [400] Disclaimer , says: July 11, 2020 at 12:29 pm GMT

When this wears thin they'll discover another killer virus and there'll be another go-round. They started off saying the lockdowns were just for a brief time and then when they got their foot in the door it was extended. Now government herding people around by diktat is a permanent feature of American society. They'll never let it go. There's already been some report of some other mysterious killer virus coming out of Kazakhstan so get ready. This is the largest transfer of wealth scheme ever, the assets of the bankrupted scooped up by the big companies.

An Easterner , says: July 11, 2020 at 12:38 pm GMT

'Most importantly, they are Bible believing Christians.'

That for me, as a Muslim, is the best guarantee that the person writing this article will have written all in good faith because he or she is answerable to God.

Overall, the article was very informative and pertinent to the situation we face today.

macilrae , says: July 11, 2020 at 12:47 pm GMT

The article cites imperfect studies in which hydroxychloroquine was found to be an ineffective therapeutic for COVID19 – imperfect because the treatment was generally started too late in the progression of the disease. The author postulates that, if treatment were begun earlier, mortality would be drastically reduced but, unfortunately, there is no study to support this and the majority of people suffering the symptoms of early-onset COVID19 will recover spontaneously anyway.

Singapore, with its superb bureaucratic infrastructure, has reported over 45,000 infections but only 26 deaths – that is 4 deaths per million population. South Korea reports 13,000+ deaths and 287 deaths (6 per million population) and Japan 20,000 cases and 981 deaths (10 per million) compare this to the USA with 364 deaths per million or the UK with 718.

I have yet to see a convincing explanation of these shocking differences and, when asked recently, a British government spokesman said that it is "too early" to start drawing international comparisons – "too early" for whom you might ask? Evidently not for those who have succumbed – by now a huge effort should have been put forth to account for the disparity – even if the explanation is demographic as is being largely claimed. I assume that national pride has stood in the way of seeking answers by sending study teams to these countries.

The article recounts a number of inexpensive treatments that might work and points to "Big Pharma" as the major reason these are not being systematically studied – that may well be an impediment in the USA particularly – so gathering of data from East Asia, where that influence is far less and where dramatic positive results are seen, is all the more urgent.

Meanwhile my family will wear masks and hunker down because we have no particular plan to implement if one of us catches this bug.

Butch , says: July 11, 2020 at 1:01 pm GMT

Here is a clue, stop doing ALL the things they tell you to do because its all designed to make you sicker. Eat real food, so many people just don't get it, its garbage in and garbage out. Curves have always been flattened by the healthy freely moving about [oops, stay home], health from being outside, in the sun, and amongst nature is vital [oops stay inside], eating good REAL food is how you have a good immune system [oops, dont want that we need sick people for the pharma devils, therefore we'll allow FAST [shit] FOOD to be readily available [no contact of course [OMG can you actually believe this crap?] Wear a mask because the covid devil lurks everywhere [oops, retard the flow of healthy oxygen into your body, breath back in your own exhalations of CO2 and bacteria so you can increase your odds of getting sick, you just cant make this twisted stuff up!!!] Social distance, thats the best one? We should be wanting to be social for many many reasons, the least of which is because we ARE social animals, but the best way to flatten any curve is, as previously stated, assimilate it [as humans have with all viruses] to develop herd immunity [something that you CANNOT get with a toxic vaccination], like Sweden and Japan. STOP watching MSM and social platforms removing truth. Actually STOP watching TV, its all designed to make you think a certain way.

Off The Reservation , says: July 11, 2020 at 1:06 pm GMT

The biggest problem with this article is that it does not address the fundamental basis of the fraud that is CV19.

The Chinese supposedly identified a new coronavirus and named it SARS-CoV-2.

Then, the WHO made a vague list of symptoms and created a syndrome called COVID19.

There is no proven connection whatsoever between the supposedly identified virus and the syndrome.

Billing codes were created that allow the assumed or tested diagnosis of CV19.

To make matters worse, a test was created which only tests for "markers" of coronavirus and has never been proven to connect to the above viruses or the above syndrome. Thus testing positive or negative really has no meaning as proven by the disconnect between symptoms and diagnosis.

Then, the government incentivized and instructed the use of the above billing codes and created the commonly known situation of people dying "with" the syndrome even though they died of other causes.

Add to that the manipulation of the case count, etc. Then, you have New York and New Jersey basically murdering people with treatment. Loved ones banned from visiting homes – for reasons they might bring the virus in – while "positive" sick patients are brought in. Reconcile that.

I am not saying a few people aren't sick, but there is no way to deal with something while these language tricks are going on.

The virus, the syndrome, and the tests, and the count of cases have no scientific connection to each other. What is it you are talking about being treated for? The flu?

CW2isComing , says: July 11, 2020 at 1:14 pm GMT
@Gleimhart Mantooso

Yes, where IS that Wonder of Modern Medicine anyway? We were breathlessly told of its soon-to-be release; I even thought that it was peculiar that the Israelis were so serendipitously working on just the right strain of coronavirus as to be in the forefront of vaccine development.

Miracles happen.

Except when they don't. And, to summarize here, there has NEVER been a stable/effective vaccine for the coronavirus family of viruses. NEVER.

As in, NEVER.

Adûnâi , says: Website July 11, 2020 at 1:22 pm GMT
@skrik bio-warfare-like attack [possibly when they 1st saw the PRRA inclusion in the decoded genome], they reacted like cut snakes and proceeded with the speed of fear-stricken Gazelles in a very largely successful attempt to *suppress* the virus. But, of course, they are communists, eh?"

Finally some sense in the sea of conspiratards. It is fascinating to observe the insanity of White nations – they will cling to their clearly delusional beliefs to the end, even when an alternative is presenting itself this whole time.

Wearing a mask apparently turns you into a slave. Believing in the existence of the virus makes you a shill. Pure anarchism, just without the bombs.

The comment #19 by UncommonGround is decent as well.

anon [327] Disclaimer , says: July 11, 2020 at 1:25 pm GMT

Best cure for C-19: Put Dr. Fauxci and Dr. Birx , ilk,
on a SpaceX ship bound for Mars.

Doesn't need to be a big ship.
Use sardine packing method.

CW2isComing , says: July 11, 2020 at 1:35 pm GMT
@Mark G. As well (and mentioned in some of the above comments) there are many studies indicating that adequate levels of Vitamin D may be protective. Best source: sunlight; then fresh fish, then supplements.

The entire point of this article is "self-rescue." It is clear to me that the "official" recommendation is to "stay home, don't come to your doctor's office/E.R. until you get shortness of breath, etc." so as to not "overload the hospital system."

The latter advice will get you killed if you are elderly and/or have certain co-morbidities. Treat yourself early on, be proactive towards you health; oh, also, maybe stop shoving Cheetos down your neck, take a walk, lose some weight?

anon [624] Disclaimer , says: July 11, 2020 at 1:48 pm GMT
@skrik

Moon of Alabama is a controlled website that censors dissenting commenters. The Covid-19 has completely blown the cover of that site and Mr. 'b'. Do not push that site. This unz.com site does not censor comments. Get back to us when Mr. 'b' (or is that German Intelligence?) decides to play his role properly again.

Gary Heavin , says: July 11, 2020 at 1:58 pm GMT
@Herald

Hi Herald,
The reason I didn't mention vitamin D3 is that I classify it under prevention rather than therapeutics.
I take 2,000 iu daily, 2,000 mg of vitamin C, 30 mg of zinc and 200 mg of magnesium to help prevent illness.

Twodees Partain , says: July 11, 2020 at 2:04 pm GMT
@Quinsat ch's postulates.

That's the main point of information needed if "need to know" is at the top of the list on how to survive. A person "diagnosed with covid19" should know that the existence of this "novel coronavirus" has not been established in any way that is based in actual science.

Such a diagnosis subjects the purportedly infected person to treatments that would be, at best, useless. Diagnosis is the starting point for a political assault conducted by means of "contact tracing" prescribed by an Israeli intelligence operation, and can't possibly include any effective medical treatment.

No medical treatment exists that can cure infection with an imaginary virus.

Gary Heavin , says: July 11, 2020 at 2:06 pm GMT
@GeeBee

Thank you for your corrections. When I found out that Ron was going to post my article on this website I was very excited due to the quality of its readership. People like you.

Really No Shit , says: July 11, 2020 at 2:08 pm GMT

A chinaman told me that lots of chopsuey with exotic wild animals worked for his country, whereas a wetback told me lots of beans and rice with hot sauce was the key to their success. Here in my neighboring neighborhood, the Borough Park, I hear that bubbies are offering up matzo ball soup with a scrawny chicken thrown in and the Bensonhurst Fredos are insisting that had the Italian government not abandoned the age old custom of over eating pasta fagioli, none of those paisans needlessly would have died. So, who do you believe?

Gary Heavin , says: July 11, 2020 at 2:10 pm GMT
@Linux_tyro

25 mg of zinc daily is what I take

Agent76 , says: July 11, 2020 at 2:19 pm GMT

July 9, 2020 CDC May Officially Downgrade COVID From An 'Epidemic'

The coronavirus mortality rate in the United States has dropped so low that the Centers for Disease Control and Prevention may soon stop calling the virus an "epidemic."

https://principia-scientific.org/cdc-may-officially-downgrade-covid-from-an-epidemic/

Twodees Partain , says: July 11, 2020 at 2:32 pm GMT
@Emslander

"the regular use of two substances I could get at the vitamin store."

What two substances?

Alfred , says: July 11, 2020 at 2:39 pm GMT
@Anon

I'm beginning to believe they want more people to die so Trump would lose the election.

I am surprised it is taking people so much time to work that one out.

The media don't want you to see this chart. That is why I won't stop shouting CASES

Anonymousse , says: July 11, 2020 at 2:53 pm GMT

I had symptomatic corona. It was a day and a half of mild fever and fatigue. Basically like the flu but not nearly as bad. Everyone else I've known that had symptomatic corona (already a small minority of those who actually got infected woth corona) experienced the same or even less.

If you're just about to die from something else anyway, yeah maybe such a mild disease can give you that last little push. At that point you need to be thinking about saying confession and your relationship to eternity not some magic drug extending your life another few months

It's just the flu bro.

Desert Fox , says: July 11, 2020 at 2:54 pm GMT

Coronavirus is one of the biggest scams, frauds, psyops, mass hypnosis, in history, see these sites for the truth about the coronavirus scam, henrymakow.com , thetruthseeker.co.uk, chuckbaldwinlive.com , thedollarvigilante.com .

Alfred , says: July 11, 2020 at 2:55 pm GMT
@Gleimhart Mantooso aled that they had designed a vaccine and tested it on hamsters. They wrote that a single dose "was able to protect hamsters against SARS-CoV-2."

Their best shots: Israeli efforts to invent a coronavirus vaccine, explained (Times of Israel)

You can be absolutely certain that the clowns above removed their masks as soon as they were off-camera.

Trinity , says: July 11, 2020 at 2:58 pm GMT

The (((CoronaRona?))) Well, put it this way, the same people pushing the (((CoronaRona))) story or the same people who told you that Germans gassed 6 gatrillion Jews in the "holocaust." You might have a better chance at seeing Santa Claus than dying from the (((CoronaRona.)))

During the riots, the weasel, Fauci and that female doctor whats her name, were nowhere to be seen, and now they have returned and the (((CoronaRona))) is being looped 24/7. My guess is that all these (((medical experts))) will recommend another lock-down until the election. IF Biden wins, which given the corruption out there, is highly likely whether we are in lock-down or not, the (((CoronaRona))) will fade away into the night. IF Trump is somehow is reelected, well the (((Antifa-BLM))) types will be having another meltdown that the (((media))) will cover 24/7, and the (((CoronaRona))) will be back page news again.

I'm (((CoronaRona))) and I approve this message.

Che Guava , says: July 11, 2020 at 3:13 pm GMT

This reply is both to Kirt and Garry Heavin.

For Kirt, yes, I think I already had it too, seven or eight weeks from NYE last year to mid-Feb. of this. As I have said several times, the area near my workplace was usually full of Chinese tourists.

I had a cough, extreme lethargy on many days, a slight fever. Water frnm my nose, always the case for me in winter, but no sneezing. I must raise the idea with my regular doc., since I saw him at least three times over that time.

As for our author, Heavin's article, he is clearly offering better ideas for treatments than big pharma, but who really needs treatment?

Those who have a persistent cold-like syndrome?

Anyome identified through the polymerase chain reaction tests, which prove nothing.

Just ignore it and it will go away seems by far the wisest course.

schrub , says: July 11, 2020 at 3:29 pm GMT

On an entirely different topic:

WARNING: FOR THOSE WHO USE NORD VPN for their VPN service

If you select NORDVPN's "CYBERSEC" option to "block ads and malicious websites" , you will no longer be able to get on sites like unz.com or many other right wing sites (like Mike Rivero's site: whatreallyhappened.com for instance).

NORDVPN's CYBERSEC will, however, allow you on all the left wing sites pushed by the ADL. This means that NORDVPN'S CYBERSEC option is probably using the ADL's filtering criteria.

I questioned NORDVPN about this "selectivity" and never received a reply.

This also means that your NORDVPN software could well be spying on you and recording your keystrokes if you try to access to certain unapproved sites EVEN IF if the CYBERSEC option hasn't chosen.

NORDVPN is now, curiously enough, based in Panama, a country which the US government has been shown in the past to have considerable influence over when the need arises. (Ask Manuel Noriega for examples)

Spread the word.

It might be time choose a different VPN sofware if you are now using NORDVPN. Anybody have any good suggestions?

Zarathustra , says: July 11, 2020 at 3:33 pm GMT

I believe!
I believe in CNN.
I believe that half of population of USA will die of Corona virus.
The other half because Corona virus infecting toe nails will become zombies.
Also their brains are now eaten out by Corona virus.
All US population will be replaced by natives from Africa.
First herd of Negroes are already swimming halfway in Atlantic toward America.

Well?
Its not really funny.
But than CNN is never funny.

CW2isComing , says: July 11, 2020 at 3:35 pm GMT
@Twodees Partain

@Emslander

Yes, why are you being cryptic here–on this site–where a free exchange of information is desirable?

Herald , says: July 11, 2020 at 3:38 pm GMT
@Alfred

Cases now mean positive tests and of course, no really knows what that means, other than that more useless tests have been carried out. As the graph clearly indicates these so called "cases" have little to do with deaths. Nor do they have anything to do with hospitalisations.

We are clearly in the midst of an almighty scam, which is much much bigger than simply getting rid of Trump.

Emslander , says: July 11, 2020 at 3:41 pm GMT
@Twodees Partain

Extract of cranberries and D-Mannos. Together they are very good. I presume that they can't cure serious problems, but they work pretty well.

I'm not a doctor and I don't even work on TV.

Alfred , says: July 11, 2020 at 3:50 pm GMT
@UncommonGround ut a thorough check.

A report in The Guardian also found that the key employees of Surgisphere included a science fiction writer and an adult movie star.

The HCQ study mess: How 3 Indian researchers put reputation of Lancet, NEJM at stake

How 3 'smart' Indian names have ruined 200-year reputation of most respected medical journals

https://www.youtube.com/embed/-6WnSiCPYyQ?feature=oembed

Zarathustra , says: July 11, 2020 at 3:55 pm GMT

But putting all attempted jokes aside and talking a little bit more seriously, CNN did become certified criminal enterprise now.

Gary Heavin , says: July 11, 2020 at 3:56 pm GMT

To Bras my pro-life libertarian position does not become "meaningless" as if my prolife and libertarianism negate each other as you suggest. It's quite simple. Libertarianism demands we not harm other persons. An unborn baby is a person.
To Che I certainly agree with you that Covid 19 has been hyped, politicized, misrepresented, etc..
If I come down with a severe upper respiratory event that is heading toward pneumonia-like symptoms, I've lost my sense of taste and smell I'm going to talk with my Doctor and try one of the therapies I've written about. I hope you do the same.

Thomas Milton , says: July 11, 2020 at 3:57 pm GMT

"What you need to know" .is that this crisis has been spun from whole cloth.

Montefrío , says: July 11, 2020 at 3:58 pm GMT
@gotmituns e before the year is out. My bucolic life has been given a shake and I'm scrambling to best position our family (we live on the same property) financially and economically when BNW arrives with a vengeance. I wish to leave my grandchildren (my son, a water well driller, is prospering, happily, but still ) wholly owned property and the houses thereon plus one. I believe the BNW will have a distinctly local air to it in rural or semi-rural communities: little travel, local employment save for telecommuters, detachment from social media, different educational strategies and opportunities, etc. If you share this belief, get cracking and pretend that the reset has already arrived and act accordingly.
schrub , says: July 11, 2020 at 4:00 pm GMT

AS an answer to my own question about a new secure VPN service, I just came upon this. Anybody have any experience with this outfit?

https://protonvpn.com/about

I now wouldn't trust any VPN whatsoever service that wasn't entirely "open source". Protonvpn claims to be "open source". (On the other hand, NORDVPN isn't open source).

https://protonvpn.com/blog/open-source/

Definition of very important term "open source" for those are unfamiliar with it:
https://opensource.org/osd

If a software isn't "open source" it could potentially be spying on you. Choosing a VPN service using "open source" software should be the PRIMARY and most critical consideration when choosing a VPN service.

Non "open source" VPN software is open to outside manipulation and possible government infiltration.

Wally , says: July 11, 2020 at 4:02 pm GMT
@Gleimhart Mantooso

asked:
"Whatever happened to that vaccine that some Israeli Genius Doctors claimed would be ready in a few weeks, which was months ago now?"

– The same thing that happened to the 'Israeli Geniuses' laughable, but "historic", attempt to put a spacecraft on the moon.

Israel's Beresheet spacecraft crashes during historic moon landing attempt : https://www.nbcnews.com/mach/science/how-watch-israel-s-beresheet-spacecraft-attempt-moon-landing-ncna993436

Alfred , says: July 11, 2020 at 4:04 pm GMT
@Emslander

It suits her personality as she is a quite orderly and methodical person. However, it means that she is incapable of critical thinking. All doctors in Australia are invited to free seminars and meals at expensive restaurants – paid for by pharmaceutical companies.

Sadly, she did not listen to my opinion about vaccines for our two girls. In the State of Victoria, they give a mandatory HPV vaccine. However, HPV is only a problem for those who are promiscuous. Furthermore, this vaccine is essentially an unknown. It is highly-expensive at some US$300 – paid for by the tax-payers. I suspect the vaccine altered the personality of one of our daughters. It is uncanny.

Astuteobservor II , says: July 11, 2020 at 4:05 pm GMT

It seems the only way to convince retards is to kill them or let them see dead bodies everywhere.

It is like the old saying in IT.

Everything is working, wtf does the company need you for.

Everything is falling apart, wtf does the company need you for.

On covid.

Lockdowns and quarantine is working, wtf, covid is Nothing, flu is worst.

Death count is now twice the number of the worst flu year, the lockdowns and quarantine are the causes, not covid.

Lincoln was right, just need to make sure the 80% retards gets fooled, the other 20% doesn't matter as their voices would be drown out by the retards.

If this covid virus is as deadly as it needs to convince the retards, nukes would have flown. I wonder how many retards understands why that is.

Zarathustra , says: July 11, 2020 at 4:13 pm GMT
@Gary Heavin

Slightly increase the daily intake of butter you moron, and you will not need to worry anymore.

Montefrío , says: July 11, 2020 at 4:21 pm GMT
@macilrae

I neither wear a mask nor hunker down and I'm a "double-vulnerable" (nearly 74 and mildly diabetic). A close lady friend is the village pharmacist and when on duty wears the mask under mild duress; neither of us wears it when alone with each other. Unless you're in a densely populated area, better to go out and get at least half an hour of sun daily, fortify yourself and family, keep the faith and don't succumb to manufactured fear, sez I.

Sparkon , says: July 11, 2020 at 4:35 pm GMT
@macilrae ak links here in the USA, sad to say. During my most recent trip to the market, I saw perhaps 7-10% of shoppers with their masks pulled down so it was covering the mouth, but not the nose. For the most part, these non-complying shoppers were the fat, ugly, slovenly, and stupid looking types one would try to avoid anyway, so the pulled-down mask is a good signal to give these types a very wide berth.

Recall that the world's experience with COVID-19 amounts to just six or seven months. Nobody knows what this virus may do in the future, but odds are it will mutate, like all viruses.

Psst: If it's just the flu, bro, why is it still spreading in the summer?

Vandal , says: July 11, 2020 at 4:41 pm GMT
@chuckywiz

The regiment I've seen published is as follows

Hydroxychloroquine 200mg twice a day for 5 days

ZPAK 500mg once a day for 5 days

Zinc Sulfate 220mg daily

Pragma , says: July 11, 2020 at 4:47 pm GMT

Mr. Heaven:

I found your figures regarding the vaccine cost and quantity remarkable, to say the least.

After some research, I could find no reference of a commitment by the UK government to purchase 80 million doses at $600 each.

I did find, however, reference to the Oxford/AstraZeneca potential vaccine AZD1222 which is estimated to cost around 2.5 euros or about $2.80 US. This appears to be the direction that the EU is going, but it is unclear if the UK will be part of it.

Could you please forward a link or reference for the source of your figures?

Gary Heavin , says: July 11, 2020 at 5:16 pm GMT
@Pragma

https://www.dailymail.co.uk/news/article-8123691/With-estimated-477-injection-potentially-billions-coronavirus-jab.html
As you can imagine, this article has been lambasted by big pharmaceutical interests.

Thim , says: July 11, 2020 at 5:19 pm GMT
@macilrae

Your family will wear masks, because you are slaves. Absolutely no one claims wearing a mask will prevent you from catching a flu or cold (Corona virus).

Bardon Kaldian , says: July 11, 2020 at 5:20 pm GMT

So, it's all a giant conspiracy Interesting: https://edition.cnn.com/2020/07/10/health/coronavirus-entire-body-effects-columbia/index.html

How coronavirus affects the entire body

TheTruthSeeker , says: July 11, 2020 at 5:30 pm GMT

Pavia, a cure that works, challenges media silence: "Plasma kills the virus"

"Plasma kills the coronavirus." The therapy developed by the Immuno-hematology Institute of Saint Matthew in Pavia is encouraging. In this exclusive interview with The Daily Compass given at the end of his experimentation, director Cesare Perotti reveals the positive results: "The treatment works; at the moment no one has died; the USA has asked for the protocols." But nobody is talking about it: "There are other interests opposing us, but we will address these after the scientific publication." This is how the shared treatment works, by "using" volunteers who have recovered to help heal those who are sick.

Reference and continuation:

https://newdailycompass.com/en/pavia-a-cure-that-works-challenges-media-silence-plasma-kills-the-virus

Rubicon , says: July 11, 2020 at 5:53 pm GMT
@Achilles Wannabe

What Achilles Wannabe writes is ABSOLUTELY CORRECT.

If I have to, the ONLY way to purchase HDC is via my Canadian brothers. Naturally, I would need an American doctor's prescription, but push comes to shove, I absolutely refuse going to ANY American "medical doctor" to treat me.

Hopefully, the Canadian prescription stores would be able to fill that prescription. If not, oh well.
Living in this dying nation is death-defying.

[Jul 10, 2020] Vitamin D deficit potencially increases the probablity to catch COVID-19

Jul 10, 2020 | www.moonofalabama.org

jean , Jul 10 2020 17:59 utc | 105

There is a racial difference in that blacks and people of color are vitamin D deficient, as are the elderly.

Vitamin D linked to low virus death rate, study finds
New COVID-19 research finds relationship in data from 20 European countries

https://www.sciencedaily.com/releases/2020/05/200507131012.htm


dbk , Jul 10 2020 18:05 utc | 107

For commenters who've remarked on the incidences of (a) obesity, (b) diabetes and (c) high blood pressure - other cardiovascular ailments (not sure anyone referred to [c] but it's on most lists), these are all ultimately rooted in poverty / stress.

For commenters who remarked on the "Southern" diet and McDonald's food, many urban neighborhoods and poor rural counties are food deserts, period. The urban elite in the South (Black and white alike) have diets that resemble those of residents of Manhattan.

For the commenter who remarked on the absence of a national health care program in the U.S. - yes, this is a major contributing factor but it's further complicated by other intersecting forms of injustice which contribute to the heightened risk for Blacks who contract the virus.

The premise of the OP is correct in my view, and the post correctly concludes the Identity Politics is being used (by both sides) to mask the real disease.

karlof1 , Jul 10 2020 18:34 utc | 108

I must applaud b for finally bringing in the Class War into his COVID-19 analysis. What you are genetically isn't the main factor; rather, it's your socio-economic-- CLASS --status that matters most regarding your potential exposure to the disease. Activists within the Outlaw US Empire have pointed to that fact going back to March, and it's certainly a big factor fueling the ongoing protests.

[Jul 10, 2020] AR Comes to the Fight Against Covid-19

Jul 10, 2020 | www.afr.com

Australian Financial Review
John Davidson
July 6, 2020

Researchers at La Trobe University in Australia have developed an augmented reality (AR) visualization of the effects of Covid-19 on the lungs, in an effort to aid diagnosis and treatment. The researchers converted two-dimensional (2D) computed tomography (CT) scans of Covid-damaged lungs into three-dimensional (3D) images. Microsoft's HoloLens 2 headset lets researchers view those images, superimposed into the space in front of their eyes. Said La Trobe's Henry Duh, "If you only see a 2D scan, without HoloLens, you need to do more mental rotations and reconstructions in order to figure out what it looks like in the body." The researchers hope to use machine learning to analyze original CT scans and identify areas of the lungs damaged by the disease.

Full Article
*May Require Paid Registration

[Jul 10, 2020] LancetGate- -Scientific Corona Lies- Big Pharma Corruption - Hydroxychloroquine Versus Remdesivir -

Jul 10, 2020 | www.zerohedge.com

LancetGate: "Scientific Corona Lies" & Big Pharma Corruption - Hydroxychloroquine Versus Remdesivir by Tyler Durden Fri, 07/10/2020 - 19:05 Twitter Facebook Reddit Email Print

Authored by Prof Michel Chossudovsky via GlobalResearch.ca,

Introduction

There is an ongoing battle to suppress Hydroxychloroquine (HCQ), a cheap and effective drug for the treatment of Covid-19. The campaign against HCQ is carried out through slanderous political statements, media smears, not to mention an authoritative peer reviewed "evaluation" published on May 22nd by The Lancet, which was based on fake figures and test trials.

The study was allegedly based on data analysis of 96,032 patients hospitalized with COVID-19 between Dec 20, 2019, and April 14, 2020 from 671 hospitals Worldwide. The database had been fabricated. The objective was to kill the Hydroxychloroquine ( HCQ) cure on behalf of Big Pharma.

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Harvard And MIT Sue

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Trump Not Happy With CDC School Guidelines

The Unreported Cases

The CDC Single Test

Censor In Chief? VP Pence To Control Coronavirus Info

The Yeezy Loan

Cruise Ships Might Be a Safer Way to Vacation During COVID-19, Health Expert Claims

While The Lancet article was retracted, the media casually blamed "a tiny US based company" named Surgisphere whose employees included "a sci-fi writer and an adult content model" for spreading "flawed data" (Guardian) . This Chicago based outfit was accused of having misled both the WHO and national governments, inciting them to ban HCQ. None of those trial tests actually took place.

While the blame was placed on Surgisphere, the unspoken truth (which neither the scientific community nor the media have acknowledged) is that the study was coordinated by Harvard professor Mandeep Mehra under the auspices of Brigham and Women's Hospital (BWH) which is a partner of the Harvard Medical School.

When the scam was revealed , Dr. Mandeep Mehra who holds the Harvey Distinguished Chair of Medicine at Brigham and Women's Hospital apologized:

I have always performed my research in accordance with the highest ethical and professional guidelines. However, we can never forget the responsibility we have as researchers to scrupulously ensure that we rely on data sources that adhere to our high standards.

It is now clear to me that in my hope to contribute this research during a time of great need, I did not do enough to ensure that the data source was appropriate for this use. For that, and for all the disruptions – both directly and indirectly – I am truly sorry. (emphasis added)

Mandeep R. Mehra, MD, MSC ( official statement on BWH website)

But that "truly sorry" note was just the tip of the iceberg. Why?

https://lockerdome.com/lad/13084989113709670?pubid=ld-dfp-ad-13084989113709670-0&pubo=https%3A%2F%2Fwww.zerohedge.com&rid=www.zerohedge.com&width=890

Studies on Gilead Science's Remdesivir and Hydroxychloroquine (HCQ) Were Conducted Simultaneously by Brigham and Women's Hospital (BWH)

While The Lancet report (May 22, 2020) coordinated by Dr. Mandeep Mehra was intended "to kill" the legitimacy of HCQ as a cure of Covid-19, another important (related) study was being carried out (concurrently) at BWH pertaining to Remdesivir on behalf of Gilead Sciences Inc. Dr. Francisco Marty, a specialist in Infectious Disease and Associate Professor at Harvard Medical School was entrusted with coordination of the clinical trial tests of the antiviral medication Remdesivir under Brigham's contract with Gilead Sciences Inc :

Brigham and Women's Hospital began enrolling patients in two clinical trials for Gilead's antiviral medication remdesivir. The Brigham is one of multiple clinical trial sites for a Gilead-initiated study of the drug in 600 participants with moderate coronavirus disease (COVID-19) and a Gilead-initiated study of 400 participants with severe COVID-19.

If the results are promising, this could lead to FDA approval, and if they aren't, it gives us critical information in the fight against COVID-19 and allows us to move on to other therapies."

While Dr. Mandeep Mehra was not directly involved in the Gilead Remdesevir BWH study under the supervision of his colleague Dr. Francisco Marty, he nonetheless had contacts with Gilead Sciences Inc: "He participated in a conference sponsored by Gilead in early April 2020 as part of the Covid-19 debate" (France Soir, May 23, 2020)

What was the intent of his (failed) study? To undermine the legitimacy of Hydroxychloroquine?

According to France Soir, in a report published after The Lancet Retraction:

The often evasive answers produced by Dr Mandeep R. Mehra , professor at Harvard Medical School, did not produce confidence, fueling doubt instead about the integrity of this retrospective study and its results . (France Soir, June 5, 2020)

Was Dr. Mandeep Mehra in conflict of interest? (That is a matter for BWH and the Harvard Medical School to decide upon).

Who are the Main Actors?

Dr. Anthony Fauci, advisor to Donald Trump, portrayed as "America's top infectious disease expert" has played a key role in smearing the HCQ cure which had been approved years earlier by the CDC as well as providing legitimacy to Gilead's Remdesivir.

Dr. Fauci has been the head of the National Institute of Allergy and Infectious Diseases (NIAID) since the Reagan administration. He is known to act as a mouthpiece for Big Pharma.

Dr. Fauci launched Remdesivir in late June (see details below). According to Fauci, Remdesevir is the "corona wonder drug" developed by Gilead Science Inc. It's a $1.6 billion dollar bonanza.

Gilead Sciences Inc: History

Gilead Sciences Inc is a Multibillion dollar bio-pharmaceutical company which is now involved in developing and marketing Remdesivir. Gilead has a long history. It has the backing of major investment conglomerates including the Vanguard Group and Capital Research & Management Co, among others. It has developed ties with the US Government.

In 1999 Gilead Sciences Inc, developed Tamiflu (used as a treatment of seasonal influenza and bird flu). At the time, Gilead Sciences Inc was headed by Donald Rumsfeld (1997-2001), who later joined the George W. Bush administration as Secretary of Defense (2001-2006). Rumsfeld was responsible for coordinating the illegal and criminal wars on Afghanistan (2001) and Iraq (2003).

Rumsfeld maintained his links to Gilead Sciences Inc throughout his tenure as Secretary of Defense (2001-2006). According to CNN Money (2005) : "The prospect of a bird flu outbreak was very good news for Defense Secretary Donald Rumsfeld [who still owned Gilead stocks] and other politically connected investors in Gilead Sciences".

Anthony Fauci has been in charge of the NIAID since 1984, using his position as "a go between" the US government and Big Pharma. During Rumsfeld's tenure as Secretary of Defense, the budget allocated to bio-terrorism increased substantially, involving contracts with Big Pharma including Gilead Sciences Inc. Anthony Fauci considered that the money allocated to bio-terrorism in early 2002 would:

"accelerate our understanding of the biology and pathogenesis of microbes that can be used in attacks, and the biology of the microbes' hosts -- human beings and their immune systems. One result should be more effective vaccines with less toxicity." (WPo report)

In 2008, Dr. Anthony Fauci was granted the Presidential Medal of Freedom by president George W. Bush "for his determined and aggressive efforts to help others live longer and healthier lives."

The 2020 Gilead Sciences Inc Remdesivir Project

We will be focussing on key documents (and events)

Chronology

February 21: Initial Release pertaining to NIH-NIAID Remdesivir placebo test trial

April 10 : The Gilead Sciences Inc study published in the NEJM on the "Compassionate Use of Remdesivir"

April 29 : NIH Release: Study on Remdesivir (Report published on May 22 in NEJM)

May 22, The BWH-Harvard Study on Hydroxychloroquine coordinated by Dr. Mandeep Mehra published in The Lancet

May 22 , Remdesivir for the Treatment of Covid-19 -- Preliminary Report (NEJM)

June 5: The (fake) Lancet Report (May 22) on HCQ is Retracted.

June 29 , Fauci announcement. The $1.6 Billion Remdevisir HHS Agreement with Gilead Sciences Inc

April 10: The Gilead Sciences Inc. study published in the NEJM on the "Compassionate Use of Remdesivir"

A Gilead sponsored report was published in New England Journal of Medicine in an article entitled "Compassionate Use of Remdesivir for Patients with Severe Covid-19" . It was co-authored by an impressive list of 56 distinguished medical doctors and scientists, many of whom were recipients of consulting fees from Gilead Sciences Inc.

Gilead Sciences Inc. funded the study which included several staff members as co-authors.

The testing included a total of 61 patients [who] received at least one dose of remdesivir on or before March 7, 2020; 8 of these patients were excluded because of missing postbaseline information (7 patients) and an erroneous remdesivir start date (1 patient) Of the 53 remaining patients included in this analysis, 40 (75%) received the full 10-day course of remdesivir, 10 (19%) received 5 to 9 days of treatment, and 3 (6%) fewer than 5 days of treatment.

The NEJM article states that "Gilead Sciences Inc began accepting requests from clinicians for compassionate use of remdesivir on January 25, 2020". From whom, From Where? According to the WHO (January 30, 2020) there were 82 cases in 18 countries outside China of which 5 were in the US, 5 in France and 3 in Canada.

Several prominent physicians and scientists have cast doubt on the Compassionate Use of Remdesivir study conducted by Gilead, focussing on the small size of the trial. Ironically, the number of patients in the test is less that the number of co-authors: "53 patients" versus "56 co-authors"

Below we provide excerpts of scientific statements on the Gilead NEJM project ( Science Media Centre emphasis added) published immediately following the release of the NEJM article:

" 'Compassionate use' is better described as using an unlicensed therapy to treat a patient because there are no other treatments available . Research based on this kind of use should be treated with extreme caution because there is no control group or randomisation, which are some of the hallmarks of good practice in clinical trials. Prof Duncan Richard , Clinical Therapeutics, University of Oxford.

"It is critical not to over-interpret this study. Most importantly, it is impossible to know the outcome for this relatively small group of patients had they not received remdesivir. Dr Stephen Griffin , Associate Professor, School of Medicine, University of Leeds.

"The research is interesting but doesn't prove anything at this point: the data are from a small and uncontrolled study. Simon Maxwell, Professor of Clinical Pharmacology and Prescribing, University of Edinburgh.

"The data from this paper are almost uninterpretable. It is very surprising, perhaps even unethical, that the New England Journal of Medicine has published it. It would be more appropriate to publish the data on the website of the pharmaceutical company that has sponsored and written up the study. At least Gilead have been clear that this has not been done in the way that a high quality scientific paper would be written. Prof Stephen Evans, Professor of Pharmacoepidemiology, London School of Hygiene & Tropical Medicine.

"It's very hard to draw useful conclusions from uncontrolled studies like this particularly with a new disease where we really don't know what to expect and with wide variations in outcomes between places and over time. One really has to question the ethics of failing to do randomisation – this study really represents more than anything else, a missed opportunity." Prof Adam Finn, Professor of Paediatrics, University of Bristol.

To review the complete document of Science Media Centre pertaining to expert assessments click here

April 29: The National Institutes of Health (NIH) Study on Remdevisir.

On April 29th following the publication of the Gilead Sciences Inc Study in the NEJM on April 10, a press release of the National Institutes of Health (NIH) on Remdevisir was released. The full document was published on May 22, by the NEJM under the title:

Remdesivir for the Treatment of Covid-19 -- Preliminary Report (NEJM)

The study had been initiated on February 21, 2020. The title of the April 29 Press Release was:

"Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery"

It's a government sponsored report which includes preliminary data from a randomized trial involving 1063 hospitalized patients. The results of the trial labelled Adaptive COVID-19 Treatment Trial (ACTT) are preliminary, conducted under the helm of Dr. Fauci's National Institute of Allergy and Infectious Diseases (NIAID) :

An independent data and safety monitoring board (DSMB) overseeing the trial met on April 27 to review data and shared their interim analysis with the study team. Based upon their review of the data, they noted that remdesivir was better than placebo from the perspective of the primary endpoint, time to recovery, a metric often used in influenza trials. Recovery in this study was defined as being well enough for hospital discharge or returning to normal activity level.

Preliminary results indicate that patients who received remdesivir had a 31% faster time to recovery than those who received placebo (p<0.001). Specifically, the median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo. Results also suggested a survival benefit, with a mortality rate of 8.0% for the group receiving remdesivir versus 11.6% for the placebo group (p=0.059). (emphasis added)

In the NIH's earlier February 21, 2020 report (released at the outset of the study), the methodology was described as follows:

A randomized, controlled clinical trial to evaluate the safety and efficacy of the investigational antiviral remdesivir in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19)

Numbers. Where? When?

The February 21 repor t confirmed that the first trial participant was "an American who was repatriated after being quarantined on the Diamond Princess cruise ship" that docked in Yokohama (Japanese Territorial Waters). "Thirteen people repatriated by the U.S. State Department from the Diamond Princess cruise ship" were selected as patients for the placebo trial test. Ironically, at the outset of the study, 58.7% of the "confirmed cases" Worldwide (542 cases out of 924) (outside China), were on the Diamond Cruise Princess from which the initial trial placebo patients were selected.

Where and When: The trial test in the 68 selected sites? That came at a later date because on February 19th (WHO data), the US had recorded only 15 positive cases (see Table Below).

"A total of 68 sites ultimately joined the study -- 47 in the United States and 21 in countries in Europe and Asia." (emphasis added)

In the final May 22 NEJM report entitled Remdesivir for the Treatment of Covid-19 -- Preliminary Report :

There were 60 trial sites and 13 subsites in the United States (45 sites), Denmark (8), the United Kingdom (5), Greece (4), Germany (3), Korea (2), Mexico (2), Spain (2), Japan (1), and Singapore (1). Eligible patients were randomly assigned in a 1:1 ratio to receive either remdesivir or placebo. Randomization was stratified by study site and disease severity at enrollment

The Washington Post applauded Anthony Fauci's announcement (April 29):

"The preliminary results, disclosed at the White House by Anthony S. Fauci, fall short of the magic bullet or cure But with no approved treatments for Covid-19, [Lie] Fauci said, it will become the standard of care for hospitalized patients The data shows that remdisivir has a clear-cut, significant, positive effect in diminishing the time to recovery," Fauci said.

The government's first rigorous clinical trial of the experimental drug remdesivir as a coronavirus treatment delivered mixed results to the medical community Wednesday -- but rallied stock markets and raised hopes that an early weapon to help some patients was at hand.

The preliminary results, disclosed at the White House by Anthony Fauci, chief of the National Institute of Allergy and Infectious Diseases, which led the placebo-controlled trial found that the drug accelerated the recovery of hospitalized patients but had only a marginal benefit in the rate of death.

Fauci's remarks boosted speculation that the Food and Drug Administration would seek emergency use authorization that would permit doctors to prescribe the drug.

In addition to clinical trials, remdesivir has been given to more than 1,000 patients under compassionate use. [also refers to the Gilead study published on April 10 in the NEJM]

The study, involving [more than] 1,000 patients at 68 sites in the United States and around the world (??) , offers the first evidence (??) from a large (??), randomized (??) clinical study of remdesivir's effectiveness against COVID-19.

The NIH placebo test study provided "preliminary results". While the placebo trial test was "randomized", the overall selection of patients at the 68 sites was not fully randomized. See the full report.

May 22: The Fake Lancet Report on Hydroxychloroquine (HCQ)

It is worth noting that the full report of the NIH-NIAID) entitled Remdesivir for the Treatment of Covid-19 -- Preliminary Report was released on May 22, 2020 in the NEJM, on the same day as the controversial Lancet report on Hydroxychloroquine.

Immediately folllowing its publication, the media went into high gear, smearing the HCQ cure, while applauding the NIH-NIASD report released on the same day.

Remdesivir, the only drug cleared to treat Covid-19, sped the recovery time of patients with the disease, "It's a very safe and effective drug," said Eric Topol, founder and director of the Scripps Research Translational Institute. "We now have a definite first efficacious drug for Covid-19, which is a major step forward and will be built upon with other drugs, [and drug] combinations."

When the Lancet HCQ article by Bingham-Harvard was retracted on June 5, it was too late, it received minimal media coverage. Despite the Retraction, the HCQ cure "had been killed".

June 29: Fauci Greenlight. The $1.6 Billion Remdesivir Contract with Gilead Sciences Inc

Dr. Anthony Fauci granted the "Greenlight" to Gilead Sciences Inc. on June 29, 2020.

