The clock frequency in the range of 2.2-2.6 GHz makes the Opteron is an interesting alternative for RISC CPU including Sun UltraSparc and IBM Power5. Some claims that it was Opteron that sunk Intel Itanics :-) The HyperTransport interconnection improves the efficiency of  SMP-type clusters. A very large (over 11,000 processor) Opteron cluster with the HyperTransport facility, the Red Storm system, has been built at Sandia National Laboratory by Cray Inc.