The semi-official US government NIH-NIAID sponsored report (May 22) entitled Remdesivir for the Treatment of Covid-19 -- Preliminary Report (NEJM) was used to justify a major agreement with Gilead Sciences Inc.

The Report was largely funded by the National Institute of Allergy and Infectious Diseases (NIAID) headed by Dr. Anthony Fauci and the National Institutes of Health (NIH).

On June 29, based on the findings of the NIH-NIAID Report published in the NEJM, the Department of Health and Human Services (HHS) announced on behalf of the Trump Adminstration an agreement to secure large supplies of the remdesivir drug from Gilead Sciences Inc. for the treatment of Covid-19 in America's private hospitals and clinics.

The earlier Gilead study based on scanty test results published in the NEJM (April 10), of 53 cases (and 56 co-authors) was not highlighted. The results of this study had been questioned by several prominent physicians and scientists.

Who will be able to afford Remdisivir? 500,000 doses of Remdesivir are envisaged at $3,200 per patient, namely $1.6 billion (see the s tudy by Elizabeth Woodworth )

The Drug was also approved for marketing in the European Union. under the brandname Veklury.

If this contract is implemented as planned, it represents for Gilead Science Inc. and the recipient US private hospitals and clinics a colossal amount of money.

[error in above title according to HHS: $3200]

According to The Trump Administration's HHS Secretary Alex Azar (June 29, 2020):

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"To the extent possible, we want to ensure that a ny American patient who needs remdesivir can get it . [at $3200] The Trump Administration is doing everything in our power to learn more about life-saving therapeutics for COVID-19 and secure access to these options for the American people."

Remdesivir for Covid-19: $1.6 Billion for a "Modestly Beneficial" Drug?

Remdesivir versus Hydroxychloroquine (HCQ)

Careful timing:

The Lancet study (published on May 22) was intended to undermine the legitimacy of Hydroxychloroquine as an effective cure to Covid-19, with a view to sustaining the $1.6 billion agreement between the HHS and Gilead Sciences Inc. on June 29th. The legitmacy of this agreement rested on the May 22 NIH-NIAID study in the NEJM which was considered "preliminary".

What Dr. Fauci failed to acknowledge is that Chloroquine had been "studied" and tested fifteen years ago by the CDC as a drug to be used against coronavirus infections. And that Hydroxychloroquine has been used recently in the treatment of Covid-19 in several countries.

According to the Virology Journal (2005) " Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". It was used in the SARS-1 outbreak in 2002. It had the endorsement of the CDC.

HCQ is not only effective, it is "inexpensive" when compared to Remdesivir, at an estimated "$3120 for a US Patient with private insurance".

Below are excerpts of an interview of Harvard's Professor Mehra (who undertook the May 22 Lancet study) with France Soir published immediately following the publication of the Lancet report (prior to its Retraction).

Dr. Mandeep Mehra: In our study, it is fairly obvious that the lack of benefit and the risk of toxicity observed for hydroxychloroquine are fairly reliable. [referring to the May 22 Lancet study]

France Soir: Do you have the data for Remdesivir?

MM: Yes, we have the data, but the number of patients is too small for us to be able to conclude in one way or another.

FS: As you know, in France, there is a pros and cons battle over hydroxychloroquine which has turned into a public health issue even involving the financial lobbying of pharmaceutical companies. Why not measure the effect of one against the other to put an end to all speculation?

MM: In fact, there is no rational basis for testing Remdesivir versus hydroxychloroquine. On the one hand, Remdesivir has shown that there is no risk of mortality and that there is a reduction in recovery time. On the other hand, for hydroxychloroquine it is the opposite: it has never been shown any advantage and most studies are small or inconclusive In addition, our study shows that there are harmful effects.

It would therefore be difficult and probably unethical to compare a drug with demonstrated harmfulness to a drug with at least a glimmer of hope.

FS: You said that there is no basis for testing or comparing Remdesivir with hydroxychloroquine, do you think you have done everything to conclude that hydroxychloroquine is dangerous?

MM: Exactly.

All we are saying is that once you have been infected (5 to 7 days after) to the point of having to be hospitalized with a severe viral load, the use of hydroxychloroquine and its derivative is not effective.

The damage from the virus is already there and the situation is beyond repair. With this treatment [HCQ] it can generate more complications

FS Mandeep Mehra declared that he had no conflict of interest with the laboratories and that this study was financed from the endowment funds of the professor's chair.

He participated in a conference sponsored by Gilead in early April 2020 as part of the Covid-19 debate.

- France Soir, translated by the author, emphasis added, May 23, 2020)

In Annex, see the followup article by France Soir published after the scam surrounding the data base of Dr. Mehra's Lancet report was revealed.

Concluding Remarks

Lies and Corruption to the nth Degree involving Dr. Anthony Fauci, "The Boston Connection" and Gilead Sciences Inc.

The Gilead Sciences Inc. Remdesivir study (50+ authors) was published in the New England Journal of Medicine (April 10, 2020).

It was followed by the NIH-NIAID Remdesivir for the Treatment of Covid-19 -- Preliminary Report on May 22, 2020 in the NEJM. And on that same day, May 22, the "fake report" on Hydroxychloroquine by BWH-Harvard Dr. Mehra was published by The Lancet.

Harvard Medical School and the BWH bear responsibility for having hosted and financed the fake Lancet report on HCQ coordinated by Dr. Mandeep Mehra.

Is there conflict of interest? BWH was simultaneously involved in a study on Remdesivir in contract with Gilead Sciences, Inc.

While the Lancet report coordinated by Harvard's Dr. Mehra was retracted, it nonetheless served the interests of Gilead Sciences Inc.

It is important that an independent scientific and medical assessment be undertaken, respectively of the Gilead Sciences Inc New England Journal of Medicine (NEMJ) peer reviewed study (April 10, 2020) as well as the NIH-NIAID study also published in the NEJM (May 22, 2020).

* * *

ANNEX

Retraction by France Soir

The fraud concerning the Lancet Report was revealed in early June. France Soir in a subsequent article (June 5, 2020) points to the Boston Connection: La connexion de Boston , namely the insiduous relationship between Gilead Sciences Inc and Professor Mehra, Harvard Medical School as well as the two related Boston based hospitals involved.

(excerpts here, to access the complete text click here translation from French by France Soir, emphasis in the original article)

The often evasive answers produced by Dr Mandeep R. Mehra, a physician specializing in cardiovascular surgery and professor at Harvard Medical School, did not produce confidence, fueling doubt instead about the integrity of this retrospective study and its results.

However, the reported information that Dr. Mehra had attended a conference sponsored by Gilead – producer of remdesivir, a drug in direct competition with hydroxychloroquine (HCQ) – early in April called for further investigation

It is important to keep in mind that Dr. Mandeep Mehra has a practice at the Brigham and Women's Hospital (BWH) in Boston.

That study relied on the shared medical records of 8,910 patients in 169 hospitals around the world, also by Surgisphere.

Funding for the study was "Supported by the William Harvey Chair in Cardiovascular Medicine at Brigham and Women's Hospital. The development and maintenance of the collaborative surgical outcomes database was funded by Surgisphere."

The study published on May 22 sought to evaluate the efficacy or otherwise of chloroquine and hydroxychloroquine, alone or in combination with a macrolide antibiotic.

It is therefore noteworthy that within 3 weeks, 2 large observational retrospective studies on large populations – 96,032 and 8,910 patients – spread around the world were published in two different journals by Dr. Mehra, Dr. Desai and other co-authors using the database of Surgisphere, Dr. Desai's company.

These two practising physicians and surgeons seem to have an exceptional working capacity associated with the gift of ubiquity.

The date of May 22 is also noteworthy because on the very same day, the date of the publication in The Lancet of the highly accusatory study against HCQ, another study was published in the New England Journal of Medicine concerning the results of a clinical trial of remdesivir.

In the conclusion of this randomized, double-blind, placebo-controlled trial, "remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection."

Concretely: on the same day, May 22nd, one study demeaned HCQ in one journal while another claimed evidence of attenuation on some patients through remdesivir in another journal.

It should be noted that one of the main co-authors, Elizabeth "Libby"* Hohmann, represents one of the participating hospitals, the Massachusetts General Hospital in Boston, also affiliated with Harvard Medical School, as is the Brigham and Women's Hospital in Boston, where Dr. Mandeep Mehra practices.

Coincidence, probably.

Upon further investigation, we discovered that the first 3 major clinical trials on Gilead's remdesivir were conducted by these two hospitals:

"While COVID-19 continues to circle the globe with scientists following on its trail, Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) are leading the search for effective treatment.

"Both hospitals are conducting clinical trials of remdesivir."

MGH has joined what the National Institute of Health (NIH) describe as the first clinical trial in the United States of an experimental treatment for COVID-19, sponsored by the National Institute of Allergy and Infectious Diseases, part of NIH . MGH is currently the only hospital in New England to participate in this trial, according to a list of sites shared by the hospital.

" It's a gigantic undertaking, with patients registered in some 50 sites across the country, getting better .

"The NIH trial, which can be adapted to evaluate other treatments, aims to determine whether the drug relieves the respiratory problems and other symptoms of COVID-19, helping patients leave hospital earlier.**

As a reminder, the NIAID/NIH is led by Antony Fauci, a staunch opponent of HCQ.

Coincidence, probably.

" At the Brigham, two additional trials initiated by Gilead , the drug developer, will determine whether it alleviates symptoms in patients with moderate to severe illness over five- and ten-days courses. These trials will also be randomized, but not placebo controlled, and will include 1,000 patients at sites worldwide. Those patients, noted Francisco Marty, MD, Brigham physician and study co-investigator, will likely be recruited at an unsettlingly rapid clip."

As a result, the first major clinical trials on remdesivir launched on March 20, whose results are highly important for Gilead, are being led by the MGH and BWH in Boston, precisely where Dr. Mehra, the main author of the May 22nd HCQ trial, is practising.

Small world! Coincidence, again, probably.

Dr. Marty at BWH expected to have results two months later. Indeed, in recent days, several US media outlets have reported Gilead's announcements of positive results from the remdesivir clinical trials in Boston.:

"Encouraging results from a new study published Wednesday on remdesivir for the treatment of patients with COVID-19.**

Brigham and Dr. Francisco Marty worked on this study, and he says the results show that there is no major difference between treating a patient with a five-day versus a 10-day regimen.

"Gilead Announces Results of Phase 3 Remdesivir Trial in Patients with Moderate COVID-19

– One study shows that the 5-day treatment of remdesivir resulted in significantly greater clinical improvement compared to treatment with the standard of care alone

– The data come on top of the body of evidence from previous studies demonstrating the benefits of remdesivir in hospitalized patients with IDVOC-19

"We now have three randomized controlled trials demonstrating that remdesivir improved clinical outcomes by several different measures," Gilead plans to submit the complete data for publication in a peer-reviewed journal in the coming weeks .

These results announced by Gilead a few days after the May 22 publication of the study in the Lancet demolishing HCQ, a study whose main author is Dr. Mehra, are probably again a coincidence.

So many coincidences adds up to coincidences? Really ?


[Jul 09, 2020] Vitamin D may be a good defense against the coronavirus, according to several new reports. Here's what you need to know-

Jul 09, 2020 | www.msn.com

While there's still no evidence that vitamin D can cure or prevent the coronavirus, three major health organizations in the UK are advising people to ensure they get enough vitamin D, from the sun or supplements, to be on the safe side.

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The Scientific Advisory Commission on Nutrition , the National Institute for Health and Care Excellence , and the Royal Society all published reports last month detailing what we know (and don't) about the coronavirus and vitamin D, concluding that we need more research to fully understand the connection.

In the meantime, however, these organizations advise a stronger emphasis on meeting the current recommended vitamin D intake, not only as a precaution against coronavirus, but for general health too.

Vitamin D is important for health, and might even stave off some illnesses

Vitamin D is an essential nutrient for health, including the immune system.

Normally, humans can produce vitamin D naturally through direct exposure to sunlight -- we also get vitamin D in certain foods, like eggs, fatty fish, and beef liver. In total, the UK recommends people get 10 micrograms of vitamin D per day; the US recommendation is slightly higher, 15 micrograms for most people, and 20 micrograms for those over 70.

Spending too much time indoors, whether in the colder winter months or in quarantine, can potentially put you at risk of a vitamin D deficiency. Not enough of the nutrient is directly linked to muscle, tooth, and bone health issues, according to the recent Royal Society report.

That could be a problem when it comes to illness -- there's some evidence that a lack of vitamin D is linked to infections, particularly in the respiratory tract, according to the Scientific Advisory Commission on Nutrition report.

But there's no evidence showing a direct cause link between vitamin D and better coronavirus outcomes

However, while COVID-19 (the disease caused by the novel coronavirus) does attack the respiratory system, there's no evidence vitamin D can cure or prevent the illness.

Several previous studies have made a link between coronavirus outcomes and vitamin D deficiency -- however, that research has included other variables that could explain the number and severity of COVID-19 cases, and the research is far from showing a causal link.

But at least one study has also shown no apparent link between vitamin D and coronavirus outcomes, leading s ome researchers to remain skeptical about the possible connection .

Previous research has cautioned consumers about exaggerated claims about vitamin D and the coronavirus, particularly with regard to supplements or extremely high doses through an IV: too much vitamin D can can cause a toxic buildup of calcium and lead to kidney issues, according to the Mayo Clinic .

As such, there's still much more research to be done on the implications of vitamin D for different coronavirus outcomes.

Charles Bangham, professor of immunology at Imperial College London and co-author of the Royal Society paper, told the Financial Times that Vitamin D deficiency could in part explain why people with darker skin tones have been hardest-hit by the coronavirus. Black and brown people have more melanin that blocks UV rays from the sun, so naturally-producing the nutrient from sunlight takes longer for people with darker skin.

... ... ...

Read more:

Huge doses of vitamin D will not cure or protect you from the coronavirus, a new report says

Copper will not protect you from the coronavirus, despite its germ-killing properties, a microbiologist says

Race is not the reason Black Americans have a higher risk of dying from the coronavirus. It's racism.

Read the original article on Insider

[Jul 08, 2020] Copper will not protect you from coronavirus despite killing germs - Insider

Jul 08, 2020 | www.insider.com

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As the US begins to tentatively return to business, despite the novel coronavirus still lurking among the population, any potential protection has become a hot commodity.

Copper metal, used in products such as door handles and key rings, is being touted as one such solution, advertised as killing the virus on contact.

But before you click "buy" on those Instagram ads for copper patches billed as "natural hygienic germ stoppers," it's important to distinguish between what copper is and isn't capable of doing against the virus.

It may help against germs in some instances, but it's not a panacea for prevention, since the coronavirus can still live on copper surfaces for hours. And it's certainly no substitute for other precautions, according to Dr. Miryam Wahrman, biology professor at William Paterson University and author of " The Hand Book: Surviving in a Germ-Filled World ."

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"From what we're dealing with now, I don't think there's a lot of evidence to support the usefulness of copper in terms of reducing infections," Wahrman told Insider.

"Germ-killing" ads include everything from copper discs and stickers to cell phone cases, bracelets and socks

There is a huge variety of copper products sold as "prevention tools," but they fall into four general categories.

There are wearables, such as face masks, but also tee-shirts laced with copper, and jewelry, which vendors claim "self-sanitize" if they come into contact with contagious particles.

Then there are "sanitizers," which are bars or discs made of or coated in copper. These are designed to be rubbed on your hands or other objects in order to sanitize them.

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Touch-tools, the third category, can vary widely, but picture something that looks like bottle opener or key. You might use these to open doors, push buttons, or even tap on touchscreens instead of directly interesting with those potentially germy surfaces.

Finally, there are copper-coated versions of everyday items you touch frequently, such as cellphone cases and door handles. The advantage of these over their ordinary counterparts is that germs (including coronavirus) can't survive as long on copper as on surfaces like plastic and other types of metal.

Copper can kill bacteria, but it's less effective against viruses

It's true that research has shown copper has antimicrobial properties -- it can kill germs on contact in several ways, including by damaging the cell membranes, but is most effective against bacteria, Wahrman explained.

"Copper is good as an antimicrobial against certain types of bacteria but when it comes to viruses, that's a whole different ballgame because viruses are not living cells," she said.

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An April 2020 study in the New England Journal of Medicine found copper is inhospitable for the novel coronavirus as well, as the virus has a much shorter lifespan on copper than on other surfaces such cloth, plastic, or even other metals.

That's important for environments where a lot of potential viral and bacterial particles are present, such as hospitals. A 2016 study found that using copper components in hospitals could help prevent patients from contracting other infections while hospitalized. According to the study, copper surfaces reduced the infection rate of patients by 58% (from 8.1% to 3.4%), and reduced the viral load on surfaces by 83%.

However, the study found the coronavirus can still survive as long as 4 hours on copper, and it could take as long as 45 minutes for copper to reduce even a substantial amount of the virus on a surface .

copper sink
The soap, not the metal on the sink, is what really helps prevent viral contamination.
Maryna Andriichenko/Getty Images
Most copper products do nothing more than lull you into a false sense of security, experts say

Touch-tools, which you can use to open doors, push buttons or otherwise interact with high-touch surfaces, might help by creating a barrier between contagions and your hand, but only if you keep the tool clean, too. If you're not careful to do that, this protective touch tool could simply be lulling you into feeling you're protected, when you're not.

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"The positive thing is, you're touching fewer surfaces," Wahrman said. "But then you're going to come into contact with the part that's been touching surfaces when you put it back in your purse or your pocket. It's going to give you a false sense of confidence and won't occur to you that you've actually transferred germs to yourself and your home."

As an antimicrobial surface, copper could potentially still slow the spread of infection. But experts say it's highly unlikely that, even in that unlikely scenario, it wouldn't instantly kill coronavirus germs.

"The suggestion that you can rub these items on your hands and that's going to keep you healthy, that's not scientifically supported, especially for viruses," Wahrman said.

And face masks containing copper might be even less helpful, since in order for it to be effective, the copper needs to come into direct contact with the virus. Copper-infused cloth would only work if the virus penetrates the fabric, defeating the purpose of the mask in the first place.

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"The face mask is a great barrier. They have a tight fiber so that they do block a lot of the viral particles and blocking them is key," Wahrman said. "If the viral passes through the mask, it's not going to interact with the metal anyway, so it's not going to make a difference."

For that direct contact to occur, items would need to be fully coated in copper across the entire surface. Even then, however, the virus wouldn't be eliminated instantly. There's an additional complication, too, with cleaning copper-coated objects, since typical cleaning products could interfere with the chemical properties of the metal that make it effective against viruses in the first place, according to research.

Copper might help on surfaces over time, but it can't prevent droplets direct from another person

None of these uses of copper address the most common form of contagious for the novel coronavirus, which is airborne infectious directly from person to person.

"The big problem with the coronavirus is that it travels in droplets from one person to another who inhales it and that's how most of the infections are happening. So there's no real way to get copper involved," Wahrman said.

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So, while copper could have some promising applications, particularly in high-risk settings such as hospitals, it's not a cure-all for the average person, and it can't replace traditional disinfectants, hand sanitizer, or good old fashioned soap and water, according to Wahrman.

"The original advice that's tried and true is wash your hands with soap and water or use alcohol based hand sanitizer, and you've really reduced the risk and reduced the germ load," she said.

Wearing a mask, washing your hands frequently, and maintaining social distancing are still your best bet against slowing the spread of the virus, per the CDC's advice .

[Jul 07, 2020] Approximately one in every 12 individuals, or 500 million people worldwide, is living with chronic viral hepatitis

Jul 07, 2020 | www.moonofalabama.org

somebody , Jul 6 2020 20:48 utc | 118

Posted by: Tuyzentfloot | Jul 5 2020 20:23 utc | 41

More math .

Perhaps the scariest numbers in microbiology relate to pathogenic microorganisms. Worldwide, 16 million people die from infectious disease every year, and many of these deaths are preventable. Approximately one in every 12 individuals, or 500 million people worldwide, is living with chronic viral hepatitis, and the estimated number of new chlamydial infections per year is approximately 50 million, more than the population of South Korea. The bacterium Clostridium botulinum produces a toxin so potent that 3 grams would be enough to kill the population of the United Kingdom and 400 grams would kill everyone on the planet.

In total, there are ∼1,400 known species of human pathogens (including viruses, bacteria, fungi, protozoa and helminths), and although this may seem like a large number, human pathogens account for much less than 1% of the total number of microbial species on the planet. On this point, ignoring questions about what actually constitutes a species, estimates for the total number of microbial species vary wildly, from as low as 120,000 to tens of millions and higher. Part of the reason for this large range is that we have only sequenced 1 × 10−22% of the total DNA on Earth (although the Earth Microbiome Project should improve this dramatically to 1 × 10−20% in the next 3 years). This means that the fraction of microbial diversity that we have sampled to date is effectively zero, a nice abstract entity to end on.

Have you ever wondered how Sarv-Cov-2 made it to discovery? Or how humans have managed to survive up to now?

[Jul 07, 2020] Why closed spaces are them main avenue of COVID-19 propagation

Jul 07, 2020 | www.moonofalabama.org

Tuyzentfloot , Jul 5 2020 20:23 utc | 41

Airborne ballpark math: we breathe about 500 l/h when sitting down and up to 10 times that when exercising. When someone is ill and pushing 500 l/h of breath into a room with a halftime of say 4 hours then after about that time this person maintains roughly 2 cubic meters of breath in that room. For a room of 100 cubic meter that would be 2% of the air. So during a workday you'd be breathing the breath of that other person at a dilution of the order of 1%. Air conditioning recycles the air (maybe not completely I don't know the ratio) so it is not ventilation where the air is replaced. Maybe airco can pick off a large part of the particles. But that is the idea, assuming various losses and a large room you would still breathing someone elses breath diluted by a factor thousand.
I haven't found data on it but I suspect half time in cool air is considerately longer.
What talking and shouting then does is increase the amount of virus material in the air but there will be a huge increase at short distance and an unknown increase at large distance.
With this reasoning the question is not whether the virus can travel through air but how easy it is. Long halflife in air increases the chance.
High threshold of number of virus particles to have an effective transmission would decrease the chance. So I would start by measuring the amount of material we can push into the air in small droplets. How much variation is there.

So meat processing: cold air and to save energy ventilation is not good. Air is recycled a lot. People doing physical labour a whole day, not sitting. Sounds tricky independently of the hygiene question of dealing with industrially forcegrown animals

tucenz , Jul 5 2020 20:29 utc | 42

Tuyzentfloot | Jul 5 2020 20:23 utc | 40

You may need to put some gallons, pounds and feet in that post for the benefit "exceptional" nation readers.

[Jul 05, 2020] The main benefit of herd immunity is that it will allow the country to function again. And that would be good for everyone, healthy and sickly alike.

Jul 05, 2020 | www.unz.com

john cronk says: July 2, 2020 at 5:18 pm GMT 500 Words

There is no exit strategy for this haphazard insanity. Once this over-reaction to a fairly innocuous infectious agent was accepted as being necessary, there's no way to ever declare reversion to normalcy.

In my opinion, rather than endlessly focussing on this not particularly interesting virus, coming up with creative signboards and banners restricting movement, wrecking people's livelihoods and painting crosses on the pavement where one must stand, we should have been onto a more obvious problem by now. What if this HAD been a deadly pathogen? Why aren't we prepared to quickly open special quarantine/treatment centers, disconnected from regular hospitals? And what are we going to do about it?

This little rehearsal showed how unprepared we are should a real existential threat arise.
But no, we must instead continue to waste our time, money and effort in playacting that this is a real biological crisis, and creating an actual breakdown in our way of life. We must continue to double down, because if we take ever more extreme action about corona, that will prove that the idiocy we've demonstrated thus far was necessary ..right?

[Hide MORE]
Given the way corona virus is being handled, one would think we don't realize that people die quite regularly, especially when they're in bad condition. Now, we're practically demanding that nobody should die from catching a microbe – that we should stay home and hold our breath until everyone is guaranteed to survive. Since when have we ever believed that? Is that how we built civilization? The civilization that we're now destroying?

There's little reason for insulin-sensitive people – with healthy immune status and without metabolic disease – to stay home, wear a mask or 'social distance' themselves. Since they won't be getting seriously ill, their staying home wouldn't help 'flatten the curve' of sick people overburdening the healthcare system (as usual, to the expense of all of us). On the contrary, active healthy people can contribute something to the economy.

The main benefit of herd immunity is that it will allow the country to function again. And that would be good for everyone, healthy and sickly alike. The metabolically/immunologically compromised will be vulnerable to catching the corona virus from anyone who's contracted it and is temporarily contagious, no matter whether the carrier's general health is good or poor. And that's the same fix that people with poor immune function are in, always and everywhere. The answer for protecting these most vulnerable people from COVID – which is only one of the many dangers to their health that they face – can be one of two things; the best one being that they start eating right. And/or, we can build as much equipment and medical facilities, where they're most needed, as they may require. Either of these solutions is much more viable, less disruptive and less expensive than what we're doing now. And with either solution, healthier people would no longer be punished for possessing normal human vitality.

While governments, health agencies and scientists take steps to upgrade the availability of care facilities, equipment and treatments, individuals should follow this
CORONA VIRUS PROTOCOL
Part A (Everyone)
Begin a therapeutic diet to quickly upgrade and regulate the immune system. This consists of, wholly or mostly:
Home cooked meat, oily fish, eggs (especially yolks), animal fat, bone broth, collagen or gelatin, and liver, and the elimination of corn, soy, canola, safflower, sunflower, grapeseed and rice bran oils as well as flours, sugar and prepared foods.

Part B (those most at risk for COVID complications- individuals with high BMI or chronic health issues, or taking prescription medications, etc.)
While following the part A protocol, take reasonable precautions to limit your exposure to possible infection from others, such as limiting time or wearing a mask when in close contact with other people.

AaronInMVD , says: Website July 2, 2020 at 6:16 pm GMT

@john cronk with this knowledge is talk about it. Lots of talk, little action. The only active pieces on the board are hopping around and trying to do a cultural revolution and proceeding with an absolute poverty of energy.

This might be the most sedentary collapse ever. The world is taking a hard turn towards a prolonged dark age and for the lack of reaction it seems people are just going with the flow. Welcome to the future. A little bit of 1984, a heavy dose of Idiocracy, and a whole bunch of pudgy kids trying to live out their Harry Potter headcanon.

Nevermind all the attention given to "Black Lives" while Black voices (Lest we forget the 'Shaun King is transracial' scandal of not long ago) are shut out of the conversation Nonsense reigns!

[Jul 03, 2020] Hydroxychloroquine lowers COVID-19 death rate, Henry Ford Health study finds - Detroit News

Notable quotes:
"... The study analyzed 2,541 patients hospitalized among the system's six hospitals between March 10 and May 2 and found 13% of those treated with hydroxychloroquine died while 26% of those who did not receive the drug died. ..."
"... Among all patients in the study, there was an overall in-hospital mortality rate of 18%, and many who died had underlying conditions that put them at greater risk, according to Henry Ford Health System. Globally, the mortality rate for hospitalized patients is between 10% and 30%, and it's 58% among those in the intensive care unit or on a ventilator." Detroit News ..."
"... A long "take down" of Fauci: https://www.unz.com/audio/kbarrett_ken-mccarthy-tony-fauci-is-corrupt-to-the-core/ ..."
"... This is not Fauci's first rodeo. He's been pumping hysteria for 36 years. He always gets it wrong. He was wrong about swine flu. He was wrong about bird flu. He was wrong about Zika. He was wrong about Ebola. He wildly exaggerated AIDS. And he always is wrong in the favor of pharmaceutical companies. And he's always wrong in favor of 'we've got to develop a vaccine now. We have to throw out all the rules. ..."
"... Observational studies are never the equivalent of double-blind randomized studies; but there can still provide important and fare more readily obtained early information about these connections and conditions. ..."
"... This stuff is hard. There are lots of variations in patient populations and treatment protocols. We have to consider doses, concomitant meds (such as azithromycin), patient status at time of treatment, age, and, comorbidities. ..."
"... the recently halted NIH trial was randomized, double-blinded; this was in a hospital setting. The prophylactic trial reported at the beginning of June in NEJM (author Boulware) was also randomized, double-blinded; this was in a prophylactic setting. ..."
Jul 03, 2020 | turcopolier.typepad.com

"A Henry Ford Health System study shows the controversial anti-malaria drug hydroxychloroquine helps lower the death rate of COVID-19 patients, the Detroit-based health system said Thursday.

Officials with the Michigan health system said the study found the drug "significantly" decreased the death rate of patients involved in the analysis.

The study analyzed 2,541 patients hospitalized among the system's six hospitals between March 10 and May 2 and found 13% of those treated with hydroxychloroquine died while 26% of those who did not receive the drug died.

Among all patients in the study, there was an overall in-hospital mortality rate of 18%, and many who died had underlying conditions that put them at greater risk, according to Henry Ford Health System. Globally, the mortality rate for hospitalized patients is between 10% and 30%, and it's 58% among those in the intensive care unit or on a ventilator." Detroit News

-----------------

No comment needed. pl

https://www.detroitnews.com/story/news/local/michigan/2020/07/02/michigan-henry-ford-health-study-finds-hydroxychloroquine-lowers-covid-19-death-rate/5365090002/


Fred , 03 July 2020 at 11:38 AM

I agree, no comment is needed. Some charges for medical malpractice and malfeasance certainly are.

John Credulous , 03 July 2020 at 01:06 PM

Fred,

There will be no accountability: The b-stards have set the standards.

A long "take down" of Fauci: https://www.unz.com/audio/kbarrett_ken-mccarthy-tony-fauci-is-corrupt-to-the-core/

BillWade` , 03 July 2020 at 01:09 PM

Damn it, it's too cheap!

Deap , 03 July 2020 at 01:54 PM

Uncharted research: areas where anti-malarial drugs are sold widely over the counter - in malaria prone parts of the world - eg: Central America, SEA and Pacific Islands. How do their covid rates relate to these specific localities (not just generalized country numbers), where ongoing prophylactic sales of OTC anti-malaria drugs are most prevalent?

Why does the CDC travel and tourism website info still recommend taking anti-malarial drugs, when the other hand of our deep state bureaucrats are screaming these drugs will kill you?

Observational studies are never the equivalent of double-blind randomized studies; but there can still provide important and fare more readily obtained early information about these connections and conditions.

jonst , 03 July 2020 at 01:56 PM

No comment/s needed perhaps. But deliciously anticipated. Here, from the Committee, and especially from the MSM. Even if only silence. Because "silence is really violence" in this case.

John Credulous , 03 July 2020 at 02:17 PM

FWIW, Jimmie Moglia's erudition is formidable, and as a stylist, not too distracting:

https://www.yourdailyshakespeare.com/2020/04/11/the-coronavirus-and-galileo/
As for me I am reminded of the advice that Timon of Athens gave to two robbers who came to see him, "Trust not the physician, for his antidotes are poison, and he slays more than you rob."

https://www.yourdailyshakespeare.com/2020/06/08/the-world-upside-down/
And here is an example, a reported 'case-study'. A prince of Persia had melancholia and suffered from the delusion of being a cow. He would moo like a cow, crying "Kill me so that a good stew may be made of my flesh," and would never eat anything. Avicenna was persuaded to treat the case and sent a message to the patient, asking him to be happy as the butcher was coming to slaughter him. The sick man rejoiced. When Avicenna approached the prince with a knife in his hand, he asked, "Where is the cow so I may kill it."

The patient then mooed like a cow to indicate where he was. He was then laid on the ground for slaughter. When Avicenna approached the patient pretending to slaughter him, he said, "The cow is too lean and not ready to be killed. He must be fed properly and I will kill it when it becomes healthy and fat. The patient was then offered food, which he ate eagerly and gradually gained strength, got rid of his delusion, and was completely cured.

How relevant may be the Avicennian case study to the current dynamics of the pandemic I will leave it to my possible and patient readers to decide.

Ulenspiegel , 03 July 2020 at 02:20 PM

"No comment needed."


What was the difference between the Michigan study and the others, which found no positive ecffect?

How do you explain the low mortality of the control group in the Michigan study?

egl , 03 July 2020 at 02:31 PM

"Limitations to our analysis include the retrospective, non-randomized, non-blinded study design."

turcopolier , 03 July 2020 at 02:51 PM

ulenspiegel

Dr. Marc Siegel a medical correspondent for Foxnews told T. Carlson weeks ago that an emergency treatment of this drug saved the life of his 96 year old father who was at the point of death, cured him overnight in fact.

Babak makkinejad , 03 July 2020 at 03:27 PM

Utenspiegel

It is a fact that cancer drugs are not uniformly effective in all patients.

The causes must be sought in the genotypes of the patients.

The differential response as well as effectiveness are not reasons to discard a therapy.

In further news on COVID-19 Treatments I have 2 items to report:

First one:

The 3-drug mixture of Azittomycin, Naproxen, and prednisolone (oral or injectable) have been used successfully for reduction of the inflammation of respiratory system.

3 systematic trials have been undertaken and results were conclusive in expediting faster recovery.

Second one:

Clinical trials in Iran (in Masih Daneshvari hospital) – indicated 100% cure of COVID-19 in 20 patients using a combination of ReciGen and Cultera (sic?) which is an AIDS drug.

A second group of patients – 152 – had a reduction in mortality of 20% as compared to those who were only receiving Cultera (sic.?)


https://www.cinnagen.com/Product.aspx?t=2&l=1&Id=66&f=3

The results are supposed to be published in the Journal of Immunopharmacotherapy.

The dosage was: 5 times day, 12 million units.

No side effects were reported.

egl , 03 July 2020 at 03:57 PM

ulenspiegel:

This stuff is hard. There are lots of variations in patient populations and treatment protocols. We have to consider doses, concomitant meds (such as azithromycin), patient status at time of treatment, age, and, comorbidities.

A big difference: the Ford study was not randomized, not double-blinded. They used a statistical technique to try to make the groups comparable on factors believed to be relevant, but this is after fact. (It's a nice technique, I've used it myself, but it doesn't magically solve all of the difficulties of retrospective analysis.)

In contrast, the recently halted NIH trial was randomized, double-blinded; this was in a hospital setting. The prophylactic trial reported at the beginning of June in NEJM (author Boulware) was also randomized, double-blinded; this was in a prophylactic setting.

Seward , 03 July 2020 at 06:00 PM

Hydroxychloroquine is the active ingredient in the tonic portion of gin and tonics, which I've been drinking for prophylactic purposes since the pandemic began.

[Jul 03, 2020] The current reserach suggests that while the G614 variant may be more infectious, it is not more pathogenic.

Jul 03, 2020 | www.moonofalabama.org

Mina , Jul 3 2020 12:57 utc | 134

"The current work suggests that while the G614 variant may be more infectious, it is not more pathogenic. There is a hope that as SARS-CoV-2 infection spreads, the virus might become less pathogenic,"

i.e. that if schools had been left open, it would have spread and became less pathogenic earlier.
https://edition.cnn.com/2020/07/02/health/coronavirus-mutation-spread-study/index.html

[Jul 02, 2020] Public Outcry Follows Gilead Decision to Charge $3000 for COVID Drug that Costs Pennies to Produce

Notable quotes:
"... Journal of Virus Eradication ..."
"... Alan MacLeod is a Staff Writer for MintPress News. After completing his PhD in 2017 he published two books: Bad News From Venezuela: Twenty Years of Fake News and Misreporting and Propaganda in the Information Age: Still Manufacturing Consent . He has also contributed to Fairness and Accuracy in Reporting , The Guardian , Salon , The Grayzone , Jacobin Magazine , Common Dreams the American Herald Tribune and The Canary . ..."
Jul 02, 2020 | www.mintpressnews.com

alifornia-based pharmaceutical giant Gilead Sciences has announced that a five-day course of its antiviral drug Remdesivir -- shown in tests to effectively fight COVID-19 -- will cost $3,120 to Americans with health insurance and $2,340 to those on Medicaid. Yet research published in April calculated that the drug could be produced at a profit for as little as $0.93 per day.

The study, led by Dr. Andrew Hill from the Department of Translational Medicine, University of Liverpool, U.K., and published in the Journal of Virus Eradication , found that a five-day course of lifesaving Remdesivir could be mass-produced for less than the cost of a Subway sandwich. So cheap is the drug that the saline solution and the syringe needed to administer it would be more costly. MintPress spoke with Dr. Hill, who was dismayed by the company's announcement.

We are in a health emergency. We can't have a situation right now where people are unable to access medicine because the prices are too high. Remdesivir is a drug that has had its development costs paid for, in large part, by independent donors like governments and ministries of health in China, the WHO, and the U.S. government. So why should a company be making money in the middle of a pandemic by selling a drug which has largely been developed independently of them?" he said.

https://platform.twitter.com/embed/index.html?creatorScreenName=AlanRMacLeod&dnt=true&embedId=twitter-widget-1&frame=false&hideCard=false&hideThread=false&id=1278229120711716865&lang=en&origin=https%3A%2F%2Fwww.mintpressnews.com%2Fpublic-outcry-gilead-charges-3000-covid-19-drug-cost-pennies%2F269110%2F&siteScreenName=MintPressNews&theme=light&widgetsVersion=9066bb2%3A1593540614199&width=500px

News of the decision led to an explosion of public anger. "As Gilead charges $3,120 for its COVID drug, Remdesivir, remember that the drug was developed with a $70,000,000 grant from the federal government paid for by American taxpayers. Once again, Big Pharma is set to profit on the people's dime," wrote former Secretary of Labor Robert Reich. "This isn't healthcare. It's extortion," appeared to be the overwhelming sentiment on social media.

Gilead itself, however, seemed not to share this sentiment. Indeed, its press release on the subject positioned its decision as a selfless and magnanimous gesture of corporate philanthropy. "We approached this with the aim of helping as many patients as possible, as quickly as possible and in the most responsible way," said its CEO, Daniel O'Day, adding that, "under normal circumstances" the company would have charged the public $12,000 per patient.

"A new low"

Remdesivir is an intravenous antiviral drug that has been used to fight other coronaviruses like SARS and MERS and has shown some effectiveness against Ebola. Although far from a miracle treatment, studies have concluded that it aids recovery, reducing the average hospital visit for COVID-19 patients from 15 days to 11 days when compared to a placebo. Like with everything coronavirus-related, there is no absolute scientific consensus. In late April, the WHO accidentally leaked a Chinese study that suggested Remdesivir may not be as effective as Gilead claims it to be. Nevertheless, the Trump administration has now bought up the entire world's stock of the drug, effectively confiscating it and shutting out every other country from the medicine.

"I've been working in medicine for 32 years and I have never seen anything like it. I've never seen a country be that brazen. We have to work together. This could be a taste of the future. They've tried to also do this with advanced orders of vaccines. Imagine if we had a 100 percent effective vaccine and it only went to Americans," Dr. Hill told MintPress .

At the moment people don't quite understand the gravity of the decision that the American government has made. This is a worldwide epidemic and we have got to remember that the clinical trials of Remdesivir were not just conducted in the United States; they were conducted around European and Chinese centers. Patients put themselves at risk to take part in an experimental drug trial, and the gratitude we get as other countries after our people were involved in these studies is to be shut out of the future supply of the drug?! It is simply ethically unacceptable. I think there are serious questions to be answered. This is a new low ground, unfortunately," he added.

https://twitter.com/leahmcelrath/status/1277821241496408071

Gilead has been under considerable public scrutiny of late. The company, which announced profits of $5.4 billion last year, has increased its value by $15 billion since the pandemic began. In December, MintPress reported that it was being sued, accused of deliberately holding back a lifesaving HIV drug to extend the profitability of their previous, inferior one. With shades of the Remdesivir announcement, the drug is sold in Australia for $8 per month, but the company charges Americans around $2,000 for the same dosage. "Gilead has a long history of profiteering," said Dr. Hill. "Its CEO is a billionaire and has been accused of tax avoidance; by keeping their intellectual property in Ireland they avoided $10 billion in taxes in 2016 and they sell drugs for between 100 and 1,000 times the cost of production. And nobody is stopping them. I think this is a taste of things to come if we don't have better controls on the pharmaceutical industry's excesses."

As of Wednesday morning, there have been 2.73 million confirmed cases of COVID-19 in the United States, the six worst days for the virus in terms of infections all occurring in the previous week.

Feature photo | A lab tech displays a package of the Remdesivir at the Eva Pharma Facility in Cairo, Egypt June 29, 2020. Amr Abdallah | Reuters

Alan MacLeod is a Staff Writer for MintPress News. After completing his PhD in 2017 he published two books: Bad News From Venezuela: Twenty Years of Fake News and Misreporting and Propaganda in the Information Age: Still Manufacturing Consent . He has also contributed to Fairness and Accuracy in Reporting , The Guardian , Salon , The Grayzone , Jacobin Magazine , Common Dreams the American Herald Tribune and The Canary .

[Jun 29, 2020] Gilead Will Charge More Than $3,000 For A Course Of COVID-19 Drug Remdesivir

Highly recommended!
Corrupt Fauci, stupid customers. IT the same neoliberal story of profiteering as a virtue all over again.
The government bought by Big Pharma, and Big Pharma out or control with questionable drugs and methods are two side of the same coin
Jun 29, 2020 | www.zerohedge.com

On Monday, Gilead disclosed its pricing plan for Gilead as it prepares to begin charging for the drug at the beginning of next month (several international governments have already placed orders). Given the high demand, thanks in part due to the breathless media coverage despite the drug's still-questionable study data, Gilead apparently feels justified in charging $3,120 for a patient getting the shorter, more common, treatment course, and $5,720 for the longer course for more seriously ill patients. These are the prices for patients with commercial insurance in the US, according to Gilead's official pricing plan.

As per usual, the price charged to those on government plans will be lower, and hospitals will also receive a slight discount. Additionally, the US is the only developed country where Gilead will charge two prices, according to Gilead CEO Daniel O'Day. In much of Europe and Canada, governments negotiate drug prices directly with drugmakers (in the US, laws dictate that drug makers must "discount" their drugs for Medicare and Medicaid plans).

But according to O'Day, the drug is priced "far below the value it brings" to the health-care system.

However, we'd argue that this actually isn't true. Remdesivir was developed by Gilead to treat Ebola, but the drug was never approved by the FDA for this use, which caused Gilead to shelve the drug until COVID-19 presented another opportunity. Even before the first study had finished, the company was already pushing propaganda about the promising nature of the drug. Meanwhile, the CDC, WHO and other organizations were raising doubts about the effectiveness of steroid medications.

Months later, the only study on the steroid dexomethasone, a cheap steroid that costs less than $50 for a 100-dose regimen, has shown that dexomethasone is the only drug so far that has proven effective at lowering COVID-19 related mortality. Remdesivir, despite the fact that it has been tested in several high quality trials, has not.

So, why is the American government in partnership with Gilead still pushing this questionable, and staggeringly expensive, medication on the public?

[Jun 28, 2020] New COVID19 treatment protocol specifically targets the cytokine storm and they use heparin for the blood clots

Jun 28, 2020 | www.moonofalabama.org

Richard Steven Hack , Jun 28 2020 14:08 utc | 3

"My hunch is that by now doctors have learned much more about the disease's progression (cytokine storm, blood clotting) and how to manage it."

I believe the UK is where the dexamethasone Study was done. Possibly more doctors are using it. The Front-Line COVID-19 Critical Care Working Group have been pushing corticosteroids as the main treatment in their MATH+ Protocol, and they believe the UK study provides evidence that they are on the right track. Their Protocol specifically targets the cytokine storm and they use heparin for the blood clots. Now if they can only get a full-fledged trial going. Unfortunately their Web site doesn't provide much info about how much traction they're getting promoting their Protocol.

The 1918 SF article proves that morons are morons no matter how many years have passed. I'm sure there were such during the Black Plague. I sincerely hope the coronavirus mutates before the second wave and starts killing all the younger people just to see their reaction when they have to bear the brunt. Can't wait for all the "it's just the flu" BS from these morons to dry up.

[Jun 28, 2020] European study links genes, blood type with risk of severe coronavirus infection

Notable quotes:
"... "Our genetic data confirm that blood group O is associated with a risk of acquiring Covid-19 that was lower than that in non-O blood groups, whereas blood group A was associated with a higher risk than non-A blood groups," the researchers wrote in their report. They found people with Type A blood had a 45% higher risk of becoming infected than people with other blood types, and people with Type O blood were just 65% as likely to become infected as people with other blood types. ..."
Jun 28, 2020 | www.blogger.com
Anonymous Fred C. Dobbs said...
European study links genes, blood type with risk of severe coronavirus infection

(CNN - June 18) A team of European scientists say they have found two genetic variations that may show who is more likely to get very sick and die from coronavirus, and they say they have also found a link to blood type.

Their findings, published Wednesday in the New England Journal of Medicine, point to a possible explanation for why some people get so seriously ill with the virus, while most barely show any symptoms at all.

(NEJM: Genomewide Association Study of Severe Covid-19 with Respiratory Failure )

They found people with Type A blood have a higher risk of catching coronavirus and of developing severe symptoms, while people with Type O blood have a lower risk.

"Our genetic data confirm that blood group O is associated with a risk of acquiring Covid-19 that was lower than that in non-O blood groups, whereas blood group A was associated with a higher risk than non-A blood groups," the researchers wrote in their report. They found people with Type A blood had a 45% higher risk of becoming infected than people with other blood types, and people with Type O blood were just 65% as likely to become infected as people with other blood types. ...

June 27, 2020 at 9:41 AM

[Jun 28, 2020] Genomewide Association Study of Severe Covid-19 with Respiratory Failure

Jun 17, 2020 | www.blogger.com
Anonymous said...
https://www.nejm.org/doi/full/10.1056/NEJMoa2020283

June 17, 2020

Genomewide Association Study of Severe Covid-19 with Respiratory Failure
By David Ellinghaus, Ph.D., Frauke Degenhardt, M.Sc., Luis Bujanda, M.D., Ph.D., Maria Buti, M.D., Ph.D., Agustín Albillos, M.D., Ph.D., Pietro Invernizzi, M.D., Ph.D., Javier Fernández, M.D., Ph.D., Daniele Prati, M.D., Guido Baselli, Ph.D., Rosanna Asselta, Ph.D., Marit M. Grimsrud, M.D., Chiara Milani, Ph.D., et al. for The Severe Covid-19 GWAS Group
Abstract

BACKGROUND

There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19....

[Jun 28, 2020] Coronavirus Causes Weaponized 'Tentacles' To Sprout From Infected Cells, Directly Inject Virus Into New Ones

Jun 28, 2020 | www.zerohedge.com

Coronavirus Causes Weaponized 'Tentacles' To Sprout From Infected Cells, Directly Inject Virus Into New Ones


by Tyler Durden Fri, 06/26/2020 - 19:25 The virus behind COVID-19 causes infected cells to sprout 'tentacles' which allow the virus to attack several nearby cells at once - poking holes which allow the disease to easily transfer inside.

This nightmare fuel was discovered by researchers led by the University of California, San Francisco.

" There are long strings that poke holes in other cells and the virus passes through the tube from cell to cell ," said UCSF's Director of the Quantitative Biosciences Institute, Professor Nevan Krogan. " Our hypothesis is that these speed up infection. "

The images taken by scientists at the National Institutes of Health (NIH) laboratory in the US and University of Freiburg in Germany will be published in the medical journal Cell on Saturday.

Most viruses do not cause infected cells to grow these tentacles . Even those that do, such as smallpox, do not have as many or the same type of branching as Sars-Cov-2, the virus behind Covid-19. - FT

According to the report, the silver lining is that the tentacle discovery may pave the way for a number of drugs to work against the disease - most of which were previously being used to treat cancer.

"It totally makes sense there's an overlap in anticancer drugs and an antiviral effect," said Prof. Krogan, who added that cancers, HIV and SARS-CoV-2 are all searching for the "Achilles heel of the cell."

Potential drugs include silmitasertib, made by Taiwan-based Senhwa Biosciences - which is working with the NIH on trials in the US. The drug works by inhibiting the CK2 enzyme which is used to build the tubes.

The drug is one of five which were found to be more effective against the virus than Gilead's remdesivir , including FDA-approved Xospata (aka gilteritinib) made by Japan-based Astellas Pharma, Eli Lily's FDA-approved abemaciclib (Verzenio) and ralimetinib, and dasatinib, made by Bristol-Meyers Squibb.

Remember, the official narrative is that the virus - which specializes in infecting humans and packs ultra-rare 'infection tentacles' - did not emerge from a Chinese biolab located at 'ground zero' for the pandemic, where scientists had previously come under international scrutiny for conducting 'gain of function' experiments in which chimeric coronaviruses were genetically engineered for the sole purpose of infecting humans.

But we digress.

play_arrow Shemp 4 Victory , 1 hour ago

Remember, the official narrative is that the virus - which specializes in infecting humans and packs ultra-rare 'infection tentacles' - did not emerge from a Chinese biolab located at 'ground zero' for the pandemic, where scientists had previously come under international scrutiny for conducting 'gain of function' experiments in which chimeric coronaviruses were genetically engineered for the sole purpose of infecting humans.

Well, the funny thing is that, despite all the hand-wringing histrionics of the Falun Gong/Epoch Times cultists, the story of a "weaponized CCP virus" is still just a clickbait fairy tale. The fact remains that there is zero evidence that the virus emerged from a Chinese biolab. Zero. Nada. Null. The empty set.

But hey, US citizen society is articulated around monetization of conflicts (among other things) and cannot do without it. This is how the US has killed the possibility of debate.

Debate as a means of investigating truth requires to accept facts. In US citizenism, admittance of facts is counter-balanced by denial of facts. Which one is better to monetize?

When it comes to US citizens, it is always good to balance admittance with denial, trying to figure out which one is the most profitable. US citizens always weigh whether it is more profitable to deny or admit facts, and they usually choose profits over truth.

It is no critical thinking here, it is no education. It is US citizenism. If it is profitable to deny facts, well, US citizens deny. And will keep denying until it is no longer profitable.

You can apply this to all fields touched by US citizens. It never misses, because US citizens nature is eternal.

Truth, justice, freedom: US motto.

JGResearch , 1 hour ago

It was made in Japan., and the U.K.

Japan's Demon Of BioWar Kawaoka Inserted HIV Force Multipliers Inside The Wuhan Virus - No governments will ever state this truth. It would lead to war and even the Chinese do want that. They want business back to normal. The Chinese are not so concern about some workers and elders who are on the public welfare.

It is still a Bio-engineered virus, but it is from Veterinary labs that are not being watched like Bio 4 labs, from second generation of Unit 731. Who knows bat and fish better than anyone else, it is the Veterinary labs. Imperial Japanese have a long history with China. For the most part, Suzuki's military-dominated cabinet favored continuing the war. For the Japanese, surrender was unthinkable -- Japan had never been successfully invaded or lost a war in its history, plus they were hit with two Atomic weapons. You think they forgot about at that?

The dark side of microbiology finds its haven inside the dozens of veterinary schools outside the authority of the WHO, CDC, NIH and equivalent professional supervisory bodies and reporting-review systems.

Exhibit A: To summarize, a decade ago at his lab in Wisconsin with generous funding from Japanese state institutions, Kawaoka was developing an "unstoppable flu", secretly derived from an illegal exhumation of the Arctic frozen corpse of an Alaskan native who died in the 1918-19 influenza pandemic, which killed up to 80 million worldwide. We learned of Kawaoka's reckless violations of science ethics from Robert Finnegan, former editor of the Jakarta Post, who was tracking the theft of MERS and other virus samples from NAMRU-2 (U.S. Navy Research Unit) by a senior local lab technician who personally smuggled the dangerous materials to U Wisconsin.

Exhibit B is a 2011 research paper by Y. Kawaoka and two colleagues at his animal virology lab at the University of Wisconsin-Madison, titled "HIV reverse-binding protein is essential for influenza A virus replication and promotes genome-trafficking in late-stage infection". Published in the Journal of Virology, September 2011, it's an admission of guilt for preparing the emergence of the Wuhan contagion.

JGResearch , 1 hour ago

The original plan: The dilution of toxicity indicates the objective as being mild symptoms diagnosed as a case of food poisoning. On a massive scale, a food poisoning scandal would lead to the shut down of fisheries and aquaculture in a huge blow to national food security.

However, what's so amazing about the Wuhan coronavirus was its regeneration after being clipped of virulence-causing genes that intensify the pain of symptoms in its victims. nCov2019 somehow reconstructed alternative sequences to replace the lopped-off gene sequence. The Japanese ignore the morphogenetic fields of the virus.

Therein lies the rub. Prophetically, Kawaoka foresaw HIV acting in unexpected ways in constructing new flu virions and their components, which likely explains how and why the at-first relatively mild version bio-engineered Wuhan coronavirus was self-altered in its third or fourth generation with highly lethal proteins, a spontaneous Gain of Function, which transformed 2019-nCov into a raging killer.

This is exactly what occurred in early January when the Chinese government banned fishing and consumption of fish along the entire 6,300 km (3,900 miles) length of the Yangtze River.

JGResearch , 1 hour ago

https://www.scmp.com/news/china/society/article/3044376/china-bans-fishing-depleted-yangtze-river-10-years-protect

https://jvi.asm.org/content/85/18/9588

https://jvi.asm.org/content/85/18

DefendYourBase , 1 hour ago

JUST DA FLU!

warsev , 2 hours ago

I've read any number of articles from "experts" in the field who claim that this thing is "engineered". The "experts" get very little play outside of a small echo chamber. I want to know when anyone with any political clout will start shouting about it more broadly. Doesn't seem likely.

Cthonic , 1 hour ago

accredited virologists are kept in line

http://tapnewswire.com/2016/02/list-of-over-100-dead-microbiologists/

Cthonic , 1 hour ago

have another 100 hits

https://time.com/3003840/malaysia-airlines-ukraine-crash-top-aids-researchers-killed-aids2014-mh17/

DFCtomm , 2 hours ago

I caught an episode of peak prosperity on youtube the other day and they were talking about supercells and multiple nuclei. This makes sense. This virus behaves more like a colonizing bacteria.

4Celts , 2 hours ago

What I was most disgusted by the " Task Force " presser today, was that the orchestrators have noticed all of the pushback on the statistics showing the small demographic that was most effected by this " virus . So , they put the maggot Fauci out there to say the " young " who are asymptomatic were the cause of the " second wave " , and they should really curb their youthful bravado and instead be very mindful that " they " could spread this to the immunodeficient , both the elderly and the child with cancer. A totally spineless, and despicable tact.

FrankDrakman , 2 hours ago

In Ontario, 1.3 million have been tested for the virus. Outside of nursing homes, only 960 have died.

Can you divide 960 by 1.3 million, "boob"? Let me help you.. 130,000 is 10%, 13,000 is 1%, and 1,300 is 0.1%

960 is .078%. In other words, you have 99.92% chance of surviving this bug. Wow, 'far more deadly than originally thought', indeed.

[Jun 28, 2020] Diabetes is linked to a higher risk of death from the new coronavirus

Jun 28, 2020 | www.blogger.com
ilsm said...
Anonymous,

https://www.nature.com/articles/d41586-020-00502-w

"11 May -- High risk of COVID-19 death for minority ethnic groups is a troubling mystery:"

"People who are not white face a substantially higher risk of dying from COVID-19 than do white people -- and pre-existing health conditions and socioeconomic factors explain only a small part of the higher risk."

"In the most sweeping study of its kind, Ben Goldacre at the University of Oxford, UK, and his colleagues examined the medical records of more than 17 million residents of England (E. Williamson et al. Preprint at medRxiv http://doi.org/dt9z; 2020). The analysis, which has not yet been peer reviewed, showed that medical conditions such as diabetes are linked to a higher risk of death from the new coronavirus."

"But the prevalence of such conditions in people who belong to minority ethnic groups plays only a small part in the heightened risk, as does the prevalence of social disadvantages such as low income. The researchers say that there is an urgent need for better measures to protect people in minority ethnic groups from the disease."

This is from Nature daily Covid 19 update. Which is good reading and covers vaccines, and anti body treatments which may be used by Autumn. See ELI Lilly and Regenron debvelopments.

June 26, 2020 at 2:51 PM

Anonymous Anonymous said...
https://www.nytimes.com/2020/06/26/us/corona-virus-latinos.html

June 26, 2020

Many Latinos Couldn't Stay Home. Now Virus Cases Are Soaring in the Community.
Rates of coronavirus infection among Latinos have risen rapidly across the United States.
By Shawn Hubler, Thomas Fuller, Anjali Singhvi and Juliette Love

June 26, 2020 at 1:48 PM

[Jun 28, 2020] Nobel Prize winner Dr Michael Levitt postulated that the virus burns out when it has infected 15-20% of the population

Jun 28, 2020 | www.blogger.com
Anonymous ilsm said...
JBR,

Thanks for your forbearances, misguided as you may be.

You do not answer questions, you do not like. Okay, with me. You could attempt to revise my conclusions on your lack of openness to countering evidence.

For Fred, from my son's latest input. Fred is an RPI alum, within a years or two, with me:

"Stockholm is the best population to test Covid theory whereby it was hit hard early and did not have lockdowns.
Nobel Prize winner Dr Michael Levitt postulated that the virus burns out when it has infected 15-20% of the population.
According to this, he's right...What does this mean for the US?
If you look at the rest of Sweden, you see a bumpier curve because different counties get hit at later times

The same will probably happen in states which were not hit hard during the first wave"

The tweet thread goes on to list the states that have not yet reached the 20% threshold, which is many, though if these states only need to reach 15-20% to exit the first wave, then most of them are at least halfway there."

https://twitter.com/gummibear737/status/1275118332887392256?fbclid=IwAR3udQL8UNl8o05RTmtpOmlxDyVb57NptU9WqwhAzUXe9J1WfKE1FF4PYnY

Why the US is in for rocky road with or without "second wave".

Concluding any of oit due to Trump is a stretch.

June 26, 2020 at 8:57 AM

[Jun 17, 2020] Polio vaccine may be useful to prep the body for COVID19.

Jun 17, 2020 | www.moonofalabama.org

Caliman , Jun 17 2020 17:28 utc | 9

Perhaps one of the well-read people here can help me find some sources. I've been puzzled by something before and it got exacerbated by the news recently that the Polio vaccine may be useful to prep the body, as it were, for COVID19.

What I'd be puzzled by is the following: we know there are four commonly circulating human coronaviruses that register as "colds" in the population, sometimes nasty but generally not dangerous, and that large %ages of us have gotten them over the years and will continue to. While these four viruses are not identical to COVID19, they are quite similar. And it seemed like there were some reports that people who had recently been sick with these more common coronaviruses had some immunity to COVID19.

Has this been investigated further? Would it not make sense, if true, that the "quick vaccine" we have been looking for could be purposeful infection by one of these common human coronaviruses? Would this not be like using the cowpox as a way to make ourselves more resistant to smallpox, which used to be done until the actual smallpox vaccine was discovered?

Anyway, anybody read anything along these lines?


hopehely , Jun 17 2020 17:47 utc | 10

@Caliman | Jun 17 2020 17:28 utc | 9
Anyway, anybody read anything along these lines?

Yes, we read it here a month ago.
albagen , Jun 17 2020 17:56 utc | 11
Well Caliman, why do you bother thinking about Covid19? It's just the flu, on tap. When they need, they open the tap. When it suits them, they close the tap. It's Covid19 on, Covid19 off. Sometimes it trickles or drips. We all will die some day.

In other words: "behave, or else we bring back the restrictions", but if the flow of money stops, we will lift them, just so that you work to produce something and keep us happy.

My suggestion: live your life to the fullest, enjoy nature and family, as if there is no covid19, no government, no bullshit. You won't regret it.

And don't forget to give feedback here, if you follow my advice.

;)

[Jun 16, 2020] Hope for patients with severe COVID-19 pneumonia

Jun 16, 2020 | www.msn.com

Trial results announced on Tuesday showed dexamethasone, which is used to reduce inflammation in other diseases such as arthritis, reduced death rates by around a third among the most severely ill of COVID-19 patients admitted to hospital.

[Jun 16, 2020] Coronavirus- Dexamethasone proves first life-saving drug by Michelle Roberts

"This is an extremely welcome result," said Peter Horby of Oxford, one of the study leaders. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide."
Lead researcher, Prof. Martin Landray, says that hospital patients should now be given the steroid without delay, but that people shouldn't try to hoard it for private use. According to the study, Dexamethasone does not appear to help milder cases - those who don't need help breathing.
The drug has been used to treat a wide range of conditions, including asthma and rheumatoid arthritis.
Notable quotes:
"... Chief investigator Prof Peter Horby said: "This is the only drug so far that has been shown to reduce mortality - and it reduces it significantly. It's a major breakthrough." ..."
Jun 16, 2020 | www.bbc.com

By Michelle Roberts Health editor, BBC News online

A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus.

The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say.

The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus.

It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.

Had the drug had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say.

And it could be of huge benefit in poorer countries with high numbers of Covid-19 patients.

About 19 out of 20 patients with coronavirus recover without being admitted to hospital. Of those who are admitted to hospital, most also recover, but some may need oxygen or mechanical ventilation. These are the high-risk patients whom dexamethasone appears to help.

The drug is already used to reduce inflammation in a range of other conditions, and it appears that it helps stop some of the damage that can happen when the body's immune system goes into overdrive as it tries to fight off coronavirus.

The body's over-reaction is called a cytokine storm and it can be deadly.

In the trial, led by a team from Oxford University, around 2,000 hospital patients were given dexamethasone and were compared with more than 4,000 who did not receive the drug.

For patients on ventilators, it cut the risk of death from 40% to 28%. For patients needing oxygen, it cut the risk of death from 25% to 20%.

Chief investigator Prof Peter Horby said: "This is the only drug so far that has been shown to reduce mortality - and it reduces it significantly. It's a major breakthrough."

Lead researcher Prof Martin Landray says the findings suggest that for every eight patients treated on ventilators, you could save one life.

For those patients treated with oxygen, you save one life for approximately every 20-25 treated with the drug.

"There is a clear, clear benefit. The treatment is up to 10 days of dexamethasone and it costs about £5 per patient. So essentially it costs £35 to save a life. This is a drug that is globally available."

Prof Landray said, when appropriate, hospital patients should now be given it without delay, but people should not go out and buy it to take at home.

Dexamethasone does not appear to help people with milder symptoms of coronavirus - those who don't need help with their breathing.

The Recovery Trial has been running since March. It included the malaria drug hydroxychloroquine which has subsequently been ditched amid concerns that it increases fatalities and heart problems.

Eric Feigl-Ding @DrEricDing Replying to @DrEricDing

5) And again, Dexamethasone is cheap, available from any pharmacy, and easily obtainable anywhere in the world. This is EXACTLY what we need, instead of a $1000 drug like remdesivir that is just marginally effective for shortening illness but not yet fully proven for mortality.

[Jun 15, 2020] These San Francisco doctors flew to New York to fight the coronavirus -- and they have a warning for us

Jun 15, 2020 | www.cnbc.com


"I've worked in a lot of settings," said Dr. Michael Peters, a pulmonary critical care doctor, was assigned to a hospital in Queens overwhelmed with Covid-19 cases. "These patients were very sick, and they had a disease that we didn't know how to take care of yet."

All of the UCSF doctors said they saw patients in their forties and fifties, who didn't meet the "typical" profile for Covid-19 because they were otherwise healthy. In the Queens hospital, where Peters worked, many of the patients were Black or Hispanic. Data shows that the virus has hit racial and ethnic minorities worse, and studies are underway to better understand why.

[Jun 13, 2020] We Don't Need No Stinking Vaccine For COVID-19

Jun 13, 2020 | www.zerohedge.com

Authored by Jeff Harris via The Ron Paul Institute for Peace & Prosperity, A Glaring Omission

With the 24/7 media circus coverage of Covid-19 I find it particularly interesting that there is an obvious glaring omission of some extremely important facts relative to dealing with a virus, especially one that is allegedly so virulent like this one. Yes, I read all about the critical need to shelter in place, stay inside away from other people, wash your hands constantly, avoid touching your eyes, nose or mouth, wear your face mask and by all means observe social distancing if you MUST venture outside for food!

Then it's repeated ad infinitum that the ONLY hope we have of ever returning to a semblance of normalcy is to have a vaccine to protect us! Then to add some drama to this narrative the media highlights their death-o-meter scoreboard with the implied threat that you'll be next IF you don't obey the rules as dictated by the "experts".

But what is assiduously avoided at all cost is any reference to our most potent defense against any virus; our body's natural immune system. Try as I might I couldn't find anything about this first line of defense on the World Health Organizations (WHO) website or Centers for Disease Control (CDC) website. It's as if it doesn't exist and is completely irrelevant.

If these organizations were genuinely concerned about the health of citizens they would obviously discuss the vital role a healthy immune system plays in protecting us from illnesses. But since they don't its obvious some other motive is at work, at least to me, and I strongly suspect to other critical thinkers as well.

We now know from the science and data that over 90% of the people exposed to Covid-19 have no symptoms at all or at worst a mild cold. The flu vaccines we have are only effective 30% to 60% of the time and the bugs change regularly so a vaccine that worked OK last year may barely work at all this year. Let's learn some more about our body's immune system.

Virus protection without a vaccine

There is an enlightening article on Web MD titled: "How to use Your Immune System to Stay Healthy". That's a pretty straight forward title now isn't it? Early on Bruce Polsky, MD, interim chairman department of medicine and chief division of infectious disease at St. Lukes-Roosevelt Hospital Center in New York City says:

"We are endowed with a great immune system that has been designed evolutionarily to keep us healthy."

The article goes on. . .

"The immune system is your body's natural defense system. It's an intricate network of cells, tissues and organs that band together to defend your body against invaders. Those invaders can include bacteria, viruses, parasites, even fungus, all with the potential to make us sick. They are everywhere-in our homes, offices and backyards. . . "

The truth is no amount of social distancing, hand washing or face mask wearing is going to eliminate our exposure to these various bugs. That's why we were created with this amazing first line of natural defense.

Here's more from Web MD . . .

"The immune system can recognize millions of different antigens. And it can produce what it needs to eradicate nearly all of them. When it's working properly, this elaborate defense system can keep health problems ranging from cancer to the common cold at bay. . . "

Wow! That's pretty amazing stuff isn't it! According to Web MD a properly functioning immune system can "keep health problems ranging from cancer to the common cold at bay." So why isn't this "science" being included in all the other health recommendations we're being bombarded with daily? It seems to me that any "expert" worth their salt would be talking about the importance of a healthy immune system to stay healthy.

But there's more . . .

The Web MD article noted that failure to eat a healthy diet, sitting around not exercising, not getting enough sleep and chronic stress can all lead to a compromised immune system. To quote Dr. Polsky again:

". . . Lifestyle aspects are very, very important."

So if our lifestyle is very, very important to staying healthy as the good doctor says ask yourself this question? Based on the Web M.D. article virtually all the results of the lockdown serve to weaken our immune systems. The stress of unemployment, constant harping about infections and rising death rates, lack of exercise and now a crack in our food distribution system all are known to weaken the human immune system.

I also find it quite interesting that large groups of people can shop at Walmart, Home Depot or other big box stores but they can't attend their local church even if it's a "drive through" service?

Web M.D. says:

"Research shows that people with close friendships and strong support systems tend to be healthier than those who lack such supports."

During times of crisis people need encouragement and their faith built up more than ever before. Mandating people huddle in fear in their homes with constant media reports of infections and death bombarding them continually is there any wonder peoples immune systems are under severe stress?

[Jun 12, 2020] Russia registers new Covid-19 drug to keep complications caused by virus 'under control'

Jun 07, 2020 | www.rt.com

Russian developers have registered a new drug that may help alleviate the harshest complications caused by Covid-19, including lung failure. It's hoped the treatment can buy time before a vaccine is found. Levilimab is the second medication to receive state approval through a fast-track mechanism, implemented to give doctors more options to tackle the virus, which has already infected more than 459,000 and killed 5,725 in Russia, according to official statistics.

"I think we'll be able to keep Covid-19 complications under control and minimize the harshest problems it causes," Dmitry Morozov, general director of Biocad, the biopharmaceutical company behind the drug, wrote on Facebook. By reducing the Covid-19 mortality rate, Levilimab will allow Russia to "buy time" before the vaccine against the coronavirus is made, and "the vaccine is surely coming soon," he added.

The drug is aimed at curbing the so-called 'cytokine storm,' a common complication from Covid-19 when the sick person's immune system overreacts to the virus and the excessive inflammation leads to fatal outcome.

"The mechanism [used in Levilimab] is known to researchers around the globe. But all the rest was done in Russia, by our company, from scratch. There's an original patented molecule," Morozov told RT.

Levilimab's highlight is that it can be administered not only to patients already in a serious condition, but used as a prophylactic to "prevent the 'cytokine storm' from occurring and allowing the patient to avoid intensive care and lung ventilation," he pointed out.

The drug, which will go into the market under the brand ILSIRA, is administered hypodermically unlike its foreign counterparts, which get into the system through the intravenous route. "One shot and you don't go into the emergency room. There are two syringes in a package. Their injected simultaneously or with some interval. And in a week the person is discharged from hospital," Morozov said.

Levilimab has proven itself as effective as its foreign counterparts and increased the speed of recovery for patients, Ekaterina Trifonova, who heads the infectious ward at the Central Clinical Hospital in Moscow, where the drug underwent clinical testing, told RT. During the first two weeks of trials, out of 45 Covid-19 patients who got the drug, ten were discharged, including a 92-year-old-man, while the rest remained in satisfactory condition, she added.

[Jun 11, 2020] WHO now says asymptomatic spread of coronavirus is 'very rare'

Jun 11, 2020 | video.foxnews.com

WHO now says asymptomatic spread of coronavirus is 'very rare'

Jun. 09, 2020 - 4:06 - World Health Organization changes its tune on asymptomatic patients spreading COVID-19; reaction from Fox News medical contributor Dr. Marc Siegel.

[Jun 11, 2020] Does asymptomatic spread exists or this is artifact of modeling and tests false positives?

Jun 11, 2020 | www.moonofalabama.org

Richard Steven Hack , Jun 11 2020 0:18 utc | 48

Coronavirus confusion reigns as World Health Organisation scrambles advice about masks and asymptomatic spread

Although numerous studies have suggested people can spread the virus before they show symptoms, the WHO has largely dismissed those as anecdotal or pointed out that they were based on modelling.

Babak Javid, an infectious diseases doctor at Cambridge University Hospital, says many scientists are persuaded by the studies published so far and think WHO should publish the data it is citing to explain why it believes transmission of the disease in people without symptoms is "rare".

"If you're going to make a really important statement like that, it would be good to back it up," Javid said. "I think WHO is an important organisation, but they've made a lot of statements that have been misleading."

[Jun 11, 2020] WHO official backtracks after claiming asymptomatic spread of coronavirus is 'very rare'

Jun 10, 2020 | video.foxnews.com

Reaction and analysis from Fox News medical contributor Dr. Marc Siegel.

[Jun 10, 2020] Coronavirus vaccine developers are chasing outbreaks before they disappear Washpost - Sic Semper Tyrannis

Jun 10, 2020 | turcopolier.typepad.com

"Coronavirus vaccine developers are chasing outbreaks before they disappear" Washpost

"The top teams rushing to develop coronavirus vaccines are alerting governments, health officials and shareholders that they may have a big problem : The outbreaks in their countries may be getting too small to quickly determine whether vaccines work

A leader of the Oxford University group, one of the furthest ahead with human trials, admits the reality is paradoxical, even "bizarre," but said the declining numbers of new infections this summer could be one of the big hurdles vaccine developers face in the global race to beat down the virus.

Even as new cases are growing worldwide, transmission rates are falling in Britain, China and many of the hardest-hit regions in the United States -- the three countries that have experimental vaccines ready to move into large-scale human testing in June, July and August." Washpost

---------------

Well, pilgrims it would seem that the Post staff does not see the irony in their own writing, or perhaps they do. There have been scattered evidences of rationality there lately. Even as Democrat governors and mayors across the country drag their feet on the re-opening of the American economy, infection rates are falling. In the Faucibirxist view of things everything depends on vaccine development (or herd immunity post holocaust). But, alas there just aren't enough new, vibrant infections to make development of the vaccines convenient. What will happen to the flow of government money to these projects if this phenomenon becomes general knowledge. Someone at the Post should be disciplined for this indiscretion. pl

https://www.washingtonpost.com/world/europe/coronavirus-vaccine-trials-astrazeneca-moderna/2020/06/09/48f28fea-a414-11ea-898e-b21b9a83f792_story.html


Fred , 10 June 2020 at 09:34 AM

"What will happen to the flow of government money to these projects if this phenomenon becomes general knowledge."

Well Fauci is almost 80 so I think he's set for life. I hear the left wants lots of redevelopment funds and jobs programs, with the attendant opportunities for graft that comes with them, for thier cities which we are all assured had neither rioting nor looting.

Jim , 10 June 2020 at 11:50 AM
Thank you Col. Lang for all the posts on novel coronavirus.

For shining light on this, this utter failure by the medical community and their various and sundry enablers in government and in business.

On these liars and charlatans and killers and criminals.

The video below is about an hour long. It is a nurse, who worked in NYC hospital, the alleged epi center of epi centers.

She basically says, without saying directly, but points to the fact that doctors were murdering patients there, it seems.

She paints a picture of doctors not as scientists but as zealots, as neo neanderthals, as craven monsters, who care not about life, the elderly, the sick, the least among us.

As Nurse Ratchets

Towards the end of video, she recounts her last day at this hospital, discussing a patient she had nursed for many days, and who was doing fine, making progress, . . . and how she was removed from his bed on direct orders, sent to the ER where she was not assigned, and 20 minutes later, the man she was caring for is dead.

These sorts of stories abound; this rage is not going away anytime soon. This is the rage, and what caused it, that our "lords and masters" who censor us and tell us black is white, and want to destroy our country. . . this is the rage they don't want to see expressed and exposed. Will they get their way?

http://edwardcurtin.com/the-undercover-epicenter-nurse-watch-weep-and-rage/


-30-

Laura Wilson , 10 June 2020 at 01:04 PM
Well...they can always test their vaccines in the USA. We seem not to be faring as well and can help out. (I believe this is a glass half-full moment.)
Walter Lang , 10 June 2020 at 01:27 PM
Laura Wilson

Still hysteric. if you are not over 65 and not in compromised health the disease is rarely fatal.

optimax , 10 June 2020 at 01:32 PM
Trump needs to stop the $600 a week federal bonus to the unemployed. My neighbor told me about how his daughter-in-law worked one day a week as a barmaid before the virus shut the bar down and made a little over a hundred a week. Oregon unemployment pays her 150 a week and with the added 600 she now makes over 7 times what she did working. How many protesters and rioters are just as flush getting paid to party in the street? Most i'd say. That makes these government funded protests a powerful voice and recruitment tool for the Democratic Party.

Ending the federal subsidy to the unemployed would reduce, if not stop, the demonstrations and mau-mauing of the country.

Fred , 10 June 2020 at 03:17 PM
optimax,

Absolutely. There were howls of protests before Minneapolis when Georgia, Florida and Texas started tellling people that if they recieved a recall to work notice from an employer and refused to go they would be considered a voluntary quit and no longer eligable for unemployment insurance payments. They'll howl again when they figure out this is all taxable income.

LA Sox Fan , 10 June 2020 at 03:21 PM
Take everything the WaPo claims with a grain of salt. There is no real worry over lower covid infections. What made Covid decrease was the lockdowns. Remove the lockdowns and covid infection rates will climb, as we are seeing in the already reopened states.

Then when fall rolls around, and people are stuck indoors again, rates will skyrocket. There will be plenty of test subjects for a vaccine.

rho , 10 June 2020 at 09:29 PM
With the spread rate of the coronavirus, any outbreak of the infection will peter out once the total immunity rate of the population approaches 65-70 percent.

In Bergamo (Italy), 57 percent a population sample have tested positive for coronavirus antibodies, which means that they must have had the infection before and are now most likely immune.

If you are a Karen, then don't listen to me, but take it from the German government's very own propaganda outlet, Deutsche Welle:

"Out of nearly 10,000 Bergamo residents who had their blood tested between April 23 and June 3, 57% had antibodies, indicating they had come into contact with the virus and developed an immune response.

Health authorities said the sample size was 'sufficiently broad' to be a reliable indicator of the presence of SARS-CoV-2 among Bergamo province's population."

https://www.dw.com/en/coronavirus-tests-show-half-of-people-in-italys-bergamo-have-antibodies/a-53739727

Nobody in Bergamo will need a coronavirus vaccine once its development is finished - whenever that may happen, if at all.

[Jun 10, 2020] Yale has published research that shows HCH + AZ has 50-fold benefits and insignificant risks

Highly recommended!
Jun 10, 2020 | www.moonofalabama.org

BM , Jun 10 2020 18:11 utc | 5

Yale has published research that shows HCH + AZ has 50-fold benefits and insignificant risks

Using Hydroxychloroquine and Other Drugs to Fight Pandemic

Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be
Ramped-Up Immediately as Key to the Pandemic Crisis

In the author's words:

COVID-19 is really two different diseases. In the first few days, it is like a very bad cold. In some people, it then morphs into pneumonia which can be life-threatening. What I found is that treatments for the cold don't work well for the pneumonia, and vice versa. Most of the published studies have looked at treatments for the cold but used for the pneumonia. I just looked at how well the treatments for the cold worked for the cold. There are five studies done this way, four of hydroxychloroquine plus azithromycin and one with hydroxychloroquine plus doxycycline, and they all show that treating the cold part of COVID-19 -- the early part -- works very well.

The article completely decimates the arguments against using HCQ + AZ or HCQ + doxycycline, specifically in early outpatient use.

uncle tungsten , Jun 10 2020 22:29 utc | 41

BM #5

re Yale HCQ study.

The article completely decimates the arguments against using HCQ + AZ or HCQ + doxycycline, specifically in early outpatient use.

It is good to see real science being applied rather than voodoo shilling for big pharma.

Still waiting for the editor resignations at Lancet and NEJM on their publication of the hoax science article.

Let me be very clear about pharmaceuticles: the interaction of two dissimilar substances can be extraordinary beneficial. My personal example is from a Specialist Pharmacologist that treated a bone disease in my thumb arising from mechanical injury. He explained thus:

The bone problem has three quite separate stages of treatment.

At the first week common antibiotic remedies are vital and effective. I was too late for that.

If that stage is missed then a common and potent antibiotic combined with a substance commonly used to treat gout is vital. The combination of the two flattens the peak of the antibiotic such that it is sustained in the bloodstream for 24 hours until the next dose of the two. A fourteen day process as I recall. It was totally successful.

If that second stage is missed then late intervention is extensive use of antibiotics and the gout remedy over months as the bone decomposition bacteria have spread throughout ones metabolism and lodge randomly to wreak havoc. This treatment regime is punishing on the body and digestive tract and many people cannot endure it.

This Specialist was a high street operator in nice office NOT a pharmacy.

So lets not be jumping to hasty dismissals of what may or may not 'work' and when. Humans vary, diets vary and propensities are highly variable. It is the responsibility of scientists to be honest and act in the best interests of humanity. Clearly the study published in the Lancet and NEJM was fake science and those journals fell for it because of either inadequate editorial investigation of the paper, confirmation bias, inadequate consideration of human consequences.

The WHO stands condemned for being suckered by fake news, confirmation bias, malign financial manipulation or perhaps inadequate investigation of the authors and claims of the paper.

[Jun 08, 2020] Doctors were allowed to consider PCR results as a factor, cautioned not to rely on them. In current situation PCR results became the definition of COVID

Jun 08, 2020 | www.moonofalabama.org

oldhippie , Jun 7 2020 23:59 utc | 45

PavewayIV @ 36

Try doing a search on Kary Mullis, creator of the PCR process. He died last year so we can only go by past statements. He always stated that PCR was completely inappropriate and meaningless for diagnostics or for any other clinical purpose.

CDC guidance on PCR until earlier this year was that doctors do diagnosis, not laboratories. Doctors were allowed to consider PCR results as a factor, cautioned not to rely on them. In current situation PCR results are the definition of COVID.

If the test is allowed to run too many cycles any sample will test positive.

And it is never entirely certain how many cycles have elapsed, clock does not tell exactly what the RNA is up to.

[Jun 06, 2020] A fraction of infected people trigger the bulk of new cases, one reason the pandemic is far from over

Jun 06, 2020 | www.moonofalabama.org

Richard Steven Hack , Jun 6 2020 5:01 utc | 101

The Science of Superspreaders
A fraction of infected people trigger the bulk of new cases, one reason the pandemic is far from over

Meanwhile, the protests happening in this convulsed nation, with people often shoulder to shoulder, set the stage for new chains of infections. Any shouting, along with sneezing and coughing (perhaps in reaction to pepper spray) will spread the virus especially easily. "All things considered, there's little doubt that these protests will translate into increased risk of transmission for Covid-19," Maimuna Majumder, an epidemiologist at Boston Children's Hospital and Harvard Medical School, tells The Atlantic.

Putting an exact number on the impact of superspreaders is nearly impossible, since not all cases are ever traced back to any original source. The going best estimate is that 20% of infected people are responsible for 80% of onward infections, says William Hanage, associate professor of epidemiology at Harvard T.H. Chan School of Public Health. Some evidence suggests as few as 10% of people trigger 80% of ongoing infections, Hanage told reporters in a recent teleconference.

Three separate studies have suggested the 20/80 ratio. A study of Hong Kong cases reached that conclusion and also found that 70% of people who contracted Covid-19 didn't spread it at all.

[Jun 05, 2020] Rush to trash hydroxychloroquine was based on faulty Surgisphere data exposes fundamental flaws in profit-based medical science

Jun 05, 2020 | www.rt.com

The latest data this disprove its efficiency in treating COVID-19, as it turned out, came from a tiny US healthcare analytics firm called Surgisphere, and calling it faulty would be excessively charitable. This is clearly a hired guns hit.

Not only is Surgisphere a company lacking in medical expertise – its employees included an "adult" entertainer and a science-fiction writer – but its CEO Sapan Desai co-authored two of the damning studies that used the firm's data to smear hydroxychloroquine, already thoroughly demonized in the media thanks to its promotion by US President Donald Trump, as a killer. All data is sourced to a proprietary database supposedly containing a veritable ocean of real-time, detailed patient information yet curiously absent from existing medical literature.

The Surgisphere-tainted study appeared to show increased risk of in-hospital deaths and heart problems with no disease-fighting benefits, confirming the suspicions of medical-industry naysayers already inclined to hate the off-patent drug due to the lack of profit potential and Trump's incessant boosterism. Italy, France, and Germany rushed to ban hydroxychloroquine, citing "an increased risk for adverse reactions with little or no benefit."

[May 31, 2020] Russian Health Ministry Approves First Domestic Drug for COVID-19

May 31, 2020 | sputniknews.com

MOSCOW (Sputnik) - The Russian Health Ministry has approved the first domestic drug, called Avifavir, for treating coronavirus patients, according to a new entry to the national drug registry. The medicine was developed by the Russian Direct Investment Fund (RDIF), a sovereign wealth fund, and ChemRar, a Russian pharmaceutical investment and R&D group.

"Avifavir is not only the first antiviral drug registered against coronavirus in Russia, but it is also perhaps the most promising anti-COVID-19 drug in the world. It was developed and tested in clinical trials in Russia in an unprecedentedly short period of time enabling Avifavir to become the first registered drug based on Favipiravir in the world", CEO of the RDIF Kirill Dmitriev said.

The final stage of Avifavir clinical trials involving 330 patients, approved by the national Health Ministry earlier in the month, is ongoing.

Previously, the new drug underwent several clinical trials at I.M. Sechenov First Moscow State Medical University, Lomonosov Moscow State University, and other medical and academic institutions.

Avifavir, is the first Russian direct antiviral drug that has proven effective in clinical trials. The drug has been used in Japan since 2014 against severe forms of influenza.

In April, the Russian Direct Investment Fund launched a project to diagnose and detect pneumonia , including that caused by the SARS-COV-2 coronavirus.

ChemRar Group includes R&D service and investment companies in the field of innovative pharmaceuticals for the development and commercialization of innovative medicines, diagnostics, preventive care, and new treatments of life-threatening diseases in Russia and abroad.

The latest data by the Russian Health Ministry shows that more than 396,000 cases of the coronavirus and 4,555 fatalities related to the disease have been confirmed in the country.

[May 30, 2020] Paul Craig Roberts Questions The Campaign Against HCQ

May 29, 2020 | www.zerohedge.com
Authored by Paul Craig Roberts,

The Covid-19 pandemic has brought out many disturbing features of our society. Misinformation, or perhaps more accurately, disinformation, abounds in the service of agendas ranging from those who interpret the virus as a useful ploy for the construction of a police state, to Big Pharma and its allies who are moving us toward mass vaccinations, to the narcissistic views of those who would sacrifice the elderly and ill rather than to be inconvenienced by being denied access to bars and beaches. Every aspect of the pandemic, including Trump's own use of HCQ, is being used against the President of the United States.

At a time when accurate information is essential, the waters are instead muddied by disinformation in the service of political, ideological, and profit agendas. The irresponsibility of those putting their self-interests first is extraordinary. It indicates that the social bond between people that made America a country has been dissolved by greed, multiculturalism, and Identity Politics. America has become a country without a common interest. It is a narcissistic state.

This article is limited to the campaign against HCQ. HCQ -- hydroxychloroquine -- has been in use for 65 years for the prevention or treatment of malaria, lupus, and rheumatoid arthritis. It is officially labeled a safe drug. Many doctors treating Covid patients have found and reported HCQ, when used early enough together with zinc and the antibiotic azithromycin to be an effective and safe treatment.

I have reported and made available many of the reports of HCQ's efficacy and safety. See for example:

Despite 65 years of safe use, HCQ is alleged to be dangerous and to cause heart attacks. Its use is officially approved only for "adolescent and adult patients hospitalized with COVID-19." Generally, by the time a patient is hospitalized the virus has progressed to a later stage in which treatment is less successful. Studies of HCQ's effectiveness, such as the VA one and apparently the more recent one reported in The Lancet, are limited to later stage hospitalized patients and seem to exclude the essential zinc component of the HCQ treatment. In other words, the studies seem to be designed to exclude from official approval the treatment that doctors have found most effective. It is not easy for a layperson to know what the studies actually say as the media report the studies in an anti-Trump manner. For the media, what is most important is criticism of Trump, not the effectiveness of a treatment.

In contrast, the untested investigational antiviral drug, Remdesivir, which has no record of safe use and is extraordinarily expensive compared to HCQ, has been given the same clearence for use. The media is not interested in the effectiveness and safety, or lack of, of this new and untested drug. Trump isn't taking it, and it is a potential profit-maker for Big Pharma. If Remdesivir fails, the failure will be used to dispose of the hope for cures and to focus on vaccination.

It is difficult to avoid the conclusion that HCQ/zinc is being sidelined in order to clear the way for a profitable vaccine and a vaccination mandate.

But the vaccines are not panning out.

The Moderna vax touted by Bill Gates and Dr. Fauci caused severe illnesses in one-fifth of the test recipients.

The other fast-tracked vaccine developed by the Oxford Vaccine Group proved ineffective. The vaccine produced insufficient antibodies to prevent Covid-19 infection.

...

A few years ago the British medical journal, The Lancet , published a paper touting the safety of HCQ. But this was before HCQ with zinc was found effective if used earlier enough against Covid-19. Covid-19 turned HCQ's effectiveness into a big problem for Big Pharma's big profits.

The solution was another study by medical professionals some of whom have ties to Big Pharma and none of whom, apparently, are involved in the treatment of Covid patients. The study lumps together people in different stages of the disease and undergoing different treatments. It touts its large sample, but many of the patients in the sample received treatment too late after the virus had reached their heart and other vital organs. Most likely the people who died from heart failure died as a result of the virus, not from HCQ.

To be effective treatment has to stop the virus early. Waiting until the patient must be hospitalized has given the virus too much of a head start. Every doctor, and there are many, who reports success with the HCQ treatment stresses early treatment. President Trump used a two-week treatment with HCQ as a prophylactic as he was constantly coming into contact with people who tested positive for the virus. Many medical professionals who are treating Covid patients also use HCQ as a prophylactic.

The Lancet study was a rush job as it was essential for Big Pharma to prevent the spread of the HCQ treatment and awareness of its safety and effectiveness. The study's authors completed the data collection around the middle of April and the study was published on May 22. As soon as it appeared, it was used to close down the World Health Organization's clinical trial of hydoxychloroquine in coronavirus patients citing safety concerns. Most likely, the trial was aborted in order to prevent an official agency from finding out that HCQ worked.

The media, of course, used the suspended trial to cast more doubt on Trump's judgment for recommending and using the treatment, the implication being that Trump had put himself at more risk from a heart attack than from the virus itself.

The Daily Mail , which is often somewhat skeptical of official reports, even misreported French virologist Didier Raoult's report ) of his success with treating 1,061 patients with HCQ/AZ as consisting of o nly a small sample of 30 patients . A small sample is considered to be inconclusive. Thus 1,061 people became 30.

The Lancet study claims a high mortality from HCQ treatment, reporting a death rate ranging from 5.1% to 13.8%. In response to a journalist when asked about this claim, Didier Raoult said that he and has colleagues have followed 4,000 of their patients so far. They have had 36 deaths and none from heart problems for a death rate of 0.009%. According to The Lancet study, he should have between 204 and 552 patients dead from heart problems. He has zero. Raoult had more than 10,000 cardiograms analysed by rythmologists (a special kind of cardiologist) searching for any sign of heart problems.

NIH's Dr. Fauci denies that Raoult's hard evidence is evidence. On May 27 Fauci said, without showing shame of his ignorance or his lie, that there's no evidence that shows the anti-malaria drug hydroxychloroquine is effective at treating COVID-19.

Perhaps what Fauci means is that no study undertaken by NIH or another Big Pharma friendly official body has been done and that only such studies constitute evidence.

When hard evidence such as Raoult's is suppressed and misreported while "studies" doctored to produce a predetermined conclusion that serves Big Pharma profits are rushed into publication, we know that money has pushed ethics out of medical research. A number of concerned people have been telling us this for some time. We are past due to listen to them.

Private medicine is profit driven, which makes it susceptible to fraud. In long ago days fraud was restrained by the moral character of doctors and the respect for truth of researchers. These restraints, never perfect, have eroded as greed turned everything, integrity itself, into a commodity that is bought and sold.

The intent is to bury HCQ as a low cost effective treatment and to put in its place a high cost alternative whether effective or not, and to supplement this enhancement of profits with mass vaccination which might do us more harm than the virus itself. Big Pharma could care less. The only value it knows is profit.

This intent has garnered the support of the French, Belgium and Italian governments . Using The Lancet study and WHO's termination of its HCQ trial as the excuse, the French government revoked its decree authorizing HCQ treatment. Belgium's health ministry issued a warning against the use of HCQ except in registered clinical trials. Italy's health agency wants HCQ's use banned outside of clinical trials and suspended authorization to use HCQ as a Covid-19 treatment.

Does this mean that Raoult and his team who by treating Covid patients with HCQ have achieved the remarkable low death rate of 0.009% are prohibited from using the proven cure to save lives? Will Raoult and his team be imprisoned if they continue to save lives? What about the people who will die from the three government's prevention of a safe and effective treatment? Will France, Belgium, and Italy accept responsibility for these lost lives?

I can't avoid wondering if the revolving door between Big Pharma and the NIH and CDC which corrupts US public health decisions also operates in France, Belgium and Italy. Are European health officials elevating themselves by climbing over the dead bodies of their victims?

[May 29, 2020] Chris Whitty - the UK's Chief Medical Officer - says that, to most people, the coronavirus is entirely harmless.

May 29, 2020 | www.moonofalabama.org

Roberto , May 28 2020 20:12 utc | 10

2 or 8 meters away from everybody? it doesn't matter.

Please go to https://www.youtube.com/watch?v=adj8MCsZKlg

In this clip from the Downing Street Corona Briefing on May 11th, Chris Whitty - the UK's Chief Medical Officer - says that, to most people, the coronavirus is entirely harmless.

Most people will never get it.
Most of the people who get it won't ever experience symptoms.
Most of the people who experience symptoms won't need medical care.
Most of the people who need medical care won't be need emergency or critical care.
And even the tiny percentage of people who need who DO need critical care will survive, regardless of risk factors or medical history.

[May 29, 2020] 'Thousands' Of Dutch COVID-19 Survivors Likely Have Permanent Lung Damage According To Top Pulmonologist

May 29, 2020 | www.zerohedge.com

COVID-19 may be far less deadly than originally projected - and asymptomatic cases may be even more common than first suspected, but for those who have caught it and come down with symptoms, the disease can result in lasting symptoms, including shortness of breath, lethargy, recurrent fevers, headaches, itchiness and other mystery problems that aren't going away .

To that end, a top pulmonologist in the Netherlands says that thousands of Dutch residents who have recovered from COVID-19 may be left with permanent lung damage , resulting in decreased lung capacity and difficulty absorbing oxygen.

A computer tomography (CT) X-ray scan shows the signature "ground glass" tissue due to COVID-19 infection,
which is caused by fluid in the lungs. Weifang Kong and Prachi P. Agarwal

According to Leon van den Toorn, Chairman of the Dutch Association of Physicians for Pulmonary Disease and Tuberculosis NVALT, people are underestimating the consequences of the coronavirus .

"In severe cases, a kind of scar formation occurs, we call this lung fibrosis. The lungs shrink and the lung tissue becomes stiffer, making it harder to get enough oxygen," Van den Toorn told Dutch newspaper AD (via the NL Times ), adding that "there may be thousands of people in the Netherlands who suffered permanent injury to the lungs from corona."

Of the 1,200 Covid-19 patients who so far recovered after admission to intensive care, "almost 100 percent went home with residual damage", he said to AD. And about half of the 6 thousand people who were hospitalized, but did not need intensive care, will have symptoms for years to come.

So far 45,500 people in the Netherlands tested positive for the coronavirus. Many did not get sick enough to need hospital care. In this group, Van den Toorn expects that permanent problems will be less serious, but still possible. - NL Times

Van den Toorn says that patients experiencing lung issues should immediately see a pulmonologist, as "there may be a low oxygen level in the blood, which is harmful to the body."

"People with a history of corona infection should be monitored closely to see if recovery is complete," he added.

Drilling down on lung issues, let's flash back to March , when a New Orleans respiratory therapist dealing with coronavirus patients told ProPublica that coronavirus patients suffering from acute respiratory distress syndrome (ARDS) are extremely difficult to oxygenate .

Authored by Lizzie Presser via ProPublica

"Normally, ARDS is something that happens over time as the lungs get more and more inflamed. But with this virus, it seems like it happens overnight . When you're healthy, your lung is made up of little balloons. Like a tree is made out of a bunch of little leaves, the lung is made of little air sacs that are called the alveoli. When you breathe in, all of those little air sacs inflate, and they have capillaries in the walls, little blood vessels. The oxygen gets from the air in the lung into the blood so it can be carried around the body.

​ A screenshot of chest radiographs of a man suspected to have COVID-19. (Obtained by ProPublica via the Radiological Society of North America, cited in the paper "Severe Acute Respiratory Disease in a Huanan Seafood Market Worker: Images of an Early Casualty" by Lijuan Qian, Jie Yu and Heshui Shi.)

"Typically with ARDS, the lungs become inflamed. It's like inflammation anywhere: If you have a burn on your arm, the skin around it turns red from additional blood flow. The body is sending it additional nutrients to heal. The problem is, when that happens in your lungs, fluid and extra blood starts going to the lungs. Viruses can injure cells in the walls of the alveoli, so the fluid leaks into the alveoli. A telltale sign of ARDS in an X-ray is what's called 'ground glass opacity,' like an old-fashioned ground glass privacy window in a shower. And lungs look that way because fluid is white on an X-ray, so the lung looks like white ground glass, or sometimes pure white, because the lung is filled with so much fluid, displacing where the air would normally be. "

...

"It first struck me how different it was when I saw my first coronavirus patient go bad. I was like, Holy shit, this is not the flu . Watching this relatively young guy, gasping for air, pink frothy secretions coming out of his tube and out of his mouth . The ventilator should have been doing the work of breathing but he was still gasping for air, moving his mouth, moving his body, struggling. We had to restrain him. With all the coronavirus patients, we've had to restrain them. They really hyperventilate, really struggle to breathe . When you're in that mindstate of struggling to breathe and delirious with fever, you don't know when someone is trying to help you, so you'll try to rip the breathing tube out because you feel it is choking you, but you are drowning . ay_arrow 3 play_arrow


Bananamerican , 5 hours ago

Oxygen toxicity, caused by excessive or inappropriate supplemental oxygen, can cause severe damage to the lungs and other organ systems. High concentrations of oxygen, over a long period of time, can increase free radical formation, leading to damaged membranes, proteins, and cell structures in the lungs. It can cause a spectrum of lung injuries ranging from mild tracheobronchitis to diffuse alveolar damage.

smacker , 4 hours ago

I think you're right about ventilators being the wrong treatment. According to some doctors the patients needed oxygen not ventilation.

I spotted here in Brazil, patients were being placed inside plastic oxygen tents neatly fitted over the top half of their beds. So their breathing remained natural.

Battlefield USA , 6 hours ago

Co-existence of coronavirus with bacterial pathogen a major cause of fatalities

Battlefield USA , 6 hours ago

Did you know that the regular run-of-the-mill pneumonia causes lung damage and a host of other problems.

You would know that if you read up on it at the CDC and NIH website.

But just keep being an ignorant brainwashed dumb-***.

Getitright2016 , 7 hours ago

As soon as symptoms appear, a person should be treated. Waiting for shortness of breath is too late. Damage has been done. Early treatment, blood thinners, HCQ with zinc and Antibiotics Zpac to prevent pneumonia.

INeverForget , 7 hours ago

**** THAT "Z-PACK".

Harnar , 7 hours ago

Z-pack gave my mother in law afib (Atrial fibrillation). Although the doctor said it was just coincidence that 3 days after starting Z-pack she was in the hospital with chest pains and needed to be on beta blockers for the rest of her life....

Unfortunately she isn't always good about remembering her pills and died a couple years later due to a brain aneurysms (which can occur if you come off beta blockers too fast or forget to take them for a few days after taking them regularly for a year)

OutaTime43 , 8 hours ago

Lung injuries happen with Pneumonia. When your cells are killed by the virus, then they are replaced with fibroid tissue (scar tissue) just like any other injury. This is of course a problem with Lungs as it reduces vital capacity. If you smoke or have other lung diseases, then it affects you more. When you're young with healthy lungs, then the damage isn't enough to affect you.

I've had CT scans of my lungs and they can still see the damage caused to my lungs from pneumonia at age 5.

charlie_don't_surf , 8 hours ago

Details??? When they don't give details be suspicious. Were these very old patients with already damaged lungs? Are these former ventilator patients and their lungs were damaged by the ventilator? Were these patients with particular genetic weaknesses or predispositions regarding lung tissue? Until there are exact details of patient demographic, pre existing disease, and the nature of their treatment take with a grain of salt.

MX_DOGG , 8 hours ago

Approximately 22.4% of adults in the Netherlands smoked in 2018. This includes 16.0% daily smokers and 6.4% occasional (non-daily) smokers . Of people in the Netherlands who reported smoking , 71.6% smoked every day

charlie_don't_surf , 8 hours ago

the smart people tell you that extensive data collection shows that 50's and under have an extremely low risk, the vast majority of deaths are extremely old, in nursing homes and the smart also will tell that the death rate was jacked up by Cuomo and some other NE dem state guvs ordering infected patients be put in the nursing homes to increase infections and deaths and the smart people will also tell you that destroying the economy will definitely greatly increase injuries, illnesses and premature death...brah...that's what smart people will tell ignorant stiffs like you but it's like talking to a tree stump...brah.

charlie_don't_surf , 8 hours ago

that's probably damage from over expansion from ventilators or just inflammation can cause capillary breakage...capillaries are weak and break easily when stressed and then of course they clot...because they clotted is normal and not a "clotting disease"...I would bet similar happens when people get a bad pneumonia...lungs bleed from tuberculosis too...probably any significant infectious process in lungs will cause bleeding...I had bleeding from strep throat when I was in college.

John C Durham , 9 hours ago

This happens where ever one doesn't get an anti-viral drug from his doctor at his office in the first day or so. The Viral attack comes and goes in about 7 days.

An anti-viral drug does no good after that and giving anti-viral drugs to a hospital patient when the viral attack is long past, just loads them up with more toxins. This has been known since Hydroxychloroquine was given against SARS years ago. It worked great there early on and many doctors starting using it again for the current big panic.

It does nothing later as demonstrated in a recent study that is being used as firepower against that drug instead of against any doctor prescribing it for late treatment in the hospital.

Hydroxychloroquine should be in everyone's medicine cabinet, available over the counter, to be used against flu, colds and any virus starting on the first day. It's safer than an aspirin and much safer than Tylenol and I bet you have had either or both in your cabinet before without triggering WWIII.

She Love Me Long Time , 9 hours ago

Just like politics, the herd has separated into two sides.

Is it really so difficult to see that both sides are wrong?

Yes, there is a virus. No, it won't kill us all. It's more deadly than the flu but it's not the ******* plague. However, this could be the equivalent of an airborne HIV-type of infection that results in chronic long-term health issues and a weakened immune system. If that's true, wearing an N95 mask when you're at the grocery store, even if it makes you look like a sissy, is the smart thing to do.

Just my 2 cents

Drachma , 9 hours ago

The important test would be to determine how many of the worst affected were regular vaccine recipients, especially the flu vaccine, which has been linked to the phenomenon of viral interference, There are at least two proposed related mechanisms of action contributing to an enhancement of disease with subsequent respiratory viral infections, especially coronavirus, after vaccination with influenza vaccine. On the one hand there is an inflammation and scarring of the interstitial membrane of the lungs, subsequent to influenza inoculation, which lessens oxygen transfer to the blood. On the other hand there is an overreaction by the immune system at the time of the secondary infection with coronavirus, as the cross-reactivity from influenza group antibodies, in this case, acts to over-stimulate the immune system, leading to excessive tissue damage and compounding the disease symptoms.

Vaccines, by their very nature, are contaminated with RNA and DNA from latent and dormant viruses from different species cell lines. Since one of the most ubiquitous viruses in the mammalian cell lines is coronavirus, and many different mammalian as well as avian cell lines are used to produce vaccines, chances are that most people with a government-scheduled vaccine history are already infected with coronavirus. Ponder that subject for a while.

Cardinal Fang , 9 hours ago

I'm no radiologist but those 3 CT scans are of different people so it is not a progression.

It appears they are from Chinese study.

So you can throw that data out the window.

Fiscal Reality , 9 hours ago

Democrat Governors LOVE to kill geezers in nursing homes. Facts matter Cuomo, Murphy,Waltz, Wolf and Witmer.

While Fauxi, Birx, the MSM, Soros, the WHO, the CDC and the DNC/CCP scream SOCIAL DISTANCING AND WEAR YOUR MASK, Dem governors build a big body count by pushing COVID infected patients back into nUrsing homes. MONEY MATTERS MORE THAN LIVES.

bunnyswanson , 9 hours ago

Medical error causing death and the controversy around how ...

healthydebate.ca › 2019/08 › topic › medical-error-cau...

Aug 1, 2019 - In May 2016, the British Medical Journal (BMJ) published an article with the headline: Medical error -- the third leading cause of death in the U.S. The article estimated that as many as 250,000 deaths per year in the United States were caused by medical error.

PrivetHedge , 9 hours ago

gasping for air, pink frothy secretions

That is a lung damaging cytokine storm that can be moderated with vitamin D and C, vitamins our government is staying remarkably quiet about. In a politics free medical system no patient would be allowed to get to that stage.

There are simple cures to these diseases:

  1. Stop Fort Detrick etc. from making them
  2. Use interferon 1, hydroxychloroquine, zinc and antibiotics to cure people before they are permanently damaged.
  3. Allow people to get sunshine and fresh air, and instead of banning useful medicines; ban junk food, GMO and the various other harmful things our government permits in our air and water.
Uncle Frank , 5 hours ago

Why? We didn't buy it the first time.

Don't lose sight of an important fact, one of the few verifiable ones in the piece -

His title - 'Chairman of the Dutch Association of Physicians for Pulmonary Disease and Tuberculosis'.

Ya think he might be motivated to go for grants by hyperbolizing the situation? I do. I'm not saying that some people aren't dying, just that pneumonia isn't ever a walk in the park, and it kills 100's of thousands every year. Try some perspective, and grow a pair. You might need to lose 100 lbs too, I can't tell from here.

JSG , 9 hours ago

Let's see the demographics of these folks. It's an incomplete story without that. My bet: it's people over 70 with pre-existing conditions so this is not remotely surprising. Their immune systems aren't as strong. Their pre-existing conditions likely already causes a lot of this damage (e.g. COPD does exactly this!)

PrivetHedge , 9 hours ago

(as directed by CCP military to the lab people)

The evidence says the CCP were the targets, not the makers.

https://www.zerohedge.com/geopolitical/us-world-leader-bio-weapons-research-production-use-against-mankind
https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787
https://www.barnesandnoble.com/w/higher-form-of-killing-robert-harris/1100618277
https://www.cnbc.com/2020/01/09/people-are-still-dying-from-mysterious-vaping-illness-as-outbreak-slows.html

smacker , 8 hours ago

Those who claim that China knowingly released this virus in China and elsewhere in Asia to attack America(!) conveniently ignore the vaping disease which was actually a severe respiratory infection.

Then there were multiple deaths in nursing homes by similar infections. All this happened months before CovID-19 came along.

Roacheforque , 10 hours ago

The question is ... is COVID 19 alone CAUSING this reaction, or is it TRIGGERING an immune system response from "something else"?

https://roacheforque.blogspot.com/2020/05/the-case-for-mikovits.html

mrjinx007 , 10 hours ago

"It first struck me how different it was when I saw my first coronavirus patient go bad. I was like, Holy ****, this is not the flu . Watching this relatively young guy, gasping for air, pink frothy secretions coming out of his tube and out of his mouth . The ventilator should have been doing the work of breathing but he was still gasping for air, moving his mouth, moving his body, struggling. We had to restrain him. With all the coronavirus patients, we've had to restrain them. They really hyperventilate, really struggle to breathe . When you're in that mindstate of struggling to breathe and delirious with fever, you don't know when someone is trying to help you, so you'll try to rip the breathing tube out because you feel it is choking you, but you are drowning .

Caused by ventilator.

[May 29, 2020] France bans use of hydroxychloroquine as coronavirus treatment

May 29, 2020 | www.moonofalabama.org

Richard Steven Hack , May 28 2020 10:11 utc | 69

France bans use of hydroxychloroquine as coronavirus treatment
The country's public health agency advised against use outside of clinical trials.
https://tinyurl.com/ybm266qn

WHO pauses study of hydroxychloroquine in global trial
The study has enrolled 3,500 patients in at least 17 countries since March.
https://tinyurl.com/ya8b4yuw

US coronavirus death toll tops 100K as Trump pushes to reopen
The tragic milestone revives debate over the handling of the pandemic.
https://tinyurl.com/ybpzormy


A day before the U.S. reached the 100,000-death mark, Trump once again blamed China for not stopping the virus before it spread across the globe, and touted his decision in January to restrict travel from China to the U.S.

"For all of the political hacks out there, if I hadn't done my job well, & early, we would have lost 1 1/2 to 2 Million People, as opposed to the 100,000 plus that looks like will be the number," he tweeted on Tuesday.

Yes, folks, *Trump* is claiming *credit* for saving 1-2 million lives! You can't make this shit up!

Mina , May 28 2020 11:47 utc | 74

Good to know, with regards to what the WHO is doing: "It is not the case that HCQ has been removed from the trial. The WHO has paused that arm of the trial to allow for a review of the interim data to see if they are seeing the same impacts on mortality as have been seen in some other studies."
https://statmodeling.stat.columbia.edu/2020/05/26/last-post-on-hydroxychloroquine-perhaps/#comment-1345645

[May 28, 2020] Is aerosol tranmission of the SARC-NCOV-2 virus possible?

May 28, 2020 | www.moonofalabama.org

Richard Steven Hack , May 28 2020 23:24 utc | 32

As for aerosols over droplets, I've been reading about that for the last month. I thought it was common knowledge. It's the obvious explanation for why some people get it and others don't. Fomites - the virus particles on surfaces - are supposedly responsible for only ten percent of transmission. The question was always to what *degree* aerosols were the transmission method over droplets. Quite a few articles I read debated that point, with evidence mounting that aerosols might have equal or more effect than droplets, at least as secondary transmission. Obviously if someone sneezes or coughs in your face at close range, droplets are the primary transmission. But there are tons of reports - and even video demonstrations on Youtube - of how far aerosols can be dispelled by breathing, talking, yelling, singing and coughs and sneezes. Aerosols can be spread up to 25 feet or more and hover in the air for up to 45 minutes, if not longer, depending on air temperature, humidity and air movement. Droplets can turn into aerosols depending on the same factors.

I started early on washing my hands religiously because due to the fact that I do not interact with hardly anyone in my building or elsewhere except during my supply runs, fomites would be the most likely way I could catch the virus. I have to use a common toilet - so touching the door and toilet lid would be my main risk. That's why I bought a thousand food service plastic gloves which I wear when using the john or going outside the building. When I return, I remove them by the recommended method, then wash my hands.

Initially I didn't have any masks because the depletion of the supply had already occurred. Now I have nineteen masks, 14 of which I use and rotate whenever going to the john or outside the building. I wear it when going to the john because I read recently that flushing a toilet aerosolizes fecal matter - and any virus particles - present in the water. In other words, you get a faceful of virus every time you flush a toilet. So close the lid before flushing. When I return, I wash my hands, remove the mask, then apply hand sanitizer or wash my hands again - which is the recommended procedure.

I now have an adequate supply of masks, hand sanitizer and disinfectant spray (with some more of the latter coming), so I think I'm in a good position to reduce my risk. But of course, as with the rest of life, it's still a crapshoot.

It will be a worse crapshoot as these idiots start crowding places I have to go to for supplies. I use convenience stores a lot and they tend to be crowded because they are very small. I also visit the Target store, but they initially had the crowding under control - because you had to wait in line to get in, which took twenty minutes or more. Now with the easing of restrictions, they have eliminated the door check, so the store is a bit more crowded, but not too much. People might still be wary, as has been suggested by some articles and polls. It's a big store, so ventilation and air movement might be better than a smaller space.

likbez , May 28, 2020 at 23:40

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@Richard Steven Hack | May 28 2020 23:24 utc | 32

The question was always to what *degree* aerosols were the transmission method over droplets

They are not mutually excusive. Aerosol transmission can theoretically occur when a droplet that contains virus particles dry out and they start chaotically move via Brownian motion of air molecules.

Looks like the virus does not die instantly in this case. After all it looks like it survives in dry state on surfaces for a day or two in the absence of sun radiation (depending on the surface -- longest on steel surfaces, shortest on copper)

[May 28, 2020] https://tinyurl.com/y9mudhmf

May 28, 2020 | tinyurl.com

Recommends blood thinners in the same manner that the Front-Line COVID-19 Critical Care Working Group does...


There is another treatment that hasn't received as much coverage possibly because it isn't one individual drug. It's a broad category of blood thinners called anticoagulants. A recent pre-proof study of over 2500 patients from the Journal of the American College of Cardiology showed that anticoagulation can decrease the mortality of critically ill patients with the coronavirus from a frightening 63% to a somewhat less daunting 29%.

Medical providers, including myself, often use prophylactic doses of blood thinners such as heparin or enoxaparin to prevent blood clots in hospitalized patients particularly in those with additional risk factors for blood clots, but now these medications are being administered to hospitalized patients who have no risk factors for clots other than having COVID-19.

Posted by: Richard Steven Hack | May 28 2020 10:22 utc | 70

[May 28, 2020] Interesting comments/reviews on the article which has supposedly debunked HCQ

May 28, 2020 | www.moonofalabama.org

Mina , May 28 2020 8:35 utc | 64

Interesting comments/reviews on the article which has supposedly debunked HCQ. (But see Somebody's links at the Nicotine-patch thread for the danger it presents in certain genetic groups)
https://pubpeer.com/publications/71DA593B9943638F1ADE6F80696914

[May 25, 2020] Two postulates of the establishment's propaganda on coronavirus

Outdoor maskism has zero to do with science, everything to do with irrational panic at best, and most of all top-down totalitarian control-seeking
Living in the Empire isn't quite as bad as being a victim of the Empire, but it's getting close.
May 25, 2020 | www.moonofalabama.org
Russ , May 25 2020 5:44 utc | 66

v> Thus in this case the propaganda has been largely monolithic:

1. Stay indoors. Don't breathe the air.

2. If you must venture into the hostile outdoors*, wear a mask**. Especially now that the air is the cleanest it's been our whole live s, do all you can to avoid breathing it.

"Covid-19 has forced modern medicine to broaden its outlook and look for new solutions, even in the wisdom of the past."

Indeed, it's clear where the establishment's propaganda has found wisdom.

Thus in this case the propaganda has been largely monolithic:

1. Stay indoors. Don't breathe the air.

2. If you must venture into the hostile outdoors*, wear a mask**. Especially now that the air is the cleanest it's been our whole live s, do all you can to avoid breathing it.

"Covid-19 has forced modern medicine to broaden its outlook and look for new solutions, even in the wisdom of the past."

Indeed, it's clear where the establishment's propaganda has found wisdom. /div

[May 25, 2020] BIG PHARMA steered public money away from pandemic research and into PROFIT-MAKING projects for years watchdog -- RT World New

Notable quotes:
"... EU money intended for underfunded public-benefit research such as preparing for a pandemic has been diverted by the pharmaceutical industry into areas where it can make more money, according to a scathing new report. ..."
"... The target of the criticism is the Innovative Medicines Initiative (IMI), a public-private partnership that was equally funded, between 2008 and 2020, by the European Federation of Pharmaceutical Industries and Associations (EFPIA) lobbying group and the European Commission to the tune of 5.3 billion euros (US$5.8 billion). The money is supposed to go to areas of "unmet medical or social need," ..."
"... "We were outraged to find evidence that the pharmaceutical industry lobby EFPIA not only did not consider funding biopreparedness (ie, being ready for epidemics such as the one caused by the new coronavirus, COVID-19) but opposed it being included in IMI's work when the possibility was raised by the European Commission in 2017, ..."
"... "The research proposed by the EC in the biopreparedness topic was small in scope," ..."
"... "IMI's projects have contributed, directly or indirectly, to better prepare the research community for the current crisis, the Ebola+ programme or the ZAPI project." ..."
"... "belated interventions when an epidemic is already underway," ..."
"... Think your friends would be interested? Share this story! ..."
May 25, 2020 | www.rt.com
EU money intended for underfunded public-benefit research such as preparing for a pandemic has been diverted by the pharmaceutical industry into areas where it can make more money, according to a scathing new report. Officials in Brussels wanted to co-fund research that would have ensured the European Union (EU) was better prepared for a pandemic akin to the one we are experiencing today. But their partners, the big pharmaceutical companies, rejected the proposal, ensuring that taxpayer money would go instead into studies with more potential for commercial application. In short big-pharma lobbyists were allowed to steer billions of euros of public funds as they saw fit, a damning new report claims.

The target of the criticism is the Innovative Medicines Initiative (IMI), a public-private partnership that was equally funded, between 2008 and 2020, by the European Federation of Pharmaceutical Industries and Associations (EFPIA) lobbying group and the European Commission to the tune of 5.3 billion euros (US$5.8 billion). The money is supposed to go to areas of "unmet medical or social need," but, in practice, corporate priorities dominate the decision-making, according to the non-governmental organization Corporate Observatory Europe (COE).

"We were outraged to find evidence that the pharmaceutical industry lobby EFPIA not only did not consider funding biopreparedness (ie, being ready for epidemics such as the one caused by the new coronavirus, COVID-19) but opposed it being included in IMI's work when the possibility was raised by the European Commission in 2017, " a new COE report said.

Also on rt.com Head of EU's top science body quits after Covid-19 response plans get bogged down by Brussels bureaucracy

The rejected proposal would have directed money into refining computer simulations and the analysis of animal testing models, potentially speeding up regulatory approval of vaccines, according to the Guardian. But a spokeswoman for the IMI called the report "misleading".

"The research proposed by the EC in the biopreparedness topic was small in scope," she said. "IMI's projects have contributed, directly or indirectly, to better prepare the research community for the current crisis, the Ebola+ programme or the ZAPI project."

ZAPI, or the Zoonotic Anticipation and Preparedness Initiative, was launched in 2015 with a budget of 20 million euros (US$21.8 million) after the Ebola epidemic a year prior. The COE report said it exemplifies a pattern of "belated interventions when an epidemic is already underway," much like this year's emergency funding of coronavirus research.

Also on rt.com Hotly-touted Oxford coronavirus VACCINE trial has only 50 percent chance of success, project leader warns

The think tank questioned whether EU public money was well applied through IMI. Much of it went into research into cancer, Alzheimer's disease and diabetes – areas that are potentially profitable and thus are given close attention by private business. But epidemic preparedness, HIV/AIDS, and poverty-related and neglected tropical diseases have been overlooked by the initiative, the report said.

Think your friends would be interested? Share this story!

[May 24, 2020] 'How Could the CDC Make That Mistake?' The government's disease-fighting agency is conflating viral and antibody tests, compromising a few crucial metrics that governors depend on to reopen their economies. Pennsylvania, Georgia, Texas, and other states are doing the same.

Notable quotes:
"... "According to CDC, the disease of obesity affects about 78 million Americans 1 and the ASMBS estimates about 24 million have severe or morbid obesity." ..."
May 24, 2020 | www.moonofalabama.org

Richard Steven Hack , May 24 2020 23:54 utc | 46

And the government botching of this crisis continues...

'How Could the CDC Make That Mistake?' The government's disease-fighting agency is conflating viral and antibody tests, compromising a few crucial metrics that governors depend on to reopen their economies. Pennsylvania, Georgia, Texas, and other states are doing the same.
https://tinyurl.com/y92ea59f

And overseas as well...

'Politicised nature' of lockdown debate delays Imperial report
https://tinyurl.com/y7csboom

And of course, the effect of that...

Nearly half of US states haven't contained their coronavirus outbreaks, a new study finds
https://tinyurl.com/yc72pd8t

And no, Sweden is not doing better...

Just 7.3% of Stockholm had Covid-19 antibodies by end of April, study shows
Official findings add to concerns about Sweden's laissez-faire strategy towards the pandemic
https://tinyurl.com/yahnmb3a

Finally, a large scale study on HCQ - 86,000 patients, with 15,000 receiving HCQ...

Trump drug hydroxychloroquine raises death risk in Covid patients, study says
https://www.bbc.com/news/world-52779309

The color of coronavirus:
COVID-19 deaths by race and ethnicity in the U.S.
https://www.apmresearchlab.org/covid/deaths-by-race

Blacks are *twice* as likely to get it as whites and Latinos. American Indians are *five times* more likely to get it. They conclude the best indicator is poverty.

From The Lancet, a study of New York patients... Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study https://tinyurl.com/yblmszsx

Between March 2 and April 1, 2020, 1150 adults were admitted to both hospitals with laboratory-confirmed COVID-19, of which 257 (22%) were critically ill.

The median age of patients was 62 years (IQR 51–72), 171 (67%) were men. 212 (82%) patients had at least one chronic illness, the most common of which were hypertension (162 [63%]) and diabetes (92 [36%]).

119 (46%) patients had obesity.

As of April 28, 2020, 101 (39%) patients had died and 94 (37%) remained hospitalised.

203 (79%) patients received invasive mechanical ventilation for a median of 18 days (IQR 9–28), 170 (66%) of 257 patients received vasopressors and 79 (31%) received renal replacement therapy.

The median time to in-hospital deterioration was 3 days (IQR 1–6).

In the multivariable Cox model, older age (adjusted hazard ratio [aHR] 1·31 [1·09–1·57] per 10-year increase), chronic cardiac disease (aHR 1·76 [1·08–2·86]), chronic pulmonary disease (aHR 2·94 [1·48–5·84]), higher concentrations of interleukin-6 (aHR 1·11 [95%CI 1·02–1·20] per decile increase), and higher concentrations of D-dimer (aHR 1·10 [1·01–1·19] per decile increase) were independently associated with in-hospital mortality.

Note: 36% had diabetes; 46% were fat. Like I've said before, "diabetes" is a code word for "fat." And how many people in the US are fat and thus at risk? "According to CDC, the disease of obesity affects about 78 million Americans 1 and the ASMBS estimates about 24 million have severe or morbid obesity."

So much for "let's just isolate the elderly"...so we can attend our baseball games this summer and stuff ourselves with crap food...

[May 24, 2020] Lung volume as an important factor in coronavirus progrnnsys

May 24, 2020 | www.moonofalabama.org

Jen , May 24 2020 23:13 utc | 41

I think lung volume is indirect indicator of how well trained the person is. Coach potatoes have low lung volume. Most sportsmen -- a high or even very high.

From WSJ article "The Healing Power of Proper Breathing" https://www.wsj.com/articles/the-healing-power-of-proper-breathing-11590098696

In the 1980s, researchers with the Framingham Study, a 70-year research program focused on heart disease, gathered two decades of data from 5,200 subjects, crunched the numbers and discovered that the greatest indicator of life span wasn't genetics, diet or the amount of daily exercise, as many had suspected. It was lung capacity. Larger lungs equaled longer lives. Because big lungs allow us to get more air in with fewer breaths. They save the body from a lot of unnecessary wear and tear.

Also a sedentary way of life with not enough movement during the day, especially during childhood and adolescence, along with poor sitting and standing postures can encourage shallow breathing instead of breathing with the whole body.

[May 23, 2020] Hydroxychloroquine After Action Report

May 23, 2020 | angrybearblog.com

Robert Waldmann | May 23, 2020 10:52 am

Healthcare Hot Topics I was a vehement advocate of prescribing hydroxychloroquine (HCQ) off label while waiting for the results of clinical trials. I wasn't all that much embarrassed to agree with Donald Trump for once. Now I feel obliged to note that my guess was totally wrong. I thought that the (uncertain) expected benefits were greater than the (relatively well known) costs.

The cost is that HCQ affects the heart beat prolonging the QT period (from when the atrium begins to contract to when the ventrical repolarizes and is read to go again). This can cause arrhythmia especially in people who already have heart problems. I understood that one might argue that all people with Covid 19 have heart problems but didn't consider that argument decisive (I probably should have).

The positive expected value of the uncertain benefits was based on strong in vitro evidence that HCQ blocks SARS Cov2 infection of human cells in culture. (this is a publication in the world's top general science journal).

Already in early May, there was evidence that any effect of HCQ on the rate of elimination of the virus must be small. In this controlled trial conducted in China , the null of no effect is not rejected. Much more importantly, the point estimates of the effects over time are all almost exactly zero. I considered the matter settled (although the painfully disappointed authors tried to argue for HCQ and that their study was not conclusive).

There are now four large retrospective studies all of which suggest no benefit from HCQ and two of which suggest it causes increased risk of death. I am going to discuss the two studies most recently reported.

One is a very large study (fairly big data goes to the hospital) published yesterday in The Lancet. In this study patients who received HCQ had a significantly higher death rate with a hazard of dying 1.335 times as high. The estimate comes from a proportional hazard model with a non parametric baseline probability and takes into account many risk factors including crucially initial disease severity. It is also important that only patients who were treated within 48 hours of diagnosis were considered.

I am, of course, dismayed by this result. I am also puzzled, because it is quite different from the result obtained in a smaller retrospective study published in JAMA

I think the practical lessons are that it seems unwise to give Covid 19 patients HCQ. Also maybe Robert Waldmann should be more humble. After the jump, I will discuss the two studies in some detail and propose an explanation of the difference in results.

[May 23, 2020] The more you know Over a third of Americans apprehensive about Covid-19 vaccine, citing rushed development trust issues -- RT

May 23, 2020 | www.rt.com

The more you know? Over a third of Americans apprehensive about Covid-19 vaccine, citing rushed development & trust issues 21 May, 2020 21:37 Get short URL The more you know? Over a third of Americans apprehensive about Covid-19 vaccine, citing rushed development & trust issues © Global Look Press / Fotostand / K. Schmitt Follow RT on RT As the Trump administration pushes for Covid-19 vaccine development on an ever-shrinking timetable and companies report lackluster early trials, 35 percent of Americans are less than thrilled about getting the shot. Operation Warp Speed, the Trump administration's unprecedented drive to create and roll out a vaccine for the coronavirus pandemic by the end of the year, may be doing more harm than good, at least where Americans' trust is concerned. Between the shockingly abbreviated timetable and the lack of long-term safety testing, almost one in four Americans (24 percent) said they were not interested in the shot, according to a Reuters poll published Thursday. An additional 11 percent were unsure about it.

Also on rt.com Study Trump cited in his latest attack on WHO does NOT EXIST, says editor-in-chief of prestigious medical journal

Compounding the distrust is the polarizing figure of President Donald Trump himself, who proudly announced the shortened timetable for vaccine development last week. Thirty-six percent of those polled by Reuters said they would be less likely to take a potential Covid-19 vaccine if it came recommended by Trump, while just 14 percent thought the president's seal of approval was a positive.

Trump's narrative flip-flops haven't helped his credibility on the vaccine front. From his early reassurances that the virus would vanish in weeks, to his public conflicts with his own health advisers over locking down and reopening the country, it's not hard to see why Americans are hesitant to fall in line behind him on this. But the problem isn't necessarily political. Nearly half of those uninterested in taking the vaccine said the speed of its development worried them, while over 40 percent said the vaccine would be riskier than actually contracting Covid-19 itself.

Read more Trump's WARP SPEED vaccine czar oversaw an infamously BOTCHED vaccination. Wonder why a THIRD of Americans want to dodge this one? Trump's WARP SPEED vaccine czar oversaw an infamously BOTCHED vaccination. Wonder why a THIRD of Americans want to dodge this one?

However, even 29 percent of those who said they were " not very interested " in the vaccine allowed they'd be willing to change their mind if the shot was approved by the Food and Drug Administration. The full approval process for vaccines usually takes over a decade, and even the most optimistic experts – including Dr. Anthony Fauci, who has become the public face of the US' Covid-19 policy – believe a shot won't be ready for another year to 18 months. Rushing a vaccine to market in the middle of a pandemic means sacrificing comprehensive safety checks for efficiency – a tradeoff that can be disastrous, as in the case of the 2009 swine flu shot Pandemrix, which caused permanent brain damage in over 1,000 British patients.

The parallels between Covid-19 and that epidemic are ominous – wildly inflated death predictions had spooked the UK government into approving Pandemrix without sufficient safety data – and it surely won't help Americans' trust in this vaccine that Trump's " vaccine czar " Moncef Slaoui ran GlaxoSmithKline's vaccine division during the swine flu debacle. Nor has it been especially heartening to discover Slaoui's extensive investments in not just Glaxo but many other drug companies working on potential vaccines.

Slaoui earned $3 million on Monday alone from Moderna, which is still considered the leading candidate in the vaccine race, even though the drug company has never brought a vaccine to market. After hyping up what were essentially meaningless preliminary results, Moderna's stock shot up 25 percent, bringing his holdings to over $10 million. He pledged to donate those earnings to " cancer research " after demands for him to divest reached a fever pitch. A vaccine produced at Oxford University hasn't fared much better, with all six rhesus monkeys who received the shot becoming infected anyway – despite a preliminary report that tried to spin the failure as representing " some " success.

Also on rt.com Define 'distribute'! Trump mobilizing MILITARY to deliver Covid-19 vaccine 'assuming we get it,' sparks conspiracy frenzy

Threats of mandatory vaccination have unsurprisingly not helped to soothe Americans' worries over a potentially unsafe vaccine. Fauci and other health officials have repeatedly warned the public that there will be no return to " normal " without a vaccine, even as lockdown restrictions are slowly lifted – a statement some have interpreted as a threat that the unvaccinated will be barred from crowded public places or travel. Harvard Law Professor Alan Dershowitz went further, declaring the government has " police power " to mandate Americans take a vaccine and claiming such power is " not debatable " constitutionally. And other experts downplayed the very real concerns voiced by poll respondents in favor of blaming the " very aggressive anti-vaccine movement ."

All this is bad news for the health experts Reuters cites, who say 70 percent of Americans would have to be immune in order to achieve " herd immunity " and stop the virus from spreading through the US, where upwards of 90,000 people have died since the pandemic began.

[May 22, 2020] Washington State conned out of a likely 'hundreds of millions of dollars' by Nigerian scammers

If Nigerian hackers can steal that much money, Israel, Chinese, and Russian, intel agencies probably are in the most Fed information systems doing what they want ;-)
Notable quotes:
"... officials in Washington State may have lost "hundreds of millions of dollars" to fraudsters filing bogus unemployment claim ..."
May 22, 2020 | www.rt.com
officials in Washington State may have lost "hundreds of millions of dollars" to fraudsters filing bogus unemployment claim s – all the way from Nigeria.

[May 22, 2020] The Remdesivir Study Is Finally Out Drug Only Helped Those On Oxygen, Finds Mortality Too High For Standalone Treatment Zero

May 22, 2020 | www.zerohedge.com

Remember when the market soared on several days in April on the Facui-touted Remdesivir study which, according to StatNews and various other unofficial sources of rumors, was a smashing success only for the optimism to fizzle as many questions emerged , and as the Gilead drug quietly faded from the public's consciousness and was replaced by various coronavirus vaccine candidates such as those made by the greatly hyped Moderna ( whose insiders just can't stop selling company stock ).

Meanwhile, those who were waiting for the official version of Remdesivir's effectiveness had to do so until 6pm on a Friday before a long holiday, and for good reason...

Friday 6 pm. Fking ridiculous. https://t.co/6Ze38BfVgN

-- Adam Feuerstein (@adamfeuerstein) May 22, 2020

... According to a pivotal study published in the New England Journal of Medicine late on Friday, Remdesivir, which was authorized to treat Covid-19 in a group of 1063 adults and children (split into two groups, one receiving placebo instead of remdesivir) who need i) supplemental oxygen, ii) a ventilator or iii) extracorporeal membrane oxygenation (ECMO), only significantly helped those on supplemental oxygen.

Meanwhile, and explaining the 6pm release on a Friday, the study also found no marked benefit from remdesivir for those who were healthier and didn't need oxygen or those who were sicker, requiring a ventilator or a heart-lung bypass machine.

The NEJM, almost apologetically, stated that "the lack of benefit seen in the other groups might have stemmed from a smaller number of patients in each group."

Still, as a result of the partial benefit for patients in the supplemental oxygen group, the study from the National Institute of Allergy and Infectious Diseases was evaluated early and led to the authorization of remdesivir before the full trial was completed.

Our findings highlight the need to identify Covid-19 cases and start antiviral treatment before the pulmonary disease progresses to require mechanical ventilation.

Some more details on the study, which was a "rank test of the time to recovery with remdesivir as compared with placebo, with stratification by disease severity":

The primary outcome measure was the time to recovery, defined as the first day, during the 28 days after enrollment, on which a patient satisfied categories 1, 2, or 3 on the eight-category ordinal scale. The categories are as follows:

  1. not hospitalized, no limitations of activities;
  2. not hospitalized, limitation of activities, home oxygen requirement, or both;
  3. hospitalized, not requiring supplemental oxygen and no longer requiring ongoing medical care (used if hospitalization was extended for infection-control reasons);
  4. hospitalized, not requiring supplemental oxygen but requiring ongoing medical care (Covid-19–related or other medical conditions);
  5. 5, hospitalized, requiring any supplemental oxygen;
  6. hospitalized, requiring noninvasive ventilation or use of high-flow oxygen devices;
  7. hospitalized, receiving invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO); and
  8. death.

The results are summarized below, highlighting the only group that showed a statistically significant improvement in outcomes as a result of taking the drug vs placebo.

A visual representation of the outcomes is below; it shows that whereas there was a modest benefit only to patients who were receiving oxygen, the results were statistically insignificant vs placebo for patients not receiving oxygen, while in a surprising twist patients on high-flow oxygen or mechanical ventilator/ECMO did modestly better in the placebo group than those taking remdesivir. Also, the overall results showed a very modest, but not statistically significant improvement in the remdesivir group vs placebo (box A).

Another disappointment: the study found that overall "mortality was numerically lower in the remdesivir group than in the placebo group, but the difference was not significant ", in other words the alleged "miracle drug" has largely the same effect as a placebo in terms of overall disease mortality.

The study authors also note that the "findings in our trial should be compared with those observed in a randomized trial from China in which 237 patients were enrolled (158 assigned to remdesivir and 79 to placebo).... That trial failed to complete full enrollment (owing to the end of the outbreak), had lower power than the present trial (owing to the smaller sample size and a 2:1 randomization), and was unable to demonstrate any statistically significant clinical benefits of remdesivir. "

Finally, the study found that while mortality was modestly lower for the remdesivir arm, it was not significantly so, at 7.1% at 14 days on drug versus 11.9% on placebo.

In conclusion, while the "preliminary findings support the use of remdesivir for patients who are hospitalized with Covid-19 and require supplemental oxygen therapy" the study goes on to warn that " given high mortality despite the use of remdesivir, it is clear that treatment with an antiviral drug alone is not likely to be sufficient."

The study's recommendation:

Future strategies should evaluate antiviral agents in combination with other therapeutic approaches or combinations of antiviral agents to continue to improve patient outcomes in Covid-19.

So a generally disappointing outcome, one which would lead to a drop in the market. Nonsense: think of all the spin, and why this is in fact great news for stocks: Remdesivir may be a dud as a "silver bullet" to curing covid, leading to statistically significant improvement in only a very limited subset of infected patients and "high mortality" for those taking it, but at least the algos will have a whole lot of other "miracle drugs" to levitate them as optimism that the next remdesivir is just around the corner. In short: rinse, rumor, and repeat... and then save the bad news for 6pm on a Friday.

Oh, and for those asking about the "official" reason why the NE Journal of Medicine waited until just the right time to make sure nobody reads the results, here it is:

I asked NEJM spox to explain the Friday 6 pm release of the remdesivir study. Her response is below. pic.twitter.com/WjNGyUv7sH

-- Adam Feuerstein (@adamfeuerstein) May 22, 2020

The full study is available here .

[May 22, 2020] Global report: don't count on vaccine, US scientist warns, as cases pass 5m

May 22, 2020 | www.theguardian.com

A top US scientist has said that people should not count on a Covid-19 vaccine being developed any time soon...

William Haseltine, the groundbreaking cancer, HIV/AIDS and human genome projects researcher, has said the best approach to the pandemic is to manage the disease through careful tracing of infections and strict isolation measures whenever it starts spreading. He said that while a vaccine could be developed, "I wouldn't count on it", and urged people to wear masks, wash hands, clean surfaces and keep a distance.

[May 21, 2020] Smokers are at a lower risk of contracting covid19 infections

May 21, 2020 | www.moonofalabama.org

J Norwich , May 19 2020 5:43 utc | 108

Prior infection with other coronavirus strains appears to confer an enhanced immune response to covid19. Smokers are at a lower risk of contracting covid19 infections. Perhaps the two observations are related? Smokers generally have poorer lung health and may be more likely to acquire lung infections such as those caused by other varieties of coronavirus and to develop antibody protection. So maybe their vulnerability to such infections has proved an advantage in this case?

Hoarsewhisperer , May 19 2020 6:05 utc | 109

"Immune warriors known as T cells help us fight some viruses, but their importance for battling SARS-CoV-2, the virus that causes COVID-19, has been unclear. Now, two studies reveal infected people harbor T cells that target the virus -- and may help them recover. Both studies also found some people never infected with SARS-CoV-2 have these cellular defenses, most likely because they were previously infected with other coronaviruses."

Thanks for drawing attention to this, b.

The T cell/Common Cold factor may help to explain why children are less likely to be infected by COVID-19 than adults. I can recall that when each of my own offspring went through that miserable, snotty-nosed toddler phase, there seemed to be no upside for them or their parents. In retrospect, maybe it was producing a hidden benefit?

[May 21, 2020] Is nikotin effective against COVID-19

May 21, 2020 | www.moonofalabama.org

gm , May 19 2020 16:13 utc | 129

With respect to highly addictive nicotine, it is not hard to find any number of "healthful" justifications for continuing with the (disgusting, imho) smoking habit.

Why, there is already an extensive body of scientific "evidence" one can latch onto that nicotine is beneficial in Parkinson's disease:

https://scholar.google.com/scholar?q=smoking+parkinson%27s+disease&hl=en&as_sdt=0&as_vis=1&oi=scholart

And of course, one can also find numerous reports nicotine also helps schizophrenics to manage their symptoms:

https://scholar.google.com/scholar?q=smoking+schizophrenia+benefits&hl=en&as_sdt=0&as_vis=1&oi=scholart

But with regard to anecdotal/unverified [touch'e] claims of nicotine benefits in covid, one should not reflexively ignore the evidence to the contrary that conflict with one's pro-nicotine bias/belief system:}

"Smokers more likely to express ACE2 protein that SARS-COV-2 uses to enter human cells"
https://medicalxpress.com/news/2020-05-smokers-ace2-protein-sars-cov-human.html

and

"Tobacco smoking increases lung entry points for COVID-19 virus"
https://medicalxpress.com/news/2020-04-tobacco-lung-entry-covid-virus.html

"They looked at the expression of ACE2, the molecule in the respiratory tract that the COVID-19 virus uses to attach to and infect human cells. They also looked at the expression of FURIN and TMPRSS2, human enzymes known to facilitate COVID-19 virus infection.

The researchers report in the American Journal of Respiratory and Critical Care Medicine a 25 percent increase in the expression of ACE2 in lung tissues from ever-smokers, people who have smoked at least 100 cigarettes during their lives, when compared with nonsmokers. Smoking also increased the presence of FURIN, but to a lower extent compared to ACE2 . TMRPSS2 expression in lungs was not associated with smoking. They also found that smoking remodeled the gene expression of cells in the lungs so that the ACE2 gene was more highly expressed in goblet cells, cells that secrete mucus in order to protect the mucous membranes in the lungs ."

But if you are totally bent on using a non-addictive feel-good drug that Israelis say may prevent/fight against the Corona-chan, try CANNABIS:

https://news.google.com/search?for=marijuana%20covid%20israel&hl=en-US&gl=US&ceid=US%3Aen

[May 21, 2020] An MD wrote this op/ed dealing with the hypoxia caused by the coronavirus and provides evidence in support of Dr. Bush's video interview

May 21, 2020 | www.moonofalabama.org

karlof1 , May 19 2020 20:56 utc | 137

An MD wrote this op/ed dealing with the hypoxia caused by the coronavirus and provides evidence in support of Dr. Bush's video interview that can be reached through the link @135 above.

Yes, the op/ed's a month old, but the dynamics of the virus haven't changed nor have the frequency of deaths within the Outlaw US Empire.

Based on the doctor's first hand testimony and other studies, the initial treatment approach advocated by Dr. Bush and its reasoning seem quite pragmatic and logical.

Comparison with Malaria yields almost no correlation aside from the malaria parasite's use of red blood cells as nurseries and lairs, which may explain why anti-malaria drugs used against COVID-19 in its initial stages have some positive results.

[May 21, 2020] Our FLCCC Working Group currently believes that, if hydroxychloroquine proves to have any benefit, it will most likely be in the earliest stage of infection, while the virus replicates and the patient is still at home, before breathing difficulties or low oxygen levels necessitate a trip to the hospital.

May 21, 2020 | www.moonofalabama.org

Richard Steven Hack , May 19 2020 4:45 utc | 106

The Front-Line COVID-19 Critical Care Working Group (EVMS is part of that group) has this to say about HCQ:
Some have asked why our initial protocol included hydroxychloroquine, the anti-viral drug that was widely touted as a cure for the COVID-19 disease that is caused by the virus. Almost all ER and ICU physicians tried it before a study published in the New England Journal of Medicine showed it to have no effect on mortality in patients with severe cases of the disease. Our FLCCC Working Group currently believes that, if hydroxychloroquine proves to have any benefit, it will most likely be in the earliest stage of infection, while the virus replicates and the patient is still at home, before breathing difficulties or low oxygen levels necessitate a trip to the hospital.

A shortened version of their current treatment protocol (PDF):
https://tinyurl.com/y836kmpc

Dr. Kory Senate Testimony before the Homeland Security and Government Affairs Committee Hearing (Vimeo video)
https://vimeo.com/415698366

Dr. Kory is Pierre Kory, M.D., M.P.A., Medical Director, Trauma & Life Support Center, Critical Care Service Chief, Associate Professor of Medicine Univ. of Wisconsin School of Medicine & Public Health - one of eight medical professionals on the FLCCC team.

Note: I do *not* explicitly endorse any of this. I am not a doctor, nor do I play one on MoA. But I find their arguments reasonable to the degree I can comprehend them.

Richard Steven Hack , May 19 2020 6:26 utc | 110

Just watched Dr. Kory's testimony before the Senate Committee I referenced above... Link again: https://vimeo.com/415698366

I recommend it to everyone. Again, I can't speak to the medicine, but I think you'll find him highly persuasive, if rather desperate to fit his arguments into the time allotted him (which he overran.)

At least we got a number for the patients treated with their complete MATH+ Protocol - merely 100 (at the time of his testimony.) That's not a high number that persuades me. But he also cites a number of other doctors around the country and in Italy who have tried corticosteroids and apparently they consider it a "game-changer" in treatment, in that it massively reduces the number of people needing to be put on ventilators. He emphasizes that the treatment is safe, physiologically sound, well-recognized as useful for the conditions caused by the virus for years, and although "off-label" for this disease it is not unusual to do "off-label" and that is supported by all the medical association ethical standards.

But he emphasizes that the treatment needs to be started as soon as respirator symptoms develop and he is concerned that too many people are avoiding going to the hospital until it's too late. This of course raises the question as to whether this is another treatment - like HCQ - that "only" works at early stages and therefore is not necessarily proven by trials, but is only supported by "observation" in the hospital.

Of course, the solution to that is run the bloody trial. Or at least use the treatment on a greater number of treatments and see how it washes out. He's concerned that they can't get the White House to listen - big surprise, there.

[May 21, 2020] On the necessity and the duration of quarantine

May 21, 2020 | www.unz.com

likbez , says: Show Comment May 21, 2020 at 9:20 pm GMT

Hi The Kremlin Stooge,

Don't forget 'Covidiots'. The frontline-worker-lovin', government-narrative-believin' social-distance welcomin' simpletons are endlessly inventive when it comes to coining contemptuous nicknames for those who don't buy into their embrace of madness. I am happy to be able to say I thought the virus was bogus from the first, and said so to anyone who would listen.

That's too simplistic. You should agree that religious nuts who attend the church in large groups despite the risk can and should be called "Covidiots". Because they are. And the people who are trying to preserve their meager income generally should not.

Why religious nuts can't move to outdoors for the same purpose like first Chirstians did, is unclear to me ;-). Not sure about Orthodox Jews, which is pretty closed sect in any case so if they want to infect each other, be my guest.

The virus causes specific for it virus pneumonia which is no joke. People who recovered still have fibroses in this lungs of different degree. That's why people who were hospitalized with COVID-19 are ineligible to serve in US army. So for those unlucky who get virus pneumonia that's a crippling disease. You can't deny this.

For around 15-20% of people over 65 infected with COVID-19 it means the death sentence -- they will never recover and either die in hospital or soon after. Men over 65 are two third of those so for old men the risk can't be discounted.

So the question is what forms and length of quarantine was optimal, not whether it should or should not be enforced. I doubt that you want to argue that night clubs should remain open. Or that wearing masks in closed spaces is redundant (in open spaces they generally are redundant, unless you are standing in line, etc)

You also need some timeout to collect the vital information about the disease using first cases, enhance the protection of medical personnel, and access the level of actual risk to the population and the economy (the USA generally wasted it and Trump was inapt; so the effect of quarantine is more questionable for this particular country).

It was not that clear in March that the risk is generally low, although we can't deny that Fauci and Co were caught without pants (or, for some sinister reason were intended to be caught this way as if they waited until epidemic got to a certain point that masks something else )

That does not excuse incompetence of Trump administration and very strange behaviors of Fauci, who spent two months and then woke up and suddenly start crying Wolf, Wolf, but the USA is very mysterious country and in no way Canadians can understand it

[May 21, 2020] New York Times continues to prop up the vaccine hype

May 21, 2020 | www.moonofalabama.org

vk , May 21 2020 0:49 utc | 55

New York Times continues to prop up the vaccine hype:

Coronavirus Live Updates: Scientists See Progress in Path to Vaccine by Next Year

In addition to this Home Page highlight, there's an opinion piece as a side dish:

What to Expect When a Coronavirus Vaccine Finally Arrives

Buried a little bit more at the bottom, there's this borderline pseudoscientific, definitely reckless article:

Prototype Vaccine Protects Monkeys From Coronavirus

There is a statistical possibility a vaccine comes out next year. But his possibility is remote. The key here is that a vaccine must be tested to the exhaustion before being ok'd by any government for mass use. Any mistake can result in a number of deaths that will make this pandemic look like child's play. My opinion is that the NYT is feeding too much enthusiasm to its readers.

Circe , May 19 2020 12:05 utc | 119

The Moderna Vaccine the media is touting as a promising, miracle breakthrough that has only been tested on a limited group of 45 people, aged 18 to 55 has Grade 3 adverse effects in 100 and 250 microgram dosage.

So they're going to lower dosage to 50 micrograms and test it on the 56 to 70 and over 70 age groups. What about the group most Americans are in: the KFC, McDonald's, IHOP group?

[May 21, 2020] It is worth reminding of criticism of the untrustworthiness of modern medical science from the editors of some of the top medical journals

Notable quotes:
"... There are some who parrot Big Pharma vested interests in ridiculing and denigrating hydroxychloroquine, despite the very notable positive results several countries such as China, Russia, Iran and Turkey have had with it, while vainly spouting the benefits of smoking despite complete lack of quality research papers supporting it and abundant quality papers against. ..."
"... Research is not created equal. There is good research (some, not so much) and there is bad research (bundles of it), mostly funded by vested interests, who where necessary direct the desired results. In general, research from China and Russia arguably tends to be higher quality and more reliable because those countries place the emphasis on health for society, not on profits for the corporations. ..."
May 21, 2020 | www.moonofalabama.org

BM , May 20 2020 6:17 utc | 146

But with regard to anecdotal/unverified [touch'e] claims of nicotine benefits in covid, one should not reflexively ignore the evidence to the contrary that conflict with one's pro-nicotine bias/belief system:}
"Smokers more likely to express ACE2 protein that SARS-COV-2 uses to enter human cells"
"Tobacco smoking increases lung entry points for COVID-19 virus"
Posted by: gm | May 19 2020 16:13 utc | 129

Touché again gm!

It is indeed desperate grasping at straws to believe that smoking will protect against Covid-19 when far higher quality research clearly indicates increased risk from smoking that the disease will be more severe (the latter also being the more plausible result).

As I commented the last time B raised this issue, there is one genuine effect of a past history of smoking that statistically reduces risk of death from Covid-19 - namely smoking significantly reduces expected lifespan, and therefore reduces the risk of living long enough to reach the highest risk age groups for severe Covid-19. Alternatively expressed - smoking kills you off first before you get a chance to be killed by Covid, if that is what you want. Post-hoc nicotine patches at a late stage deny you even that advantage.

There are some who parrot Big Pharma vested interests in ridiculing and denigrating hydroxychloroquine, despite the very notable positive results several countries such as China, Russia, Iran and Turkey have had with it, while vainly spouting the benefits of smoking despite complete lack of quality research papers supporting it and abundant quality papers against.

At this point it is worth reminding of criticism of the untrustworthiness of modern medical science from the editors of some of the top medical journals:

Skeptical of medical science reports?

"It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as editor of The New England Journal of Medicine"
Angell M. Drug Companies & Doctors: A Story of Corruption. The New York Review of Books magazine.

More recently, Richard Horton, editor of The Lancet, wrote that "The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness"
Horton R. Offline: What is medicine's 5 sigma? www.thelancet.com.

The first of these two commentaries on clinical research publications appeared in 2009, the second in April of this year. These statements are being taken seriously, coming as they do from the experiences of editors of two of the world's most prestigious medical journals. The first article showed how the relationships between pharmaceutical companies and academic physicians at prestigious universities impacted certain drug-related publications and the marketing of prescription drugs. Potential conflicts of interest seemed to abound: millions of dollars in consulting and speaking fees to physicians who promoted specific drugs, public research dollars being used by a researcher to test a drug owned by a company in which the researcher held millions of dollars in shares, failure of university researchers to disclose income from drug companies, company subsidies to physician continuing education, publishing practice guidelines involving drugs in which the authors have a financial interest, using influential physicians to promote drugs for unapproved uses, bias in favor of a product coming from failure to publish negative results and repeated publication of positive results in different forms. The author, Marcia Angell, cited the case of a drug giant that had to agree to settle charges that it deliberately withheld evidence that its top-selling anti-depressant was ineffective and could be harmful to certain age groups. ...

Richard Horton's statement was part of his comments on a recent symposium on reliability and reproducibility of research in the biomedical sciences and addresses a broader area of concern. Some of the problems he identified are seen in the veterinary literature. They include inadequate number of subjects in the study, poor study design, and potential conflicts of interest. He notes that the quest for journal impact factor is fuelling competition for publication in a few high reputation journals. He warns that "our love of 'significance' pollutes the literature with many a statistical fairy-tale" ...

Research is not created equal. There is good research (some, not so much) and there is bad research (bundles of it), mostly funded by vested interests, who where necessary direct the desired results. In general, research from China and Russia arguably tends to be higher quality and more reliable because those countries place the emphasis on health for society, not on profits for the corporations.

@Flatulus @16 "sources"
Christian Drosten, chief virologist Charité Berlin in his podcast no 31. Available with transcript here.
Posted by: b | May 18 2020 16:42 utc | 32

B, have you looked into the Big Pharma vested interests of Drosten yet? I suggest you do so.

[May 20, 2020] Adding insult to injury Spike in Covid-19 robocalls fraud

Few things can be more annoying than answering the phone while you're in the middle of something -- and then being greeted by a recording. If you receive a robocall trying to sell you something (and you haven't given the caller your written permission), it's an illegal call. You should hang up. Then, file a complaint with the FTC and the National Do Not Call Registry.
May 20, 2020 | www.rt.com

From phony positive Covid-19 test results to deceptive offers of financial relief, robocalls have proliferated amid the pandemic, separating Americans from millions of precious dollars at a time when few can afford to lose money.

One particularly nasty scam sees the target receive a text or phone call warning them they've been exposed to the virus, tricking them into providing personal information while in a state of panic. Another cruel variant dangles the possibility of virus-related financial relief if they just give up their bank account details or wire the scammer a small " fee " – a tempting prospect at a time when half of American workers are unlikely to see a paycheck this month and upwards of 36 million have filed for unemployment since the pandemic began. Phony treatments – in which the target orders a miracle cure, only to never receive it – comprise some 22 percent of coronavirus-related robocalls, making them the most common pandemic scam.

Even those who haven't been personally scammed by a robocaller have experienced stress because of them, Provision found; 70 percent of millennials are concerned a parent or grandparent will be preyed upon by the automated scammers, who frequently impersonate government authorities like the Social Security Administration or the Internal Revenue Service in order to con their targets out of bank account information or other personal data. In fact, nearly two in five robocalls (39 percent) claim to be the SSA, with 38 percent impersonating the IRS and 33 percent pretending to be debt collectors.

The Covid-19 scams are apparently quite effective, robbing Americans of over $13.4 million of their hard-earned cash in the first three months of 2020 alone, according to the Federal Trade Commission. That number doesn't include scams that haven't been discovered by their victims, or those that go unreported to the FTC – meaning the real figure is likely much higher.

[May 20, 2020] Beware of fake contact tracers, N.J. officials warn

May 20, 2020 | www.nytimes.com

Beware of fake contact tracers, N.J. officials warn.

New Jersey officials warned residents on Wednesday to be wary of fraudsters identifying themselves as contact tracers in order to obtain financial information.

In recent weeks, as health departments have hired legitimate tracers to track the spread of the coronavirus, fake tracers have been sending people text messages looking for insurance information and bank account and social security numbers, said Judith Persichilli, the state health commissioner.

Real contact tracers do not ask for such things, the state said.

A legitimate tracer will call, identify themselves as part of a local health department, and explain to the person on the phone that they may have come into contact with someone who tested positive for the virus.

Scams around the virus, unemployment benefits and stimulus checks have proliferated nationwide , the authorities say.

Gov. Philip D. Murphy said "there is a special place in hell" for people who would scam others during the pandemic.

Mr. Murphy also reported the state's daily virus fatalities: 168, bringing the overall death toll to 10,747.

[May 20, 2020] Breakthrough South Korean Study Finds Recovered COVID Patients Who Test Positive Aren't Infectious

May 19, 2020 | www.zerohedge.com
In what appears to be yet another strike against public officials like LA County's Barbara Ferrer - that is, Democrats and others who insist that lockdowns should continue perhaps until a vaccine has been discovered and that police should punish anyone who dares violate these orders - a study from the Korean Centers for Disease Control and Prevention has found that patients who test positive for COVID-19 after recovering from the illness appear to be shedding dead copies of the virus. That would suggest that these patients are not infectious, the scientists said, which helped dispel fears that some patients can remain infectious for months after being infected. While the study doesn't answer every question about the virus's longevity - such as patients who almost appear to have developed a "chronic" form of the illness because their symptoms have persisted for so long.

But still, the finding was greeted as a major relief, and, if anything, should encourage economies to reopen more quickly, as a potential trigger for reinfection that had panicked some experts appears to be a non-issue.

The research also undermines the reliability of 'antibody' tests like the ones NY Gov Andrew Cuomo insisted would be 'critical' for NY's reopening.

The results mean health authorities in South Korea will no longer consider people infectious after recovering from the illness. Research last month showed that so-called PCR tests for the coronavirus's nucleic acid can't distinguish between dead and viable virus particles, potentially giving the wrong impression that someone who tests positive for the virus remains infectious.

The research may also aid in the debate over antibody tests, which look for markers in the blood that indicate exposure to the novel coronavirus. Experts believe antibodies probably convey some level of protection against the virus, but they don't have any solid proof yet. Nor do they know how long any immunity may last.

A recent study in Singapore showed that recovered patients from severe acute respiratory syndrome, or SARS, are found to have "significant levels of neutralizing antibodies" nine to 17 years after initial infection, according to researchers including Danielle E. Anderson of Duke-NUS Medical School.

Other scientists have found higher levels of IgM, an antibody that appears in response to exposure to an antigen, in children, according to an article published on medRxiv. That suggests younger populations have the potential to produce a more potent defense against Covid-19. The study has not been certified by peer review.

Bloomberg offers a succinct review of some of the research into the infectious qualities of the virus, and the efficacy of antibodies in keeping patients safe from reinfection. As BBG shows, studies of SARS, which is related to the virus that causes COVID-19, suggest that antibodies keep patients safe for years, undermining warnings about a possible second wave, or worries that the virus might become endemic, which were recently raised by the WHO.

The research may also aid in the debate over antibody tests, which look for markers in the blood that indicate exposure to the novel coronavirus. Experts believe antibodies probably convey some level of protection against the virus, but they don't have any solid proof yet.

Nor do they know how long any immunity may last.

A recent study in Singapore showed that recovered patients from severe acute respiratory syndrome, or SARS, are found to have "significant levels of neutralizing antibodies" nine to 17 years after initial infection, according to researchers including Danielle E. Anderson of Duke-NUS Medical School.

Other scientists have found higher levels of IgM, an antibody that appears in response to exposure to an antigen, in children, according to an article published on medRxiv. That suggests younger populations have the potential to produce a more potent defense against Covid-19. The study has not been certified by peer review.

The study's findings are apparently convincing enough for South Korean health authorities to no longer require patients to be re-tested after they've recovered from COVID-19 and all symptoms have subsided.

As a result of the findings in the South Korea study, authorities said that under revised protocols, people should no longer be required to test negative for the virus before returning to work or school after they have recovered from their illness and completed their period of isolation.

"Under the new protocols, no additional tests are required for cases that have been discharged from isolation," the Korean CDC said in a report. The agency said it will now refer to "re-positive" cases as "PCR re-detected after discharge from isolation."

Some coronavirus patients have tested positive again for the virus up to 82 days after becoming infected. Almost all of the cases for which blood tests were taken had antibodies against the virus.

If nothing else, this study is just the latest reminder of how much we don't know about the virus.

[May 20, 2020] Here's a source of excellent n95 masks. They are 3m 8210 PLUS

May 20, 2020 | www.unz.com

Alden , says: Show Comment May 10, 2020 at 2:53 pm GMT

@Al t from wood like cherry and walnut Unlike the medical masks with the 3 flapping edges, dust doesn't come in through the seal.

The medical masks are 6 inch long rectangles that are open at the bottom and 2 sides. According to the 2 Drs I saw , they're useless for preventing germs and viruses coming in.

The 3m 8210 PLUS n95 masks work to keep the finest softest dust out if you think you need a mask. And you can use them for days if you're not sanding and using dangerous materials.

The only reason I looked at was after I used a really strong toxic paint stripper all day long. The stripper was orange. I saw that the outside of the mask was orange from the fumes. But the inside was still white, no orange. So that mask prevented the fumes going through to my nose and mouth.

[May 20, 2020] Men's Blood Contains High Levels of Enzyme That Helps COVID-19 Infect Cells Study

May 20, 2020 | www.unz.com

vot tak , says: Show Comment May 12, 2020 at 12:22 am GMT

Men's Blood Contains High Levels of Enzyme That Helps COVID-19 Infect Cells – Study

https://sputniknews.com/science/202005111079275898-mens-blood-contains-high-levels-of-enzyme-that-helps-covid-19-infect-cells -- study/

"A new study published in the European Heart Journal on Monday has provided scientific evidence that men have higher concentrations of ACE2 in their blood than women. ACE2, which is found in organs such as the heart, kidney, intestines and others, is the receptor required for cellular entry of SARS-CoV-2, the virus that causes COVID-19.

While the ACE2 receptor is normally helpful to the human body, as it stabilizes one's blood pressure and regulates blood vessel dilation, it is also the target of SARS-CoV-2's spike protein. Once the spike protein has attached itself to the receptor, the novel coronavirus is able to invade the human cell and infect an individual.

"When we found that one of the strongest biomarkers, ACE2, was much higher in men than in women, I realised that this had the potential to explain why men were more likely to die from COVID-19 than women," said Iziah Sama, a doctor at University Medical Center (UMC) Groningen who co-led the study.

Findings from the recent study further advanced scientists' presumption that the ACE2 is a key component to how COVID-19, the respiratory disease caused by the novel coronavirus, creeps to the lungs.

"ACE2 is a receptor on the surface of cells. It binds to the coronavirus and allows it to enter and infect healthy cells after it has been modified by another protein on the surface of the cell, called TMPRSS2," explained Dr. Adriaan Voors, a professor of cardiology at UMC Groningen who led the study. "High levels of ACE2 are present in the lungs and, therefore, it is thought to play a crucial role in the progression of lung disorders related to COVID-19."

The study, which relied on blood samples from several thousand participants, also found that heart failure patients prescribed drugs that target the renin-angiotensin-aldosterone system, like angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), did not have higher concentrations of ACE2 in their blood.

"ACE inhibitors and ARBs are widely prescribed to patients with congestive heart failure, diabetes or kidney disease," Reuters noted.

"Our findings do not support the discontinuation of these drugs in COVID-19 patients as has been suggested by earlier reports," explained Voors."

[May 20, 2020] If 20% recovered enough for herd immunity?

May 20, 2020 | www.unz.com

Alfred , says: Show Comment May 9, 2020 at 3:29 pm GMT

@KA From April 12, 2009 to April 10, 2010, CDC estimated there were 60.8 million cases (range: 43.3-89.3 million), 274,304 hospitalizations (range: 195,086-402,719), and 12,469 deaths (range: 8868-18,306) in the United States due to the H1N1pdm09 virus

This is interesting.

The population of the USA in 2010 was 308 million. The number of infected was 60.8 million. That suggests that herd immunity was reached when 19.7% of the population was infected.

That magical number of 20% has been repeated by me in a number of comments here. I don't claim to have originated it.

[May 20, 2020] There are several papers on pubmed suggesting the use of doxycycline to treat COVID-19

May 20, 2020 | www.unz.com

Harold Smith , says: Show Comment May 6, 2020 at 9:15 pm GMT

@Anon Speaking of antibiotics, there are several papers on pubmed suggesting the use of doxycycline to treat COVID-19 (and the ARB drug telmisartan is apparently another off-the-shelf treatment possibility).

In silico modeling shows that doxycycline might inhibit SARS-CoV-2 PLpro and 3CLpro; plus it has an anti-inflammatory effect. Doxy is highly bioavailable and crosses the blood brain barrier.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102550/

Apparently some clinical trials with doxycycline for COVID-19 are in the works.

https://clinicaltrials.gov/ct2/show/NCT04371952

[May 19, 2020] Does COVID-19 attack hemoglobin cells?

May 19, 2020 | www.moonofalabama.org

karlof1 , May 18 2020 22:57 utc | 85

What if the virus causing COVID-19 is first doing great injury to hemoglobin which then allows bacteriological infections to do their work? People are showing hypoxia, not all, just what become the worst cases. Those factors are part of an hypothesis developed by Dr. Zach Bush, a physician specializing in internal medicine, endocrinology and hospice care, that gets presented during this 1 hour 20 minute interview that covers more than just the COVID-19 issue. When finished, you'll have a completely different appreciation for the term Environmental Science.

[May 19, 2020] A team of doctors in Bangladesh claims success in treating patients with COVID-19 using doxycycline and ivermectin:

May 19, 2020 | www.moonofalabama.org

Jen , May 19 2020 2:59 utc | 104

A team of doctors in Bangladesh claims success in treating patients with COVID-19 using doxycycline and ivermectin:

Kamal Kant Kohli, "Doxycycline And Ivermectin Combo May Be New Effective Covid 19 Treatment"

Doxycycline is an anti-malarial drug that was patented in 1957, became commercial in 1967 and is now a generic drug. Ivermectin , used to treat parasitic infestations, is available in the US as a generic prescription drug. Both drugs do have side effects. It will be interesting to see if either drug gets much attention in the global press beyond the medical literature if the Bangladeshi doctors continue to have success in treating their patients.

Jim , May 19 2020 3:28 utc | 106

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf

Eastern Virginia Medical school covid treament protocol
Pretty recent update (may 14th)

[May 16, 2020] FDA Halts Bill Gates-Backed COVID-19 Testing Program

Notable quotes:
"... SCAN is backed by The Bill and Melinda Gates Foundation and the University of Washington Medicine. The testing program was sending free test kits to participants' homes in the Seattle Metropolitan Area, with the goal of testing people in the region to get a sense of how the virus was spreading through the community. ..."
May 16, 2020 | www.zerohedge.com

About a month after Bill Gates criticized President Trump's decision to suspend funding to the World Health Organization (WHO), the federal government has just halted a Seattle-based COVID-19 testing program backed by Gates.

What are the odds, right?

"Please discontinue patient testing and return of diagnostic results to patients until proper authorization is obtained," the Food & Drug Administration (FDA) wrote in a memo, addressed to the Seattle Coronavirus Assessment Network (SCAN), according to The New York Times .

SCAN posted an update on its website on Thursday (May 14) describing how the FDA had asked it to "pause" testing while it receives further guidance on new procedures for its COVID-19 test kits that collect samples at home.

The FDA "recently clarified its guidance for home-based, self-collected samples to test for COVID-19. We have been notified that a separate federal emergency use authorization (EUA) is required to return results for self-collected tests," the post read.

"The FDA has not raised any concerns regarding the safety and accuracy of SCAN's test, but we have been asked to pause testing until we receive that additional authorization."

An FDA spokesperson told The Times, the home collection test kits raised some concerns about "safety and accuracy that required the agency's review."

The issue in the Seattle case appears to be that the test results are being used not only by researchers for surveillance of the virus in the community but that the results are also being returned to patients to inform them.

The two kinds of testing — surveillance and diagnostic — fall under different F.D.A. standards. In a pure surveillance study, the researchers may keep the results just for themselves. But coronavirus testing has largely revolved around getting results returned to doctors who can share the results with patients.

"We had previously understood that SCAN was being conducted as a surveillance study," the spokesperson said.

SCAN is backed by The Bill and Melinda Gates Foundation and the University of Washington Medicine. The testing program was sending free test kits to participants' homes in the Seattle Metropolitan Area, with the goal of testing people in the region to get a sense of how the virus was spreading through the community.

[May 16, 2020] Side effect of untested vassine can be crippling

May 16, 2020 | www.moonofalabama.org

juliania , May 16 2020 13:41 utc | 88

As there have been some comments relating to the development of a vaccine against the virus, I made a search this morning relating to the Bill and Melinda Gates foundation's record in funding such developments. I tried to stay away from the articles that seemed to be inflammatory but did find this article dated today at indianexpress.com: "Can't penalise US NGO for violating drug trial norms" related to a previous drug trial involvement of the foundation. Here are the opening paragraphs:
The NDA government Friday told the Supreme Court that no specific penalties could be imposed on the Bill and Melinda Gates Foundation-funded Programme for Appropriate Technology in Health (PATH) for violating norms in conducting the vaccination trials on tribal girls in Andhra Pradesh and Gujarat.

Pointing out that the current legal regime had no provision of penalties, the Ministry of Health and Family Welfare has expressed its inability to proceed against the NGO PATH despite a parliamentary panel recommending strict actions.

The article would seem to advise caution in urging such trials on the part of the US government with respect to a vaccine for the covid virus, as they also have taken place in other countries, with unforseen complications for some of the participants. It is often the case that strong medicinal remedies are available to poor people on a trial basis. These days I'm remembering the John Le Carre novel, "The Constant Gardener". If my library were open I'd be rereading it.

The old saying 'haste makes waste' needs to be kept in mind.

Trailer Trash , May 16 2020 14:25 utc | 96

> I made a search this morning relating to the Bill and Melinda Gates
>Posted by: juliania | May 16 2020 13:41 utc | 88

Thank you for this. I've been wondering about the noise swirling around Gates and vaccine shenanigans and how much of it is true. I would not be surprised to learn that he really did harm many people with his PATH project.

It's well understood in the computer industry that Gates was an abusive bully to his employees while wrecking every company he crossed paths with, whether they were the competition or a partner. No reason to think it would be different with his new projects.

I'll take my chances with the evil virus before I'll take a dose of a Gates' vaccine.

[May 16, 2020] Any drugs out of patent will be discredited by big pharma lobbyists. It seems a number of drugs do have an impact on the covid-19 set of symptoms.

May 16, 2020 | www.moonofalabama.org

Peter AU1 , May 16 2020 11:18 utc | 73

Any drugs out of patent will be discredited by big pharma lobbyists. It seems a number of drugs do have an impact on the covid-19 set of symptoms.

At one point in time, I was diagnosed with 'chronic fatigue syndrome'. It is a bullshit diagnosis, basically the scrap heap for undiagnosed disease. I looked up research on the subject at the the time. There was a couple of interesting contrasts.

One research project simply took in a mob that had been diagnosed with chronic fatigue syndrome, and of course found nothing in various trials.

Another project took in a cohort with exactly the same symptoms, and found that a pathogen was indeed causing their problems.

A number of drugs on anecdotal evidence (and perhaps the observations of Chinese doctors unencombered by lobbyists are anecdotal) do help certain patients.
Each drug may not be a cure all for all people with COVID-19, but it seems these do help various patients depending on their symptoms and the way the virus is attacking them.

With that in mind, I would be keeping an eye on China rather than US big pharma.
Big pharma may well come up with a you beaut cure all, but in the mean time I would be looking at doctors unencombered by big pharma for something that will help.


BM , May 16 2020 13:59 utc | 91

WaPo: Drug promoted by Trump as coronavirus 'game changer' increasingly linked to deaths
Posted by: b | May 16 2020 9:39 utc | 61

b,
do you have any conception of the lobbying methods used by Big Pharma?
Do you have any conception of the financial clout they have available for protecting their interests?
Do you have any conceptions of the influence they have, of the revolving doors between Big Pharma, pharmaceutical regulatory bodies, medical schools and every single level of the medical industry?
Do you have any conception of the way pharmaceutical registration works, and of the corrupt and fraudulent practices used to obtain authorisation for drugs?

It is one gigantic spaghetti pot of corruption and deception. Boeing/FAA is miniscule and almost angelic by comparison (and far less deadly also).


Coincidentally I have direct first-hand experience of both sides of the activities of Big Pharma concerning one specific highly effective cancer drug that the world's biggest Pharma corporations have tried for the last 40 years to eradicate (finally almost successful by 2014, unfortunately). I have direct first-hand experience of the highest praise they share amongst their own top elites of the efficacy of that competitor's medicine against all known types of cancer. I also have close 2nd hand inside knowledge of their efforts to purchase the patents for that same medicine for vast sums of money. I also personally know the proprietor and developer of that same medicine, and have witnessed and experienced first hand some of the fraudulent and criminal methods Big Pharma have used non-stop for 40 years to try to force my friend out of business, together with the lies and deception they have used publicly falsely alleging its "danger" and "inefficacy", together even with using police to illegally force parents to stop using it for their seriously ill children who had already dramatically benefited from its use, and forcing doctors to stop using it for treatment. I also have extensive 2nd hand knowledge of their activities to that effect, and have good reason to believe they are true. I have also used that medicine myself, to great effect, and closely know a medical practice which has used it with considerable medical success, and of the coercion they also experienced not to use it.

The way the Western medical establishment has handled the question of the use of chloroquine and closely related drugs for Covid-19 is in every single respect and at every level 100% typical of Big Pharma disinformation projects .

The very fact that the US medical establishment approved use of hydroxychloroquine under specific conditions that ensure it is used exclusively at a very late stage after the virus has ceased to replicate guarantees that all or almost all major Western hydroxychloroquine trials will be negative - because it is a specific and known requirement of hydroxychloroquine therapy that the therapy is conducted early whilst the virus is stil replicating - later it is known to be useless. The approval of its use under such conditions is the specific result of Big Pharma influence . That is how they operate all the time.

Big Pharma is no more honest about either the safety or the efficacity of its products than are the White Helmets about their activities in Syria. Many of the most dangerous drugs sold by the biggest companies are approved on the basis of very small, improperly balanced trials, sometimes fraudulently conducted. Trials which give the wrong result are routinely hidden. Research on toxicity and dangerous side-effects are routinely inadequate, frequently fraudulent or knowingly misleading, and legal requirements for drug authorisations are frequently waived on the basis of influence campaigns. This is especially so for new chemotherapy drugs, which are intrinsically highly toxic and are normally used at very close to the fatal dose. There is no level playing field at all, quite the contrary.

Big Pharma do not profit from cures - they profit from selling very expensive drugs, and they are far more ruthless than the White Helmets in destroying any potential threat to their profits. There is no more effective threat to the World-View of Big Pharma - as I know from first hand experience - than effective cures, especially where they are cheap and unpatentable, or the patents are owned outside the cabal. Any such cure must be destroyed at all costs.

Several of the Big Pharma companies in recent years have been given multi-billion dollar fines for the fraud and subversion they have utilised in obtaining authorisation for drugs which are dangerous to the patient, and for their marketing of drugs known to be dangerous.

The patent for chloroquine and its derivatives has expired. It has been widely used for many years, its hazards and limitations are thoroughly documented, and it is in this respect - under proper supervision with respect to its known hazards and limitations and qualified by them - incomparably safer than any new and barely tested pharmaceutical drug or vaccine such as Remdesivir. It is cheaply produced around the world. Therefore, no full-scale well-controlled randomised clinical trial of hydroxychloroquine treatment for Covid-19 will ever be conducted in a major Western country. Big Pharma will ensure that.

BM , May 16 2020 16:24 utc | 112
One does have to wonder whether it is simply a matter that the difficulty in the US concerning early diagnosis is the real problem that makes use of the drug impractical here. Perhaps we just don't have the resources, teams of testers and physicians and nurses, for the accuracy and careful monitoring of patients in early stage infection required when using this drug.
Posted by: juliania | May 16 2020 15:17 utc | 103

I'm afraid it's not anything to do with early diagnosis, it is only about profit. As Blue Dotterel said, it is about profit, not curing patients. For Big Pharma the very last thing they want is for the patient to be cured - a dead patient is far more profitable. No wonder Gilead holds the more promising GS-441524 off the market, because they can make more profit from a more expensive useless drug that will be in patent for far longer.

Big Pharma expects to make many trillions of dollars profit per year on Covid-19, as they do on cancer. The more Covid cases, the more profits. The less effective the efforts to reduce infections, the more profits. The less availability of PPE, the more profits. The more chaotic and irrational the government policies, the more profit. Big Pharma profits at every step.

They will stop at nothing to block proper trials of hydroxychloroquine - including bribery, coercion, and sabotage, not just massive disinformation. They will spend billions just to block
proper trials, using myriad different methods of subterfuge and subversion. That is just small change compared to the profits they want and expect.

The entire philosophy of Western medicine is a dying patient - it is corrupt, it is dishonest, its entire foundations are fraudulent. There is an urgent need for a whole new paradigm for medicine that is based on maximising the health of society, not on maximising profit.

There is a story I heard on television several decades ago - I think it was true, but I am not certain - about an old Chinese tradition. Villagers would pay a regular monthly fee to the doctor, as long as they stay healthy. As soon as they fall sick they stop paying, and the doctor has to cure them (without charge). Only when they get better will they resume the normal regular payments. Think about it, what is the best interest of the doctor towards his patient? He has an investment in their good health. Now compare the Western system. What interest does the doctor have in the patient's health? If the patient is sick for 4 times as long and then dies, is the doctor richer or poorer? If the doctor gives drugs with side effects, which need more drugs against the side effects, will he be richer or poorer? If there are two drugs available, one cheap, one expensive, which one does the doctor prefer?

Think about it Juliana, the last time you went to a hospital, how much did it cost? How many useless medicines did the doctor give you, versus how many basic essential medicines?

Western medicine is a big scam. It is a business. The second biggest business in the world after war.

That is why I reject Western medicine. For 20 years I have used only non-Western medicine.

[May 16, 2020] WaPo: for a certain type of patients hydroxychloroquine promoted by Trump as coronavirus 'game changer' increasingly linked to deaths

May 16, 2020 | www.moonofalabama.org

b , May 16 2020 9:39 utc | 61

@fairleft

You want to continue to promote Trump's wonder medicine? Than leave this place and go elsewhere.

You are obviously not well informed about the issue anyway.

WaPo: Drug promoted by Trump as coronavirus 'game changer' increasingly linked to deaths

Clinical trials, academic research and scientific analysis indicate that the danger of the Trump-backed drug is a significantly increased risk of death for certain patients. Evidence showing the effectiveness of hydroxychloroquine in treating covid-19 has been scant. Those two developments pushed the Food and Drug Administration to warn against the use of hydroxychloroquine outside of a hospital setting last month, just weeks after it approved an emergency use authorization for the drug.

Alarmed by a growing cache of data linking the anti-malaria drug to serious cardiac problems, some drug safety experts are now calling for even more forceful action by the government to discourage its use. Several have called for the FDA to revoke its emergency use authorization, given hydroxychloroquine's documented risks.

"They should say, 'We know there are harms, and until we know the benefits, let's hold off,' " said Joseph Ross, a professor of medicine and public health at Yale University, who added that the original authorization may have been warranted but new evidence has emerged about the drug's risks.

"I'm surprised it hasn't been revoked yet," said Luciana Borio, who served as director for medical and biodefense preparedness of the National Security Council and was acting chief scientist at the FDA.
...
Yogen Kanthi, assistant professor in the division of cardiovascular medicine at the University of Michigan, said that it has been clear that the combination of hydroxychloroquine and azithromycin -- used to treat bacterial infections -- could lead to cardiac arrhythmias, which cause the heart to beat irregularly or too fast or slow. Many patients hospitalized for covid-19 had underlying cardiovascular disease that put them at higher risk for arrhythmias, "so it shouldn't be surprising we saw an increase in death," he said.
AD

"The question has been answered that if you have the infection and it's significant enough to be in the hospital, the drug doesn't seem to do anything for you," he said. "It may be the horse is out of the barn."

Many hospitals have stopped using the drug outside of clinical trials.

"We no longer are keeping large quantities and have returned most of it," said Nishaminy Kasbekar, director of pharmacy for the Penn Presbyterian Medical Center in Philadelphia. "I think they should revoke the EUA because clearly based on the data it is no longer considered a treatment for covid."
...
A study of Veterans Affairs patients hospitalized with the coronavirus found no benefit and higher death rates among those taking hydroxychloroquine, researchers said last month.

More than 27 percent of patients treated with hydroxychloroquine died, and 22 percent of those treated with the combination therapy died, compared with an 11.4 percent death rate in those not treated with the drugs, the study said.


fairleft , May 16 2020 13:13 utc | 82

Posted by: b | May 16 2020 9:39 utc | 61

This is what I thought, you've been damaged by Trump Derangent Syndrome (TDS), so you insult with a childish phrase like "Trump's wonder medicine." You actually erased a medical doctor's respectful and evidence-laden disagreement with your 'line'. In any case, I'm not participating in the childish Trump/antiTrump, pro-hydroxychloroquine/anti-hydroxychloroquine, pro-lockdown/anti-lockdown discourse. The evidence is split on all of these issues. You cite your evidence, those who disagree with you cite theirs. Believe it or not, neither side in the disagreement are demons.

I don't have a strong opinion on Hydroxychloroquine, but it's just that it had been widely and uncontroversially used in China from early on in the fight against Covid-19. Then, after Trump mentioned it positively, it became controversial. A classic TDS timeline doesn't mean anything factually, but it naturally raises a rational person's skepticism about the extremely negative claims suddenly appearing in places like the Washington Post and other classic TDS places. I'm not expert enough to weigh the evidence, and neither are you, b, but even a brief internet search shows China-produced scientific studies of Hydroxychloroquine showing positive results:

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial
https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3

"But for TTCR, the body temperature recovery time and the cough remission time were significantly shortened in the HCQ treatment group. Besides, a larger proportion of patients with improved pneumonia in the HCQ treatment group (80.6%, 25 of 31) compared with the control group (54.8%, 17 of 31)."

Chinese study finds hydroxychloroquine useful in controlling Covid mortality

"The mortality rate in the HCQ group stood at 18.8 percent against 43.5 percent in the non-HCQ group, the study noted.

"'Hydroxychloroquine treatment is significantly associated with a decreased mortality in critically-ill Covid-19 patients,' the researchers wrote. ...

"The Chinese researchers, however, also suggest that despite their findings, the randomized double-blind-control study was needed to provide stronger evidence."

So there is evidence on both sides, as contributors more expert than you or me have told you repeatedly. Non-experts don't know who's right, or if this disagreement will reach some nuanced "you're both partly right" conclusion. I will humbly continue to be open to both sides of the argument. Get well soon from TDS, b.

BM , May 16 2020 13:59 utc | 91
WaPo: Drug promoted by Trump as coronavirus 'game changer' increasingly linked to deaths
Posted by: b | May 16 2020 9:39 utc | 61

b,
do you have any conception of the lobbying methods used by Big Pharma?
Do you have any conception of the financial clout they have available for protecting their interests?
Do you have any conceptions of the influence they have, of the revolving doors between Big Pharma, pharmaceutical regulatory bodies, medical schools and every single level of the medical industry?
Do you have any conception of the way pharmaceutical registration works, and of the corrupt and fraudulent practices used to obtain authorisation for drugs?

It is one gigantic spaghetti pot of corruption and deception. Boeing/FAA is miniscule and almost angelic by comparison (and far less deadly also).


Coincidentally I have direct first-hand experience of both sides of the activities of Big Pharma concerning one specific highly effective cancer drug that the world's biggest Pharma corporations have tried for the last 40 years to eradicate (finally almost successful by 2014, unfortunately). I have direct first-hand experience of the highest praise they share amongst their own top elites of the efficacy of that competitor's medicine against all known types of cancer. I also have close 2nd hand inside knowledge of their efforts to purchase the patents for that same medicine for vast sums of money. I also personally know the proprietor and developer of that same medicine, and have witnessed and experienced first hand some of the fraudulent and criminal methods Big Pharma have used non-stop for 40 years to try to force my friend out of business, together with the lies and deception they have used publicly falsely alleging its "danger" and "inefficacy", together even with using police to illegally force parents to stop using it for their seriously ill children who had already dramatically benefited from its use, and forcing doctors to stop using it for treatment. I also have extensive 2nd hand knowledge of their activities to that effect, and have good reason to believe they are true. I have also used that medicine myself, to great effect, and closely know a medical practice which has used it with considerable medical success, and of the coercion they also experienced not to use it.

The way the Western medical establishment has handled the question of the use of chloroquine and closely related drugs for Covid-19 is in every single respect and at every level 100% typical of Big Pharma disinformation projects .

The very fact that the US medical establishment approved use of hydroxychloroquine under specific conditions that ensure it is used exclusively at a very late stage after the virus has ceased to replicate guarantees that all or almost all major Western hydroxychloroquine trials will be negative - because it is a specific and known requirement of hydroxychloroquine therapy that the therapy is conducted early whilst the virus is stil replicating - later it is known to be useless. The approval of its use under such conditions is the specific result of Big Pharma influence . That is how they operate all the time.

Big Pharma is no more honest about either the safety or the efficacity of its products than are the White Helmets about their activities in Syria. Many of the most dangerous drugs sold by the biggest companies are approved on the basis of very small, improperly balanced trials, sometimes fraudulently conducted. Trials which give the wrong result are routinely hidden. Research on toxicity and dangerous side-effects are routinely inadequate, frequently fraudulent or knowingly misleading, and legal requirements for drug authorisations are frequently waived on the basis of influence campaigns. This is especially so for new chemotherapy drugs, which are intrinsically highly toxic and are normally used at very close to the fatal dose. There is no level playing field at all, quite the contrary.

Big Pharma do not profit from cures - they profit from selling very expensive drugs, and they are far more ruthless than the White Helmets in destroying any potential threat to their profits. There is no more effective threat to the World-View of Big Pharma - as I know from first hand experience - than effective cures, especially where they are cheap and unpatentable, or the patents are owned outside the cabal. Any such cure must be destroyed at all costs.

Several of the Big Pharma companies in recent years have been given multi-billion dollar fines for the fraud and subversion they have utilised in obtaining authorisation for drugs which are dangerous to the patient, and for their marketing of drugs known to be dangerous.

The patent for chloroquine and its derivatives has expired. It has been widely used for many years, its hazards and limitations are thoroughly documented, and it is in this respect - under proper supervision with respect to its known hazards and limitations and qualified by them - incomparably safer than any new and barely tested pharmaceutical drug or vaccine such as Remdesivir. It is cheaply produced around the world. Therefore, no full-scale well-controlled randomised clinical trial of hydroxychloroquine treatment for Covid-19 will ever be conducted in a major Western country. Big Pharma will ensure that.

Blue Dotterel , May 16 2020 14:17 utc | 94
Turkey uses Chloroquine as well
"Koca explained that unlike the other countries, in Turkey doctors do not advise people with symptoms such as fever, store throat and coughing to take antipyretics and stay at home, but invite them to hospital and immediately start treatment by administering chloroquine to the people in suspicious cases without waiting for the results from the test results.

Another difference between the methods Turkey and other countries use is that in addition to chloroquine, an antibiotic, called azithromycin, is used in the early stages of the treatment, Koca noted."
https://www.hurriyetdailynews.com/turkish-model-proves-effective-in-covid-19-treatment-154220

So one has to wonder

Blue Dotterel , May 16 2020 14:17 utc | 94
Turkey uses Chloroquine as well
"Koca explained that unlike the other countries, in Turkey doctors do not advise people with symptoms such as fever, store throat and coughing to take antipyretics and stay at home, but invite them to hospital and immediately start treatment by administering chloroquine to the people in suspicious cases without waiting for the results from the test results.

Another difference between the methods Turkey and other countries use is that in addition to chloroquine, an antibiotic, called azithromycin, is used in the early stages of the treatment, Koca noted."
https://www.hurriyetdailynews.com/turkish-model-proves-effective-in-covid-19-treatment-154220

So one has to wonder

Hoarsewhisperer , May 16 2020 14:46 utc | 98
...
The very fact that the US medical establishment approved use of hydroxychloroquine under specific conditions that ensure it is used exclusively at a very late stage after the virus has ceased to replicate guarantees that all or almost all major Western hydroxychloroquine trials will be negative-
...
Posted by: BM | May 16 2020 13:59 utc | 91

I'm calling bullshit on that claim.
Whoever made it is an ignoramus with no knowledge, or understanding, of what Clinical Trials involve, how many variables have to be tested, nor why it takes so long for such trials to reach a 'safe' set of recommendations. If ever...

Trailer Trash , May 16 2020 15:36 utc | 105
>I'm calling bullshit on that claim.

Unfortunately the poster doesn't state what is wrong with the claim. Assertions that another poster is ignorant are not relevant. Neither are appeals to authority.

BM , May 16 2020 16:24 utc | 112
One does have to wonder whether it is simply a matter that the difficulty in the US concerning early diagnosis is the real problem that makes use of the drug impractical here. Perhaps we just don't have the resources, teams of testers and physicians and nurses, for the accuracy and careful monitoring of patients in early stage infection required when using this drug.
Posted by: juliania | May 16 2020 15:17 utc | 103

I'm afraid it's not anything to do with early diagnosis, it is only about profit. As Blue Dotterel said, it is about profit, not curing patients. For Big Pharma the very last thing they want is for the patient to be cured - a dead patient is far more profitable. No wonder Gilead holds the more promising GS-441524 off the market, because they can make more profit from a more expensive useless drug that will be in patent for far longer.

Big Pharma expects to make many trillions of dollars profit per year on Covid-19, as they do on cancer. The more Covid cases, the more profits. The less effective the efforts to reduce infections, the more profits. The less availability of PPE, the more profits. The more chaotic and irrational the government policies, the more profit. Big Pharma profits at every step.

They will stop at nothing to block proper trials of hydroxychloroquine - including bribery, coercion, and sabotage, not just massive disinformation. They will spend billions just to block
proper trials, using myriad different methods of subterfuge and subversion. That is just small change compared to the profits they want and expect.

The entire philosophy of Western medicine is a dying patient - it is corrupt, it is dishonest, its entire foundations are fraudulent. There is an urgent need for a whole new paradigm for medicine that is based on maximising the health of society, not on maximising profit.

There is a story I heard on television several decades ago - I think it was true, but I am not certain - about an old Chinese tradition. Villagers would pay a regular monthly fee to the doctor, as long as they stay healthy. As soon as they fall sick they stop paying, and the doctor has to cure them (without charge). Only when they get better will they resume the normal regular payments. Think about it, what is the best interest of the doctor towards his patient? He has an investment in their good health. Now compare the Western system. What interest does the doctor have in the patient's health? If the patient is sick for 4 times as long and then dies, is the doctor richer or poorer? If the doctor gives drugs with side effects, which need more drugs against the side effects, will he be richer or poorer? If there are two drugs available, one cheap, one expensive, which one does the doctor prefer?

Think about it Juliana, the last time you went to a hospital, how much did it cost? How many useless medicines did the doctor give you, versus how many basic essential medicines?

Western medicine is a big scam. It is a business. The second biggest business in the world after war.

That is why I reject Western medicine. For 20 years I have used only non-Western medicine.

[May 16, 2020] Remdesivir is a drug looking for a disease

May 16, 2020 | www.moonofalabama.org

abierno , May 15 2020 19:34 utc | 10

Deep thanks for the comment on Remdesivir. I've seen this appraisal in the medical community but not in any public commentary. It was developed to address Ebola and failed miserably. Tagged "a drug looking for a disease."

[May 15, 2020] The games cats play: a cat which went out of the house and met a cat already infected with Covid-19 comes back home and infects its own human servant

May 15, 2020 | www.moonofalabama.org

oldhippie , May 15 2020 22:32 utc | 27

The New England Journal of Medicine (NEJM)has a correspondence about cats:

Transmission of SARS-CoV-2 in Domestic Cats

Cats can get infected with the SARS-CoV-2 virus and do replicate it strongly in their respiratory system. But the cats do not get sick and show no symptoms. During the study three infected cats were each put into the same cage as a not-infected cat. They transmitted the disease to the previously non-infected ones. The researchers tested if the viruses the cats produce are still able to grow on human tissues. Unfortunately they are.

This means that a cat which went out of the house and met a cat who's owner has Covid-19 might come back home and infect its own human servant. Household cats may also play a role in the infection chain between household members. Any cat owner who goes into lockdown or is quarantined at home must also quarantine the cat. So far COVID lives in cats, Siberian tigers, bats, pangolins, raccoon dogs, ferrets. Only commonality here is they are all mammals. There have been a couple reports that it lives in dogs as well. If conclusions can be drawn from this it would seem to be a simple and indiscriminate virus. And we must mask our dogs, mask our cats, make them wear diapers if they go outside.

[May 15, 2020] French researchers High temperatures ineffective against coronavirus TheHill

May 15, 2020 | thehill.com

The novel coronavirus can survive in high temperatures, researchers said, casting doubt on suggestions that the threat will subside in the summer.

Researchers from the University of Aix-Marseille in France, led by Remi Charrel and Boris Pastorino, found that the virus survived in 140-degree Fahrenheit temperatures typically used to disinfect research labs, The Jerusalem Post reported .

It took 15 minutes of exposure to 197.6-degree temperatures to kill the virus, the newspaper noted, adding that the study had yet to be peer-reviewed.

Researchers did say the lower temperature should be sufficient to deactivate the virus in samples with smaller loads but added that the higher temperature was necessary for larger loads and concluded that disinfecting chemicals were a better option.

Earlier research has reached similar conclusions.

A National Academies of Sciences (NAS) panel told the White House in early April that previous research suggesting a connection between temperature and the virus's transmissibility was flawed. "There is some evidence to suggest that [the coronavirus] may transmit less efficiently in environments with higher ambient temperature and humidity; however, given the lack of host immunity globally, this reduction in transmission efficiency may not lead to a significant reduction in disease spread" without efforts such as social distancing, the NAS report stated, noting that SARS and MERS are not seasonal.

[May 15, 2020] Uncovering Why the COVID-19 Virus Is So Infectious and Efficiently Evades Immune Responses

May 15, 2020 | scitechdaily.com

SARS-CoV-2 , the virus that causes COVID-19 , is highly infectious. Curiously, in many patients, it triggers poor immune responses, which prolongs illness. This helps the virus spread widely, exacerbating the global pandemic. In a new study published in the Proceedings of the National Academy of Sciences , researchers at the University of Minnesota identified the biochemical mechanism that may explain how the virus infects people efficiently while evading their immune responses.

This study, led by Fang Li, a professor in the College of Veterinary Medicine, examined the mechanism by which SARS-CoV-2 enters cells. Specifically, the team of scientists investigated how the virus "unlocks" human cells using a surface spike protein as the "key." They made three important findings:

"Typically when a virus develops mechanisms to evade immune responses, it loses its potency to infect people," said Li. "However, SARS-CoV-2 maintains its infectivity using two mechanisms. First, during its limited exposure time, the tip of the viral key grabs a receptor protein on human cells quickly and firmly. Second, the pre-activation of the viral key allows the virus to more effectively infect human cells."

Li says that recognizing the evasiveness of SARS-CoV-2 is important for designing antibody drugs and vaccines. Antibody drugs would need to overpower the tip of the hidden viral key by latching onto it very quickly and tightly during its limited exposure time. Alternatively, drugs can target other parts of the viral key that are more exposed.

Li recommends that successful antiviral strategies will need to consider both the potency of the virus and its evasiveness.

Reference: "Cell entry mechanisms of SARS-CoV-2" by Jian Shang, Yushun Wan, Chuming Luo, Gang Ye, Qibin Geng, Ashley Auerbach and Fang Li, 6 May 2020, Proceedings of the National Academy of Sciences .
DOI: 10.1073/pnas.2003138117

The study is coauthored by postdoctoral researchers Jian Shang, Yushun Wan, and Chuming Luo, graduate students Gang Ye and Qibin Geng, and junior scientist Ashley Auerbach. The National Institutes of Health funded the study.

[May 15, 2020] Dirty games of big pharma

Notable quotes:
"... I've seen this appraisal in the medical community but not in any public commentary. It was developed to address Ebola and failed miserably. Tagged "a drug looking for a disease." ..."
May 15, 2020 | www.moonofalabama.org

Stonebird , May 15 2020 20:46 utc | 14

The remdesivir drug by the company Gilead gets hyped as a potential useful drug against the Covid-19 disease. This even after a serious study from China published in Lancet found it useless:

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

The result:

In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits.

A not completed Adaptive COVID-19 Treatment Trial (ACTT) by the National Institute of Allergy and Infectious Diseases also found that remdesivir does not change the mortality of serious Covid-19 cases. But it found that the drug may lead to a faster recovery. That has led to run on the hard to produce drug and confusion about its distribution .

But the real scandal behind this is that Gilead has a second drug, GS-441524, that is more promising and much easier to produce. STAT published a strong call on Gilead to release it immediately:

Gilead should ditch remdesivir and focus on its simpler and safer ancestor

The authors have the suspicion that Gilead has an ignoble motive for holding back the better drug as its patent will run out sooner:

The attractive profile of GS-441524 from both manufacturing and clinical perspectives raises this question: Why hasn't Gilead opted to advance this compound to the clinic? We would be remiss for not mentioning patents, and thus profits. The first patent on GS-441524 was issued in 2009, while the first patent for remdesivir was issued in 2017.
...
Given GS-441524's optimal properties, we -- along with the millions of people awaiting an effective treatment for Covid-19 -- are left to wonder why Gilead isn't giving it the same attention it is giving remdesivir. The world can only hope it isn't for the sake of protecting its intellectual property.
Surely it is profit that Gilead is after? I have heard quoted that one dose of remdesivir is about $1'000 so a "full" cure (whatever that may be) is $30'000. The second drug is almost certainly much cheaper.

They may think about reducing the cost if they find it is being given to the cat.

abierno , May 15 2020 19:34 utc | 11

Deep thanks for the comment on Remdesivir. I've seen this appraisal in the medical community but not in any public commentary. It was developed to address Ebola and failed miserably. Tagged "a drug looking for a disease."

[May 14, 2020] Interesting *opinion* piece supporting HCQ over remdesivir.

May 14, 2020 | www.moonofalabama.org

Richard Steven Hack , May 13 2020 6:29 utc | 213

Interesting *opinion* piece supporting HCQ over remdesivir. I take no position on this argument - unlike many here - except that as I've said before, we need a *good* set of studies on both (and every other treatment, which includes the EVMS treatment I discuss above) and then a decent review study to interpret the results for us laymen. Perhaps that's another case of "good luck with that" any time before, say, five or ten years from now...

A Tale of Two Drugs: Money vs. Medical Wisdom
https://tinyurl.com/yadpyktu


Richard Steven Hack , May 13 2020 6:39 utc | 214

Ah, the same doctor referenced above as author of the "A Tale of Two Drugs" has another *opinion* article on the same topic - HCQ. Again, I have no idea whether her statements are factual, although presumably her quoting the CDC on HCQ is accurate, which in itself is interesting if true.

Doctors and Patients Are Pawns in a Dangerous Political Brinkmanship
https://tinyurl.com/ycpxcjry


On duration of use: "CDC has no limits on the use of hydroxychloroquine for the prevention of malaria. When hydroxychloroquine is used at higher doses for many years, a rare eye condition called retinopathy has occurred. People who take hydroxychloroquine for more than five years should get regular eye exams."

NOTE: CDC guidelines for use in malaria do not even mention the "fatal heart arrhythmia" hyped in the fear-mongering articles in the media. Rheumatology guidelines for HCQ in lupus and rheumatoid arthritis (RA) do not require a baseline EKG to check heart rhythm, although doctors might order one before prescribing HCQ if needed for a patient with heart disease. SARS-CoV-2 itself, which can damage to the heart, may be responsible for some heart problems now blamed on HCQ.

Hausmeister , May 13 2020 13:35 utc | 223
@ b
Did you read what you linked here?
https://www.nejm.org/doi/full/10.1056/NEJMoa2012410?query=featured_home

„Conclusions

In this observational study involving patients with Covid-19 who had been admitted to the hospital, hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of the composite end point of intubation or death. Randomized, controlled trials of hydroxychloroquine in patients with Covid-19 are needed. (Funded by the National Institutes of Health.)"

According to what we learnt in the meantime the use of HCQ at a quite late stadium of this illness is as meaningless as most likely the use of Remdisivir (another kind of pure antiviral medicament) would have been. The only thing what one can learn from this study isthat HCQ apparently did not damage people. So your sentence „...to be as false as the promotion of the useless but potentially dangerous Hydroxychloroquine as a therapy for Covid-19." is just nonsense.

[May 14, 2020] UCSF Health Hospital Epidemiology and Infection Prevention COVID-19 Global Clinical Knowledge Base

May 14, 2020 | www.moonofalabama.org

Richard Steven Hack , May 13 2020 6:13 utc | 212

People might find this resource useful...

UCSF Health Hospital Epidemiology and Infection Prevention COVID-19 Global Clinical Knowledge Base
https://tinyurl.com/y9qu3qs6


The goal of this site is to compile a comprehensive but curated directory of publicly-available practice guidelines, clinical protocols, and other resources related to COVID-19. We hope this resource will encourage clinicians and medical organizations to share knowledge and compare practices with peers.

Submitted resources are reviewed by a team of medical professionals for accuracy and relevance. We do not specifically endorse any resource posted on this site.

[May 12, 2020] How coronavirus attacks the human body - The Washington Post

May 12, 2020 | www.washingtonpost.com

How coronavirus attacks the human body - The Washington Post It mostly spares the young. Until it doesn't: Last week, doctors warned of a rare inflammatory reaction with cardiac complications among children that may be connected to the virus. On Friday, New York Gov. Andrew M. Cuomo (D) announced 73 children had fallen severely ill in the state and a 5-year-old boy in New York City had become the first child to die of the syndrome. Two more children had succumbed as of Saturday.

That news has shaken many doctors, who felt they were finally grasping the full dimensions of the disease in adults. "We were all thinking this is a disease that kills old people, not kids," Reich said.

Mount Sinai has treated five children with the condition. Reich said each started with gastrointestinal symptoms, which turned into inflammatory complications that caused very low blood pressure and expanded their blood vessels. This led to heart failure in the case of the first child who died.

"The pattern of disease was different than anything else with covid," he said.

"We were all thinking this is a disease that kills old people, not kids," said David Reich, president of Mount Sinai Hospital in Manhattan. (Jeenah Moon/Reuters)

Of the millions, perhaps billions, of coronaviruses, six were previously known to infect humans.

Four cause colds that spread easily each winter, barely noticed. Another was responsible for the outbreak of severe acute respiratory syndrome that killed 774 people in 2003. Yet another sparked the outbreak of Middle East respiratory syndrome in 2012, which kills 34 percent of the people who contract it. But few do.

SARS-CoV-2, the bad seed of the coronavirus family, is the seventh. It has managed to combine the infectiousness of its cold-causing cousins with some of the lethality of SARS and MERS. It can spread before people show symptoms of disease, making it difficult to control, especially without widespread and accurate testing. At the moment, social distancing is the only effective countermeasure .

It has infected 4 million people around the globe, killing more than 280,000, according to the Johns Hopkins University Coronavirus Resource Center. In the United States, 1.3 million have been infected and more than 78,000 have died.

Had SARS or MERS spread as widely as this virus, Rasmussen said, they might have shown the same capacity to attack beyond the lungs. But they were snuffed out quickly, leaving only a small sample of disease and death.

Paramedics bring home a woman with covid-19 who underwent an emergency C-section because she was gravely ill. After extensive care, including time on a ventilator, she was released from a hospital in Stamford, Conn., and she has a healthy newborn. (John Moore/Getty Images)

Trying to define a pathogen in the midst of an ever-spreading epidemic is fraught with difficulties. Experts say it will be years until it is understood how the disease damages organs and how medications, genetics, diets, lifestyles and distancing impact its course.

"This is a virus that literally did not exist in humans six months ago," said Geoffrey Barnes, an assistant professor at the University of Michigan who works in cardiovascular medicine. "We had to rapidly learn how this virus impacts the human body and identify ways to treat it literally in a time-scale of weeks. With many other diseases, we have had decades."

In the initial days of the outbreak, most efforts focused on the lungs. SARS-CoV-2 infects both the upper and lower respiratory tracts, eventually working its way deep into the lungs, filling tiny air sacs with cells and fluid that choke off the flow of oxygen.

But many scientists have come to believe that much of the disease's devastation comes from two intertwined causes.

The first is the harm the virus wreaks on blood vessels, leading to clots that can range from microscopic to sizable. Patients have suffered strokes and pulmonary emboli as clots break loose and travel to the brain and lungs. A study in the Lancet, a British medical journal, showed this may be because the virus directly targets the endothelial cells that line blood vessels.

The second is an exaggerated response from the body's own immune system, a storm of killer "cytokines" that attack the body's own cells along with the virus as it seeks to defend the body from an invader.

Research and therapies are focused on these phenomena. Blood thinners are being more widely used in some hospitals . A review of records for 2,733 patients, published Wednesday in the Journal of the American College of Cardiology, indicates they may help the most seriously ill.

"Things change in science all the time. Theories are made and thrown out. Hypotheses are tweaked. It doesn't mean we don't know what we are doing. It means we are learning," said Deepak Bhatt, executive director of interventional cardiology at Brigham and Women's Hospital in Boston.

Inflammation of those endothelial cells lining blood vessels may help explain why the virus harms so many parts of the body, said Mandeep Mehra, a professor of medicine at Harvard Medical School and one of the authors of the Lancet study on how covid-19 attacks blood vessels.

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That means defeating covid-19 will require more than antiviral therapy, he said.

"What this virus does is it starts as a viral infection and becomes a more global disturbance to the immune system and blood vessels -- and what kills is exactly that," Mehra said. "Our hypothesis is that covid-19 begins as a respiratory virus and kills as a cardiovascular virus."

The thinking of kidney specialists has evolved along similar lines. Initially, they attributed widespread and severe kidney disease to the damage caused by ventilators and certain medications given to intensive-care patients, said Daniel Batlle, a professor of medicine at Northwestern University Feinberg School of Medicine.

Then they noticed damage to the waste-filtering kidney cells of patients even before they needed intensive care. And studies out of Wuhan found the pathogen in the kidneys themselves, leading to speculation the virus is harming the organ.

"There was nothing unique at first," Batlle said. But the new information "shows this is beyond the regular bread-and-butter acute kidney injury that we normally see."

Like other coronaviruses, SARS-Cov-2 infiltrates the body by attaching to a receptor, ACE2, found on some cells. But the makeup of the spikes that protrude from this virus is somewhat different, allowing the virus to bind more tightly. As a result, fewer virus particles are required to infect the host. This also may help explain why this virus is so much more infectious than SARS, Rasmussen said.

Other factors can't be ruled out in transmission, she said, including the amount of virus people shed and how strictly they observe social distancing rules.

Once inside a cell, the virus replicates, causing chaos. ACE2 receptors, which help regulate blood pressure, are plentiful in the lungs, kidneys and intestines -- organs hit hard by the pathogen in many patients. That also may be why high blood pressure has emerged as one of the most common preexisting conditions in people who become severely ill with covid-19.

A colorized scan of a cell (shown in red) infected with SARS-COV-2 virus particles (shown in yellow), isolated from a patient sample. (National Institute of Allergy and Infectious Diseases)

The receptors differ from person to person, leading to speculation that genetics may explain some of the variability in symptoms and how sick some people become.

Those cells "are almost everywhere, so it makes sense that the virus would cause damage throughout the body," said Mitchell Elkind, a professor of neurology at Columbia University's College of Physicians and Surgeons and president-elect of the American Heart Association.

Inflammation spurs clotting as white blood cells fight off infection. They interact with platelets and activate them in a way that increases the likelihood of clotting, Elkind said.

Such reactions have been seen in severe infections, such as sepsis. But for covid-19, he said, "we are seeing this in a large number of people in a very short time, so it really stands out."

"The virus can attack a lot of different parts of the body, and we don't understand why it causes some problems for some people, different problems for others -- and no problems at all for a large proportion," Elkind said.

Coughlin, in critical condition at a hospital in Connecticut, deteriorated quickly after she reached the emergency room. Her fever shot up to 105 and pneumonia developed in her lungs.

On Wednesday, she called her six daughters on FaceTime, telling them doctors advised she go on a ventilator.

"If something happens to me, and I don't make it, I'm at peace with it," she told them.

The conversation broke daughter Coleman's heart.

"I am deciding to help her go on a ventilator, and she may never come off," she said. "That could have been my last phone conversation with her."

Illustrations from iStock. Edited by Carol Eisenberg . Photo editing by Nick Kirkpatrick . Copy-edited by Jennifer Anderson and Thomas Floyd. Design and development by Tyler Remmel.

Read more:

Coronavirus destroys lungs. But doctors are finding its damage in kidneys, hearts and elsewhere.

Young and middle-aged people, barely sick with covid-19, are dying of strokes

Children are falling ill with perplexing inflammatory syndrome thought to be linked to covid-19

A mysterious blood-clotting complication is killing coronavirus patients

Frostbite' toes and other peculiar rashes may be signs of hidden coronavirus infection, especially in the young

[May 12, 2020] https://www.newsbiella.it/2020/04/28/leggi-notizia/argomenti/speciale-coronavirus-4/articolo/idrossiclorochina-vs-covid-19-una-terapia-considerata-efficace-ma-controversa-il-parere-dellinfet-4.html

May 12, 2020 | www.newsbiella.it

Posted by: cirsium | May 11 2020 23:44 utc | 43

[May 11, 2020] Do you need a personal oximeter to fight coronavirus? by By Jane Ridley

Vital for old people who live alone. Especially for those with hypertension
Apr 08, 2020 | nypost.com

ver since coronavirus survivor Andy Cohen told listeners of "Andy Cohen Live" March 30 that owning a pulse oximeter provided a source of relief for him, interest in the humble medical device has soared.

The small, handheld units, which normally attach to your finger or toe, monitor your oxygen-saturation level -- which, if that level dips below 90%, can be an indicator that you have COVID-19.

"Oximeters measure how efficient the lungs are at getting the blood filled with oxygen," Dr. Eric Cioe-Pena, director of global health at Northwell Health , tells The Post. "Most healthy people's reading of oxygen in the blood is 100%.

"We are seeing lower levels in coronavirus patients because the virus impedes their ability to oxygenate the blood. There is fluid, instead of air, in their lungs, and so, when the blood passes through those organs, it doesn't get oxygen."

The doctor, based in New Hyde Park, LI, adds that he has treated COVID-19 sufferers with blood-oxygen levels as low as 55% and even 27%.

Speaking on his radio show, Cohen, 51, said, "You could scare yourself and think: 'Oh my God, my lungs don't feel right,' but you could use this pulse oximeter and see, OK, actually, you're fine, you're within the range." CNN host Chris Cuomo, 49, who currently has the coronavirus , has also been testing his oxygen levels daily using an oximeter, according to his wife, Cristina, who shared an extensive update on Cuomo's health earlier this week.

No wonder people are scrambling to purchase their own oximeters, which can be found at pharmacies and online for anywhere from $20 to $50.

see also Andy Cohen reveals what it was like to have coronavirus His symptoms included a fever, tightness in his chest, a...

But Cioe-Pena maintains that healthy people don't need them. Not only that, a rush on the devices could cause problems at hospitals and other emergency facilities that require them, similar to the situation that played out over N95 masks and other gear for essential medical workers .

"The issue is supply and demand," explains Cioe-Pena, adding that the information given by an oximeter about oxygen is really "only good if you have the ability to supply supplementary oxygen, like you can in a hospital." He notes as well that folks with "underlying conditions such as diabetes, hypertension or chronic lung disease" might need to have access to oximeters more than the average healthy person with fears of contracting the coronavirus.

[May 10, 2020] Can pulse oximeters detect coronavirus How they work and more by Dale Smith

Notable quotes:
"... According to the Mayo Clinic, a normal pulse oximeter oxygen level reading is between 95% and 100% , and anything less than 90% is considered dangerously low, or hypoxic. Some doctors have reported COVID-19 patients entering the hospital with oxygen levels at 50% or below . ..."
May 08, 2020 | www.cnet.com

Some doctors are recommending these small, inexpensive devices to help monitor symptoms.

A pulse oximeter attaches to a finger and uses light to detect the level of oxygen in your blood.

As coronavirus testing efforts continue to ramp up and face masks are now a part of everyday life, a small diagnostic tool that clips to the tip of your finger is fast becoming a must-have gadget in the fight against the coronavirus . It's called a pulse oximeter, and it painlessly checks your blood oxygen level, which can be affected by lung diseases such as COVID-19.

The device was already starting to surge in popularity as word got around that people with the coronavirus frequently arrive at the hospital with abnormally low oxygen levels . After an op-ed piece in The New York Times recommended the use of pulse oximeters to detect a frightening condition called "silent hypoxia," sales of the devices skyrocketed . Many models are sold out or on lengthy backorder online. Same with brick-and-mortar drug stores, supermarkets and box stores.

[May 10, 2020] Monoclonal antibodies Drug inspired by an old treatment could be 'next big thing for Covid-19' - CNN

May 10, 2020 | www.cnn.com

At least five US teams have cloned antibodies to Covid-19, paving the way for cutting-edge treatments that could be what one researcher calls "an immunity bridge" before a vaccine comes along. The treatment is monoclonal antibody therapy, and the antibodies come from people who have recovered from the novel coronavirus. Researchers then take the blood, select the most potent antibodies, and make them into a drug. One company, Regeneron Pharmaceuticals, hopes to have a treatment available to patients as early as the end of the summer. "I think monoclonal antibody therapy has enormous promise as the next big thing for Covid-19," said Dr. Peter Hotez, a vaccine specialist at Baylor University School of Medicine who is not involved in the research. Monoclonal antibody therapy is a modern take on convalescent plasma, where someone who has recovered from coronavirus donates blood to someone who is currently ill. Read More Even if convalescent plasma is effective -- it's still being studied -- it has two shortcomings. First, one person can only give so much blood. Second, the donor might not have enough strong antibodies for the blood donation to be effective. To develop a monoclonal antibody treatment, researchers cull through thousands of antibodies to find the best ones, and then clone them potentially in unlimited amounts. Many other illnesses are treated with monoclonal antibodies, such as various forms of cancer, HIV, asthma, lupus, multiple sclerosis and various forms of cancer, but of course there's no guarantee it could work for Covid-19. What happens if a coronavirus vaccine is never developed? It has happened before <img alt="What happens if a coronavirus vaccine is never developed? It has happened before" src="//cdn.cnn.com/cnnnext/dam/assets/200428210047-coronavirus-new-york-0320-large-169.jpg"> What happens if a coronavirus vaccine is never developed? It has happened before "One of the things about the search is it's a little bit like finding a needle in a haystack. We're all searching for the magical antibody that's a silver bullet," said Dr. James Crowe, who's leading the Covid-19 monoclonal antibody effort at Vanderbilt University Medical Center. Regeneron is hoping to start clinical trials for an antibody treatment for coronavirus in humans as soon as next month, and if everything goes right, perhaps have a treatment ready for widespread distribution by the end of the summer. "We generated thousands of [antibodies] and then selected the most powerful and potent ones to grow up into an antibody cocktail," said company president Dr. George Yancopoulos. Like any treatment under development, it might not pan out. But if it does, it could treat coronavirus and possibly also prevent infection for a period of time. A vaccine would likely offer longer lasting immunity, but that would likely take longer to develop, with the earliest estimates set at January. "I think antibodies will be finished first, and will be the bridge toward longer immunity, which will be conferred by vaccines," said Crowe, director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center. 'A guided nuclear warhead' In mid-January, researchers at the Rockefeller University in New York City heard from the National Institutes of Health: Get to work because we hope to have coronavirus antibodies cloned by the spring. About two months later, Rockefeller researcher Jill Horowitz found herself handing out fliers outside a supermarket in New Rochelle, New York, inviting people who'd recovered from coronavirus to learn more about the Rockefeller study. They won the fight against coronavirus. Here&#39;s what life looks like on the other side <img alt="They won the fight against coronavirus. Here&amp;#39;s what life looks like on the other side" src="//cdn.cnn.com/cnnnext/dam/assets/200416042613-03-coronavirus-recovery-large-169.jpg"> They won the fight against coronavirus. Here's what life looks like on the other side The city -- and in particular one synagogue -- had been hit hard by a coronavirus outbreak. "I'm Jewish, and I'm Orthodox, and I know people at Young Israel. I have friends in New Rochelle. Our kids went to school together, so I could go into the community and make my case," said Horowitz, executive director of strategic operations in the immunology laboratory at Rockefeller. In all, more than 100 people donated blood for the study, many of them from the New Rochelle community. Some of their stories will be told in an upcoming documentary, " Rebel Blood The Race to Cure Covid-19 ." The lead scientist in Rockefeller's monoclonal antibody effort compares it to battle, noting that convalescent plasma has been used for more than a century. "If you're thinking about a war, and you're fighting a war with a drug that came out of the early part of the 20thcentury, the monoclonal antibody is like a guided nuclear warhead in comparison," said Dr. Michel Nussenzweig, a professor at Rockefeller. Research by several US teams Several other US teams also say they've cloned antibodies, including Vanderbilt, Regeneron, Lilly Pharmaceuticals and Distributed Bio. Regeneron anticipates starting clinical trials next month and hopes to provide "hundreds of thousands of doses" to patients by the end of the summer, Yancopoulos said. The company already makes monoclonal antibodies for several illnesses, including cancer, arthritis and asthma. "We're using the same exact technology now to come up with a specific tailored approach against Covid-19," Yancopoulos said. Get CNN Health's weekly newsletter Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team. Other companies gave a longer timeline. For example, Crowe, the doctor at Vanderbilt, said he anticipates it will be around the first quarter of next year before his team might have a Covid monoclonal antibody treatment ready to distribute. He said it's a good sign that several teams are working on monoclonal antibodies. "I think the more groups we have working on it, all the better, and the more shots on goal we have for getting an effective prevention or treatment," he said.

CNN's Dr. Minali Nigam, Devon Sayers and Wes Bruer contributed to this report.

[May 09, 2020] Is Fauci corrupt? The story of Remdesevir approval suggest that YES.

Does Dr Fauci enjoy indirect financial ties to Gilead? Does he own the stock?
Notable quotes:
"... Basically, this was a negative trial. Of the 255 patients screened, 237 met the eligibility criteria, and 158 were assigned to the remdesivir group, with 79 assigned to placebo control. Unfortunately, remdesivir treatment was not associated with a shorter time to clinical improvement, and mortality was not different between the two groups. ..."
"... It does look very fishy to me. Endpoint or outcome switching, particularly late in a clinical trial is a huge red flag. ..."
"... There are also other reasons to question this trial, including how no confidence intervals were reported, that not even an abstract was published, just a press release with, as Heathers put it, "two results in four lines": ..."
"... I remain very suspicious that the NIH study was announced the same day that a negative study out of China of remdesivir was published. It just seems too convenient. Maybe I'm being overly suspicious. Maybe I'm too suspicious. Maybe I'm falling prey to conspiracy mongering. However, in the Trump era, when the Trump administration has politicized previously (mostly) apolitical government agencies as never before, it's hard not to wonder. ..."
"... He was unimpressed by remdesivir's modest benefit. "It was expected to be a whopping effect," Topol added. "It clearly does not have that." ..."
"... Indeed, given that the pre-test probability of remdesivir having a significant effect was low, meaning that this trial is probably just noise: ..."
"... But Gilead will make billions and billions of dollars ..."
"... Could Anthony Fauci explain why the investigators of the NIAID remdesivir trial did change the primary outcome during the course of the project (16th April)? Removing "death" from primary outcome is a surprising decision. ..."
"... The most common adverse effects in studies of remdesivir for COVID-19 include respiratory failure and blood biomarkers of organ impairment, including low albumin, low potassium, low count of red blood cells, low count of platelets that help with clotting, and yellow discoloration of the skin. Other reported side effects include gastrointestinal distress, elevated transaminase levels in the blood (liver enzymes), and infusion site reactions. ..."
"... So, if it does shorten duration, is it worth potential liver damage, respiratory failure and organ impairment? In other words is the cure potentially as bad as the disease. ..."
"... For yet another drug that was supposed to be a game changer, I am unimpressed by its results. The whole mechanism is wrong. A drug with this mechanism would need to be almost a prophylactic for it to be hugely effective. ..."
"... Fauci didn't seem to have any problem cautioning against unwarranted optimism for CQ/HCQ even while DJT was championing the stuff. What is different about this? . ..."
"... So, what did Fauci say about chloroquine? ""We've got to be careful that we don't make that majestic leap to assume that this is a knockout drug. We still need to do the kinds of studies that definitely prove whether any intervention is truly safe and effective," Fauci, who is also a member of the White House coronavirus task force, said during an interview on "Fox & Friends. . . "We don't operate on how you feel, we operate on what evidence and data is," Fauci said, adding that it was "not a very robust study" or "overwhelmingly strong."" (Concha, 2020 Apr 3) ..."
"... Now, what did he say about Remdesivir: "Speaking to reporters from the White House, Fauci said he was told data from the trial showed a "clear-cut positive effect in diminishing time to recover." Fauci said the median time of recovery for patients taking the drug was 11 days, compared with 15 days in the placebo group. He said the mortality benefit of remdesivir "has not yet reached statistical significance." ..."
"... Disappointingly, the lock down seems to have made a number of people irrational. Just a quick post to expound on my Fauci post for those who see the world as binary – ie: black or white. These people think you either support Fauci 100% or 0% and a single criticism of any Fauci statement means 0% support of Fauci. I do not happen to worship at the altar of Fauci or any scientist and recognize all are subject to errors – including myself. I view the world in a more nuanced manner than those with the black/white delusion. I find I can disagree with some things a person says or stands for and agree with some other things they say or do. ..."
"... I am of the opinion that Fauci made a mistake here. The evidence for Remdesiver is nowhere near good enough for it to become the standard of care. ..."
"... On the other hand, watching the White House performance from afar, I can see the administration is dysfunctional and is run by a narcissistic bully, who will publicly turn on anyone who disagrees with them. ..."
"... I believe that is the main thrust of this Orac article – that the evidence for Remdesiver efficacy is sorely lacking. ..."
May 09, 2020 | respectfulinsolence.com
Remdesivir: Gilead wins with unimpressive results announced by press release On Wednesday, Dr. Anthony Fauci announced positive results for the antiviral drug remdesivir treating COVID-19. They were unimpressive and, suspiciously, announced by press release rather than scientific paper. It's all very fishy, but one thing's for sure. Gilead Sciences will make boatloads of money. I've been writing a lot about the unjustified and premature hype over hydroxychloroquine, an anti-malarial drug with mild immunosuppressive activity that is also used to treat rheumatoid arthritis and other autoimmune diseases and how the drug probably doesn't work against COVID-19, despite its being hyped by President Trump and his sycophants, toadies, and lackeys on Fox News, Dr. Mehmet Oz , Dr. Phil , Dr. Didier Raoult , and a bevy of irresponsible fame seeking doctors who have no idea how to do a proper clinical study.

There are, however, other drugs being hyped out there, drugs that might actually have a better chance of turning out to be effective treatments for COVID-19. Chief among these is remdesivir, the experimental antiviral drug being tested by Gilead Sciences.

Remdesivir is an adenosine (a nucleotide) analog that inhibits viral RNA polymerases. It is incorporated into RNA made by the virus, causing the premature termination of the RNA molecule, thus interfering with viral replication. The drug was originally developed to treat Ebola and Marburg but was ultimately found to be ineffective against these viruses . Because it inhibits the replication of a number of RNA viruses, it was only natural that it would be considered as a possible treatment for COVID-19, and Gilead has been relentlessly promoting it as such as the company has been working to carry out clinical trials.

What prompted me to write about remdesivir were headlines like Dr. Anthony Fauci says Gilead's remdesivir will set a new 'standard of care' for coronavirus treatment that started popping up on Wednesday afternoon:

White House health advisor Dr. Anthony Fauci said Wednesday that data from a coronavirus drug trial testing Gilead Sciences' antiviral drug remdesivir showed "quite good news" and sets a new standard of care for Covid-19 patients.

Speaking to reporters from the White House, Fauci said he was told data from the trial showed a "clear-cut positive effect in diminishing time to recover."

Fauci said the median time of recovery for patients taking the drug was 11 days, compared with 15 days in the placebo group. He said the mortality benefit of remdesivir "has not yet reached statistical significance."

The results suggested a survival benefit, with a mortality rate of 8% for the group receiving remdesivir versus 11.6% for the placebo group, according to a statement from the National Institutes of Health released later Wednesday.

"This will be the standard of care," Fauci, director of the National Institute of Allergy and Infectious Diseases, added. "When you know a drug works, you have to let people in the placebo group know so they can take it."

My skeptical antennae started twitching immediately, because on the same day a study from China was published in The Lancet that was far less impressive. In fact, it was a negative trial. What also got my skeptical antennae all aflutter twitching away was how the results of the remdesivir trial were announced. Normally, when a study is announced to the press, it's upon publication of the paper, and the press release is issued either the same day or the evening before publication. As of last night, as I wrote this, however, the actual paper reporting the results of the clinical trial had not yet been published. As I perused Twitter on Wednesday, I found even more reasons for skepticism.

So, before I get to the study touted by Dr. Fauci, let's review some history.

Remdesivir: The early days versus COVID-19 (like, you know, three weeks ago)

The first data published on remdesivir was a single-arm uncontrolled trial that somehow got published three weeks ago in The New England Journal of Medicine . This was peak COVID-19 publishing, when an uncontrolled case series of patients with severe COVID-19 treated with remdesivir under compassionate was published in a super high impact journal like NEJM and made headlines as a result. Be that as it may, the case series examined 61 patients with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing room air or who were receiving oxygen support. They received a 10-day course of remdesivir, consisting of 200 mg given intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. (Remdesivir is an intravenous drug.) The authors reported clinical improvement in 68% of evaluable patients:

Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.

The case series also did not collect viral load data to confirm potential antiviral activity in humans or any association between declines in viral load and clinical improvement. Basically, when you get right down to it, this study was not really much better than Didier Raoult's crappy study of his hydroxychloroquine/azithromycin combination, but that didn't stop the authors from concluding that comparisons with contemporaneous cohorts "suggest that remdesivir may have clinical benefit in patients with severe Covid-19." In reality, like Raoult's trials, this trial said nothing about the efficacy of remdesivir against COVID-19 other than that the drug could be given to COVID-19 patients with a reasonable safety profile.

Less than week later, as related by Derek Lowe , came news that two clinical trials of remdesivir in China, one for severe disease and one for moderate disease had been suspended. (They still are.) Lowe noted that both trials had the notice: "The epidemic of COVID-19 has been controlled well at present, no eligible patients can be recruited." The apparent explanation was "the stringent inclusion criteria for the trials – apparently patients had to have no previous therapy with any other experimental agent to enroll, and that eliminates a lot of people." Around the same time, Adam Feuerstein and Matthew Herper published a story in STAT, Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment :

The University of Chicago Medicine recruited 125 people with Covid-19 into Gilead's two Phase 3 clinical trials. Of those people, 113 had severe disease. All the patients have been treated with daily infusions of remdesivir.

"The best news is that most of our patients have already been discharged, which is great. We've only had two patients perish," said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.

Her comments were made this week during a video discussion about the trial results with other University of Chicago faculty members. The discussion was recorded and STAT obtained a copy of the video.

Derek Lowe discussed this story in depth, and I largely agree with him that the leak of the video to STAT was a serious breach of clinical trial ethics and protocol. (I'm not alone in suspecting that it was almost certainly intentional to jack up Gilead's stock price, a result that was achieved.) Lowe also noted:

But now that it's out there, let's talk about what's in the leak. Gilead stock jumped like a spawning salmon in after-market trading on this, and one of the reasons was that that 113 of the 125 patients were classed as having "severe disease". People ran with the idea that these must have been people on ventilators who were walking out of the hospital, but that is not the case. As AndyBiotech pointed out on Twitter, all you had to do was read the trial's exclusion criteria : patients were not even admitted into the trial if they were on mechanical ventilation. Some will have moved on to ventilation during the trial, but we don't know how many (the trial protocol has these in a separate group).

Note also that this trial is open-label; both doctors and patients know who is getting what, and note the really key point: there is no control arm. This is one of the trials mentioned in this post on small-molecule therapies as being the most likely to read out first, but it's always been clear that the tradeoff for that speed is rigor. The observational paper that was published on remdesivir in the NEJM had no controls either, of course, and that made it hard to interpret. Scratch that, it made it impossible to interpret. It will likely be the same with this trial – the comparison is between a five-day course of remdesivir and a ten-day course, and the primary endpoint is the odds ratio for improvement between the two groups.

Again, these data, such as they are, are no more useful than Didier Raoult's data on hydroxychloroquine and azithromycin to treat COVID-19, but this brings us to the Chinese trial published in The Lancet on Wednesday.

The Chinese randomized clinical trial

The Chinese trial published two days ago is the first randomized, double-blind, placebo-controlled clinical trial of remdesivir to treat COVID-19, but it was also one of the studies halted. Eligible patients were adults admitted to the hospital with laboratory-confirmed SARS-CoV-2 whose symptoms had lasted less than 12 days before enrollment and who had an oxygen saturation on room air of 94% or less or a ratio of arterial oxygen partial pressure to fractional inspired oxygen of 300 mm Hg or less (another measure of hypoxia), and radiologically confirmed pneumonia.

Patients were randomly assigned in a 2:1 ratio to intravenous remdesivir at the same dose as the NIH trial touted by Dr. Fauci or the same volume of placebo infusions for 10 days and were permitted concomitant use of lopinavir–ritonavir, interferons, and corticosteroids. The primary endpoint was time to clinical improvement up to day 28, defined at the time from randomization to the point of a decline of two levels on a six-point ordinal scale of clinical status (from 1=discharged to 6=death) or discharged alive from hospital, whichever came first. An intention-to-treat analysis was carried out.

Basically, this was a negative trial. Of the 255 patients screened, 237 met the eligibility criteria, and 158 were assigned to the remdesivir group, with 79 assigned to placebo control. Unfortunately, remdesivir treatment was not associated with a shorter time to clinical improvement, and mortality was not different between the two groups. Subgroup analysis looking for hypotheses found that there was a trend towards a shorter duration of symptoms (not statistically significant) in patients treated with remdesivir who had had symptoms for less than ten days. Most disappointingly, there was no detectable difference in viral load between the remdesivir groups and the placebo controls. Again, basically this was a negative study with only the barest hint that remdesivir might -- I repeat, might -- work if administered earlier in the course of COVID-19. That's some pretty thin gruel.

Which brings us to the NIH trial of remdesivir touted by Anthony Fauci.

The NIH press release for its remdesivir trial.

The results of the NIH remdesivir trial can, unfortunately, only be gleaned from the press release and news stories so far:

For the first time, a major study suggests that an experimental drug works against the new coronavirus, and U.S. government officials said Wednesday that they would work to make it available to appropriate patients as quickly as possible.

In a study of 1,063 patients sick enough to be hospitalized, Gilead Sciences's remdesivir shortened the time to recovery by 31% -- 11 days on average versus 15 days for those just given usual care, officials said. The drug also might be reducing deaths, although that's not certain from the partial results revealed so far.

"What it has proven is that a drug can block this virus," the National Institutes of Health's Dr. Anthony Fauci said.

"This will be the standard of care," and any other potential treatments will now have to be tested against or in combination with remdesivir, he said.

Here is the press release , posted to the National Institute of Allergy and Infectious Diseases website:

Hospitalized patients with advanced COVID-19 and lung involvement who received remdesivir recovered faster than similar patients who received placebo, according to a preliminary data analysis from a randomized, controlled trial involving 1063 patients, which began on February 21. The trial (known as the Adaptive COVID-19 Treatment Trial, or ACTT), sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is the first clinical trial launched in the United States to evaluate an experimental treatment for COVID-19.

An independent data and safety monitoring board (DSMB) overseeing the trial met on April 27 to review data and shared their interim analysis with the study team. Based upon their review of the data, they noted that remdesivir was better than placebo from the perspective of the primary endpoint, time to recovery, a metric often used in influenza trials. Recovery in this study was defined as being well enough for hospital discharge or returning to normal activity level.

Preliminary results indicate that patients who received remdesivir had a 31% faster time to recovery than those who received placebo (p<0.001). Specifically, the median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo. Results also suggested a survival benefit, with a mortality rate of 8.0% for the group receiving remdesivir versus 11.6% for the placebo group (p=0.059).

More detailed information about the trial results, including more comprehensive data, will be available in a forthcoming report. As part of the U.S. Food and Drug Administration's commitment to expediting the development and availability of potential COVID-19 treatments, the agency has been engaged in sustained and ongoing discussions with Gilead Sciences regarding making remdesivir available to patients as quickly as possible, as appropriate. The trial closed to new enrollments on April 19. NIAID will also provide an update on the plans for the ACTT trial moving forward. This trial was an adaptive trial designed to incorporate additional investigative treatments.

As you can see, the difference in mortality was not statistically significantly different, although that could just be because of inadequate numbers. It's also very important to note the part about the adaptive trial design of this trial, which puts Dr. Fauci's comment about how remdesivir will become the "standard of care" going forward into the proper context. In this particular trial , multiple different drugs can be compared to placebo or standard of care. The idea is that, if a signal of efficacy is found with one drug, that drug becomes "standard of care" and the trial is adapted to study how adding other experimental drugs compares to the "standard of care." So what Dr. Fauci meant was that, based on the finding, going forward remdesivir will become the "standard of care" arm for the trial and the experimental arm will become remdesivir plus another experimental therapeutic. However, given that the FDA is on the verge of issuing an emergency use authorization for remdesivir to treat COVID-19, it looks as though remdesivir will become standard-of-care in general soon.

But back to the results. Derek Lowe observed:

it's worth noting that had there been "clear and substantial evidence of a treatment difference" during the trial that the DSMB was to have halted the study at that point. We can infer that nothing rose to that level, then: we have a difference, but not substantial enough to have ended the trial prematurely.

It's also worth noting some things posted on Twitter about the trial. For instance, Waller Gellad noted:

Since NIH remdesivir trial is in the news

was there an explanation about why the primary outcome (now positive) was changed last month to 'time until clinical recovery?' @matthewherper https://t.co/fCTc1EGI1d pic.twitter.com/W1hAACnO1r

-- Walid Gellad, MD MPH (@walidgellad) April 29, 2020

It's very odd that the primary endpoint was changed:

Thread that summarizes my concerns with Remdesivir press release (not science) as well.

Changing the endpoint midtrial this way is like hosting a race for one destination then declaring wherever you end up after running for an hour is the finish line. https://t.co/XMUXYW3njp

-- Mark Hoofnagle (@MarkHoofnagle) April 30, 2020

This long Twitter thread explains:

Here's Fauci talking about it. Give him a listen, sharpen your ears at about 0.30.

"The primary endpoint was the time to recovery, namely the ability to be discharged."

He's right, it was.

On April 16th. https://t.co/U6Cx3XSOJ6

-- 🏴James Heathers 🏴 (@jamesheathers) April 30, 2020

I'll summarize, so that you don't have to scroll through a Twitter thread if you don't want to. As James Heathers and Waller Gellad noted, the original primary outcome of the trial when it was registered on March 20. The original primary endpoint of the trial was an 8-point severity scale (death, on ventilator, hospitalized with oxygen, all the way down to discharged with no limits on activity) but was changed to time to recovery. There's still a similar scale for the secondary endpoints, but no numbers for that were reported. (Any bets on whether the results are negative?) This change was apparently made on or around April 16.

Gellad also notes:

last thing:
Here is the results table for the negative lancet trial of remdesivir. The highlighted results are what the primary outcome for the NIH trial was until 2 weeks ago. https://t.co/niQ65zgLF2

We need to see that outcome, in addition to time until recovery. pic.twitter.com/ptXGhPx13N

-- Walid Gellad, MD MPH (@walidgellad) April 30, 2020

It does look very fishy to me. Endpoint or outcome switching, particularly late in a clinical trial is a huge red flag. Don't get me wrong. There can be legitimate scientific reasons to switch primary endpoints of a trial. as James Heathers puts it:

Sometimes it becomes clear after you start that the registration is incomplete or wrong. Sometimes you have a better idea after you start. Sometimes your thinking changes.

Other times, you're trying to cherry-pick the results.

-- James Heathers 🏴 (@jamesheathers) April 30, 2020

There are also other reasons to question this trial, including how no confidence intervals were reported, that not even an abstract was published, just a press release with, as Heathers put it, "two results in four lines":

(2) the results in the press release. I call this 'two results, four sentences' – press releases describe the results in incredibly brief terms, usually the two most positive outcomes w the briefest explanation possible. He's me bitching about it earlier. https://t.co/FQlaAQaytG

-- James Heathers 🏴 (@jamesheathers) April 30, 2020

Basically, if you have two "good" results and twenty "bad" or uninterpretable results, what do you do? What are you going to tell people? The two "good" results, of course!

Gary Schwitzer has a nice summary of the negative reactions to the trial and how it was announced.

The bottom line

I remain very suspicious that the NIH study was announced the same day that a negative study out of China of remdesivir was published. It just seems too convenient. Maybe I'm being overly suspicious. Maybe I'm too suspicious. Maybe I'm falling prey to conspiracy mongering. However, in the Trump era, when the Trump administration has politicized previously (mostly) apolitical government agencies as never before, it's hard not to wonder.

Adding to my suspicion is the fact that the study was reported in a press release, rather than being published, which makes me wonder if the press release was written to counter the negative study from China that would certainly have tanked Gilead's stock prices. Yes, I know that the press release reported that this decis, apparently the announcement was decided upon after April 27 meeting of the data and safety monitoring board overseeing this trial, but the outcome switching so late in the trial makes me very suspicious. Yes, the explanation, which should have been in the press release, along with an acknowledgment that the primary outcome/endpoint had been changed, but wasn't is not unreasonable:

NIAID explains why endpoint of remdesivir trial was changed: pic.twitter.com/Zpl08nd4PL

-- Meg Tirrell (@megtirrell) April 30, 2020

Then there was this news report in which Fauci claimed that concerns about leaks fueled the announcement:

He expressed concern that leaks of partial information would lead to confusion. Since the White House was not planning a daily virus briefing, Fauci said he was invited to release the news at a news conference with Louisiana Gov. John Bel Edwards(D). "It was purely driven by ethical concerns," Fauci told Reuters in a telephone interview.

"I would love to wait to present it at a scientific meeting, but it's just not in the cards when you have a situation where the ethical concern about getting the drug to people on placebo dominates the conversation."

An independent data safety and monitoring board, which had looked at the preliminary results of the NIAID trial, determined it had met its primary goal of reducing hospital stays.

On Tuesday evening, that information was conveyed in a conference call to scientists studying the drug globally.

"There are literally dozens and dozens of investigators around the world," Fauci said. "People were starting to leak it." But he did not give details of where the unreported data was being shared.

I smell bullshit here. What probably really happened is that he was under enormous pressure to release the results. It was also unwise to discuss the results with so many scientists until the manuscript reporting the results of the trial had at least been submitted for publication. I agree with the scientists who had "expected it [the trial data] to be presented simultaneously in a detailed news release, a briefing at a medical meeting or in a scientific journal, allowing researchers to review the data." I also agree with Dr. Eric Topol, referring to the Chinese RCT and this one:

"That's the only thing I'll hang my hat on, and that was negative," said Dr. Eric Topol, director and founder of the Scripps Research Translational Institute in La Jolla, California.

He was unimpressed by remdesivir's modest benefit. "It was expected to be a whopping effect," Topol added. "It clearly does not have that."

Indeed, given that the pre-test probability of remdesivir having a significant effect was low, meaning that this trial is probably just noise:

Unfortunately, by the time you are symptomatic with a virus, you are usually already high/peak viral load. So, when you give an antiviral to someone who is already ill, the damage from the virus is largely done. It's there in big numbers and in the cells.

-- Mark Hoofnagle (@MarkHoofnagle) May 1, 2020

Indeed, I'm not only unimpressed with the modest benefit reported, I question whether there really was any benefit at all, particularly in light of the Chinese trial, which found zero difference in viral load in the remdesivir group.

The whole thing looks damned fishy, and we can't judge the study until it's actually published. Meanwhile, whatever the true reasons for releasing the study results this way, mission accomplished. The negative effect of the Chinese study on Gilead's stock price was successfully countered and remdesivir becomes a de facto standard of care for patients hospitalized with COVID-19. Worse, no further trials of remdesivir versus placebo will be possible, because it's been declared that remdesivir "works" against COVID-19 and is the new standard of care! As Mark Hoofnagle put it in a great Twitter thread, that echoes my thoughts:

By the end of the day, reports that FDA is going to emergently approve remdesivir for treatment of COVID.

Gilead gets what they want. No one will want to be in a control arm in further trials and they will argue all future trials must be noninferiority.

-- Mark Hoofnagle (@MarkHoofnagle) May 1, 2020

Absolute genius. You have to salute them. On the day a negative trial of their drug is reported, based on a press release they took over the news cycle, and with some midstream edits to their endpoints their now "positive" trial wins them FDA approval and a halted trial.

-- Mark Hoofnagle (@MarkHoofnagle) May 1, 2020

It's worse than that. If remdesivir is now the "standard of care" for hospitalized COVID-19 patients, it now becomes unethical to randomize them to a placebo group testing ANY new drug for COVID-19. Trials will now have to compare remdesivir alone to remdesivir plus experimental drug. We'll probably never know now for sure if remdesivir is truly effective against COVID-19.

But Gilead will make billions and billions of dollars.

Related The FDA's emergency use authorization of chloroquine and hydroxychloroquine for COVID-19: Dangerous politics, not science

Yesterday, the FDA issued emergency use authorization for hydroxychloroqine and chloroquine to treat COVID-19. Politics, not science, is why.

By Orac Orac is the nom de blog of a humble surgeon/scientist who has an ego just big enough to delude himself that someone, somewhere might actually give a rodent's posterior about his copious verbal meanderings, but just barely small enough to admit to himself that few probably will. That surgeon is otherwise known as David Gorski ...

John Kane says: May 2, 2020 at 8:52 am

In long twitter exchange mainly led by James Heathers, has anyone noticed that there are a series of tweets by Didier Raoult ?

One tweet reads:

Could Anthony Fauci explain why the investigators of the NIAID remdesivir trial did change the primary outcome during the course of the project (16th April)? Removing "death" from primary outcome is a surprising decision.

In a quick search of the web I found the following two:

WHAT ARE SIDE EFFECTS OF REMDESIVIR (RDV)?

In the Ebola trial, researchers noted side effects of remdesivir (RDV) that included:

Typical antiviral drug side effects include:

Nausea
Vomiting

Found at: https://www.rxlist.com/consumer_remdesivir_rdv/drugs-condition.htm

Side effects

The most common adverse effects in studies of remdesivir for COVID-19 include respiratory failure and blood biomarkers of organ impairment, including low albumin, low potassium, low count of red blood cells, low count of platelets that help with clotting, and yellow discoloration of the skin. Other reported side effects include gastrointestinal distress, elevated transaminase levels in the blood (liver enzymes), and infusion site reactions.

Other possible side effects of remdesivir include:

Infusion‐related reactions. Infusion‐related reactions have been seen during a remdesivir infusion or around the time remdesivir was given.[8] Signs and symptoms of infusion‐related reactions may include: low blood pressure, nausea, vomiting, sweating, and shivering.

Increases in levels of liver enzymes, seen in abnormal liver blood tests. Increases in levels of liver enzymes have been seen in people who have received remdesivir, which may be a sign of inflammation or damage to cells in the liver.

Found at: https://en.wikipedia.org/wiki/Remdesivir

So, if it does shorten duration, is it worth potential liver damage, respiratory failure and organ impairment? In other words is the cure potentially as bad as the disease.

And, as Orac and many commenters have made more than clear, one more example of Trump's government, ignoring science, and jumping to conclusions.

And once more I suggest reading the following:

Jeanne Lenzer and Shannon Brownlee (April 28, 2020). Pandemic Science Out of Control. Issues in Science and Technology. Available at: https://issues.org/pandemic-science-out-of-control/

Joel A. Harrison, PhD, MPH says: May 2, 2020 at 7:05 pm
ADDENDUM

I found the following: "Particular laboratory features have also been associated with worse outcomes (table 2). These include: Elevated liver enzymes"

Found at: https://www.uptodate.com/contents/coronavirus-disease-2019-covid-19-epidemiology-virology-clinical-features-diagnosis-and-prevention?search=coronavirus-disease-2019-covid-19- demiology-virology-clinical-features-diagnosis-and-prevention&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

So, one of the side-effects has been associated with worse outcomes. Not exactly a ringing endorsement of Remdesivir.

Chris Preston says: May 2, 2020 at 6:52 pm
For yet another drug that was supposed to be a game changer, I am unimpressed by its results. The whole mechanism is wrong. A drug with this mechanism would need to be almost a prophylactic for it to be hugely effective.
Tim says: May 3, 2020 at 11:33 am

One thing they discovered is that the proteins involved have zinc atoms incorporated into their structure. This won't surprise any biochemists, as zinc-containing proteins are common. But there's been a steady flow of fringe treatments for the disease -- including some involving chloroquine derivatives -- in which zinc was a key component. We'll have to see whether that changes now that it's clear that zinc is needed to make copies of the virus (assuming that fact registers at all with the people prone to promoting fringe therapies).

https://arstechnica.com/science/2020/05/scientists-get-an-atomic-level-look-at-how-a-drug-blocks-the-coronavirus/

What is that saying about zinc? I've always heard that zinc was a good thing to have a high intracellular level of it to protect against viruses besides also being needed to make NO.

https://arstechnica.com/science/2020/05/nih-cuts-coronavirus-funding-amid-trump-comments-and-conspiracy-theories/

Joel A. Harrison, PhD, MPH says: May 4, 2020 at 1:11 pm
@ Reality

So: "Fauci just dropped down a level or two in my estimation of his commitment to rationality."

Let's look at the "Reality": "America needs a federal government that assertively promotes and helps to coordinate that, not one in which experts like Tony Fauci and Deborah Birx tiptoe around a president's tender ego."

I wouldn't want to be in Fauchi's shoes. If he openly criticizes Trump, he is out and staying in allows him to have some effect. Damned if he does and damned if he doesn't. So, he has to balance his "committment to rationality" to trying to modify/reduce the insanity of Trump. If he resigned or was fired, could he have more of an influence? Maybe, maybe not. I would not want to be in his shoes! ! ! Personally, I would probably resign and try to get our media to listen to me. Just standing next to Trump would turn my stomach.

So, maybe you should live up to your "name" and evaluate "reality" not an idealistic world.

Reality says: May 4, 2020 at 2:22 pm
So you wouldn't say what Fauci said and would quit, eh, Joel?
I wouldn't say what Fauci said about "standard of care" which is basically his endorsement of this.
I believe Orac wouldn't make that statement endorsing Remdesivir as the "standard of care".
I don't know of any self-respecting scientist who would make such a statement no matter what the pressure.
If I was pressured by DJT I would object but maybe agree to not make any statement pro or con about the subject – so as to keep my position and influence but if someone asked me to say something I thought was not true I would not do it and refuse.
.
Fauci didn't seem to have any problem cautioning against unwarranted optimism for CQ/HCQ even while DJT was championing the stuff. What is different about this?
.

That is the Reality of this Fauci statement.

A. Harrison, PhD, MPH says: May 4, 2020 at 4:31 pm
@ Reality

You write: "Fauci didn't seem to have any problem cautioning against unwarranted optimism for CQ/HCQ even while DJT was championing the stuff. What is different about this?"

Yep; but the only studies promoting CQ/HCQ was a fraudulent one in France and an in vitro study.

What about Remdesivir? First it is a nucleic acid analogue designed to directly disrupt replication of the viral genome. Chloroquine/Hydroxychloroquine were not even remotely designed to target viruses, though they have a moderate dampening effect on immune reactions, so they work for autoimmune diseases (e.g., lupus, rheumatoid arthritis); but, as I wrote in a previous exchange, the immune response in an autoimmune disease compared to a cytokine storm is like comparing 20 mile per hour winds to a category 5 hurricane, 160 mph winds. In addition, chloroquine/hydroxychloroquine have a large number of mild side-effects and some really serious major ones.

So, what did Fauci say about chloroquine? ""We've got to be careful that we don't make that majestic leap to assume that this is a knockout drug. We still need to do the kinds of studies that definitely prove whether any intervention is truly safe and effective," Fauci, who is also a member of the White House coronavirus task force, said during an interview on "Fox & Friends. . . "We don't operate on how you feel, we operate on what evidence and data is," Fauci said, adding that it was "not a very robust study" or "overwhelmingly strong."" (Concha, 2020 Apr 3)

Now, what did he say about Remdesivir: "Speaking to reporters from the White House, Fauci said he was told data from the trial showed a "clear-cut positive effect in diminishing time to recover." Fauci said the median time of recovery for patients taking the drug was 11 days, compared with 15 days in the placebo group. He said the mortality benefit of remdesivir "has not yet reached statistical significance."

The results suggested a survival benefit, with a mortality rate of 8% for the group receiving remdesivir versus 11.6% for the placebo group, according to a statement from the National Institutes of Health released later Wednesday. "This will be the standard of care," Fauci, director of the National Institute of Allergy and Infectious Diseases, added. "When you know a drug works, you have to let people in the placebo group know so they can take it." "What it has proven is a drug can block this virus," he said. (Lovelace, 2020 Apr 29)

"The data shows that remdesivir has a clear-cut, significant, positive effect in diminishing the time to recovery," Fauci said at the White House on Wednesday. The data he referred to is from a large study of more than 1,000 patients from multiple sites around the world. Patients either received the drug, called remdesivir, or a placebo.

Dr. Michael Saag, associate dean for global health at the University of Alabama at Birmingham, said the results seemed promising. Antiviral drugs such as remdesivir tend to work earlier in the course of an illness, so "the thing that I think is important in this study is the patients had advanced disease," said Saag, who is not involved with any remdesivir trials. (NBC News (2020 Apr 29)

Hospitalized patients with advanced COVID-19 and lung involvement who received remdesivir recovered faster than similar patients who received placebo, according to a preliminary data analysis from a randomized, controlled trial involving 1063 patients, which began on February 21. The trial (known as the Adaptive COVID-19 Treatment Trial, or ACTT), sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is the first clinical trial launched in the United States to evaluate an experimental treatment for COVID-19.

An independent data and safety monitoring board (DSMB) overseeing the trial met on April 27 to review data and shared their interim analysis with the study team. Based upon their review of the data, they noted that remdesivir was better than placebo from the perspective of the primary endpoint, time to recovery, a metric often used in influenza trials [my emphasis]. Recovery in this study was defined as being well enough for hospital discharge or returning to normal activity level. . .

Results also suggested a survival benefit, with a mortality rate of 8.0% for the group receiving remdesivir versus 11.6% for the placebo group (p=0.059). the group receiving remdesivir versus 11.6% for the placebo group (National Institute of Allergy and Infectious Diseases (2020 Apr 29).

So, first I'd bet you don't understand how nucleic acid analogues work?
Second, though I tend not to rely on one study, this one was fairly large and the shortening of time to recovery was clinically significant, "defined as being well enough for hospital discharge or returning to normal activity level." And Dr. Michael Saag: "Antiviral drugs such as remdesivir tend to work earlier in the course of an illness, so "the thing that I think is important in this study is the patients had advanced disease,"

Standard of Care is more a legal definition than a clinical one. Basically it reduces risk of malpractice lawsuits.

While I probably would not have called it "standard of care", instead clearly stating that based on the recent trial, it is currently the best we have to offer or something to that effect.

So, Fauci didn't call it a cure, didn't claim it reduced mortality, though indications it did, and based on over 1,000 patients, found it reduced hospitalization and return to normal life by a clinically significant margin, the standard used for flu studies. Again, I would have been more cautious in my working; but your rank attack on a man who knows more about infectious diseases that you, I, and many others, a man who has dedicated his life to preventing and dealing with them is just plain sickening. Your black and white view of Fauci is how antivaccinationists and other adherers to unscience see the world. And an MPH probably means a couple of lower level epidemiology courses. So, the old saying: A little knowledge is a dangerous thing, coupled with a personality that prefers a dichotomous world is very very problematic.

Only time and further studies will tell if Remdesivir really does shorten recovery time and, perhaps, also lowers mortality. Right now, we have nothing else and I wouldn't jump on something because of this; but the over 1,000 patient study isn't nothing.

Just to be clear, Orac's critique is valid; but, as he says, by this time one becomes perhaps overly skeptical given Trump's insanity. How cautious should Fauci have been? People are becoming desperate. The risks from Remdesivir are extremely low, so currently, either use it or continue as is.

If there were significant risks and the one study had been one a much smaller group, the scales would be different. And, though Orac is right they changed the outcome points, as mentioned, shortening of recovery time is a criterion used for treatment of flu, so, though not, perhaps, the best end-point, it is certainly not the same as some studies using endpoints such as lowered cholesterol without looking at deaths. They did look at deaths and though not significant, in the right direction. By the way, do you even understand significance levels? Though only one study, p=0.059 isn't far from p=0.05.

References:

Reality says: May 5, 2020 at 10:58 am
Disappointingly, the lock down seems to have made a number of people irrational. Just a quick post to expound on my Fauci post for those who see the world as binary – ie: black or white. These people think you either support Fauci 100% or 0% and a single criticism of any Fauci statement means 0% support of Fauci. I do not happen to worship at the altar of Fauci or any scientist and recognize all are subject to errors – including myself. I view the world in a more nuanced manner than those with the black/white delusion. I find I can disagree with some things a person says or stands for and agree with some other things they say or do.

My criticism of Fauci in regard to his remdesivir endorsement does not mean I have 0% support for Fauci it means that with that statement and some others my positive view of him is now ~80% but not 100% and I will have to check up on what he is endorsing to make sure that I agree with it just like I do with any other scientist/person.

BTW – If some were to check my Disqus account history (Reality022) you would find posts strongly defending Fauci against the Loony Libertarians who seem to think he is the debil.
.
Now to a second point:

There appears to be a group of Fauci apologists who, to excuse Fauci's statement, say it is due to 'pressure from Trump/the administration'.
I do not subscribe to this excuse and think it is a horrible thing to say for 2 reasons:

1) There is absolutely no evidence that this statement was made under pressure. That idea is totally invented in the minds of the Fauci apologists in their attempt to exonerate Fauci.

2) It is a horrible thing to say about Fauci. I take him at his word. If he said it he meant it. The excuse actually means that Fauci's word is so untrustworthy that he can be pressured into being dishonest about his scientific opinions and only the apologists can tell us when he is lying or actually relating his honest view. The apologists are basically saying Fauci is dishonest.

I have much more respect for the man and believe he is honest but in this case merely wrong.
.
That is all I'm going to say about this subject as some people are going off the rails with their binary view of the world. (snicker)

A. Harrison, PhD, MPH says: May 5, 2020 at 11:06 am

@ Reality

And you continue to miss the point that "Standard of Care" is mainly a legal term. Are you that dense? It is you who stated your opinion of Fauci sank, so your binary view of the world. Try reading my other comments, closely, maybe you will learn something; but I doubt it. "Reality", lacks reality testing. Reply

Preston says: May 5, 2020 at 8:18 pm

I tend to agree. I am of the opinion that Fauci made a mistake here. The evidence for Remdesiver is nowhere near good enough for it to become the standard of care. But then I am not the one having to make these decisions under difficult circumstances. I don't pretend to understand why Fauci might have made the comment, so don't see a lot of point in speculating about it.

On the other hand, watching the White House performance from afar, I can see the administration is dysfunctional and is run by a narcissistic bully, who will publicly turn on anyone who disagrees with them. I also see there are people within and around the White House who are happy to tell whatever lies they think Trump wants to hear, either through fear or hope for advancement. I understand why people would add 2 and 2 and come up with 5.

Reality says: May 5, 2020 at 9:28 pm
Chris Preston said, "I am of the opinion that Fauci made a mistake here. The evidence for Remdesiver is nowhere near good enough for it to become the standard of care."

I believe that is the main thrust of this Orac article – that the evidence for Remdesiver efficacy is sorely lacking.

Quoting Orac's article above: "In reality, like Raoult's trials, this trial said nothing about the efficacy of remdesivir against COVID-19 other than that the drug could be given to COVID-19 patients with a reasonable safety profile."
.
I agree with your 2nd paragraph and think that Fauci is not one of those administration toadies and is being honest and has merely made a mistake perhaps brought about through grasping-at-straws desperation as described in a current SBM article.

I, as well, do not know why Fauci made the statement but to me it is very disrespectful of the man to use as an excuse that he is dishonest enough to lie like a toady when pressured by Trump.

I think we are essentially in agreement about this matter.
Have fun.

Denice Walter says: May 5, 2020 at 10:05 pm
re dysfunctional administration.. narcissistic bully et al

It seems that the aforementioned will now " wind down" the Covid task force ( The Hill reports) but Drs Fauci and Birx will still be involved in some capacity.

AS though the battle is already won. Hah! CA and the NY area are reporting lower numbers of deaths and hospital admissions BUT whilst
other areas are increasing theirs.

Maybe the Orange One imagines that if we discuss Covid less, people will think it's gone, go back to work, buy stuff and the economy will flourish. Ignore it and it'll go away. Wishful thinking as usual.

Joel A. Harrison, PhD, MPH says: May 5, 2020 at 10:55 pm
@ Chris Preston

Apparently you lack understanding of English. As I explained even grandfathered in medical treatments with no hard scientific evidence are considered the standard of care, that is, if a doctor uses them he/she lessens risk of lawsuits. Standard of care doesn't mean a high level of scientific validity.

I guess I am wasting my time. Think of it this way, if allowed for compassionate use advised by ones doctor, then doctor may not be protected against lawsuits. Unfortunately, as something I read a long time ago, even in Colonial times Americans would rather sue than eat breakfast. Just one more sickness of American exceptionalism, so maybe, just maybe, all Fauci was doing was trying to reduce this risk.

Tim says: May 5, 2020 at 10:56 pm
No shit???

https://www.youtube.com/embed/KzRhcjOG1es?version=3&rel=1&fs=1&autohide=2&showsearch=0&showinfo=1&iv_load_policy=1&wmode=transparent

At least, he had the googles on; Wouldn't want him to get fibres in his eyes.,

Aarno Syvänen says: May 6, 2020 at 12:34 am
Not to mention that CDC closed the lab. So CDC is not part of great vaccine conspiracy, after all. Huge news, I would say. One could mention, too, that Johnson & Johnson get COVID vaccine contract. So Dorit Reiss' plots are not very effective, ater all. Reply
Natalie White says: May 6, 2020 at 10:30 am
Aarno, you made me curious about how much $$$$ and how many companies. A list of the Convid19, oops, I mean Covid19 cash! https://www.fool.com/investing/2020/04/07/here-are-all-the-companies-working-on-covid-19-vac.aspx
Natalie White says: May 9, 2020 at 10:20 am
@Aarno- Sometimes the CDC gets it right and sometimes, well .. sometimes you can't truss it. https://arstechnica.com/science/2020/04/cdcs-failed-coronavirus-tests-were-tainted-with-coronavirus-feds-confirm/

https://www.youtube.com/embed/am9BqZ6eA5c

Natalie White says: May 9, 2020 at 11:47 am
Aarno writes, "Not to mention that CDC closed the lab." Yes, sometimes they get it right. Then, they fail miserably like this https://www.the-scientist.com/news-opinion/cdc-lab-contamination-delayed-coronavirus-testing-67438

Confidence meter less than zero.

Natalie White says: May 6, 2020 at 9:40 am
Hmm . Problems with the Wuhan Lab and those nasty bats back in 2018. Just another coincidence, I suppose. Weird. So many coincidences. https://www.washingtonpost.com/opinions/2020/04/14/state-department-cables-warned-safety-issues-wuhan-lab-studying-bat-coronaviruses/ Reply
Joel A. Harrison, PhD, MPH says: May 6, 2020 at 2:18 pm
@ Natalie White

You write: Hmm . Problems with the Wuhan Lab and those nasty bats back in 2018. Just another coincidence, I suppose. Weird. So many coincidences."

From a recent article in the Atlantic:

scientists have also identified about 500 other coronaviruses among China's many bat species. "There will be many more -- I think it's safe to say tens of thousands," says Peter Daszak of the EcoHealth Alliance, who has led that work. Laboratory experiments show that some of these new viruses could potentially infect humans. SARS-CoV-2 likely came from a bat, too.

It seems unlikely that a random bat virus should somehow jump into a susceptible human. But when you consider millions of people, in regular contact with millions of bats, which carry tens of thousands of new viruses, vanishingly improbable events become probable ones. In 2015, Daszak's team found that 3 percent of people from four Chinese villages that are close to bat caves had antibodies that indicated a previous encounter with SARS-like coronaviruses. "Bats fly out every night over their houses.

Some of them shelter from rain in caves, or collect guano for fertilizer," Daszak says. "If you extrapolate up to the rural population, across the region where the bats that carry these viruses live, you're talking 1 [million] to 7 million people a year exposed." Most of these infections likely go nowhere. It takes just one to trigger an epidemic.

Ed Yong (2020 Apr 29). Why the Coronavirus Is So Confusing. Available at: https://www.theatlantic.com/health/archive/2020/04/pandemic-confusing-uncertainty/610819/

Note. he links to peer-reviewed journal articles. So, as the second paragraph makes clear, antibodies to bat coronaviruses exist in the population, etc. Add this to the sequencing of the genome that shows just how close it is to the 2003 SARS corona virus and to bat coronaviruses and, as usual, your moronic "coincidences" just lacks any validity.

Note also that his article links to many other good ones.

As I've written before, nature is quite capable of creating really nasty microbes.

Natalie White says: May 6, 2020 at 10:17 am

Oh this guy needs a dishonorable mention, Harvard traitor, Charles Leiber. "has received more than $15,000,000 in grant funding from the National Institutes of Health (NIH) and Department of Defense (DOD)." Our tax dollars hard at work for this POS.

Dude is still collecting a paycheck. https://www.justice.gov/opa/pr/harvard-university-professor-and-two-chinese-nationals-charged-three-separate-china-related Reply

Aarno Syvänen says: May 6, 2020 at 11:00 am

This is our guy:
Charles M. Lieber
Semiconductor nanowires: A platform for nanoscience and nanotechnology
MRS Bulletin
Volume 36, Issue 12 (Laser micro- and nanofabrication of biomaterials)December 2011 , pp. 1052-1063
DOI: https://doi.org/10.1557/mrs.2011.26
So COVID 19 was not involved. One should indeed not serve two masters, DOD and a Chinese university Reply
Joel A. Harrison, PhD, MPH says: May 6, 2020 at 4:48 pm
@ Natalie White

You write: "Hmm . Problems with the Wuhan Lab and those nasty bats back in 2018. Just another coincidence, I suppose. Weird. So many coincidences."

From a recent article by Ed Yong (2020 Apr 29). "Why the Coronavirus Is So Confusing: A guide to making sense of a problem that is now too big for any one person to fully comprehend." The Atlantic. Available at: https://www.theatlantic.com/health/archive/2020/04/pandemic-confusing-uncertainty/610819/

Note that he links to a number of excellent articles, including the two that the following is based on:

"scientists have also identified about 500 other coronaviruses among China's many bat species. "There will be many more -- I think it's safe to say tens of thousands," says Peter Daszak of the EcoHealth Alliance, who has led that work. Laboratory experiments show that some of these new viruses could potentially infect humans. SARS-CoV-2 likely came from a bat, too.

It seems unlikely that a random bat virus should somehow jump into a susceptible human. But when you consider millions of people, in regular contact with millions of bats, which carry tens of thousands of new viruses, vanishingly improbable events become probable ones. In 2015, Daszak's team found that 3 percent of people from four Chinese villages that are close to bat caves had antibodies that indicated a previous encounter with SARS-like coronaviruses. "Bats fly out every night over their houses. Some of them shelter from rain in caves, or collect guano for fertilizer," Daszak says. "If you extrapolate up to the rural population, across the region where the bats that carry these viruses live, you're talking 1 [million] to 7 million people a year exposed." Most of these infections likely go nowhere. It takes just one to trigger an epidemic."

So, 3 percent of people had antibodies to bat corona viruses. As the above explains, it is quite probable that the current virus came from someone infected by a bat. Now, since sequencing of the current SARS-Cov-2 has found its genome quite close to the 2003 SARS virus and to several bat coronavirus genomes, goes against your sick need to blame the Chinese. A coincidence is not even close to any type of proof, except in the mind of a moron like you looking to place blame. And there is a great book on "coincidences": David J. Hand (2014). "The Improbability Principle: Why Coincidences, Miracles, and Rare Events Happen Every Day." Basically, what someone might think is a rare coincidence isn't.

And, the major blame for what is happening in the U.S. is a combination of Trump and overall American unappreciation for Public Health and, thus, pandemic preparedness. When it comes to cutting funding, first to go.

I realize that real research, logic, etc. have NO effect on moron's like you; but, hopefully, others monitoring this exchange are open-minded.

And as Aarno pointed out, you attacked someone who had nothing to do with COVID. He worked with the Wuhan Institute of Technology; yep, in Wuhan and that's it. It's a large city dimwit. More importantly, he has been charged, not found guilty. I realize that the old adage innocent until proven guilty doesn't apply to anyone you chose to attack. You just don't know when to stop. YOU ARE DESPICABLE! Reply

[May 07, 2020] The Puzzling Questions of the Coronavirus: A Doctor Addresses 6 Questions That Are Stumping Physicians

Notable quotes:
"... Originally published at The Conversation ..."
"... Editor's Note: As researchers try to find treatments and create a vaccine for COVID-19, doctors and others on the front lines continue to find perplexing symptoms. And the disease itself has unpredictable effects on various people. Dr. William Petri, a professor of medicine at the University of Virginia Medical School, answers questions about these confusing findings. ..."
"... Even before symptoms arise ..."
"... Differences in susceptibility to a virus is one of the main working hypotheses regarding the disease Chronic Fatigue Syndrome (a.k.a. myalgic encephalomyelitis (ME), and systemic exertion intolerance disease (SEID). ..."
"... It is possible that the virus is spreading within crowded and substandard apartment complexes. One possible mechanism? Toilets, as an outbreak of SARs in 2003 demonstrated: https://www.cnn.com/2013/02/21/world/asia/sars-amoy-gardens/index.html ..."
"... In addition in poorly maintained buildings just going out in the hallways to put out your garbage, for example, might well expose a home bound residents to viruses lingering on common surfaces. ..."
"... The city of Hong Kong is even more crowded than New York, but last I checked its virus deaths and hospitalizations were much lower. ..."
"... This link has the slides Cuomo used plus more details: https://www.cnbc.com/2020/05/06/ny-gov-cuomo-says-its-shocking-most-new-coronavirus-hospitalizations-are-people-staying-home.html ..."
"... some aspect of their domiciles, such as plumbing or ventilation; or are they permitting non-household individuals to visit them. ..."
"... It would be interesting to see if there is a connection between the virus and apartments/co-living. ..."
"... Indians and Pakistani's in particular seem to have been hit very hard in the UK, and yet the same can't be said in their home countries. ..."
"... The drug, made by the US company Gilead Sciences, is an antiviral that was trialled in Ebola, but which failed to show benefits in Africa. ..."
"... Here is a study on an early transmission site in China, where incidents of infection seem to correlate to ventilated air flow in a restaurant: COVID-19 Outbreak Associated with Air Conditioning in Restaurant, Guangzhou, China, 2020 https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article ..."
"... Here is a not-yet-reviewed preprint of a study of two buses transporting attendees to and from an event in China. One bus (#2) had a suspected "index patient" (IP), the other didn't. https://twitter.com/zeynep/status/1255579524047220741 ..."
"... Interestingly, the conference itself produced few further cases, these were all traced to prolonged interactions with the IP. Generally with viruses, some critical mass of virions must accumulate in sufficient number to produce infection, and total net exposure may approximately correlate with severity. Untreated recirculated air bearing virus-laden droplets may lead to repeated exposure and increase concentration of virions in individuals. ..."
May 07, 2020 | www.nakedcapitalism.com

Yves here. While a list of coronavirus "known unknowns" is useful, I imagine most readers would have focused on other questions, like "When will we know how much if any immunity you get from contracting the virus?" However, this article likely reflects issues that seem to be coming up in layperson discussions .which in turn reflects the informational nuggets that attract media attention.

Originally published at The Conversation

Editor's Note: As researchers try to find treatments and create a vaccine for COVID-19, doctors and others on the front lines continue to find perplexing symptoms. And the disease itself has unpredictable effects on various people. Dr. William Petri, a professor of medicine at the University of Virginia Medical School, answers questions about these confusing findings.

Some evidence suggests that patients experience low oxygen saturation days before they appear in the ER. If so, is there a way to treat patients earlier?

Even before symptoms arise, people infected with SARS-CoV-2 show damage to their lungs. This is likely why low oxygen saturation – that is, below-normal oxygen levels in their blood – occurs before the patient goes to the ER . Restoring those levels to normal is presumed, though not proven, to be beneficial; giving patients supplemental oxygen via a nasal cannula, a flexible tube that delivers oxygen, placed just inside the nostrils, will restore oxygen to normal levels unless disease worsens to the extent that mechanical ventilation is needed.

Young adults are having strokes with COVID-19. Does this suggest the illness is more of a vascular disease than a lung disease in that age group ?

COVID-19 can be a devastating disease to multiple organs and systems in the body, including the vascular and immune systems. A lung infection is the primary cause of disease and death. There are examples of the clotting system being activated and causing strokes, perhaps caused by an immune system responding abnormally to COVID-19 .

The Centers for Disease Control and Prevention recently updated its official list of symptoms. Does this suggest anything unusual about COVID-19?

This new information is due to a greater number of infected individuals being studied . The update simply reflects a better understanding of the full spectrum of illness due to COVID-19, from asymptomatic to presymptomatic to severe and fatal infections.

How can so many people experience such mild symptoms and others quickly die from it?

One of the most fascinating aspects of these diseases is the huge difference that individuals experience with an infection. In our own research, we have found that many children in the U.S. infected with cryptosporidia have no symptoms, yet this parasite is a major killer of infants in the developing world. After an infection of SARS-CoV-2, the severity of the illness is likely due in part to how the patient's immune system responds; an overzealous immune response may cause death through what is called colloquially a " cytokine storm. ." We do not know yet if cytokine storms occur more in one group than another – for example, older versus younger.

The disease appears now to affect various other organs – heart and kidney, for example. What does this suggest?

What we know most clearly is that infection starts only in human cells with the ACE2 receptor – that is, in a cell that is capable of receiving the virus. That is present not only in the lungs, but in other cells as well, including those in the intestine and in the nasal mucosa, which lines the nasal cavity. When those cells are infected, the immune system is activated. A consequence is that both the heart and kidney are affected.

Why are some countries not experiencing as much COVID-19 as the U.S., Europe and China?

I think it's too early in the pandemic to know if certain countries or populations are relatively less susceptible. The younger overall age of a population could be a primary factor. Or perhaps the virus, so far at least, has not had time to spread more widely in these countries.


PlutoniumKun , May 7, 2020 at 10:12 am

I'd add that the FT has a very good free to read article on the 'unknowns' around the virus: From Blood Clots to 'Covid Toe', the Medical Mysteries of Coronavirus.

The Rev Kev , May 7, 2020 at 10:25 am

The thing about this virus is that it seems to be the Swiss Army knife of the virus world. Instead of a simple virus, as time goes along you find out that it has all sorts of weird and damaging effects in all sorts of places. And that just because you get it does not mean that the won't get the next strain.

We aren't even sure how to treat it and financial interest are clouding the search for a treatment. It is like we just can't get a handle on just what this virus really is or just what it does to the human body.

Synoia , May 7, 2020 at 11:41 am

The Eco-sphere strikes back? There are a lot of humans to infect, appears to the virus as a bountiful place to inhabit.

Lee , May 7, 2020 at 10:34 am

Differences in susceptibility to a virus is one of the main working hypotheses regarding the disease Chronic Fatigue Syndrome (a.k.a. myalgic encephalomyelitis (ME), and systemic exertion intolerance disease (SEID).

The assumption is that the symptoms represent a relatively rare immune system over-reaction in a relatively small percentage of the population to a viruses that in the vast majority of persons is part of their normal viral load producing no symptoms.

Hana M , May 7, 2020 at 10:50 am

Yet another puzzling note on Coronavirus transmission. Sixty-six percent of coronavirus hospital admissions in New York in a recent study cited by Gov. Cuomo, were people who had been staying home. Most of the cases were elderly, and either retired or unemployed. The vast majority had other conditions. And African-Americans and Hispanics were disproportionately affected. My apologies for not linking to the original study–I'm still trying to track it down.

https://www.forbes.com/sites/lisettevoytko/2020/05/06/majority-of-new-coronavirus-cases-in-new-york-are-from-people-staying-at-home-not-traveling-or-working/#792178af1655

It is possible that the virus is spreading within crowded and substandard apartment complexes. One possible mechanism? Toilets, as an outbreak of SARs in 2003 demonstrated: https://www.cnn.com/2013/02/21/world/asia/sars-amoy-gardens/index.html

In addition in poorly maintained buildings just going out in the hallways to put out your garbage, for example, might well expose a home bound residents to viruses lingering on common surfaces.

Bob Hertz , May 7, 2020 at 10:54 am

The city of Hong Kong is even more crowded than New York, but last I checked its virus deaths and hospitalizations were much lower.

Hana M , May 7, 2020 at 4:26 pm

Hong Kong and New York are completely different on so many levels apart from population density. The differences are more instructive than the similarities. Hong Kong had a devastating experience with the SARs coronovirus epidemic in 2003 so they had a much clearer idea what they were dealing with; much of the early response (masks, increased social hygiene) was a bottom up response by people who had gone through it before.

https://www.straitstimes.com/asia/east-asia/coronavirus-sense-of-crisis-scars-from-sars-help-keep-cases-in-hong-kong-lower-than

The HK response to COVID-19 was also earlier, more targeted, both more draconian in some ways and much less so in others.

https://www.sfgate.com/science/article/How-Hong-Kong-kept-COVID-19-at-bay-15254007.php .

Still, the two apartment building outbreaks I've referenced in these threads both occurred in Hong Kong.

Hana M , May 7, 2020 at 10:58 am

This link has the slides Cuomo used plus more details: https://www.cnbc.com/2020/05/06/ny-gov-cuomo-says-its-shocking-most-new-coronavirus-hospitalizations-are-people-staying-home.html

Hana M , May 7, 2020 at 11:00 am

What a surprise! You're on your own, says Cuomo.

'"Much of this comes down to what you do to protect yourself. Everything is closed down, government has done everything it could, society has done everything it could. Now it's up to you," Cuomo said.'

IsabelPS , May 7, 2020 at 11:13 am

"How can so many people experience such mild symptoms and others quickly die from it?"

There seems to be another possibility, that SARS-CoV-2 can infect both the upper respiratory tract (like the coronavirus responsible for the common cold) and the lower respiratory tract, eventually causing pneumonia (like the SARS-CoV)

anon in so cal , May 7, 2020 at 12:38 pm

This is an alarming development, not least because anti lockdown GOP and Libertarian types have jumped on it to argue that the lockdowns are misguided. The news item raises many questions, such as, are the afflicted individuals getting the virus from groceries; some aspect of their domiciles, such as plumbing or ventilation; or are they permitting non-household individuals to visit them. Obviously, more detailed data are needed.

PlutoniumKun , May 7, 2020 at 11:02 am

It would be interesting to see if there is a connection between the virus and apartments/co-living.

The one thing for sure is that this virus is extremely contagious for those who are vulnerable. A colleague of mine cocooned himself with his two elderly parents in their detached suburban house at the very beginning of this, back in late February (he could see it coming). I know he was very cautious in order to protect them. But both his parents died from it over the last 2 weeks, and he is only just recovering from it. So far as I know, he has no idea how the infection got into the house.

Synoia , May 7, 2020 at 11:50 am

Is the address data for the death available? It would be interesting to look for correlation between Covid deaths and the ages of the apartment complex.

Hana M , May 7, 2020 at 12:53 pm

What a terrifying story! Really we are so far behind on the basic public health detective work and analysis that we need to do to beat this.

rtah100 , May 7, 2020 at 5:12 pm

We have been isolating since mid- March. All food delivered and disinfected, post heat-treated. Never eaten a healthier diet or taken more vitamins. Been out (beach and moor) just a handful of times, no contact, always hand sanitizer etc.

Nevertheless, still had three colds!

Viruses are damn infectious.

Also, pace the Kawasaki-like syndrome in children putatively linked to sars-cov-2, true Kawasaki syndrome has no known causal agent but it is believed to be infectious in origin because it is reliably linked to wind: when it blows from central Asia, cases spike in Japan and Hawaii.

Could Sars-cov-2 be hitching a ride on the wind / pollen and infecting people long distance?

Oso , May 7, 2020 at 12:20 pm

Hana M, good post and links

"It is possible that the virus is spreading within crowded and substandard apartment complexes. One possible mechanism? Toilets, as an outbreak of SARs in 2003 demonstrated"

brought to mind one of the possible causes among my community (field workers). porta pottys are badly maintained as well as in short supply. among the many hazards, also particle board living quarters where people sleep in shifts.

Oso , May 7, 2020 at 1:45 pm

you're welcome Hana M.
also, along similar lines a group of us here in oakland (with some city council buy in) are asking for a black new deal dealing with covid-19. demands are specific as well as linked to available funding. i'll share them if ur interested.

Oregoncharles , May 7, 2020 at 4:08 pm

We've been having groceries and other items delivered; one just arrived. This leads to a big disinfecting operation, focused on containers, sacks, etc. I even wash all the veggies before bringing them in. It's more trouble than doing the shopping was, but so far it's worked. We're healthy so far, salt over shoulder.

Fortunately there's minimal infection here, but it is present.

I'm just thinking if you DON'T disinfect the packaging and then your hands, you might well introduce the virus.

Ignacio , May 7, 2020 at 6:18 pm

Indeed, two weeks after a lockdown most hospitalizations must be originated in contagions inside houses or residential buildings where most direct or indirect contacts occur. This suggests that fomites-led contagions are important in Covid-19 transmission. During a lockdown, with very few getting in and out one should basically beware about touching things like doors, elevator buttons, or light switches rather than breathing contaminated air. In buildings with wealthy residents someone will be paid to keep all these surfaces clean once or twice a day but in less wealthy sites it has to be done by oneself.

cnchal , May 7, 2020 at 8:31 pm

> . . . Sixty-six percent of coronavirus hospital admissions in New York in a recent study cited by Gov. Cuomo, were people who had been staying home.

Anyone check if there is a stack of empty Amazon boxes in the corner? Every one of their warehouses has infected workers, and we all know how much people like to push the buy button and crack that whip.

Hana M , May 7, 2020 at 10:51 am

More on the toilet problem with technical notes and 'news you can use': https://waterandhealth.org/disinfect/preventing-infection/can-coronavirus-spread-through-defective-bathroom-sewage-pipes/

CuriosityConcern , May 7, 2020 at 10:58 am

I had a thought yesterday, and it probably has nothing to do with COVID19, but remember the vaping injuries to young people last year? What if those were early infections transmitted via infected vape devices or accessories? Points against this being true: didn't appear to be any spread among medical personnel treating the vape injury population.

Final verdict if I remember right was some form of vitamin e being in the vape liquid. Points in favor: I thought certain quarters were not satisfied with the vit e explanation. Just wild speculation on my part, but interesting idea, no?

Code Name D , May 7, 2020 at 3:37 pm

I remember hearing a roomer that smokers were more susceptible to covid. Not seen anything to support that though.

ShamanicFallout , May 7, 2020 at 4:12 pm

It is actually now appearing to be the opposite- smoking (and/or nicotine) is something of a prophylactic. There have been several links floating around here discussing this. Not sure how definite the conclusions though.

Also, I am untrained in any of this stuff, though have been following, but it seems that something that hits a small majority of people very hard, while so many seem to not even know they have it, says to me it's some specific genetic issue.

Hayek's Heelbiter , May 7, 2020 at 11:17 am

https://www.the-scientist.com/research-round-up/could-the-black-death-protect-against-hiv-54468

Strangely enough, one possible explanation of why ethnic minorities are more susceptible to Corona virus is the same reason that Northern Europeans seem to have greater resistance to HIV. Corona virus and HIV both are single-stranded RNA viruses. (And why remdesivir, effective against Ebola [a double-stranded RNA virus] is also showing effectiveness against Corona virus).

If you are alive today and have Northern European ancestry, they were quite likely survivors of the Black Death with a mutation that disables CCR-5 . It's Evolution 101.

Africa, Asia and the Americas were never exposed to the plague with the same virulence that Northern Europe was, and thus populations there did not develop the same level of of immunity that has lingered in people with Northern European ancestry.

As this is already a plausible theory for HIV, I have been unable to find the same research on Coronavirus as to whether people who are immune to it somehow have similarly disabled receptors on ACE-2.

Synoia , May 7, 2020 at 11:48 am

How could the two Black Death plagues, the 1347one and the 1665 affect your hypothesis?

I believe the 1347 plague was not brought to the west by sea, as it predates the Portuguese exploration of the sea route to the orient.

The Historian , May 7, 2020 at 12:03 pm

There are many good books on the Black Plague of 1347 and how it originated and spread. The most common theory is that it came with the Huns as they attacked shipping ports on the Black Sea which were connected to the overland shipping routes to China. Yes, Europe had trade with the Orient before the Portuguese rounded Africa. And then the ships in the Black Sea started bringing it west to ports in Italy and beyond.

For a simple yet historically accepted theory of the Black Plague, there is a well done course on Great Courses Plus, as well as a ton of written histories. Just search your favorite bookstore.

Harold , May 7, 2020 at 2:31 pm

By "Huns" do you mean Mongols? The disease is endemic to the grasslands of Mongolia and also the Western United States. Supposedly Genoese traders brought it to Constantinople from their ports in the Crimea, I thought.

The Historian , May 7, 2020 at 6:19 pm

Yes, it is probably more correct to call them Mongols because that is who they were fighting under, although some of the midieval historians that I have been reading called them Tartars and Huns, based on what tribes they belonged to. And Caffa, the city where the plague probably got its foothold, was both in Crimea and a port on the Black Sea. And yes, it did strike Constantinople first but since the topic was Europe proper, I just stated that ships brought it to Italy.

Hayek's Heelbiter , May 7, 2020 at 12:12 pm

https://www.scientificamerican.com/article/the-mutant-genes-behind-the-black-death/

https://www.sciencemag.org/news/2014/02/black-death-left-mark-human-genome

PlutoniumKun , May 7, 2020 at 1:01 pm

I'm not really convinced – for one thing I'd always understood that the Black Death did hit many other populations, they just weren't recorded so well (I can stand corrected by this, I don't know the latest research). It also doesn't explain why so far the home countries of those ethnicities that have been hit so hard in the west – East Asians, Iranians, SE Asians, have so far not been hit so hard by Covid. Indians and Pakistani's in particular seem to have been hit very hard in the UK, and yet the same can't be said in their home countries. This is why I suspect that a mix of socio economic (there is evidence that non-white healthcare workers are more likely to be put on the frontline), plus dietary/vitamin D related explanations may be stronger.

But its an interesting theory, nonetheless.

Synoia , May 7, 2020 at 1:28 pm

East Asians, Iranians, SE Asians, have so far not been hit so hard by Covid. Indians and Pakistani's in particular seem to have been hit very hard in the UK, and yet the same can't be said in their home countries.

Ambient Temperatures are very different, and there are some reports of less virulence in hotter climates.

PlutoniumKun , May 7, 2020 at 2:13 pm

Iran and a large chunk of Pakistan is actually quite cold in winter and early Spring. Tehran temperatures only went above a max of 20C in the last 2 weeks or so. Much of the temperature range of that region is not all that different from the inland cities of northern Italy and Spain.

HotFlash , May 7, 2020 at 4:53 pm

Indians and Pakistani's in particular seem to have been hit very hard in the UK, and yet the same can't be said in their home countries.

I wonder, are there differenced betw first or second generation immigrants? Age groups? Another factor that seems to correlate is vaccination for tuberculosis. The BCG vaccine (which is the only tuberculosis vaccine, although there are several strains and manufacturers of it) is mandatory in a number of countries, including India and Pakistan. Some countries never did it, and others have ended or limited their TB vaccination programs as cases of TB diminished.

There are lots of variables to work out -- lockdown, distancing, age of population, co-morbidities, yada yada. But just doing a deeper dive into Spain is interesting. Universal vaccination program started in 1965 for all newborns, no booster, and stopped in 1981, except for at-risk children. So that is a cohort of approx 49 to 55 year olds vaccinated. It would be interesting to see if the mortality rate was different in that group. Bonus! Basque region children are automatically considered 'at-risk' and have been vaccinated up to present! We have a control group! Would love to see data on that.

Here are the charts, people, go crazy. 91-divoc , this is deaths normalized for population, and the BCG World Atlas .

Bsoder , May 7, 2020 at 2:27 pm

Too bad Evolution 101 or 202 is not taught in red states, just not how god does things.

Science Officer Smirnoff , May 7, 2020 at 4:02 pm

Reply to Hayek's Heelbiter
May 7, 2020 at 11:17 am
On remdesivir:
The drug, made by the US company Gilead Sciences, is an antiviral that was trialled in Ebola, but which failed to show benefits in Africa. -- The Guardian Thu 23 Apr 2020 15.35 EDT
[emphasis added]

Hayek's Heelbiter , May 7, 2020 at 6:55 pm

https://en.wikipedia.org/wiki/Remdesivir
Nevertheless (emphasis mine)

As an adenosine nucleotide triphosphate analog, the active metabolite of remdesivir interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease its predominant effect (as in Ebola) is to induce an irreversible chain termination. Unlike with many other chain terminators, this is not mediated by preventing addition of the immediately subsequent nucleotide, but is instead delayed, occurring after five additional bases have been added to the growing RNA chain.[56] Hence remdesivir is classified as a delayed chain terminator.

[56] Tchesnokov EP, Feng JY, Porter DP, Götte M (April 2019). "Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir". Viruses. 11 (4): 326. doi:10.3390/v11040326. PMC 6520719. PMID 30987343.

Carolinian , May 7, 2020 at 1:01 pm

A useful discussion of the models versus evidence schools of epidemiology. While the evidence school sounds a lot more like science, the models school currently has the upper hand given the emergency nature of the response. Are they "assuming a can opener?"

https://bostonreview.net/science-nature/jonathan-fuller-models-v-evidence

Cuibono , May 7, 2020 at 1:17 pm

My questions

  1. how important is asymptomatic transmission?
  2. what is the relative importance of different locales of transmission
  3. does prior SARS infection provide protection

Ignacio , May 7, 2020 at 6:50 pm

Your first two questions are unfortunately very difficult to address.

I think asymptomatic or nearly asymptomatic direct transmission is very important when there is not awareness of disease in the community. Then, there is fomites-led transmission which is even more elusive than asymptomatic direct transmission. So, when you detect someone with symptoms in a community if then everyone is tested it is almost certain some more will show positive. A couple of days later some many more will. So when first symptoms appear everyone must be isolated from each other, clean all surfaces, masks mandatory, and if the community includes some medical and other care full protection by and for the providers. Suddenly the community transforms into something resembling a military camp in wartime.

What i find most difficult is to decide what discipline to keep BEFORE the first case appears.

John k , May 7, 2020 at 2:03 pm

Everybody's different, flu only kills a very small fraction, granted elderly get shots. Maybe some differences are nutritional.

My thought is that there is a wide variety of vitamin d and zinc levels in those that get the virus, and that low levels worsen the outcome. And maybe nicotine also provides protection.

Diets low in red meat and oysters typically mean low zinc, plus local soils may be low, too I saw an indication North American soils are generally low. Poor people on cheap diets likely get little red meat. Hiding inside means low vit d, plus many seniors like me anyway seek shade to avoid harmful rays. And most living seniors stopped smoking, so no nicotine input.

I take vit d, plus zinc in a multi, have zinc lozenges on hand if I get symptoms, and if they worsen would add nicotine patch.

Bsoder , May 7, 2020 at 2:32 pm

American soils remain the richest in the world. Zinc would be a mineral and mined. There's no evidence based data to indicate for people in general zinc going to do anything. But if makes you happy sure why not. I'd ask my doc for a blood test on minerals and a vitamin panel. Then you'd know.

rd , May 7, 2020 at 7:31 pm

It is a function of regional geology. The northern US and Canada were largely glaciated and the soils are very recent (<100,000 years old) and so have not leached their nutrients and miinerals out. The rolling farmed plains of Western NY, OH, IL, KS, NE, etc. are glacial till plains or old glacial lakebeds. The Russian steppes are similar. Much of the major floodplains come from such soils and are rich as well (e.g. Mississippi).

Much of the South and California are old soils that are classified as "residual", basically bedrock weathered in place with a lot of leaching over hundreds of thousands or millions of years. These regions often have limited crops that can be grown or require a lot of fertilizer and maintenance. The same issues hold true for much ot the tropics (the reason why the Amazon rainforest has slash and burn agriculture to open up new areas that are temporarily rich.

Bob , May 7, 2020 at 2:39 pm

Regarding why are some countries not experiencing as much COVID-19 as the U.S., Europe and China, my personal non-scientifcally vetted opinion is that this this virus spreads indoors. Fresh air, ozone and UV radiation are all natural disinfectants. Outdoors, coughs and sneezes are dispersed via the wind.

This could also explain why the disease is concentrated in urban settings like NYC, present in warm weather locations like Singapore and implies it won't necessarily go away come the summer. On the other hand, the poorest citizens in the poorest countries spend a lot of time outdoors and don't seem to be as hard hit. Though this has been attributed to a lack of testing, their homes aren't hermetically sealed and climate controlled like those in the US, Europe or China which I believe leads to a lower infection rate. That being said, people who live in urban slums are certainly vulnerable.

Moshe Braner , May 7, 2020 at 3:59 pm

There is also the issue, recently somewhat in the news, of different genetic variants of the virus. I've heard the claim that that explains why NY has been hit harder than the US West Coast – that the variant in NY supposedly came from Italy, while the West Coast got it from China. Of course they also spend more time outdoors on the West Coast than in NY, especially in February.

WhoaMolly , May 7, 2020 at 3:40 pm

I wonder if air conditioning systems could be contributing to infections by recirculating the air inside buildings.

My reasoning:

rd , May 7, 2020 at 7:33 pm

Commercial real estate is probably going to have to increase their fresh air exchange and potentially install electrostatic filters if they don't have them. Without that, offices are likely to be unhealthy.

neo-realist , May 7, 2020 at 10:05 pm

Offices have been unhealthy, air wise, for years. We just cough, hack, adapt, deal.

dk , May 7, 2020 at 7:41 pm

The short answer is yes.

The term for the motile form of a virus is virion , one or more strands for RNA (of DNA but SARS-CoV-19 is RNA) enclosed in a fatty lipid capsule ("capsid"), usually with protruding receptors with which the virion can attach to and inject it RNA strand into a host cell. Coronaviruses have characteristically prominent "spikes," receptors that extend beyond the capsid surface.

Basically, virions are little blobs of fat. When exposed directly to air they quickly rancidify and the exposed RNA strand disintegrates. Riding air pollution particles is possible but unlikely, as many of these kinds of particles have surfaces antagonistic to the fatty capsid. However, exhaled particulate droplets suspended in air can pass through coarse filtration. HEPA filters are designed to trap such droplets, UV irradiation can "cook" them.

Here is a study on an early transmission site in China, where incidents of infection seem to correlate to ventilated air flow in a restaurant: COVID-19 Outbreak Associated with Air Conditioning in Restaurant, Guangzhou, China, 2020 https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article

The Figure 1 illustration helps to visualize this: https://wwwnc.cdc.gov/eid/article/26/7/20-0764-f1

Here is a not-yet-reviewed preprint of a study of two buses transporting attendees to and from an event in China. One bus (#2) had a suspected "index patient" (IP), the other didn't. https://twitter.com/zeynep/status/1255579524047220741

From the article: "In both buses and conference rooms, central air-conditioners were in indoor re-circulation mode."

Interestingly, the conference itself produced few further cases, these were all traced to prolonged interactions with the IP. Generally with viruses, some critical mass of virions must accumulate in sufficient number to produce infection, and total net exposure may approximately correlate with severity. Untreated recirculated air bearing virus-laden droplets may lead to repeated exposure and increase concentration of virions in individuals.

[May 07, 2020] As of a few weeks ago in one NJ hospital Plaquenil (hydroxychloroquine) was the standard treatment, along with azithromycin and zinc which is the most common protocol.

May 07, 2020 | turcopolier.typepad.com

Valissa , 06 May 2020 at 06:03 PM

Eakens, thanks for the link to the Plandemic video! I was chatting with my sister today and she recommended it as well.

BTW, my sister is a nurse in NJ in a hospital about 60 mi south of NYC near the shore. Several wards in her hospital were converted to ICUs to handle the influx of covid patients, so I have been asking her what meds they are given. As of a few weeks ago Plaquenil (hydroxychloroquine) was the standard treatment, along with azithromycin and zinc which is the most common protocol. Most patients are getting this and to quote her directly: "It's standard treatment and saving lives daily." She is perplexed by the politicization. While she is a conservative, the great majority of her coworkers are not.

The other two standard treatments added more recently to their covid protocols are tocizulamab (IL-6) and plasma with antibodies.

Here is a recent article on the tocizulamb, which I had never heard of before my sister mentioned it.

https://www.msn.com/en-us/health/medical/tocilizumab-drug-shows-coronavirus-treatment-promise-doctor-says/ar-BB13HNun

optimax , 06 May 2020 at 11:23 PM
Teachers want their students back in the classroom before they start thinking for themselves. (drum roll). The NYT published a letter from a middle school girl who says she learns better, faster and deeper, distance learning than in class. Teachers have to spend too much time dealing with disruptive knuckleheads. Teachers didn't put up with any crap when I went to school.

Doctors that use hydroxychloroquine as a covid treatment report up to a 90% success rate, and works best when given early. On the other hand, the ebola wonder drug shortens the hospital stay from 15 to 11 days. I don't understand Ain't So Bright's, and many of the "experts," dismissal of of what treating physicians report an effective treatment in favor of one that less effictive. I trust the observations of the doctors on the ground more than some office dweller reading numbers, the most important ones being those in his paycheck.